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Article: Lipid Signaling During Gamete Maturation.

Mostafa, Sherif / Nader, Nancy / Machaca, Khaled

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 814876

Abstract: Cell lipids are differentially distributed in distinct organelles and within the leaflets of the bilayer. They can further form laterally defined sub-domains within membranes with important signaling functions. This molecular and spatial complexity ... ...

Abstract	Cell lipids are differentially distributed in distinct organelles and within the leaflets of the bilayer. They can further form laterally defined sub-domains within membranes with important signaling functions. This molecular and spatial complexity offers optimal platforms for signaling with the associated challenge of dissecting these pathways especially that lipid metabolism tends to be highly interconnected. Lipid signaling has historically been implicated in gamete function, however the detailed signaling pathways involved remain obscure. In this review we focus on oocyte and sperm maturation in an effort to consolidate current knowledge of the role of lipid signaling and set the stage for future directions.
Language	English
Publishing date	2022-06-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.814876
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lipid Signaling During Gamete Maturation

Sherif Mostafa / Nancy Nader / Khaled Machaca

Frontiers in Cell and Developmental Biology, Vol

2022 Volume 10

Abstract	Cell lipids are differentially distributed in distinct organelles and within the leaflets of the bilayer. They can further form laterally defined sub-domains within membranes with important signaling functions. This molecular and spatial complexity offers optimal platforms for signaling with the associated challenge of dissecting these pathways especially that lipid metabolism tends to be highly interconnected. Lipid signaling has historically been implicated in gamete function, however the detailed signaling pathways involved remain obscure. In this review we focus on oocyte and sperm maturation in an effort to consolidate current knowledge of the role of lipid signaling and set the stage for future directions.
Keywords	oocyte ; egg ; sperm ; glycerolphospholipid ; sphingolipid ; ceramides ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of body mass index on survival after spinal cord injury.

Fallah, Nader / Noonan, Vanessa K / Thorogood, Nancy P / Kwon, Brian K / Kopp, Marcel A / Schwab, Jan M

Frontiers in neurology

2024 Volume 14, Page(s) 1269030

Abstract: Introduction: Increased mortality after acute and chronic spinal cord injury (SCI) remains a challenge and mandates a better understanding of the factors contributing to survival in these patients. This study investigated whether body mass index (BMI) ... ...

Abstract	Introduction: Increased mortality after acute and chronic spinal cord injury (SCI) remains a challenge and mandates a better understanding of the factors contributing to survival in these patients. This study investigated whether body mass index (BMI) measured after acute traumatic SCI is associated with a change in mortality. Methods: A prospective longitudinal cohort study was conducted with 742 patients who were admitted to the Acute Spine Unit of the Vancouver General Hospital between 2004 and 2016 with a traumatic SCI. An investigation of the association between BMI on admission and long-term mortality was conducted using classification and regression tree (CART) and generalized additive models (spline curves) from acute care up to 7.7 years after SCI (chronic phase). Multivariable models were adjusted for (i) demographic factors (e.g., age, sex, and Charlson Comorbidity Index) and (ii) injury characteristics (e.g., neurological level and severity and Injury Severity Score). Results: After the exclusion of incomplete datasets ( Discussion: Mortality risk (1 month to 7.7 years after SCI) was associated with differences in BMI at admission. Further research is needed to better understand the underlying mechanisms. Given an established association of BMI with metabolic determinants, these results may suggest unknown neuro-metabolic pathways that are crucial for patient survival.
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1269030
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Article: Progesterone induces meiosis through two obligate co-receptors with PLA2 activity.

Nader, Nancy / Zarif, Lubna / Halama, Anna / Yadav, Sharan / Dib, Maya / Attarwala, Nabeel / Chen, Qiuying / Suhre, Karsten / Gross, Steven S / Machaca, Khaled

bioRxiv : the preprint server for biology

2023

Abstract: The steroid hormone progesterone (P4) regulates multiple aspects of reproductive and metabolic physiology. Classical P4 signaling operates through nuclear receptors that regulate transcription. In addition, P4 signals through membrane P4 receptors (mPRs) ...

Abstract	The steroid hormone progesterone (P4) regulates multiple aspects of reproductive and metabolic physiology. Classical P4 signaling operates through nuclear receptors that regulate transcription. In addition, P4 signals through membrane P4 receptors (mPRs) in a rapid nongenomic modality. Despite the established physiological importance of P4 nongenomic signaling, its detailed signal transduction remains elusive. Here, using
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.09.556646
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Article: Incidence and prevalence of traumatic spinal cord injury in Canada using health administrative data.

Thorogood, Nancy P / Noonan, Vanessa K / Chen, Xiaozhi / Fallah, Nader / Humphreys, Suzanne / Dea, Nicolas / Kwon, Brian K / Dvorak, Marcel F

Frontiers in neurology

2023 Volume 14, Page(s) 1201025

Abstract: Introduction: Incidence and prevalence data are needed for the planning, funding, delivery and evaluation of injury prevention and health care programs. The objective of this study was to estimate the Canadian traumatic spinal cord injury (TSCI) ... ...

