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Article ; Online: Effects of anthracycline chemotherapy and Kuan-Sin-Yin on the spectral indices of arterial pulse waveforms in breast cancer patients.

Chen, Chao-Tsung / Huang, Tzu-Wei / Chou, Yi-Sheng / Cheng, Chi-Feng / Wu, Hung-Bo / Hsu, Chung-Hua / Hsiu, Hsin

Clinical hemorheology and microcirculation

2023 Volume 84, Issue 4, Page(s) 345–358

Abstract: ... chemotherapy between with (Group KSY) and without (Group NKSY) receiving Kuan-Sin-Yin (KSY) treatment.Radial ...

Abstract	The vascular structure and function are potentially useful biomarkers for tumor detection. Treatment with chemotherapeutic agents may impair vascular function and increase the risk of cardiovascular disease. This study aimed to use noninvasive pulse waveform measurements to identify differences in the frequency-domain indices of the pulse waveform in breast-cancer patients following anthracycline chemotherapy between with (Group KSY) and without (Group NKSY) receiving Kuan-Sin-Yin (KSY) treatment.Radial blood pressure waveform (BPW) signals were measured noninvasively for 3 minutes in 31 patients, and the FACT-G, BFI-T, and EORTC QLQ-C30 questionnaires were administered. The following pulse indices were calculated for 10 harmonics: the amplitude proportion and its coefficient of variation, and the phase angle and its standard deviation.The changes in spectral BPW indices were more prominent in Group NKSY than in Group KSY, especially for the decreases in BPW variability indices. Scores on the FACT-G, BFI-T, and EORTC QLQ-C30 questionnaires suggested that the quality of life following chemotherapy was better in Group KSY.The identified decreases in pulse variability indices could be related to the greater impairment of regulatory activities in Group NKSY. The present findings may be meaningful in developing techniques with advantages such as being noninvasive and time-saving to evaluate the blood supply and physiological conditions following chemotherapy or other treatment strategies in cancer patients.
MeSH term(s)	Humans ; Female ; Quality of Life ; Breast Neoplasms/drug therapy ; Anthracyclines/adverse effects ; Medicine, Chinese Traditional/methods ; Surveys and Questionnaires
Chemical Substances	Anthracyclines
Language	English
Publishing date	2023-01-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1381750-4
ISSN	1875-8622 ; 1386-0291
ISSN (online)	1875-8622
ISSN	1386-0291
DOI	10.3233/CH-221602
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Article ; Online: Traditional Chinese medicine Kuan-Sin-Yin decoction inhibits cell mobility via downregulation of CCL2, CEACAM1 and PIK3R3 in hepatocellular carcinoma cells.

Chen, Chueh-Tan / Chen, Chian-Feng / Lin, Tung-Yi / Hua, Wei-Jyun / Hua, Kate / Tsai, Ching-Yao / Hsu, Chung-Hua

Journal of ethnopharmacology

2023 Volume 317, Page(s) 116834

Abstract: Ethnopharmacological relevance: Kuan-Sin-Yin (KSY) is a traditional Chinese medical decoction ...

