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  1. Article ; Online: Real-world evidence of the association between blood pressure elevation and coronary artery disease and stroke in Japan.

    Kai, Hisashi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 5, Page(s) 1073–1074

    MeSH term(s) Humans ; Coronary Artery Disease/epidemiology ; Blood Pressure ; Japan/epidemiology ; Stroke/epidemiology ; Stroke/etiology ; Hypertension/epidemiology ; Autonomic Nervous System Diseases
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-01156-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3898: Show issues Location:
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  2. Article: [Multiorgan Thromboembolism due to Thrombus in the Remnant Superior Pulmonary Vein After Left Upper Division Segmentectomy:Report of a Case].

    Mizobuch, Kai / Matsuoka, Hisashi / Yamada, Ryo / Yoshida, Mitsuteru / Tanida, Nobuyuki

    Kyobu geka. The Japanese journal of thoracic surgery

    2024  Volume 77, Issue 1, Page(s) 72–75

    Abstract: A 67 years old male had underwent left upper division segmentectomy. On the sixth day after surgery, he had developed unconsciousness, aphasia and unilateral spatial neglect. Brain MRI revealed a cerebral infarction, and percutaneous cerebral ... ...

    Abstract A 67 years old male had underwent left upper division segmentectomy. On the sixth day after surgery, he had developed unconsciousness, aphasia and unilateral spatial neglect. Brain MRI revealed a cerebral infarction, and percutaneous cerebral thrombectomy was performed. Enhanced computed tomography revealed thrombus formation in the remnant superior pulmonary vein (SPV), left renal infarction and right acute limb ischemia. After starting anticoagulant therapy with apixaban the thrombus reduced and neurological symptoms improved. A thrombus in the SPV may cause serious whole body organ infarction in the same way as a left atrial thrombus. It was suggested that left upper division segmentectomy was associated with the risk of remnant pulmonary vein thrombosis.
    MeSH term(s) Humans ; Male ; Aged ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/surgery ; Pneumonectomy/methods ; Lung Neoplasms/surgery ; Thromboembolism/surgery ; Thrombosis/surgery ; Infarction
    Language Japanese
    Publishing date 2024-03-11
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Renin angiotensin (RA) system inhibitors in Patients with COVID-19]

    Kai, Hisashi

    Japan Medical Journal

    Abstract: The novel coronavirus disease 2019 (COVID-19) pandemic that appeared suddenly in Wuhan, Hubei Province, China, at the end of 2019 and quickly swept the world, has continued to increase with more than 13 4 million people infected and 580,000 deaths as of ... ...

    Abstract The novel coronavirus disease 2019 (COVID-19) pandemic that appeared suddenly in Wuhan, Hubei Province, China, at the end of 2019 and quickly swept the world, has continued to increase with more than 13 4 million people infected and 580,000 deaths as of July 16, 2020 There is no way to see the end of the disease With the lifting of the declaration of a state of emergency, however, the number of cases in Japan is on the rise again, particularly in urban areas such as Tokyo, although the number of cases decreased in May It has been hypothesized that renin-angiotensin (RA) inhibitors, such as angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors, may increase the risk of COVID-19 infection and adversely affect the severity of the disease and mortality in the COVID-19 epidemic It has spread not only to doctors, but also to patients and the general public via the Internet and mass media I am sure I am not the only one who feared that this hypothesis, if true, would be a serious problem I would like to consider the possibility of a second or third wave, and how to deal with RA inhibitors as the era of with COVID-19 is expected to continue for a long time to come
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #684414
    Database COVID19

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  4. Article ; Online: Anti-hypertensive medication adherence in the REQUIRE trial: post-hoc exploratory evaluation.

    Kario, Kazuomi / Kai, Hisashi / Nanto, Shinsuke / Yokoi, Hiroyoshi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 8, Page(s) 2044–2047

    Abstract: Maintaining medication adherence is important in treating hypertension, especially resistant hypertension (RH), and variable medication adherence can confound results in blood pressure trials. This post-hoc analysis evaluated adherence at baseline and 3 ... ...