Abstract	Introduction: Incidence and prevalence data are needed for the planning, funding, delivery and evaluation of injury prevention and health care programs. The objective of this study was to estimate the Canadian traumatic spinal cord injury (TSCI) incidence, prevalence and trends over time using national-level health administrative data. Methods: ICD-10 CA codes were used to identify the cases for the hospital admission and discharge incidence rates of TSCI in Canada from 2005 to 2016. Provincial estimates were calculated using the location of the admitting facility. Age and sex-specific incidence rates were set to the 2015/2016 rates for the 2017 to 2019 estimates. Annual incidence rates were used as input for the prevalence model that applied annual survivorship rates derived from life expectancy data. Results: For 2019, it was estimated that there were 1,199 cases (32.0 per million) of TSCI admitted to hospitals, with 123 (10% of admissions) in-hospital deaths and 1,076 people with TSCI (28.7 per million) were discharged in Canada. The estimated number of people living with TSCI was 30,239 (804/million); 15,533 (52%) with paraplegia and 14,706 (48%) with tetraplegia. Trends included an increase in the number of people injured each year from 874 to 1,199 incident cases (37%), an older average age at injury rising from 46.6 years to 54.3 years and a larger proportion over the age of 65 changing from 22 to 38%, during the 15-year time frame. Conclusion: This study provides a standard method for calculating the incidence and prevalence of TSCI in Canada using national-level health administrative data. The estimates are conservative based on the limitations of the data but represent a large Canadian sample over 15 years, which highlight national trends. An increasing number of TSCI cases among the elderly population due to falls reported in this study can inform health care planning, prevention strategies, and future research.
Language	English
Publishing date	2023-07-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1201025
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Article ; Online: Effectiveness of an Electronic Medical Record-Based Recognition Tool for the Identification of Incidental Pulmonary Nodules.

Mahajan, Amit K / Collar, Nancy / Bari, Mahwish / Nader, Abe / Muldowney, Frances / Patel, Priya P / Weyant, Michael J / Druckenbrod, Glenn G / Oliverio, Patrick / Moynihan, John / Deeken, John F

Journal of bronchology & interventional pulmonology

2023 Volume 30, Issue 4, Page(s) 373–378

Abstract: Background: Incidental pulmonary nodules (IPNs) are lung nodules detected on imaging studies performed for an unrelated reason. Approximately 1.6 million IPNs are detected in the United States every year. Unfortunately, close to 1.1 million (69%) of ... ...

Abstract	Background: Incidental pulmonary nodules (IPNs) are lung nodules detected on imaging studies performed for an unrelated reason. Approximately 1.6 million IPNs are detected in the United States every year. Unfortunately, close to 1.1 million (69%) of these IPNs are not managed with appropriate follow-up care. The goal of this study was to assess the utility of a noncommercial electronic medical record (EMR)-based IPN keyword recognition program in identifying IPNs and the ability of lung navigators to communicate these findings to patients. Methods: This is a observational, implementation study aimed identify IPNs using an EMR-based protocol and to relay results of findings to patients. The patient population included patients 16 and older undergoing computed tomography (CT) chest, CT chest/abdomen, CT angiogram chest, CT chest/abdomen/pelvis, and chest radiography through the radiology department within a large community tertiary medical campus between June 2019 and August 2020. EPIC EMR were queried using criteria designed to find IPNs. A lung navigator reviewed these cases and sorted them into categories based on their size and risk status. After identification of risk factors, actions were taken to directly communicate results to patients. Results: Seven hundred and fifty-three patients were found to have true IPNs without a history of active malignancy involving the lung. On the basis of radiographic measurements, 60% of the nodules identified were <6 mm, 17% were between 6 and 8 mm, 22% were >8 mm, and 12% were deemed nodular opacities. Lung navigators were able to contact a total of 637 (87%) individuals with IPNs and results were directly communicated. Of the 637 patients identified to have an IPN, a total of 12 (2%) cancers were diagnosed. Conclusion: We have here demonstrated that the development of an EMR-based keyword recognition platform for the identification of IPNs is a useful and successful tool for communication of IPN findings to patients using lung navigators.
MeSH term(s)	Humans ; Lung Neoplasms/diagnostic imaging ; Electronic Health Records ; Multiple Pulmonary Nodules/diagnostic imaging ; Lung ; Tomography, X-Ray Computed/methods ; Incidental Findings
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000905
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Zs.A 4027: Show issues

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Article ; Online: Correction: Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2.

Nader, Nancy / Dib, Maya / Hodeify, Rawad / Courjaret, Raphael / Elmi, Asha / Hammad, Ayat S / Dey, Raja / Huang, Xin-Yun / Machaca, Khaled

PLoS biology

2021 Volume 19, Issue 2, Page(s) e3001117

Abstract: This corrects the article DOI: 10.1371/journal.pbio.3000901.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pbio.3000901.].
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3001117
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Article ; Online: Correction

Nancy Nader / Maya Dib / Rawad Hodeify / Raphael Courjaret / Asha Elmi / Ayat S Hammad / Raja Dey / Xin-Yun Huang / Khaled Machaca

PLoS Biology, Vol 19, Iss 2, p e

Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2.

