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Book ; Online ; E-Book: The Computational Mechanics of Bone Tissue

Belinha, Jorge / Manzanares-Céspedes, Maria-Cristina / Completo, António M. G.

Biological Behaviour, Remodelling Algorithms and Numerical Applications

(Lecture Notes in Computational Vision and Biomechanics, ; 35)

2020

Abstract: This book offers a timely snapshot of computational methods applied to the study of bone tissue. The bone, a living tissue undergoing constant changes, responds to chemical and mechanical stimuli in order to maximize its mechanical performance. Merging ... ...

Author's details	edited by Jorge Belinha, Maria-Cristina Manzanares-Céspedes, António M. G. Completo
Series title	Lecture Notes in Computational Vision and Biomechanics, ; 35 Lecture notes in computational vision and biomechanics
Collection	Lecture notes in computational vision and biomechanics
Abstract	This book offers a timely snapshot of computational methods applied to the study of bone tissue. The bone, a living tissue undergoing constant changes, responds to chemical and mechanical stimuli in order to maximize its mechanical performance. Merging perspectives from the biomedical and the engineering science fields, the book offers some insights into the overall behavior of this complex biological tissue. It covers three main areas: biological characterization of bone tissue, bone remodeling algorithms, and numerical simulation of bone tissue and adjacent structures. Written by clinicians and researchers, and including both review chapters and original research, the book offers an overview of the state-of-the-art in computational mechanics of bone tissue, as well as a good balance of biological and engineering methods for bone tissue analysis. An up-to-date resource for mechanical and biomedical engineers seeking new ideas, it also promotes interdisciplinary collaborations to advance research in the field.
Keywords	Regenerative medicine ; Tissue engineering ; Biomedical engineering ; Mechanical engineering ; Computer mathematics ; Regenerative Medicine/Tissue Engineering ; Biomedical Engineering and Bioengineering ; Biomedical Engineering/Biotechnology ; Mechanical Engineering ; Computational Science and Engineering
Subject code	612.75
Language	English
Size	1 online resource (XIV, 241 p. 68 illus., 45 illus. in color.)
Edition	1st ed. 2020.
Publisher	Springer International Publishing ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-37541-2 ; 3-030-37540-4 ; 978-3-030-37541-6 ; 978-3-030-37540-9
DOI	10.1007/978-3-030-37541-6
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Cannabidiol regulates behavioral and brain alterations induced by spontaneous alcohol withdrawal.

Gasparyan, Ani / Navarrete, Francisco / Navarro, Daniela / Manzanares, Jorge

Neuropharmacology

2023 Volume 233, Page(s) 109549

Abstract: The main goal of this study was to evaluate if the administration of cannabidiol (CBD) regulates behavioral and gene expression alterations induced by spontaneous alcohol withdrawal (SAW) in mice. Increasing doses of ethanol were administered to C57BL/6J ...

Abstract	The main goal of this study was to evaluate if the administration of cannabidiol (CBD) regulates behavioral and gene expression alterations induced by spontaneous alcohol withdrawal (SAW) in mice. Increasing doses of ethanol were administered to C57BL/6J male mice for 15 days (2.5, 3 and 3.5 g/kg/12 h, p. o.), and SAW was studied at 6, 12, 24, and 72 h after the last ethanol administration. The efficacy of acute CBD (10, 20, and 40 mg/kg, i. p.) to regulate behavioral changes induced by SAW was explored at 6 h. Gene expression analyses of cannabinoid receptors 1 (Cnr1) and 2 (Cnr2), mu-opioid receptor (Opmr1), and proopiomelanocortin (Pomc) in the nucleus accumbens (NAcc), and Pomc and tyrosine hydroxylase (Th) in the ventral tegmental area (VTA), were carried out by real time-PCR. Pearson correlation was used to identify potential associations between the gene expression data and the anxiety-like behaviors. Biostatistical studies suggest associations between gene expression data and the anxiogenic behaviors in mice exposed to the SAW model and treated with VEH and 40 mg/kg of CBD. Mice exposed to the SAW model showed significant somatic withdrawal signs, anxiety-like behaviors, and remarkable changes in the gene expression of all brain targets at 6 h. CBD dose-dependently normalized the behavioral, somatic withdrawal signs and anxiety-like behaviors and modulated gene expression changes in the NAcc, but not in the VTA. The results of this study suggest that CBD may regulate specific alcohol withdrawal-associated alterations. However, further studies are required to explore the possible mechanisms involved.
MeSH term(s)	Male ; Animals ; Mice ; Cannabidiol/pharmacology ; Alcoholism/drug therapy ; Alcoholism/metabolism ; Pro-Opiomelanocortin/metabolism ; Substance Withdrawal Syndrome/metabolism ; Mice, Inbred C57BL ; Brain/metabolism ; Ventral Tegmental Area/metabolism ; Ethanol
Chemical Substances	Cannabidiol (19GBJ60SN5) ; Pro-Opiomelanocortin (66796-54-1) ; Ethanol (3K9958V90M)
Language	English
Publishing date	2023-04-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2023.109549
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Article: Editorial: The Search for Biomarkers in Psychiatry.