    Abstract Maintaining medication adherence is important in treating hypertension, especially resistant hypertension (RH), and variable medication adherence can confound results in blood pressure trials. This post-hoc analysis evaluated adherence at baseline and 3 months using available urine samples from the REQUIRE trial, comparing 24-h ambulatory systolic blood pressure (ASBP) lowering effects of ultrasound renal denervation (uRDN) versus sham in RH. At baseline, 45% (26/58) patients showed poor adherence. Among patients with good baseline adherence, adherence was unchanged at 3 months, and uRDN patients had a decreased ASBP whereas sham patients did not. In poorly adherent patients, sham patients showed a trend towards increased adherence and a significant ASBP reduction, whereas uRDN patients did not change. Accordingly, adherence changes and the resultant ASBP reduction in poorly adherent sham patients may explain the lack of between-group difference seen in REQUIRE. Monitoring and maintaining medication adherence is important for future interventional studies in RH.
    MeSH term(s) Humans ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Blood Pressure/physiology ; Blood Pressure Monitoring, Ambulatory ; Hypertension ; Hypotension ; Kidney ; Medication Adherence ; Prospective Studies ; Sympathectomy/methods ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01333-8
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  5. Article ; Online: Blood pressure management in patients with type 2 diabetes mellitus.

    Kai, Hisashi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2017  Volume 40, Issue 8, Page(s) 721–729

    Abstract: Hypertension aggravates macrovascular and microvascular diseases and mortality in patients with type 2 diabetes mellitus (T2DM). The current Japanese Society of Hypertension Guidelines of the Management of Hypertension (JSH 2014) recommends that ... ...

    Abstract Hypertension aggravates macrovascular and microvascular diseases and mortality in patients with type 2 diabetes mellitus (T2DM). The current Japanese Society of Hypertension Guidelines of the Management of Hypertension (JSH 2014) recommends that antihypertensive medication should be initiated concomitantly with lifestyle modification when blood pressure (BP) is ⩾130/80 mm Hg and that target levels of office and home BP should be <130/80 mm Hg and <125/75 mm Hg, respectively, in T2DM patients. Considering more favorable metabolic profiles and renoprotective effects than other classes of antihypertensive agents, angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers are recommended as the first-line therapy for patients with hypertension and T2DM in JSH 2014. However, the target BP and the first-line therapy remain controversial because of the paucity of high-quality evidence with consistency. It is suggested that BP management should be tailored for each patient with T2DM, based on tolerability and considerations of comorbidity.
    Language English
    Publishing date 2017-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/hr.2017.55
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  6. Article ; Online: Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors-lessons from available evidence and insights into COVID-19.

    Kai, Hisashi / Kai, Mamiko

    Hypertension research : official journal of the Japanese Society of Hypertension

    2020  Volume 43, Issue 7, Page(s) 648–654

    Abstract: The rapid spread of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to an ongoing pandemic of coronavirus disease 2019 (COVID-19). Recently, angiotensin-converting enzyme 2 (ACE2) has been shown to be a ... ...

    Abstract The rapid spread of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to an ongoing pandemic of coronavirus disease 2019 (COVID-19). Recently, angiotensin-converting enzyme 2 (ACE2) has been shown to be a functional receptor for SARS-CoV-2 to enter host target cells. Given that angiotensin receptor blockers (ARBs) and an ACE inhibitor (ACEI) upregulated ACE2 expression in animal studies, the concern might arise regarding whether ARBs and ACEIs would increase the morbidity and mortality of COVID-19. On the other hand, animal data suggested a potential protective effect of ARBs against COVID-19 pneumonia because an ARB prevented the aggravation of acute lung injury in mice infected with SARS-CoV, which is closely related to SARS-CoV-2. Importantly, however, there is no clinical or experimental evidence supporting that ARBs and ACEIs either augment the susceptibility to SARS-CoV-2 or aggravate the severity and outcomes of COVID-19 at present. Until further data are available, it is recommended that ARB and ACEI medications be continued for the treatment of patients with cardiovascular disease and hypertension, especially those at high risk, according to guideline-directed medical therapy based on the currently available evidence.
    MeSH term(s) Angiotensin II/physiology ; Angiotensin Receptor Antagonists/adverse effects ; Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Animals ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/etiology ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/physiology ; Pneumonia, Viral/etiology ; SARS-CoV-2
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Angiotensin II (11128-99-7) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Ace2 protein, mouse (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-020-0455-8
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  7. Article: [Hypertension: The Points of Management of Hypertensions--Based on the JSH 2014 Hypertension Guidelines--. Topics: IV. Treatment for hypertension associated with cerebrovascular disease/heart disease].

