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  1. Article ; Online: Effect of Lactate on Epigenetic Regulation in the Development of Hepatitis B Virus-related Hepatocellular Carcinoma.

    Mahmoudvand, Shahab / Shokri, Somayeh

    Journal of clinical and translational hepatology

    2022  Volume 10, Issue 5, Page(s) 786–787

    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2022.00274
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  2. Article: The possibility of hepatitis C reactivation in COVID-19 patients treated with corticosteroids.

    Shokri, Somayeh / Mahmoudvand, Shahab

    Annals of hepatology

    2022  Volume 27, Issue 4, Page(s) 100704

    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; Antiviral Agents/adverse effects ; COVID-19 ; Hepacivirus/genetics ; Hepatitis B Surface Antigens ; Hepatitis B virus/physiology ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Humans ; Virus Activation
    Chemical Substances Adrenal Cortex Hormones ; Antiviral Agents ; Hepatitis B Surface Antigens
    Language English
    Publishing date 2022-04-06
    Publishing country Mexico
    Document type Letter
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.1016/j.aohep.2022.100704
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6221: Show issues Location:
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  3. Article ; Online: The possibility of hepatitis C reactivation in COVID-19 patients treated with corticosteroids

    Somayeh Shokri / Shahab Mahmoudvand

    Annals of Hepatology, Vol 27, Iss 4, Pp 100704- (2022)

    2022  

    Keywords Specialties of internal medicine ; RC581-951
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Interactions between SARS coronavirus 2 papain-like protease and immune system: A potential drug target for the treatment of COVID-19.

    Mahmoudvand, Shahab / Shokri, Somayeh

    Scandinavian journal of immunology

    2021  Volume 94, Issue 4, Page(s) e13044

    Abstract: Coronaviruses (CoVs) are a large family of respiratory viruses which can cause mild to moderate upper respiratory tract infections. Recently, new coronavirus named as Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified which ... ...

    Abstract Coronaviruses (CoVs) are a large family of respiratory viruses which can cause mild to moderate upper respiratory tract infections. Recently, new coronavirus named as Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified which is a major threat to public health. Innate immune responses play a vital role in a host's defence against viruses. Interestingly, CoVs have evolved elaborate strategies to evade the complex system of sensors and signalling molecules to suppress host immunity. SARS-CoV-2 papain-like protease (PLpro), as an important coronavirus enzyme, regulates viral spread and innate immune responses. SCoV-2 PLpro is multifunctional enzyme with deubiquitinating (DUB) and deISGylating activity. The PLpro can interact with key regulators in signalling pathways such as STING, NF-κB, cytokine production, MAPK and TGF-β and hijack those to block the immune responses. Therefore, the PLpro can be as an important target for the treatment of COVID-19. Until now, several drugs or compounds have been identified that can inhibit PLpro activity. Here we discuss about the dysregulation effects of PLpro on immune system and drugs that have potential inhibitors for SCoV-2 PLpro.
    MeSH term(s) Antiviral Agents/administration & dosage ; Antiviral Agents/immunology ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/virology ; Coronavirus Papain-Like Proteases/immunology ; Coronavirus Papain-Like Proteases/metabolism ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; Immune System/immunology ; Immune System/metabolism ; NF-kappa B/immunology ; NF-kappa B/metabolism ; Protein Binding/drug effects ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism ; SARS-CoV-2/physiology ; Viral Proteins/immunology ; Viral Proteins/metabolism
    Chemical Substances Antiviral Agents ; Cytokines ; NF-kappa B ; Viral Proteins ; Coronavirus Papain-Like Proteases (EC 3.4.22.2) ; papain-like protease, SARS-CoV-2 (EC 3.4.22.2)
    Language English
    Publishing date 2021-08-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/sji.13044
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Prevalence of Epstein-barr Virus (EBV) among Patients with Oral Squamous Cell Carcinoma from Ahvaz, Iran: A Case-Control Study.

    Habibollah, Mirzaei / Azarakhsh, Azaran / Shahab, Mahmoudvand / Somayeh, Shokri / Shahram, Bagheri / Ali, Ramezani / Shahram, Jalilian

    Archives of Razi Institute

    2023  Volume 78, Issue 5, Page(s) 1495–1502

    Abstract: Epstein-Barr virus (EBV), one of the most significant causes of lymphoid and epithelial cancers, has been linked to oral carcinogenesis; however, this etiological association remains controversial. To investigate this association, the present study aimed ...