Garcia-Gutierrez, Maria S / Manzanares, Jorge / Navarrete, Francisco

Frontiers in psychiatry

2021 Volume 12, Page(s) 720411

Language	English
Publishing date	2021-07-12
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2021.720411
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Article: Editorial: Cannabidiol treatment in neurotherapeutic interventions, volume II.

Gonzalez-Cuevas, Gustavo / Navarrete, Francisco / Garcia-Gutierrez, Maria S / de Guglielmo, Giordano / Manzanares, Jorge

Frontiers in pharmacology

2023 Volume 14, Page(s) 1163991

Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1163991
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Article ; Online: CBD-mediated regulation of heroin withdrawal-induced behavioural and molecular changes in mice.

Navarrete, Francisco / Gasparyan, Ani / Manzanares, Jorge

Addiction biology

2022 Volume 27, Issue 2, Page(s) e13150

Abstract: Cannabidiol (CBD) may represent a promising therapeutic tool for treating opioid use disorder (OUD). This study was aimed to evaluate the effects of CBD on the behavioural and gene expression alterations induced by spontaneous heroin withdrawal. Thirty ... ...

Abstract	Cannabidiol (CBD) may represent a promising therapeutic tool for treating opioid use disorder (OUD). This study was aimed to evaluate the effects of CBD on the behavioural and gene expression alterations induced by spontaneous heroin withdrawal. Thirty hours after cessation of 8-day heroin treatment (5, 10, 20 and 40 mg·kg
MeSH term(s)	Animals ; Cannabidiol/pharmacology ; Heroin/metabolism ; Heroin/pharmacology ; Male ; Mice ; Nucleus Accumbens ; Substance Withdrawal Syndrome/metabolism ; Ventral Tegmental Area/metabolism
Chemical Substances	Cannabidiol (19GBJ60SN5) ; Heroin (70D95007SX)
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1324314-7
ISSN	1369-1600 ; 1355-6215
ISSN (online)	1369-1600
ISSN	1355-6215
DOI	10.1111/adb.13150
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Article: Unveiling behavioral and molecular neuroadaptations related to the antidepressant action of cannabidiol in the unpredictable chronic mild stress model.

García-Gutiérrez, María Salud / Navarro, Daniela / Austrich-Olivares, Amaya / Manzanares, Jorge

Frontiers in pharmacology

2023 Volume 14, Page(s) 1171646

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1171646
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Article ; Online: Pharmacological strategies for post-traumatic stress disorder (PTSD): From animal to clinical studies.

Gasparyan, Ani / Navarro, Daniela / Navarrete, Francisco / Manzanares, Jorge

Neuropharmacology

2022 Volume 218, Page(s) 109211

Abstract: Post-traumatic stress disorder (PTSD) is a disabling psychiatric condition with a critical familiar, personal, and social impact. Patients diagnosed with PTSD show various symptoms, including anxiety, depression, psychotic episodes, and sleep ... ...

