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  1. Article: Circulating Levels of Monocytic Myeloid-Derived Suppressor Cells (M-MDSC) and CXCL-8 in Non-Small Cell Lung Cancer (NSCLC).

    Zadian, Seyed Sajjad / Adcock, Ian M / Salimi, Babak / Mortaz, Esmaeil

    Tanaffos

    2021  Volume 20, Issue 1, Page(s) 15–21

    Abstract: ... monocytic (M-MDSCs) and their expansion play a role in cancer progression. Recruitment to the cancer site ... of serum CXCL8 was measured by the ELISA method.: Results: The frequency of circulating M-MDSCs was ... Conclusion: Our data confirm a higher frequency of circulating M-MDSCs, but not G-MDSCs, in the blood ...

    Abstract Background: Myeloid-derived suppressor cells (MDSC) are categorized as granulocytic (G-MDSCs) and monocytic (M-MDSCs) and their expansion play a role in cancer progression. Recruitment to the cancer site depends upon the presence of a chemoattractant. We aimed to investigate the presence of MDSC subtypes and of interleukin-8 (CXCL-8) in the peripheral blood in lung cancer subtypes including non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients.
    Materials and methods: Peripheral blood samples of 26 NSCLC patients, 18 SCLC patients, and 8 healthy control donors (HDs) were harvested and the surface expression of CD14, CD15, CD11b, and HLA-DR on MDSCs was measured using flow cytometry. The level of serum CXCL8 was measured by the ELISA method.
    Results: The frequency of circulating M-MDSCs was significantly higher in patients with NSCLC than in SCLC and HDs. In contrast, there was no statistical difference concerning the frequency of circulating G-MDSCs between the three groups. The concentration of CXCL-8 was significantly higher in the NSCLC and SCLC patients than in HD control with no significant difference between NSCLC and SCLC groups. There was no correlation between serum CXCL8 and G-MDSC levels.
    Conclusion: Our data confirm a higher frequency of circulating M-MDSCs, but not G-MDSCs, in the blood of those suffering from NSCLC but not for SCLC cases. Measuring MDSC subtypes and serum chemotactic factors may have implications for the differential diagnosis of NSCLC.
    Language English
    Publishing date 2021-07-27
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2233372-1
    ISSN 1735-0344
    ISSN 1735-0344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: CC16: A Treatable Trait in Asthma?

    Bloom, Chloe I / Adcock, Ian M

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 7, Page(s) 745–746

    Language English
    Publishing date 2023-08-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202307-1255ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Widespread dissemination of CTX-M-15 genotype extended-spectrum-β-lactamase-producing enterobacteriaceae among patients presenting to community hospitals in the southeastern United States.

    Chen, Luke F / Freeman, Joshua T / Nicholson, Brad / Keiger, Anna / Lancaster, Sarah / Joyce, Maria / Woods, Christopher W / Cook, Evelyn / Adcock, Linda / Louis, Susan / Cromer, Andrea L / Sexton, Daniel J / Anderson, Deverick J

    Antimicrobial agents and chemotherapy

    2013  Volume 58, Issue 2, Page(s) 1200–1202

    Abstract: ... Virginia from 2010 to 2012. Fifty-three (80%) ESBL-producing isolates contained CTX-M enzymes; CTX-M-15 was ... the commonest type of E. coli, accounting for 48% of CTX-M-15-producing and 66% of CTX-M-14-producing isolates ... In conclusion, the CTX-M genotype and ST131 E. coli were common among ESBL isolates from U.S ...

    Abstract Extended-spectrum-β-lactamase (ESBL)-producing organisms are increasingly prevalent. We determined the characteristics of 66 consecutive ESBL-producing isolates from six community hospitals in North Carolina and Virginia from 2010 to 2012. Fifty-three (80%) ESBL-producing isolates contained CTX-M enzymes; CTX-M-15 was found in 68% of Escherichia coli and 73% of Klebsiella isolates. Sequence type 131 (ST131) was the commonest type of E. coli, accounting for 48% of CTX-M-15-producing and 66% of CTX-M-14-producing isolates. In conclusion, the CTX-M genotype and ST131 E. coli were common among ESBL isolates from U.S. community hospitals.
    MeSH term(s) Aged ; Aged, 80 and over ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology ; Escherichia coli/classification ; Escherichia coli/genetics ; Escherichia coli/isolation & purification ; Gene Expression ; Hospitals, Community ; Humans ; Klebsiella/classification ; Klebsiella/genetics ; Klebsiella/isolation & purification ; Middle Aged ; Multilocus Sequence Typing ; North Carolina/epidemiology ; Virginia/epidemiology ; beta-Lactamases/genetics
    Chemical Substances beta-lactamase CTX-M-15 (EC 3.5.2.-) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2013-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01099-13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  4. Article ; Online: MicroRNAs in Human Disease: Commentary.

