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Article ; Online: A tale of two diseases: Sarcoidosis, COVID-19 and new therapeutic options with dual RAS inhibition and tetanus-diphtheria vaccine.

Ozbalci, Demircan

2021 Volume 152, Page(s) 110619

Abstract: Sars Cov-2, the pathogen which belongs to the beta coronavirus family that is responsible for COVID-19, uses Angiotensin Converting Enzyme 2 (ACE2) as a receptor, which is responsible for controlling the actions of renin-angiotensin system (RAS). Sars ... ...

Abstract	Sars Cov-2, the pathogen which belongs to the beta coronavirus family that is responsible for COVID-19, uses Angiotensin Converting Enzyme 2 (ACE2) as a receptor, which is responsible for controlling the actions of renin-angiotensin system (RAS). Sars Cov-2 - ACE2 binding leads to a RAS mediated immune response, which targets especially lungs to form ARDS, which in turn, is the most important cause of mortality in COVID-19. CD8
MeSH term(s)	COVID-19 ; Diphtheria Toxoid ; Humans ; Peptidyl-Dipeptidase A/metabolism ; Renin-Angiotensin System ; SARS-CoV-2 ; Sarcoidosis ; Tetanus
Chemical Substances	Diphtheria Toxoid ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
Language	English
Publishing date	2021-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2021.110619
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Article ; Online: Malignancy-related mir-210, mir-373 and let-7 levels are affected in iron deficiency anemia.

Sak, Ruveyda / Ozbalci, Demircan / Alanoglu, Emine Guchan / Ozturk, Kuyas Hekimler

African health sciences

2024 Volume 23, Issue 3, Page(s) 245–253

Abstract: Background: Hypoxia is the hallmark of iron deficiency anemia (IDA) and in hypoxic environment, significant changes are observed in malignancy-related microRNAs (miRNA). Our aim is to examine whether there is any difference in the levels of miR-210, miR- ...

Abstract	Background: Hypoxia is the hallmark of iron deficiency anemia (IDA) and in hypoxic environment, significant changes are observed in malignancy-related microRNAs (miRNA). Our aim is to examine whether there is any difference in the levels of miR-210, miR-373 and let-7, which are directly related to malignancies in patients with IDA. Methods: Thirty-five female patients with IDA between the ages of 18-65 and 10 healthy controls were included in the study. Patients who received oral iron therapy, who had inflammatory disease, and who were pregnant were excluded from the study. Student t Test was used for comparing variables with normal distribution in two independent groups, and Mann-Whitney U Test was used for variables without normal distribution. Comparison of categorical data was made using the chi-square test. Results: The mean hemoglobin and ferritin level were 10,78±0,93 and 6.28±5,76 respectively. Plasma miR-210 expression were found as -7.27±2.23 and -6.15±0,88 in IDA and control group respectively (p = 0.022). Plasma miRNA-373 were -7.36±2,58 and -6,96±1,93 and let-7 expression were 2.14±2,15 and 3,57±2,21 in IDA and control group. (p = 0.65 and p = 0.20, respectively). Conclusions: Plasma miR-210 expression was significantly up-regulated and miR-373 and let-7 expression was down-regulated, though insignificantly, in IDA group.
MeSH term(s)	Pregnancy ; Humans ; Female ; Anemia, Iron-Deficiency/genetics ; Hemoglobins/analysis ; MicroRNAs/genetics ; Chi-Square Distribution
Chemical Substances	Hemoglobins ; MicroRNAs ; MIRN210 microRNA, human ; MIRN373 microRNA, human
Language	English
Publishing date	2024-02-03
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2240308-5
ISSN	1729-0503 ; 1680-6905
ISSN (online)	1729-0503
ISSN	1680-6905
DOI	10.4314/ahs.v23i3.30
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Zs.A 3851: Show issues

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Article ; Online: Adipose tissue indices predict prognosis in hodgkin lymphoma.