Abstract	Post-traumatic stress disorder (PTSD) is a disabling psychiatric condition with a critical familiar, personal, and social impact. Patients diagnosed with PTSD show various symptoms, including anxiety, depression, psychotic episodes, and sleep disturbances, complicating their therapeutic management. Only sertraline and paroxetine, two selective serotonin reuptake inhibitors, are approved by different international agencies to treat PTSD. In addition, these drugs are generally combined with psychotherapy to achieve positive results. However, these pharmacological strategies present limited efficacy. Nearly half of the PTSD patients do not experience remission of symptoms, possibly due to the high prevalence of psychiatric comorbidities. Therefore, in clinical practice, other off-label medications are common, even though the effectiveness of these drugs needs to be further investigated. In this line, antipsychotics, antiepileptics, adrenergic blockers, benzodiazepines, and other emerging pharmacological agents have aroused interest as potential therapeutic tools to improve some specific symptoms of PTSD. Thus, this review is focused on the most widely used drugs for the pharmacological treatment of PTSD with a translational approach, including clinical and preclinical studies, to emphasize the need to develop safer and more effective medications.
MeSH term(s)	Animals ; Anxiety Disorders/drug therapy ; Paroxetine ; Serotonin Uptake Inhibitors/therapeutic use ; Sertraline/therapeutic use ; Stress Disorders, Post-Traumatic/drug therapy
Chemical Substances	Serotonin Uptake Inhibitors ; Paroxetine (41VRH5220H) ; Sertraline (QUC7NX6WMB)
Language	English
Publishing date	2022-08-13
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2022.109211
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Article: Cannabidiol and Sertraline Regulate Behavioral and Brain Gene Expression Alterations in an Animal Model of PTSD.

Gasparyan, Ani / Navarrete, Francisco / Manzanares, Jorge

Frontiers in pharmacology

2021 Volume 12, Page(s) 694510

Abstract: This study evaluated the effects of cannabidiol (CBD) and/or sertraline (STR) on behavioral and gene expression alterations induced by a new chronic animal model of post-traumatic stress disorder (PTSD). C57BL/6J male mice were repeatedly exposed to ... ...

Abstract	This study evaluated the effects of cannabidiol (CBD) and/or sertraline (STR) on behavioral and gene expression alterations induced by a new chronic animal model of post-traumatic stress disorder (PTSD). C57BL/6J male mice were repeatedly exposed to physical and psychogenic alternate stressful stimuli. Fear-related memory and anxiety-like behaviors were evaluated. The effects of the administration of CBD (20 mg/kg, i.p.) and/or STR (10 mg/kg, p.o.) were analyzed on behavioral and gene expression changes induced by the model of PTSD. Gene expression alterations of targets related with stress regulation, endocannabinoid and serotonergic systems were analyzed by real-time PCR. The results revealed an increased and long-lasting fear-related memory and anxiety-like behaviors in mice exposed to the animal model of PTSD. Treatment with CBD improved these behaviors in PTSD animals, effects that were significantly potentiated when combined with STR. Gene expression analyses revealed a long-term increase of corticotropin releasing factor (
Language	English
Publishing date	2021-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.694510
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Article ; Online: Regulation of Cortico-Thalamic JNK1/2 and ERK1/2 MAPKs and Apoptosis-Related Signaling Pathways in PDYN Gene-Deficient Mice Following Acute and Chronic Mild Stress.

Yáñez-Gómez, Fernando / Ramos-Miguel, Alfredo / García-Sevilla, Jesús A / Manzanares, Jorge / Femenía, Teresa

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: The crosstalk between the opioidergic system and mitogen-activated protein kinases (MAPKs) has a critical role in mediating stress-induced behaviors related to the pathophysiology of anxiety. The present study evaluated the basal status and stress- ... ...