Abstract	Ethnopharmacological relevance: Kuan-Sin-Yin (KSY) is a traditional Chinese medical decoction, designed based on the classic Si-Jun-Zi-Tang decoction and used clinically to improve the synergic effects of energy promotion, liver function and cancer related symptom and quality of life. However, the anti-hepatocellular carcinoma (HCC) function of KSY is unclear. Aim of the study: This study aimed to investigate the anti-mobility activity of KSY on HCC cells and elucidate its molecular mechanism. Materials and methods: Two malignancy hepatocellular carcinoma cells, Mahlavu and SK-Hep-1, were used for the test of cell proliferation via alarm blue assay. The wound healing and Transwell assays were used to determine the anti-mobility activity of KSY in HCC cells. Cell morphology was analyzed via confocal microscopy. The genomic profile of KSY-treated HCC cells was analyzed by microarray. The potential signaling pathways and bio-functions of KSY-mediated genes were analyzed by ingenuity pathway analysis (IPA). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the messenger RNA (mRNA) level of indicated gene. Results: KSY did not affect cell viability of HCC cells but significantly inhibited cell migration and invasion in those HCC Mahlavu and SK-Hep-1 cells. In parallel, KSY induced changes in morphology of HCC cells via re-modulating actin cytoskeleton. KSY upregulated 1270 genes but reduced 1534 genes in Mahlavu cells. KSY regulated various gene networks which controlled cell migration, invasion and movement. Specifically, KSY reduced expression of chemokine (C-C motif) ligand 2 (CCL2), which is correlated to cell mobility, and concomitantly downregulated mRNA levels of phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) and CEA cell adhesion molecule 1 (CEACAM1). Conclusion: These findings indicated that regulation of CCL2-mediated PIK3R3 and CEACAM1 may be involved in KSY inhibited cell mobility. Moreover, KSY may be a potential a Chinese decoction for reducing cell mobility.
MeSH term(s)	Humans ; Medicine, Chinese Traditional ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Down-Regulation ; Quality of Life ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Chemokine CCL2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism
Chemical Substances	CD66 antigens ; CCL2 protein, human ; Chemokine CCL2 ; PIK3R3 protein, human (EC 2.7.1.137) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2023-06-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116834
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Article ; Online: Traditional Chinese medicine Kuan-Sin-Yin decoction inhibits cell mobility via downregulation of CCL2, CEACAM1 and PIK3R3 in hepatocellular carcinoma cells

Chen, Chueh-Tan / Chen, Chian-Feng / Lin, Tung-Yi / Hua, Wei-Jyun / Hua, Kate / Tsai, Ching-Yao / Xu, Zhonghua

Journal of Ethnopharmacology. 2023 Dec., v. 317 p.116834-

2023

Abstract: Kuan-Sin-Yin (KSY) is a traditional Chinese medical decoction, designed based on the classic Si-Jun ...

Abstract	Kuan-Sin-Yin (KSY) is a traditional Chinese medical decoction, designed based on the classic Si-Jun-Zi-Tang decoction and used clinically to improve the synergic effects of energy promotion, liver function and cancer related symptom and quality of life. However, the anti-hepatocellular carcinoma (HCC) function of KSY is unclear. This study aimed to investigate the anti-mobility activity of KSY on HCC cells and elucidate its molecular mechanism. Two malignancy hepatocellular carcinoma cells, Mahlavu and SK-Hep-1, were used for the test of cell proliferation via alarm blue assay. The wound healing and Transwell assays were used to determine the anti-mobility activity of KSY in HCC cells. Cell morphology was analyzed via confocal microscopy. The genomic profile of KSY-treated HCC cells was analyzed by microarray. The potential signaling pathways and bio-functions of KSY-mediated genes were analyzed by ingenuity pathway analysis (IPA). Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the messenger RNA (mRNA) level of indicated gene. KSY did not affect cell viability of HCC cells but significantly inhibited cell migration and invasion in those HCC Mahlavu and SK-Hep-1 cells. In parallel, KSY induced changes in morphology of HCC cells via re-modulating actin cytoskeleton. KSY upregulated 1270 genes but reduced 1534 genes in Mahlavu cells. KSY regulated various gene networks which controlled cell migration, invasion and movement. Specifically, KSY reduced expression of chemokine (C-C motif) ligand 2 (CCL2), which is correlated to cell mobility, and concomitantly downregulated mRNA levels of phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) and CEA cell adhesion molecule 1 (CEACAM1). These findings indicated that regulation of CCL2-mediated PIK3R3 and CEACAM1 may be involved in KSY inhibited cell mobility. Moreover, KSY may be a potential a Chinese decoction for reducing cell mobility.
Keywords	Oriental traditional medicine ; carcinoma ; cell adhesion molecules ; cell movement ; cell proliferation ; cell viability ; chemokines ; confocal microscopy ; energy ; genes ; genomics ; hepatoma ; ligands ; liver function ; messenger RNA ; microarray technology ; microfilaments ; polymerase chain reaction ; quality of life ; Kuan-Sin-Yin ; Hepatocellular carcinoma ; Cell motility ; Chemokine (C-C motif) ligand 2
Language	English
Dates of publication	2023-12
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116834
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Article ; Online: Characterization and antioxidant activities of the polysaccharides from Radix Cyathulae officinalis Kuan.