    Kai, Hisashi

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2015  Volume 104, Issue 2, Page(s) 232–239

    MeSH term(s) Antihypertensive Agents/therapeutic use ; Cerebrovascular Disorders/complications ; Cerebrovascular Disorders/therapy ; Heart Diseases/complications ; Heart Diseases/therapy ; Humans ; Hypertension/complications ; Hypertension/therapy ; Japan ; Practice Guidelines as Topic ; Stroke/drug therapy
    Chemical Substances Antihypertensive Agents
    Language Japanese
    Publishing date 2015-11-12
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.104.232
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  8. Article: [Intercostal Lung Hernia after Minimally Invasive Cardiac Surgery (MICS)-Aortic Valve Replacement (AVR) Surgery].

    Nanjo, Kazumasa / Matsuoka, Hisashi / Mizobuchi, Kai / Yoshida, Mitsuteru / Tanida, Nobuyuki

    Kyobu geka. The Japanese journal of thoracic surgery

    2023  Volume 76, Issue 3, Page(s) 201–204

    Abstract: A 51 years old male had underwent aortic valve replacement (AVR) by minimally invasive cardiac surgery (MICS) for aortic regurgitation. About one year after the surgery, bulging of the wound and pain appeared. His chest computed tomography showed an ... ...

    Abstract A 51 years old male had underwent aortic valve replacement (AVR) by minimally invasive cardiac surgery (MICS) for aortic regurgitation. About one year after the surgery, bulging of the wound and pain appeared. His chest computed tomography showed an image of the right upper lobe protruding from the thoracic cavity through the right second intercostal space, and the patient was diagnosed as having an intercostal lung hernia and the surgical treatment was performed using a unsintered hydroxyapatite and poly-L-lactide (u-HA/PLLA) mesh plate and monofilament polypropylene (PP) mesh. Postoperative course was uneventful without any evidence of recurrence.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency ; Thoracic Cavity ; Polypropylenes ; Cardiac Surgical Procedures ; Hernia/diagnostic imaging ; Hernia/etiology
    Chemical Substances hydroxyapatite-polylactide ; Polypropylenes
    Language Japanese
    Publishing date 2023-02-27
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
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  9. Article: [Blood pressure variability-induced aggravation of hypertensive organ damages].

    Kai, Hisashi

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73, Issue 11, Page(s) 1939–1945

    Abstract: There is increasing evidence that not only the elevation of systolic and diastolic blood pressure(BP) but also the increase in BP variability (or fluctuation) are associated with hypertensive organ damages and the morbidity and mortality of ... ...

    Abstract There is increasing evidence that not only the elevation of systolic and diastolic blood pressure(BP) but also the increase in BP variability (or fluctuation) are associated with hypertensive organ damages and the morbidity and mortality of cerebrovascular and cardiovascular events, as well as cognitive dysfunction. However, the molecular mechanism whereby the increase in BP variability aggravates hypertensive organ damages remains unknown. Thus, we created a rat chronic model of a combination of hypertension and large BP variability by performing bilateral sino-aortic denervation in spontaneously hypertensive rat. A series of our studies using this model revealed that large BP variability induces chronic myocardial inflammation by activating local angiotensin II and mineralocorticoid receptor systems and thereby aggravates cardiac hypertrophy and myocardial fibrosis, leading to systolic dysfunction, in hypertensive hearts. In addition, large BP variability induces the aggravation of arteriolosclerotic changes and ischemic cortical fibrosis in hypertensive kidney via local angiotensin II system. It is interesting that the initial target sites of the large BP variability are the intramyocardial arterioles in the heart and pre-glomerular arterioles in the juxtamedullary renal cortex, so called "strain vessels". Accordingly, we advocate new concept that the large BP-induced aggravation of hypertensive organ damage is attributable to "strain vessel vasculopathy".
    MeSH term(s) Animals ; Blood Pressure ; Blood Pressure Determination ; Humans ; Hypertension/complications ; Time Factors
    Language Japanese
    Publishing date 2015-11
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19

    Kai, Hisashi / Kai, Mamiko

    Hypertension Research

    2020  Volume 43, Issue 7, Page(s) 648–654

    Keywords Internal Medicine ; Physiology ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1175297-x
    ISSN 0916-9636
    ISSN 0916-9636
    DOI 10.1038/s41440-020-0455-8
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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