Abstract	The crosstalk between the opioidergic system and mitogen-activated protein kinases (MAPKs) has a critical role in mediating stress-induced behaviors related to the pathophysiology of anxiety. The present study evaluated the basal status and stress-induced alterations of cortico-thalamic MAPKs and other cell fate-related signaling pathways potentially underlying the anxiogenic endophenotype of PDYN gene-deficient mice. Compared to littermates, PDYN knockout (KO) mice had lower cortical and or thalamic amounts of the phospho-activated MAPKs c-Jun N-terminal kinase (JNK1/2) and extracellular signal-regulated kinase (ERK1/2). Similarly, PDYN-KO animals displayed reduced cortico-thalamic densities of total and phosphorylated (at Ser191) species of the cell fate regulator Fas-associated protein with death domain (FADD) without alterations in the Fas receptor. Exposure to acute restraint and chronic mild stress stimuli induced the robust stimulation of JNK1/2 and ERK1/2 MAPKs, FADD, and Akt-mTOR pathways, without apparent increases in apoptotic rates. Interestingly, PDYN deficiency prevented stress-induced JNK1/2 and FADD but not ERK1/2 or Akt-mTOR hyperactivations. These findings suggest that cortico-thalamic MAPK- and FADD-dependent neuroplasticity might be altered in PDYN-KO mice. In addition, the results also indicate that the PDYN gene (and hence dynorphin release) may be required to stimulate JNK1/2 and FADD (but not ERK1/2 or Akt/mTOR) pathways under environmental stress conditions.
MeSH term(s)	Mice ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/physiology ; Apoptosis/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Mitogen-Activated Protein Kinase Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Phosphorylation ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2023-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032303
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Article ; Online: The administration of sertraline plus naltrexone reduces ethanol consumption and motivation in a long-lasting animal model of post-traumatic stress disorder.

Gasparyan, Ani / Navarrete, Francisco / Manzanares, Jorge

Neuropharmacology

2021 Volume 189, Page(s) 108552

Abstract: This study was aimed to evaluate the effects of sertraline (STR) and/or naltrexone (NTX) on ethanol consumption and motivation in an animal model of post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD). Male C57BL/6J mice were submitted ... ...

Abstract	This study was aimed to evaluate the effects of sertraline (STR) and/or naltrexone (NTX) on ethanol consumption and motivation in an animal model of post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD). Male C57BL/6J mice were submitted to an intermittent and progressively increasing stressful stimuli simulating PTSD behavioural features. Behavioural alterations were explored by the fear conditioning (FC), novelty suppressed feeding test (NSFT) and acoustic startle response (ASR) paradigms. Afterwards, mice were evaluated in the voluntary ethanol consumption (VC) and the oral ethanol self-administration (OEA) paradigms. The effects of STR (10 mg/kg) and/or NTX (0.7 mg/kg) on ethanol consumption and motivation were analysed in the OEA. Furthermore, relative gene expression analyses of tyrosine hydroxylase (Th), mu-opioid receptor (Oprm1) and 5-hydroxitryptamine transporter (Slc6a4) were performed in the ventral tegmental area (VTA), nucleus accumbens (NAcc) and dorsal raphe nucleus (DR), respectively. PTSD-like mice presented increased fear-related memory, anxiety-like behaviours, and startle response, as well as enhanced ethanol consumption and motivation in the VC and OEA paradigms. Interestingly, STR plus NTX combination significantly reduced ethanol intake and motivation in the OEA. Gene expression analyses revealed reduced Th and Oprm1 whereas Slc6a4 gene expression increased in PTSD-like mice. STR and/or NTX modulated Th and Slc6a4 gene expression changes in PTSD-like mice. Furthermore, NTX increased Oprm1 gene expression revealing a synergistic action when combined with STR. These results provide evidence about the efficacy of the STR plus NTX to attenuate ethanol reinforcement and motivation in an animal model of PTSD and AUD dual pathology.
MeSH term(s)	Alcohol Deterrents/administration & dosage ; Alcohol Drinking/drug therapy ; Alcohol Drinking/metabolism ; Alcohol Drinking/psychology ; Animals ; Antidepressive Agents/administration & dosage ; Disease Models, Animal ; Drug Therapy, Combination ; Male ; Mice ; Mice, Inbred C57BL ; Motivation/drug effects ; Motivation/physiology ; Naltrexone/administration & dosage ; Self Administration ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Sertraline/administration & dosage ; Stress Disorders, Post-Traumatic/drug therapy ; Stress Disorders, Post-Traumatic/metabolism ; Stress Disorders, Post-Traumatic/psychology ; Stress, Psychological/drug therapy ; Stress, Psychological/metabolism ; Stress, Psychological/psychology ; Time Factors
Chemical Substances	Alcohol Deterrents ; Antidepressive Agents ; Serotonin Plasma Membrane Transport Proteins ; Slc6a4 protein, mouse ; Naltrexone (5S6W795CQM) ; Sertraline (QUC7NX6WMB)
Language	English
Publishing date	2021-04-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2021.108552
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