Han, Xingfa / Shen, Shian / Liu, Tieqiu / Du, Xiaogang / Cao, Xiaohan / Feng, Haibo / Zeng, Xianyin

International journal of biological macromolecules

2015 Volume 72, Page(s) 544–552

Abstract: ... officinalis Kuan, and its chemical characteristics, monosaccharide composition and antioxidant activities were ...

Abstract	A water-soluble polysaccharide (PSRC) was extracted and purified from the roots of Radix Cyathulae officinalis Kuan, and its chemical characteristics, monosaccharide composition and antioxidant activities were characterized. The average of molecular weight (Mw) of PSRC was 182 kDa. The majority of monosaccharide components of PSRC was glucose (relative mass 48.8%) with lower levels of mannose, rhamnose, galactose, fructose and arabinose (relative mass of 15.7, 14.3, 10.6, 6.1 and 4.5%, respectively). In vitro assays revealed that RSRC possessed potent scavenging activities against DPPH, hydroxyl and superoxide anion radicals. Oral administration of PSRC significantly enhanced antioxidant enzyme activities (including total superoxide dismutase, copper-zinc superoxide dismutase (Cu,Zn-SOD), manganese superoxide dismutase (Mn-SOD), glutathione peroxidase and catalase (CAT)) and capacities of scavenging superoxide anion and hydroxyl radicals, markedly lowered lipid peroxidation formation of malondialdehyde and significantly up-regulated mRNA expressions of Cu,Zn-SOD, Mn-SOD, CAT, glutathione peroxidase 1, thioredoxin 1 and thioredoxin 2, in a d-galactose-induced aging mouse model. Taken together, these findings demonstrate that PSRC could be used as a novel promising source of natural antioxidants and antiaging drugs.
MeSH term(s)	Amaranthaceae/chemistry ; Animals ; Antioxidants/administration & dosage ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Catalase/biosynthesis ; Glutathione/biosynthesis ; Glutathione Peroxidase/biosynthesis ; Humans ; Lipid Peroxidation/drug effects ; Mice ; Oxidation-Reduction/drug effects ; Plant Roots/chemistry ; Polysaccharides/administration & dosage ; Polysaccharides/chemistry ; Polysaccharides/isolation & purification ; RNA, Messenger/biosynthesis ; Superoxide Dismutase/biosynthesis
Chemical Substances	Antioxidants ; Polysaccharides ; RNA, Messenger ; glutathione peroxidase GPX1 (EC 1.11.1.-) ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1) ; superoxide dismutase 2 (EC 1.15.1.1) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2015-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2014.09.007
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Article: Characterization and antioxidant activities of the polysaccharides from Radix Cyathulae officinalis Kuan

Han, Xingfa / Haibo Feng / Shian Shen / Tieqiu Liu / Xianyin Zeng / Xiaogang Du / Xiaohan Cao

International journal of biological macromolecules. 2015 Jan., v. 72

2015

Abstract: ... officinalis Kuan, and its chemical characteristics, monosaccharide composition and antioxidant activities were ...