    Abstract Epstein-Barr virus (EBV), one of the most significant causes of lymphoid and epithelial cancers, has been linked to oral carcinogenesis; however, this etiological association remains controversial. To investigate this association, the present study aimed to determine the prevalence of EBV in cancerous and non-cancerous oral tissues from Ahvaz, Iran. In total, 164 blocks of formalin-fixed paraffin-embedded tissues from oral squamous cell carcinoma (OSCC), including 76 tongue squamous cell carcinomas and 88 non-cancerous tongue tissues, were collected from Ahvaz Imam Khomeini Hospital, Ahvaz, Iran, from December 2014 to March 2019, for this case-control study. The tissues were cut into 15-μm-thick sections, and DNA was extracted using a solution of Phenol, Chloroform, and Isoamyl Alcohol. The EBV detection and typing were performed using nested polymerase chain reaction. The EBV was detected in 9 (5.48%) out of the 164 samples studied, including 4 (5.26%) of the 76 SCC cases and 5 (5.68%) of the 88 samples in the control group (P>0.05). The EBV was positive in 2.40% of the 83 male and 8.6% of the 81 female samples (P>0.05). In terms of the histological grades of the case group, 3 (3/57) and 1 (1/13) of the EBV-positive samples were well and moderately differentiated, respectively (P>0.05). For EBV typing, the 9 EBV-positive samples were tested, and it was found that 2 and 7 of the cases were EBV type I and II, respectively. Results of the current study demonstrated the low frequency of EBV in Iranian patients with OSCC, with EBV type II predominating. Further studies are required to clarify the association between EBV and OSCC.
    MeSH term(s) Humans ; Male ; Female ; Herpesvirus 4, Human/genetics ; Squamous Cell Carcinoma of Head and Neck ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/veterinary ; Carcinoma, Squamous Cell/genetics ; Iran/epidemiology ; Mouth Neoplasms/epidemiology ; Mouth Neoplasms/veterinary ; Mouth Neoplasms/genetics ; Epstein-Barr Virus Infections/epidemiology ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/pathology ; Case-Control Studies ; Prevalence ; Head and Neck Neoplasms
    Language English
    Publishing date 2023-10-31
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2555498-0
    ISSN 2008-9872 ; 0365-3439
    ISSN (online) 2008-9872
    ISSN 0365-3439
    DOI 10.22092/ARI.2023.78.5.1495
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  6. Article ; Online: Design of a multi-epitope-based vaccine consisted of immunodominant epitopes of structural proteins of SARS-CoV-2 using immunoinformatics approach.

    Mahmoudvand, Shahab / Esmaeili Gouvarchin Ghaleh, Hadi / Jalilian, Farid Azizi / Farzanehpour, Mahdieh / Dorostkar, Ruhollah

    Biotechnology and applied biochemistry

    2023  Volume 70, Issue 3, Page(s) 1189–1205

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown rapid global spread and has resulted in a significant death toll worldwide. In this study, we aimed to design a multi-epitope vaccine against SARS-CoV-2 based on structural proteins S, ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown rapid global spread and has resulted in a significant death toll worldwide. In this study, we aimed to design a multi-epitope vaccine against SARS-CoV-2 based on structural proteins S, M, N, and E. We identified B- and T-cell epitopes and then the antigenicity, toxicity, allergenicity, and similarity of predicted epitopes were analyzed. T-cell epitopes were docked with corresponding HLA alleles. Consequently, the selected T- and B-cell epitopes were included in the final construct. All selected epitopes were connected with different linkers and flagellin and pan-HLA DR binding epitopes (PADRE) as an adjuvant were used in the vaccine construct. Furthermore, molecular docking was used to evaluate the complex between the final vaccine construct and two alleles, HLA-A*02:01 and HLA-DRB1*01:01. Finally, codons were optimized for in silico cloning into pET28a(+) vector using SnapGene. The final vaccine construct comprised 11 CTL, HTL, and B-cell epitopes corresponding to 394 amino acid residues. In silico evaluation showed that the designed vaccine might potentially promote an immune response. Further in vivo preclinical and clinical testing is required to determine the safety and efficacy of the designed vaccine.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19/prevention & control ; Immunodominant Epitopes/genetics ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/chemistry ; Epitopes, B-Lymphocyte/genetics ; Epitopes, B-Lymphocyte/chemistry ; COVID-19 Vaccines/genetics ; Molecular Docking Simulation ; Computational Biology/methods
    Chemical Substances Immunodominant Epitopes ; Epitopes, T-Lymphocyte ; Epitopes, B-Lymphocyte ; COVID-19 Vaccines
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 883433-7
    ISSN 1470-8744 ; 0885-4513
    ISSN (online) 1470-8744
    ISSN 0885-4513
    DOI 10.1002/bab.2431
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1865: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Long noncoding RNAs in respiratory viruses: A review.

