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Article ; Online: Wheeling and Dealing With Antigen Presentation in Tuberculosis.

Hudrisier, Denis / Neyrolles, Olivier

2016 Volume 24, Issue 3, Page(s) 166–168

Abstract: In tuberculosis, antigens are transferred from infected to uninfected dendritic cells. Does this favor T lymphocyte response and anti-mycobacterial host defense? In a recent report published in Cell Host & Microbe, Ernst and colleagues show that ... ...

Abstract	In tuberculosis, antigens are transferred from infected to uninfected dendritic cells. Does this favor T lymphocyte response and anti-mycobacterial host defense? In a recent report published in Cell Host & Microbe, Ernst and colleagues show that Mycobacterium tuberculosis seems to have hijacked this mechanism for its own benefit.
MeSH term(s)	Antigen Presentation ; Antigens, Bacterial/immunology ; CD4-Positive T-Lymphocytes/immunology ; Lymphocyte Activation ; Mycobacterium tuberculosis ; Tuberculosis/immunology
Chemical Substances	Antigens, Bacterial
Language	English
Publishing date	2016-03
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	1158963-2
ISSN	1878-4380 ; 0966-842X
ISSN (online)	1878-4380
ISSN	0966-842X
DOI	10.1016/j.tim.2016.01.001
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Article: Wheeling and Dealing With Antigen Presentation in Tuberculosis

Hudrisier, Denis / Olivier Neyrolles

Trends in microbiology. 2016 Mar., v. 24, no. 3

2016

Abstract	In tuberculosis, antigens are transferred from infected to uninfected dendritic cells. Does this favor T lymphocyte response and anti-mycobacterial host defense? In a recent report published in Cell Host & Microbe, Ernst and colleagues show that Mycobacterium tuberculosis seems to have hijacked this mechanism for its own benefit.
Keywords	antigen presentation ; antigens ; dendritic cells ; Mycobacterium tuberculosis ; T-lymphocytes ; tuberculosis
Language	English
Dates of publication	2016-03
Size	p. 166-168.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1158963-2
ISSN	1878-4380 ; 0966-842X
ISSN (online)	1878-4380
ISSN	0966-842X
DOI	10.1016/j.tim.2016.01.001
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Article ; Online: Antigen smuggling in tuberculosis.

Hudrisier, Denis / Neyrolles, Olivier

Cell host & microbe

2014 Volume 15, Issue 6, Page(s) 657–659

Abstract: The importance of CD4 T lymphocytes in immunity to M. tuberculosis is well established; however, how dendritic cells activate T cells in vivo remains obscure. In this issue of Cell Host & Microbe, Srivastava and Ernst (2014) report a mechanism of antigen ...

Abstract	The importance of CD4 T lymphocytes in immunity to M. tuberculosis is well established; however, how dendritic cells activate T cells in vivo remains obscure. In this issue of Cell Host & Microbe, Srivastava and Ernst (2014) report a mechanism of antigen transfer for efficient activation of antimycobacterial T cells.
MeSH term(s)	Animals ; Antigens, Bacterial/metabolism ; CD4-Positive T-Lymphocytes/microbiology ; Dendritic Cells/microbiology ; Mycobacterium tuberculosis/pathogenicity
Chemical Substances	Antigens, Bacterial ; Mycobacterium tuberculosis antigens (144058-44-6)
Language	English
Publishing date	2014-06-24
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2014.05.018
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Article ; Online: A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4

Anna, François / Lopez, Jodie / Moncoq, Fanny / Blanc, Catherine / Authié, Pierre / Noirat, Amandine / Fert, Ingrid / Souque, Philippe / Nevo, Fabien / Pawlik, Alexandre / Hardy, David / Goyard, Sophie / Hudrisier, Denis / Brosch, Roland / Guinet, Françoise / Neyrolles, Olivier / Charneau, Pierre / Majlessi, Laleh

Mucosal immunology

2022 Volume 15, Issue 6, Page(s) 1389–1404

Abstract: Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II endosomal pathway and elicit ... ...

Abstract	Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II endosomal pathway and elicit CD4
MeSH term(s)	Mice ; Animals ; CD8-Positive T-Lymphocytes ; CD4-Positive T-Lymphocytes ; Dendritic Cells ; Mice, Inbred C57BL ; Genetic Vectors/genetics
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2411370-0
ISSN	1935-3456 ; 1933-0219
ISSN (online)	1935-3456
ISSN	1933-0219
DOI	10.1038/s41385-022-00566-z
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Article ; Online: The Host Microbiota Contributes to Early Protection Against Lung Colonization by

Dumas, Alexia / Corral, Dan / Colom, André / Levillain, Florence / Peixoto, Antonio / Hudrisier, Denis / Poquet, Yannick / Neyrolles, Olivier

Frontiers in immunology

2018 Volume 9, Page(s) 2656

Abstract: Tuberculosis (TB), caused by the airborne bacterial ... ...