Abstract	A water-soluble polysaccharide (PSRC) was extracted and purified from the roots of Radix Cyathulae officinalis Kuan, and its chemical characteristics, monosaccharide composition and antioxidant activities were characterized. The average of molecular weight (Mw) of PSRC was 182kDa. The majority of monosaccharide components of PSRC was glucose (relative mass 48.8%) with lower levels of mannose, rhamnose, galactose, fructose and arabinose (relative mass of 15.7, 14.3, 10.6, 6.1 and 4.5%, respectively). In vitro assays revealed that RSRC possessed potent scavenging activities against DPPH, hydroxyl and superoxide anion radicals. Oral administration of PSRC significantly enhanced antioxidant enzyme activities (including total superoxide dismutase, copper-zinc superoxide dismutase (Cu,Zn-SOD), manganese superoxide dismutase (Mn-SOD), glutathione peroxidase and catalase (CAT)) and capacities of scavenging superoxide anion and hydroxyl radicals, markedly lowered lipid peroxidation formation of malondialdehyde and significantly up-regulated mRNA expressions of Cu,Zn-SOD, Mn-SOD, CAT, glutathione peroxidase 1, thioredoxin 1 and thioredoxin 2, in a d-galactose-induced aging mouse model. Taken together, these findings demonstrate that PSRC could be used as a novel promising source of natural antioxidants and antiaging drugs.
Keywords	2,2-diphenyl-1-picrylhydrazyl ; animal models ; antioxidant activity ; antioxidants ; arabinose ; catalase ; drugs ; enzyme activity ; fructose ; galactose ; gene expression regulation ; glucose ; glutathione peroxidase ; hydroxyl radicals ; in vitro studies ; lipid peroxidation ; malondialdehyde ; mannose ; messenger RNA ; molecular weight ; oral administration ; polysaccharides ; rhamnose ; roots ; superoxide anion ; superoxide dismutase
Language	English
Dates of publication	2015-01
Size	p. 544-552.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2014.09.007
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Article ; Online: Novel polysaccharide from Radix Cyathulae officinalis Kuan can improve immune response to ovalbumin in mice.

Feng, Haibo / Du, Xiaogang / Liu, Juan / Han, Xingfa / Cao, Xiaohan / Zeng, Xianyin

International journal of biological macromolecules

2014 Volume 65, Page(s) 121–128

Abstract: ... from the Radix Cyathulae officinalis Kuan (RCPS) for its adjuvant potential on the specific cellular and ...

Abstract	This study was designed to investigate the effects of oral administration of the polysaccharide from the Radix Cyathulae officinalis Kuan (RCPS) for its adjuvant potential on the specific cellular and humoral immune responses in mice. In this study, our data demonstrated that oral administration of RCPS significantly enhanced the phagocytic capacity of peritoneal macrophage, splenocyte proliferation, the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTL) and OVA-speciﬁc IgG, IgG1, IgG2a, and IgG2b antibody titers. Furthermore, RCPS promoted the level of interleukin-2(IL-2), IFN-γ and IL-4 in CD4(+)T cells and level of IFN-γ in CD8(+)T cells. In addition, RCPS enhanced the expression of CD40(+), CD80(+) and CD86(+) on the dendritic cells (DCs). Importantly, RCPS down-regulated the frequency of CD4(+)CD25(+)Foxp3(+)Treg cells. Taken together, these results suggested that RCPS could increase both cellular and humoral immune responses via up-regulating DCs maturation, and suppressing Treg frequency.
MeSH term(s)	Achyranthes/chemistry ; Adjuvants, Immunologic/administration & dosage ; Adjuvants, Immunologic/pharmacology ; Administration, Oral ; Animals ; Body Weight/drug effects ; Cell Proliferation/drug effects ; Cytokines/metabolism ; Dendritic Cells/cytology ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Gene Expression Regulation/drug effects ; Humans ; Immunoglobulin G/metabolism ; K562 Cells ; Lymphocytes/cytology ; Lymphocytes/drug effects ; Lymphocytes/immunology ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/immunology ; Mice ; Ovalbumin/immunology ; Phagocytosis/drug effects ; Polysaccharides/administration & dosage ; Polysaccharides/pharmacology ; Spleen/cytology
Chemical Substances	Adjuvants, Immunologic ; Cytokines ; Immunoglobulin G ; Polysaccharides ; Ovalbumin (9006-59-1)
Language	English
Publishing date	2014-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2014.01.017
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Article ; Online: Effects of Kuan-Sin-Yin decoction on immunomodulation and tumorigenesis in mouse tumor models.

Li, Tsai-Feng / Lin, Ching-Cheng / Tsai, Hui-ping / Hsu, Chung-Hua / Fu, Shu-Ling

BMC complementary and alternative medicine

2014 Volume 14, Page(s) 488

Abstract: Background: Complementary therapies are widely used among cancer patients. Kuan-Sin-Yin (KSY ...