    Kesheh, Mina Mobini / Mahmoudvand, Shahab / Shokri, Somayeh

    Reviews in medical virology

    2021  Volume 32, Issue 2, Page(s) e2275

    Abstract: Long noncoding RNAs (lncRNAs) are defined as RNA molecules longer than 200 nucleotides that can regulate gene expression at the transcriptional or post-transcriptional levels. Both human lncRNAs and lncRNAs encoded by viruses can modulate the expression ... ...

    Abstract Long noncoding RNAs (lncRNAs) are defined as RNA molecules longer than 200 nucleotides that can regulate gene expression at the transcriptional or post-transcriptional levels. Both human lncRNAs and lncRNAs encoded by viruses can modulate the expression of host genes which are critical for viral replication, latency, activation of signalling pathways, cytokine and chemokine production, RNAi processing, expression of interferons (IFNs) and interferon-stimulated genes (ISGs). Studies on lncRNAs as key regulators of host-virus interactions may give new insights into therapeutic strategies for the treatment of related diseases. This current review focuses on the role of lncRNAs, and their interactions with respiratory viruses including influenza A virus (IAV), respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
    MeSH term(s) COVID-19 ; Humans ; Influenza A virus/genetics ; Interferons/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; SARS-CoV-2/genetics ; Virus Replication
    Chemical Substances RNA, Long Noncoding ; Interferons (9008-11-1)
    Language English
    Publishing date 2021-07-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1086043-5
    ISSN 1099-1654 ; 1052-9276
    ISSN (online) 1099-1654
    ISSN 1052-9276
    DOI 10.1002/rmv.2275
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3308: Show issues Location:
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  8. Article ; Online: Interplay between cellular metabolism and DNA viruses.

    Zandi, Milad / Shokri, Somayeh / Mahmoudvand, Shahab / Hosseinzadeh Adli, Ahmad / Mohammadi, Ramin / Haddadi, Azita

    Journal of medical virology

    2022  Volume 94, Issue 11, Page(s) 5163–5173

    Abstract: Viruses as intracellular pathogens take over the host metabolism and reprogram to facilitate optimal virus production. DNA viruses can cause alterations in several metabolic pathways, including aerobic glycolysis also known as the Warburg effect, pentose ...

    Abstract Viruses as intracellular pathogens take over the host metabolism and reprogram to facilitate optimal virus production. DNA viruses can cause alterations in several metabolic pathways, including aerobic glycolysis also known as the Warburg effect, pentose phosphate pathway activation, and amino acid catabolism such as glutaminolysis, nucleotide biosynthesis, lipid metabolism, and amino acid biosynthesis. The available energy for productive infection can be increased in infected cells via modification of different carbon source utilization. This review discusses the metabolic alterations of the DNA viruses that will be the basis for future novel therapeutic approaches.
    MeSH term(s) Amino Acids ; DNA Viruses ; Glycolysis/physiology ; Humans ; Metabolic Networks and Pathways ; Virus Replication ; Viruses/genetics
    Chemical Substances Amino Acids
    Language English
    Publishing date 2022-07-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28018
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: A comprehensive review of highly pathogenic avian influenza (HPAI) H5N1: An imminent threat at doorstep.

    Charostad, Javad / Rezaei Zadeh Rukerd, Mohammad / Mahmoudvand, Shahab / Bashash, Davood / Hashemi, Seyed Mohammad Ali / Nakhaie, Mohsen / Zandi, Keivan

    Travel medicine and infectious disease

    2023  Volume 55, Page(s) 102638

    Abstract: Avian influenza viruses (AIVs) are globally challenging due to widespread circulation and high mortality rates. Highly pathogenic avian influenza (HPAI) strains like H5N1 have caused significant outbreaks in birds. Since 2003 to 14 July 2023, the World ... ...