Özbalcı, Demircan / Erdoğan, Mehmet / Alanoğlu, Emine Güçhan / Şengül, Sevim Süreyya / Yüceer, Kamuran / Eroğlu, Hande Nur / Yağcı, Samet

Leukemia research

2024 Volume 138, Page(s) 107457

Abstract: Introduction background: This study evaluated the impact of adipose tissue indices on prognosis of HL.: Methods: Fifty-five patients with newly diagnosed Hodgkin Lymphoma were evaluated retrospectively for association with adipose tissue indices ( ... ...

Abstract	Introduction background: This study evaluated the impact of adipose tissue indices on prognosis of HL. Methods: Fifty-five patients with newly diagnosed Hodgkin Lymphoma were evaluated retrospectively for association with adipose tissue indices (total abdominal tissue volume, radiodensity, subcutaneous and visceral adipose tissue SUVmax value and prognostic factors for Hodgkin Lymphoma such as IPS-3, IPS-7, stage, sedimentation, progression free and overall survival. Results: For IPS-3, SAT SUVmax and TAAT radiodensity were significantly increased in high-risk patients (2and 3) compared to group 0 and 1. For IPS-7, total abdominal adipose volume was significantly decreased in high-risk patients, SAT SUVmax significantly increased in high-risk patients and decreased in low-risk patients. In addition, SAT SUVmax was significantly increased in patients with high sedimentation rate, with B symptoms and who passed away during follow-up. SAT SUVmax showed moderate positive correlation with sedimentation, IPS-3, IPS-7, and stage. In addition, it was observed that TAAT radiodensity and SAT SUVmax were significantly better for determining prognosis than other adipose tissue indices. Roc analysis showed that the diagnostic value of all adipose tissue indices in predicting IPS-3 and IPS-7 prognoses were statistically significant. Conclusion: SAT SUVmax and TAAT radiodensity were two new and independent markers with diagnostic value in predicting prognosis.
MeSH term(s)	Humans ; Hodgkin Disease/diagnostic imaging ; Retrospective Studies ; Disease-Free Survival ; Prognosis ; Adipose Tissue/diagnostic imaging
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2024.107457
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Zs.A 1321: Show issues

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Article: Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia.

Ozbalci, Demircan / Alanoglu, Emine Guchan / Findos, Eda / Eroglu, Hande Nur

Journal of medical biochemistry

2023 Volume 42, Issue 2, Page(s) 274–281

Abstract: Background: Alterations of plateletcrit and mean platelet volume (MPV) and pathogenesis of chronic lymphocytic leukaemia (CLL) have been linked to various inflammatory disorders. The prognostic impact of plateletcrit and MPV were evaluated.: Methods: ...

Abstract	Background: Alterations of plateletcrit and mean platelet volume (MPV) and pathogenesis of chronic lymphocytic leukaemia (CLL) have been linked to various inflammatory disorders. The prognostic impact of plateletcrit and MPV were evaluated. Methods: MPV and plateletcrit levels of both CLL and control group were compared and then in CLL patients, additional diseases, leukocyte count, platelet count, lactate dehydrogenase, Rai stage, progression-free and overall survival, mutations, if any, and chemotherapy, if any, were recorded. Then, the relationship between MPV and plateletcrit values and these parameters were evaluated in CLL patients. Results: Platelet and plateletcrit values were found to be significantly lower in CLL patients than the control group (p<0.001) for both. Plateletcrit and MPV values of patients who did not receive chemotherapy were higher than those who received chemotherapy (p=0.03, p=0.02, respectively). Being over 75 years old, plateletcrit value less than 0.1565 %, platelet level below 175 x 109/L, and leukocyte count greater than 53.5 x 109/L was found to significantly reduce overall survival. Male gender, each stage increase, plateletcrit less than 0.1565 % and leukocyte count greater than 53.5 x 109/L was related to reduce treatment-free survival in CLL patients. Conclusions: Plateletcrit can be a viable prognostic marker for defining both treatment free and overall survival.
Language	English
Publishing date	2023-03-22
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	2387367-X
ISSN	1452-8258
ISSN	1452-8258
DOI	10.5937/jomb0-39375
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Zs.A 3112: Show issues

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Article ; Online: Probiyotiklerin Biyogüvenilirlik Özellikleri “Probiyotikler”

Ebru Demir / Gülden Başyiğit Kılıç / Demircan Özbalcı

Turkish Journal of Agriculture: Food Science and Technology, Vol 7, Iss 4, Pp 639-

2019 Volume 645

Abstract: Probiyotikler yeterli miktarda tüketildiğinde sağlık üzerinde birçok fayda sağlayan canlı mikroorganizmalar olarak tanımlanır. Laktik asit bakterileri (LAB) süt, et, meyve ve sebze gibi gıdaların doğal florasında bulunmakta ve fermente gıdaların ... ...