Abstract	Background: Complementary therapies are widely used among cancer patients. Kuan-Sin-Yin (KSY) decoction, a popular qi-promoting herbal medicine, was constituted with several herbs known to exhibit immunomodulating or anticancer activity. After combining these herbs as a compound formula, it is necessary to reassess the immunomodulation effects, the effects on tumor growth, and possible toxicity of KSY. Methods: The anti-cancer effects of KSY in vivo were determined by measuring the tumor volumes, anticancer-associated cytokines (IFN-gamma, TNF-alpha, IL-2, and IL-12), accumulation of tumor infiltrating leukocytes (TILs), proliferation and apoptosis-related molecular markers (Ki-67, p53, p21, activated caspase 3, and cleaved PARP), and an in situ TUNEL assay. The body weight and serum chemistry of treated mice were also assessed. In vitro, the effects of KSY were evaluated using MTT assay, BrdU incorporation assay and cell growth curve. Results: In vivo, KSY suppressed bladder or lung cancer growth but did not promote the production of cytokines nor increase the accumulation of TILs. The expression of p53 and p21 in KSY-treated mice were increased. The numbers of apoptotic tumor cells and the expression of apoptosis marker proteins (Caspase 3 and cleaved PARP) were not significantly elevated after KSY treatment. In vitro, the viability and proliferation of tumor cells, but not normal cells, were suppressed by KSY treatment. No significant toxicity was found in KSY-treated mice. Conclusions: KSY suppressed the tumor growth in vivo and in vitro, which resulted from its cytostatic effects on cancer cells, rather than the induction of anti-cancer immunity. Under these experimental conditions, no apparent toxicity was observed.
MeSH term(s)	Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Apoptosis/drug effects ; Carcinogenesis/drug effects ; Caspase 3/metabolism ; Cell Proliferation/drug effects ; Cell Transformation, Neoplastic/drug effects ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Immunomodulation/drug effects ; Interleukin-12/metabolism ; Interleukin-2/metabolism ; Lung Neoplasms/immunology ; Lung Neoplasms/metabolism ; Lung Neoplasms/prevention & control ; Mice ; Phytotherapy ; Tumor Necrosis Factor-alpha/metabolism ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/prevention & control
Chemical Substances	Antineoplastic Agents, Phytogenic ; Drugs, Chinese Herbal ; Interleukin-2 ; Tumor Necrosis Factor-alpha ; Interleukin-12 (187348-17-0) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2014-12-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/1472-6882-14-488
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Book ; Online: A generalized stepwise procedure with improved power for multiple inequalities testing/ Yu-chin Hsu; Chung-ming Kuan; Meng-feng Yen

Hsu, Yu-chin / Kuan, Chung-ming / Yen, Meng-feng

(IEAS working paper ; 13,001)

2013

Series title	IEAS working paper ; 13,001
Keywords	Data snooping ; Familiywise error rate ; Least favorable configuration ; Multiple inequalities testing ; Reality Check ; SPA test ; Stepwise test
Language	English
Size	Online-Ressource (30 S.)
Publisher	Inst. of Economics
Publishing place	Taibei
Document type	Book ; Online
Note	IMD-Felder maschinell generiert
Database	ECONomics Information System

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Article ; Online: Enhancement of the immune responses to foot-and-mouth disease vaccination in mice by oral administration of a novel polysaccharide from the roots of Radix Cyathulae officinalis Kuan (RC).

Feng, Haibo / Du, Xiaogang / Tang, Jing / Cao, Xiaohan / Han, Xingfa / Chen, Zhiyu / Chen, Yanger / Zeng, Xianyin

Cellular immunology

2013 Volume 281, Issue 2, Page(s) 111–121

Abstract: ... from the Radix Cyathulae officinalis Kuan (RCPS) for its adjuvant potential on the FMDV-specific cellular and ...