    M Adcock, Ian / Mumby, Sharon

    Iranian journal of allergy, asthma, and immunology

    2021  Volume 20, Issue 3, Page(s) 259–262

    Abstract: This letter to the editor has not an abstract. ...

    Abstract This letter to the editor has not an abstract.
    MeSH term(s) Humans ; MicroRNAs
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2021-06-06
    Publishing country Iran
    Document type Editorial ; Comment
    ZDB-ID 2488724-9
    ISSN 1735-5249 ; 1735-1502
    ISSN (online) 1735-5249
    ISSN 1735-1502
    DOI 10.18502/ijaai.v20i3.6341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Recent evidence from omic analysis for redox signalling and mitochondrial oxidative stress in COPD.

    Mumby, Sharon / Adcock, Ian M

    Journal of inflammation (London, England)

    2022  Volume 19, Issue 1, Page(s) 10

    Abstract: COPD is driven by exogenous and endogenous oxidative stress derived from inhaled cigarette smoke, air pollution and reactive oxygen species from dysregulated mitochondria in activated inflammatory cells within the airway and lung. This is compounded by ... ...

    Abstract COPD is driven by exogenous and endogenous oxidative stress derived from inhaled cigarette smoke, air pollution and reactive oxygen species from dysregulated mitochondria in activated inflammatory cells within the airway and lung. This is compounded by the loss in antioxidant defences including FOXO and NRF2 and other antioxidant transcription factors together with various key enzymes that attenuate oxidant effects. Oxidative stress enhances inflammation; airway remodelling including fibrosis and emphysema; post-translational protein modifications leading to autoantibody generation; DNA damage and cellular senescence. Recent studies using various omics technologies in the airways, lungs and blood of COPD patients has emphasised the importance of oxidative stress, particularly that derived from dysfunctional mitochondria in COPD and its role in immunity, inflammation, mucosal barrier function and infection. Therapeutic interventions targeting oxidative stress should overcome the deleterious pathologic effects of COPD if targeted to the lung. We require novel, more efficacious antioxidant COPD treatments among which mitochondria-targeted antioxidants and Nrf2 activators are promising.
    Language English
    Publishing date 2022-07-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2164385-4
    ISSN 1476-9255
    ISSN 1476-9255
    DOI 10.1186/s12950-022-00308-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A mechanistic insight into severe COPD: the nose as a surrogate for the airways.

    Yao, Xin / Adcock, Ian M / Mumby, Sharon

    ERJ open research

    2023  Volume 9, Issue 6

    Abstract: A severe COPD signature in bronchial and nasal epithelial cells reflects reduced tissue repair and ECM ... ...

    Abstract A severe COPD signature in bronchial and nasal epithelial cells reflects reduced tissue repair and ECM regulation
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Editorial
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00647-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Peripheral nerve stimulation: A neuromodulation-based approach.

    Luckey, Alison M / Adcock, Katherine / Vanneste, Sven

    Neuroscience and biobehavioral reviews

    2023  Volume 149, Page(s) 105180

    Abstract: Recent technological improvements have positioned us at the threshold of innovative discoveries that will assist in new perspectives and avenues of research. Increased attention has been directed towards peripheral nerve stimulation, particularly of the ... ...

    Abstract Recent technological improvements have positioned us at the threshold of innovative discoveries that will assist in new perspectives and avenues of research. Increased attention has been directed towards peripheral nerve stimulation, particularly of the vagus, trigeminal, or greater occipital nerve, due to their unique pathway that engages neural circuits within networks involved in higher cognitive processes. Here, we question whether the effects of transcutaneous electrical stimulation are mediated by synergistic interactions of multiple neuromodulatory networks, considering this pathway is shared by more than one neuromodulatory system. By spotlighting this attractive transcutaneous pathway, this opinion piece aims to acknowledge the contributions of four vital neuromodulators and prompt researchers to consider them in future investigations or explanations.
    MeSH term(s) Humans ; Transcutaneous Electric Nerve Stimulation ; Vagus Nerve/physiology ; Vagus Nerve Stimulation ; Head ; Attention
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2023.105180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1371: Show issues Location:
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  8. Article ; Online: Wound healing and pain sensitivity following caustic paste disbudding in dairy calves.

    Drwencke, Alycia M / Adcock, Sarah J J / Tucker, Cassandra B

    Journal of dairy science

    2023  Volume 106, Issue 9, Page(s) 6375–6387

    Abstract: Caustic paste disbudding is increasing in popularity on commercial dairy farms in the United States, but little research has explored the pain and welfare implications beyond the acute period of this procedure. In contrast, researchers have reported it ... ...