Abstract	Probiyotikler yeterli miktarda tüketildiğinde sağlık üzerinde birçok fayda sağlayan canlı mikroorganizmalar olarak tanımlanır. Laktik asit bakterileri (LAB) süt, et, meyve ve sebze gibi gıdaların doğal florasında bulunmakta ve fermente gıdaların üretiminde kültür olarak kullanılmaktadır. Bu bakteriler insan ve hayvanların bağırsak, ağız ve deri, üriner sistemin mikrobiyotalarında da bulunurlar ve bu ekosistemlerde faydalı etki gösterebilirler. Bazı Lactobacillus türleri, Bifidobacterium spp., Saccharomyces boulardii ve diğer bazı mikroorganizmalar sağlığa yararlı olmak amacıyla, gıda takviyesi şeklinde probiyotik olarak kullanılmaktadır. Probiyotiklerin, tedavi sürecinde olan hastaların çoğunda yarar sağladığı bilinse de, bağışıklık sistemi baskılanmış hastalarda risklerin mevcut olduğu belirtilmektedir. Organ ve immün yetmezliği olan ve gastrointestinal bariyerde bozulmaları bulunan hastalarda probiyotiklerin kullanımının enfeksiyonlara neden olabileceğine dair bulgular giderek artmaktadır. Probiyotiklerin bir tedavi seçeneği olarak kullanılması için olumsuz etkilerinin olmadığının kanıtlarla tespit edilmesi gereklidir. Öncelikle probiyotik olarak kullanılacak LAB’nin tanımlanmasında klasik biyokimyasal testlerin yetkin bir laboratuvarda moleküler yöntemlerle tamamlanması önemlidir. Farklı antibiyotiklere direnç, virülans faktörlerinin varlığı ve biyojenik aminlerin sentezi probiyotik bakterilerin güvenilirliği için öncelikle incelenen parametrelerdir. Probiyotiklerin güvenilirliğinin değerlendirilmesinde; probiyotik suşun farmakokinetiği ve probiyotik suş ile konakçı arasındaki etkileşimler üzerine çalışmalar bulunmaktadır. Probiyotikler için güvenlik ve kullanım protokolleri ile ilgili gerekli standartlar bulunmamaktadır. Probiyotiklerin, bir hastalığın tedavisi veya önlenmesi amacıyla kullanılabilmesi için daha fazla bilgiye ihtiyaç duyulmaktadır. Probiyotiklerin olumsuz etki gösterme olasılığını belirleyebilmek için probiyotik kullanımı hakkındaki bilgilerin revizyonu önemlidir.
Keywords	probiyotik ; laktik asit bakterileri ; biyogüvenilirlik ; virülans gen ; başlatıcı/destek kültür ; Agriculture ; S ; Agriculture (General) ; S1-972
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	Turkish Science and Technology Publishing (TURSTEP)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interference of D-dimer levels from heterophilic antibody in COVID-19: A serious concern in treatment and follow-up of patients.

Ozbalci, Demircan / Doguc, Duygu Kumbul / Yilmaz, Gulruhsar / Ozturk, Onder / Sirin, Fevziye Burcu / Akcam, Fusun Zeynep

International journal of laboratory hematology

2021 Volume 44, Issue 1, Page(s) e13–e16

MeSH term(s)	Adult ; Antibodies, Heterophile/blood ; COVID-19/blood ; COVID-19/diagnosis ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Follow-Up Studies ; Hematologic Tests ; Humans ; Male ; Middle Aged ; SARS-CoV-2/isolation & purification
Chemical Substances	Antibodies, Heterophile ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
Language	English
Publishing date	2021-08-18
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.13654
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Zs.A 1499: Show issues

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Article: Peripheral FLT-3 ligand levels as a pathobiological parameter duringthe clinical course of acute myeloid leukemia.