Abstract	Foot-and-mouth disease (FMD) is a kind of the important animal infectious disease caused by the foot-and-mouth disease virus (FMDV). Thus, the aim of this study was to determine the effects of the polysaccharide from the Radix Cyathulae officinalis Kuan (RCPS) for its adjuvant potential on the FMDV-specific cellular and humoral immune responses in mice. In this study, our findings shows that oral administration of RCPS significantly enhanced the phagocytic capacity of peritoneal macrophage, splenocyte proliferation, the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTL) and IgG, IgG1, IgG2a, and IgG2b antibody titers. Furthermore, RCPS promoted the level of IL-2, IFN-γ and IL-4 in CD4(+)T cells and level of IFN-γ in CD8(+)T cells. In addition, RCPS enhanced the expression of CD40(+), CD80(+) and CD86(+) on DCs. Importantly, RCPS could up-regulated the mRNA level of MHC I, MHC II, TLR-2, TLR-4. Interestingly, RCPS down-regulated the frequency of CD4(+)CD25(+)Foxp3(+)Treg cells. Taken together, these results demonstrate that RCPS can enhance both cellular and humoral immune responses via up-regulating DCs maturation through TLR2, TLR4 signaling pathway, and suppressing Treg frequency.
MeSH term(s)	Adjuvants, Immunologic/administration & dosage ; Administration, Oral ; Amaranthaceae/chemistry ; Animals ; Cytokines/immunology ; Cytokines/metabolism ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Female ; Foot-and-Mouth Disease/immunology ; Foot-and-Mouth Disease/prevention & control ; Foot-and-Mouth Disease/virology ; Foot-and-Mouth Disease Virus/immunology ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin G/metabolism ; K562 Cells ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/immunology ; Major Histocompatibility Complex/genetics ; Major Histocompatibility Complex/immunology ; Mice ; Mice, Inbred ICR ; Phagocytosis/immunology ; Plant Roots/chemistry ; Polysaccharides/administration & dosage ; Polysaccharides/immunology ; Reverse Transcriptase Polymerase Chain Reaction ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 2/immunology ; Vaccination
Chemical Substances	Adjuvants, Immunologic ; Cytokines ; Immunoglobulin G ; Polysaccharides ; TLR2 protein, human ; Toll-Like Receptor 2
Language	English
Publishing date	2013-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2013.02.004
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Article: Novel polysaccharide from Radix Cyathulae officinalis Kuan can improve immune response to ovalbumin in mice

Feng, Haibo / Juan Liu / Xianyin Zeng / Xiaogang Du / Xiaohan Cao / Xingfa Han

International journal of biological macromolecules. 2014 Apr., v. 65

2014

Abstract: ... from the Radix Cyathulae officinalis Kuan (RCPS) for its adjuvant potential on the specific cellular and ...

Abstract	This study was designed to investigate the effects of oral administration of the polysaccharide from the Radix Cyathulae officinalis Kuan (RCPS) for its adjuvant potential on the specific cellular and humoral immune responses in mice. In this study, our data demonstrated that oral administration of RCPS significantly enhanced the phagocytic capacity of peritoneal macrophage, splenocyte proliferation, the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTL) and OVA-speciïc IgG, IgG1, IgG2a, and IgG2b antibody titers. Furthermore, RCPS promoted the level of interleukin-2(IL-2), IFN-Î³ and IL-4 in CD4+T cells and level of IFN-Î³ in CD8+T cells. In addition, RCPS enhanced the expression of CD40+, CD80+ and CD86+ on the dendritic cells (DCs). Importantly, RCPS down-regulated the frequency of CD4+CD25+Foxp3+Treg cells. Taken together, these results suggested that RCPS could increase both cellular and humoral immune responses via up-regulating DCs maturation, and suppressing Treg frequency.
Keywords	adjuvants ; antibodies ; cytotoxic T-lymphocytes ; dendritic cells ; humoral immunity ; immune response ; immunoglobulin G ; interferon-gamma ; interleukin-2 ; interleukin-4 ; macrophages ; mice ; natural killer cells ; oral administration ; ovalbumin ; polysaccharides ; splenocytes
Language	English
Dates of publication	2014-04
Size	p. 121-128.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2014.01.017
Database	NAL-Catalogue (AGRICOLA)

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