2021 Volume 3001117

Abstract: This corrects the article DOI:10.1371/journal.pbio.3000901.]. ...

Abstract	[This corrects the article DOI:10.1371/journal.pbio.3000901.].
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An Analysis of Positron Emission Tomography Maximum Standard Uptake Value Among Patients With Head and Neck Cancer Receiving Photon and Proton Radiation.

Youssef, Irini / Mohamed, Nader / Kallini, Daniel / Zakeri, Kaveh / Lin, Haibo / Han, Dong / Qi, Hang / Nosov, Anton / Riaz, Nadeem / Chen, Linda / Yu, Yao / Dunn, Lara Ann / Sherman, Eric J / Wray, Rick / Schöder, Heiko / Lee, Nancy Y

International journal of radiation oncology, biology, physics

2024

Abstract: Purpose: One main advantage of proton therapy versus photon therapy is its precise radiation delivery to targets without exit dose, resulting in lower dose to surrounding healthy tissues. This is critical, given the proximity of head and neck tumors to ... ...

Abstract	Purpose: One main advantage of proton therapy versus photon therapy is its precise radiation delivery to targets without exit dose, resulting in lower dose to surrounding healthy tissues. This is critical, given the proximity of head and neck tumors to normal structures. However, proton planning requires careful consideration of factors, including air-tissue interface, anatomic uncertainties, surgical artifacts, weight fluctuations, rapid tumor response, and daily variations in setup and anatomy, as these heterogeneities can lead to inaccuracies in targeting and creating unwarranted hotspots to a greater extent than photon radiation. In addition, the elevated relative biological effectiveness at the Bragg peak's distal end can also increase hot spots within and outside the target area. Methods and materials: The purpose of this study was to evaluate for a difference in positron emission tomography (PET) standard uptake value (SUV) after definitive treatment, between intensity modulated proton therapy (IMPT) and intensity modulated photon therapy (IMRT). In addition, we compared the biologic dose between PET areas of high and low uptake within the clinical target volume-primary of patients treated with IMPT. This work is assuming that the greater SUV may potentially result in greater toxicities. For the purposes of this short communication, we are strictly focusing on the SUV and do not have correlation with toxicity outcomes. To accomplish this, we compared the 3- and 6-month posttreatment fluorodeoxyglucose PET scans for 100 matched patients with oropharyngeal cancer treated definitively without surgery using either IMPT (n = 50) or IMRT (n = 50). Results: Our study found a significant difference in biologic dose between the high- and low-uptake regions on 3-month posttreatment scans of IMPT. However, this difference did not translate to a significant difference in PET uptake in the clinical target volume-primary at 3 and 6 months' follow-up between patients who received IMPT versus IMRT. Conclusions: Studies have proposed that proton's greater relative biological effectiveness at the Bragg peak could lead to tissue inflammation. Our study did not corroborate these findings. This study's conclusion underscores the need for further investigations with ultimate correlation with clinical toxicity outcomes.
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2024.03.011
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Zs.A 1218: Show issues

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Article ; Online: Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2.

Nader, Nancy / Dib, Maya / Hodeify, Rawad / Courjaret, Raphael / Elmi, Asha / Hammad, Ayat S / Dey, Raja / Huang, Xin-Yun / Machaca, Khaled

PLoS biology

2020 Volume 18, Issue 11, Page(s) e3000901

Abstract: The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Here we ...

Abstract	The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Here we show that the topology of mPRβ is similar to adiponectin receptors and opposite to that of G-protein-coupled receptors (GPCRs). Using Xenopus oocyte meiosis as a well-established physiological readout of nongenomic P4 signaling, we demonstrate that mPRβ signaling requires the adaptor protein APPL1 and the kinase Akt2. We further show that P4 induces clathrin-dependent endocytosis of mPRβ into signaling endosome, where mPR interacts transiently with APPL1 and Akt2 to induce meiosis. Our findings outline the early steps involved in mPR signaling and expand the spectrum of mPR signaling through the multitude of pathways involving APPL1.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Signal Transducing/physiology ; Animals ; Endocytosis ; Endosomes/metabolism ; Female ; Meiosis/physiology ; Oocytes/metabolism ; Progesterone/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Progesterone/metabolism ; Signal Transduction ; Xenopus Proteins/metabolism ; Xenopus Proteins/physiology ; Xenopus laevis
Chemical Substances	Adaptor Proteins, Signal Transducing ; Appl1 protein, Xenopus ; Receptors, G-Protein-Coupled ; Receptors, Progesterone ; Xenopus Proteins ; progesterone receptor B ; Progesterone (4G7DS2Q64Y) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2020-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3000901
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