Abstract	Tuberculosis (TB), caused by the airborne bacterial pathogen
MeSH term(s)	Animals ; Cytokines/immunology ; Dysbiosis/immunology ; Dysbiosis/microbiology ; Dysbiosis/pathology ; Female ; Lung/immunology ; Lung/microbiology ; Lung/pathology ; Mice ; Microbiota/immunology ; Mucosal-Associated Invariant T Cells/immunology ; Mucosal-Associated Invariant T Cells/pathology ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Tuberculosis, Pulmonary/immunology ; Tuberculosis, Pulmonary/microbiology ; Tuberculosis, Pulmonary/pathology ; Tuberculosis, Pulmonary/prevention & control
Chemical Substances	Cytokines
Language	English
Publishing date	2018-11-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.02656
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Article ; Online: A Pulmonary

Journal of immunology (Baltimore, Md. : 1950)

2021 Volume 207, Issue 7, Page(s) 1857–1870

Abstract: The lungs harbor multiple resident microbial communities, otherwise known as the microbiota. There is an emerging interest in deciphering whether the pulmonary microbiota modulate local immunity, and whether this knowledge could shed light on mechanisms ... ...

Abstract	The lungs harbor multiple resident microbial communities, otherwise known as the microbiota. There is an emerging interest in deciphering whether the pulmonary microbiota modulate local immunity, and whether this knowledge could shed light on mechanisms operating in the response to respiratory pathogens. In this study, we investigate the capacity of a pulmonary
MeSH term(s)	Animals ; Cells, Cultured ; Disease Models, Animal ; Humans ; Lactobacillus/physiology ; Lung/immunology ; Lung/microbiology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mycobacterium tuberculosis/physiology ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Pneumonia ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/immunology ; Tuberculosis, Pulmonary/immunology
Chemical Substances	Nuclear Receptor Subfamily 1, Group F, Member 3 ; Rorc protein, mouse
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2001044
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Article ; Online: Suitability of various membrane lipophilic probes for the detection of trogocytosis by flow cytometry.

Daubeuf, Sandrine / Bordier, Christine / Hudrisier, Denis / Joly, Etienne

Cytometry. Part A : the journal of the International Society for Analytical Cytology

2009 Volume 75, Issue 5, Page(s) 380–389

Abstract: Trogocytosis is a recently discovered phenomenon whereby lymphocytes capture fragments of the plasma membrane from antigen presenting cells (APCs). Using APCs labeled with widely used fluorescent lipophilic probes, we previously described a trogocytosis ... ...

Abstract	Trogocytosis is a recently discovered phenomenon whereby lymphocytes capture fragments of the plasma membrane from antigen presenting cells (APCs). Using APCs labeled with widely used fluorescent lipophilic probes, we previously described a trogocytosis analysis protocol (TRAP) useful to understand the mechanisms and biological consequences of this process and to identify lymphocytes reacting specifically with antigen-bearing APCs. We have compared the suitability of 22 different fluorescent lipophilic probes for use in TRAP assays with cytotoxic T lymphocytes (CTL). The criteria we used were: simple and efficient incorporation in APC membranes, minimal passive diffusion among cells but efficient transfer onto T cells during trogocytosis. Sphingosin-based probes were found to incorporate inefficiently into cells. For others with unsaturated lipid chains, we found a tendency for extensive passive diffusion. In the end, about a third of the probes tested were found to be suitable in TRAP assays, which all carry either C16 or C18 saturated carbon chains, including some that can be excited with a red laser. Moreover, we found it possible to combine TRAP assays based on lipophilic probes with intracellular cytokine detection. We have identified a set of new lipophilic fluorescent probes suitable for TRAP assays in combination with intracellular staining.
MeSH term(s)	Animals ; Antigen-Presenting Cells/metabolism ; Cell Line, Tumor ; Cell Membrane/metabolism ; Flow Cytometry/methods ; Fluorescent Dyes/chemistry ; Interferon-gamma/metabolism ; Mice ; T-Lymphocytes, Cytotoxic/metabolism
Chemical Substances	Fluorescent Dyes ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2009-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099868-5
ISSN	1552-4930 ; 0196-4763 ; 1552-4922
ISSN (online)	1552-4930
ISSN	0196-4763 ; 1552-4922
DOI	10.1002/cyto.a.20679
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Zs.A 1688: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: What is trogocytosis and what is its purpose?