    Abstract Caustic paste disbudding is increasing in popularity on commercial dairy farms in the United States, but little research has explored the pain and welfare implications beyond the acute period of this procedure. In contrast, researchers have reported it takes 7 to 9 wk, on average, for hot-iron disbudding wounds to re-epithelialize in dairy calves. Our objective was to describe wound healing and sensitivity following caustic paste disbudding. Jersey and Holstein female calves were disbudded using caustic paste (H. W. Naylor Company Inc.) at 3 d of age (n = 18), and control calves received a sham procedure (n = 15). Before disbudding, calves received a local block and a nonsteroidal anti-inflammatory drug. Calves ≥34 kg and <34 kg at birth had 0.3 or 0.25 mL of paste applied per unshaved horn bud, respectively. Following disbudding, wounds were scored 2×/wk for the presence or absence of 8 tissue categories, including the final stages: new epithelium and fully healed. Control calves were removed from the experiment after 6 wk to be hot-iron disbudded. Mechanical nociceptive threshold (MNT) measures were collected weekly to evaluate wound sensitivity until calves were removed from the study or healed. Wounds were slow to re-epithelialize (16.2 ± 5.7 wk, mean ± SD; range: 6.2-32.5 wk) and contract to be considered fully healed (18.8 ± 6 wk, mean ± SD; range: 8.7-34.1 wk). Compared with non-disbudded controls, paste calves exhibited lower MNT values for all 6 wk (mean ± SE; control: 1.46 ± 0.16; paste: 1.18 ± 0.12 N). These data indicate that wounds from caustic paste disbudding are more sensitive than undamaged tissue for at least 6 wk and take twice as long to heal compared with cautery methods described in the literature. In conclusion, caustic paste disbudding wounds took 18.8 wk to fully heal and were more sensitive than intact horn buds for 6 wk. Future work should examine whether aspects of paste application (e.g., amount used, time rubbed in, calf age, pain mitigation) could improve healing time and sensitivity.
    MeSH term(s) Animals ; Cattle ; Female ; Caustics ; Horns/surgery ; Pain/veterinary ; Wound Healing ; Iron
    Chemical Substances Caustics ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2023-23238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Overcoming steroid insensitivity in respiratory disease

    Adcock, Ian M.

    2008  

    Author's details ed. by Ian M. Adcock
    Keywords Respiratory Tract Diseases / drug therapy ; Adrenal Cortex Hormones / therapeutic use ; Drug Resistance ; Drug Resistance / therapeutic use ; Respiratory organs/Diseases/Chemotherapy ; Steroid drugs ; Drug resistance
    Subject code 616.200461
    Language English
    Size X, 292 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT015372679
    ISBN 0-470-05808-0 ; 978-0-470-05808-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 2085 order for loan Magazin

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  10. Article ; Online: Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?

    Jahankhani, Kasra / Ahangari, Fatemeh / Adcock, Ian M / Mortaz, Esmaeil

    Biochimie

    2023  Volume 213, Page(s) 130–138

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown diverse life-threatening effects, most of which are considered short-term. In addition to its short-term effects, which has claimed many millions of lives since 2019, the long-term ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown diverse life-threatening effects, most of which are considered short-term. In addition to its short-term effects, which has claimed many millions of lives since 2019, the long-term complications of this virus are still under investigation. Similar to many oncogenic viruses, it has been hypothesized that SARS-CoV-2 employs various strategies to cause cancer in different organs. These include leveraging the renin angiotensin system, altering tumor suppressing pathways by means of its nonstructural proteins, and triggering inflammatory cascades by enhancing cytokine production in the form of a "cytokine storm" paving the way for the emergence of cancer stem cells in target organs. Since infection with SARS-CoV-2 occurs in several organs either directly or indirectly, it is expected that cancer stem cells may develop in multiple organs. Thus, we have reviewed the impact of coronavirus disease 2019 (COVID-19) on the vulnerability and susceptibility of specific organs to cancer development. It is important to note that the cancer-related effects of SARS-CoV-2 proposed in this article are based on the ability of the virus and its proteins to cause cancer but that the long-term consequences of this infection will only be illustrated in the long run.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/metabolism ; Renin-Angiotensin System ; Cytokines/metabolism ; Neoplasms
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-05-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 120345-9
    ISSN 1638-6183 ; 0300-9084
    ISSN (online) 1638-6183
    ISSN 0300-9084
    DOI 10.1016/j.biochi.2023.05.014
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