    Abstract Avian influenza viruses (AIVs) are globally challenging due to widespread circulation and high mortality rates. Highly pathogenic avian influenza (HPAI) strains like H5N1 have caused significant outbreaks in birds. Since 2003 to 14 July 2023, the World Health Organization (WHO) has documented 878 cases of HPAI H5N1 infection in humans and 458 (52.16%) fatalities in 23 countries. Recent outbreaks in wild birds, domestic birds, sea lions, minks, and etc., and the occurrence of genetic variations among HPAI H5N1 strains raise concerns about potential transmission and public health risks. This paper aims to provide a comprehensive overview of the current understanding and new insights into HPAI H5N1. It begins with an introduction to the significance of studying this virus and highlighting the need for updated knowledge. The origin and evaluation of HPAI H5N1 are examined, shedding light on its emergence, and spread across different geographic regions. The genome organization and structural biology of the H5N1 virus are explored, providing insights into its molecular composition and key structural features. This manuscript also delves into the phylogeny, evolution, mutational trends, reservoirs, and transmission routes of HPAI H5N1. The immune response against HPAI H5N1 and its implications for vaccine development are analyzed, along with an exploration of the pathogenesis and clinical manifestations of HPAI H5N1 in human cases. Furthermore, diagnostic tools and preventive and therapeutic strategies are discussed, highlighting the current approaches and potential future directions for better management of the potential pandemic.
    Language English
    Publishing date 2023-08-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2023.102638
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    Zs.A 6236: Show issues Location:
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  10. Article: NBS superfood: a promising adjunctive therapy in critically ill ICU patients with omicron variant of COVID-19.

    Mosadegh, Mehrdad / Khalkhali, Aref / Erfani, Yousef / Nezamdoost, Manije / Hashemi, Seyyed Hamid / Azizi Jalilian, Farid / Ansari, Nastaran / Mahmoudvand, Shahab / Mamani, Mojgan / Abdoli, Elham / Amini, Razieh / Kalvandi, Gholamreza

    AMB Express

    2024  Volume 14, Issue 1, Page(s) 33

    Abstract: This clinical trial aimed to assess the impact of Nutrition Bio-shield superfood (NBS) on clinical status among critically ill ICU patients suffering from acute respiratory distress syndrome (ARDS) due to the Omicron variant of COVID-19. A total of 400 ... ...

    Abstract This clinical trial aimed to assess the impact of Nutrition Bio-shield superfood (NBS) on clinical status among critically ill ICU patients suffering from acute respiratory distress syndrome (ARDS) due to the Omicron variant of COVID-19. A total of 400 patients with confirmed Omicron-related ARDS were randomly assigned to either the intervention group (n = 200) or the control group (n = 200). Patients in the intervention group received 1.5 g of NBS powder daily for 2 weeks in addition to standard antiviral treatment, while the control group received a placebo alongside standard antiviral therapy. Serum samples were collected from all patients in both groups, and various clinical and laboratory parameters, including ESR, CRP, D-Dimer, CPK, WBC count, lymphocyte count, and lymphocyte percentage, were measured using established methodologies. Following a 14-day intervention period, the intervention group exhibited a significant reduction in mean serum levels of CRP (15.39 vs. 48.49; P < 0.001), ESR (14.28 vs. 34.03; P < 0.001), D-Dimer (485.18 vs. 1009.13; P = 0.001), and CPK (68.93 vs. 131.48; P < 0.001) compared to the control group. Conversely, a significant increase was observed in the mean serum levels of lymphocytes (1537.06 vs. 1152.60; P < 0.001) in the intervention group after 14 days of treatment compared to the control group. The remarkable reduction in inflammatory markers and mortality rates observed with NBS supplementation alongside standard antiviral treatment underscores its crucial role in mitigating inflammation and achieving an important milestone in the fight against COVID-19.
    Language English
    Publishing date 2024-03-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2621432-5
    ISSN 2191-0855
    ISSN 2191-0855
    DOI 10.1186/s13568-024-01690-8
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