Joly, Etienne / Hudrisier, Denis

Nature immunology

2003 Volume 4, Issue 9, Page(s) 815

MeSH term(s)	Animals ; Antigen-Presenting Cells/cytology ; Antigen-Presenting Cells/immunology ; Cell Communication/immunology ; Cell Membrane/immunology ; Humans ; Lymphocyte Activation/immunology ; Lymphocytes/cytology ; Lymphocytes/immunology
Language	English
Publishing date	2003-09
Publishing country	United States
Document type	Letter
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/ni0903-815
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Article ; Online: Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells.

Aucher, Anne / Magdeleine, Eddy / Joly, Etienne / Hudrisier, Denis

Blood

2008 Volume 111, Issue 12, Page(s) 5621–5628

Abstract: Upon recognition of their respective cellular partners, T and B cells acquire their antigens by a process of membrane capture called trogocytosis. Here, we report that various inhibitors of actin polymerization or of kinases involved in intracellular ... ...

Abstract	Upon recognition of their respective cellular partners, T and B cells acquire their antigens by a process of membrane capture called trogocytosis. Here, we report that various inhibitors of actin polymerization or of kinases involved in intracellular signaling partially or fully inhibited trogocytosis by CD8(+) and CD4(+) T cells, whereas they had no effect on trogocytosis by B cells. Similarly, trogocytosis by T cells was inhibited at 4 degrees C, whereas in B cells it was independent of temperature, indicating that trogocytosis by B cells does not rely on active processes. By contrast, most inhibitors we tested impaired both T-cell and B-cell activation. The differential effect of inhibitors on T-cell and B-cell trogocytosis was not due to the higher affinity of the B-cell receptor for its cognate antigen compared with the affinity of the T-cell receptor for its own antigen, but it correlated tightly with the abilities of T cells and B cells to form conjugates with their target cells in the presence of inhibitors. Trogocytosis thus has different requirements in different cell types. Moreover, the capture of membrane antigen by B cells is identified as a novel signaling-independent event of B-cell biology.
MeSH term(s)	Actin Cytoskeleton/immunology ; Animals ; Antigen Presentation/immunology ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line ; Cell Membrane/immunology ; Cell Membrane/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins/metabolism ; Lymphocyte Activation ; Mice ; Mice, Transgenic ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism ; Receptors, Antigen, B-Cell/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction/immunology ; Syk Kinase ; src-Family Kinases/antagonists & inhibitors ; src-Family Kinases/metabolism
Chemical Substances	Enzyme Inhibitors ; Intracellular Signaling Peptides and Proteins ; Phosphoinositide-3 Kinase Inhibitors ; Receptors, Antigen, B-Cell ; Receptors, Antigen, T-Cell ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; SYK protein, human (EC 2.7.10.2) ; Syk Kinase (EC 2.7.10.2) ; Syk protein, mouse (EC 2.7.10.2) ; src-Family Kinases (EC 2.7.10.2)
Language	English
Publishing date	2008-04-01
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2008-01-134155
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Article ; Online: Intercellular transfer of antigen-presenting cell determinants onto T cells: molecular mechanisms and biological significance.

Hudrisier, Denis / Bongrand, Pierre

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2002 Volume 16, Issue 6, Page(s) 477–486

Abstract: Upon physiological stimulation, receptors with tyrosine kinase activity (RTK) are rapidly internalized together with their soluble ligands. T cell activation is the consequence of recognition by the T cell receptor (TCR) of specific peptide-major ... ...

Abstract	Upon physiological stimulation, receptors with tyrosine kinase activity (RTK) are rapidly internalized together with their soluble ligands. T cell activation is the consequence of recognition by the T cell receptor (TCR) of specific peptide-major histocompatibility protein complexes (peptide-MHC) present at the membrane of antigen-presenting cells (APC). The TCR belongs to the RTK family and is known to be endocytosed upon ligand recognition. It differs from most other RTK in that its ligand, the peptide-MHC complex, is membrane bound and the TCR-ligand interaction is quite weak. Recent experiments have shown that the TCR ligand becomes internalized by T cells upon stimulation. Here we review current knowledge on the molecular mechanisms by which the membrane-bound MHC molecules can be transferred onto T cells, and propose hypotheses on the role this phenomenon could play in physio-pathological situations involving T cells.
MeSH term(s)	Animals ; Antigen Presentation ; Antigen-Presenting Cells/immunology ; Cell Communication ; Cell Membrane/metabolism ; Forecasting ; Histocompatibility Antigens/metabolism ; Ligands ; Lymphocyte Activation ; Models, Immunological ; Peptides/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Secretory Vesicles/metabolism ; T-Lymphocytes/immunology
Chemical Substances	Histocompatibility Antigens ; Ligands ; Peptides ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2002-03-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.01-0933rev
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