Şahin, Memduh / Haznedaroğlu, İbrahim Celalettin / Özbalcı, Demircan

Turkish journal of medical sciences

2016 Volume 46, Issue 6, Page(s) 1889–1893

Abstract: Background/aim: FLT-3 ligand is a growth factor affecting the hematopoietic lineage. The aim of this study was to evaluate the variability of peripheral FLT-3 ligand during the clinical course of acute myeloid leukemia (AML) patients.: Materials and ... ...

Abstract	Background/aim: FLT-3 ligand is a growth factor affecting the hematopoietic lineage. The aim of this study was to evaluate the variability of peripheral FLT-3 ligand during the clinical course of acute myeloid leukemia (AML) patients. Materials and methods: Twenty-four patients were enrolled in this study in order to assess alterations in the circulating levels of FLT-3 ligand during the clinical course of AML. Results: We studied the association in the diagnostic period between the FLT-3 ligand and peripheral blood cells together with serum electrolytes. FLT-3 ligand levels (pg/mL) during the aplastic period due to remission induction and consolidation were higher than the levels at initial diagnosis. On the other hand, the diagnostic and remission induction values of leukocytes and FLT-3 ligand showed an inverse association. These results indicate to us that higher white cell counts are associated with lower FLT-3 ligand levels. We also found a reversed association between FLT-3 ligand and serum lactate dehydrogenase level. However, there was no association between FLT-3 ligand and other serum electrolyte levels. We also found higher FLT-3 ligand levels in male patients. Conclusion: Our study demonstrates the inverse proliferative action of FLT-3 ligand on the early myeloid lineage. In addition, this study showed us that FLT-3 receptor inhibition during chemotherapy-induced aplasia causes a compensative ligand overexpression.
MeSH term(s)	Humans ; Leukemia, Myeloid, Acute ; Male ; Membrane Proteins
Chemical Substances	Membrane Proteins ; flt3 ligand protein
Language	English
Publishing date	2016-12-20
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-1504-87
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Zs.A 3242: Show issues

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Article: Successful management of imatinib despite alopecia and nail necrosis.

Ergene, Ulku / Ozbalci, Demircan

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2013 Volume 48, Issue 2, Page(s) 271–272

Abstract: Imatinib mesylate selectively inhibits bcr/abl and other non-specific tyrosine kinases, such as c-kit and platelet derived growth factor (PDGF) receptor and successfully used to treat chronic myeloid leukaemia (CML). In most cases, the drug is well ... ...

Abstract	Imatinib mesylate selectively inhibits bcr/abl and other non-specific tyrosine kinases, such as c-kit and platelet derived growth factor (PDGF) receptor and successfully used to treat chronic myeloid leukaemia (CML). In most cases, the drug is well tolerated: however, side effects can be seen. Hair loss and paronychia inflammation were often reported with Imatinib, but total alopecia was rarely mentioned. We report a CML patient who was presented with alopecia and paronychia inflammation probably induced by imatinib therapy. We have successfully treated our patient by cessation and then re-applying therapy with lower doses after improvement of lesions and have not found a similar report in literature.
MeSH term(s)	Alopecia/chemically induced ; Alopecia/pathology ; Benzamides/administration & dosage ; Benzamides/adverse effects ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Male ; Middle Aged ; Necrosis ; Paronychia/chemically induced ; Paronychia/pathology ; Piperazines/administration & dosage ; Piperazines/adverse effects ; Pyrimidines/administration & dosage ; Pyrimidines/adverse effects
Chemical Substances	Benzamides ; Piperazines ; Pyrimidines ; Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2013-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2013.01.002
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Zs.A 1739: Show issues

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Article: Hairy Cell Leukemia and cutaneous involvement.

Ergene, Ulkü / Ozbalcı, Demircan / Işisağ, Aydın

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2012 Volume 46, Issue 2, Page(s) 231–232

MeSH term(s)	Antigens, CD/blood ; Antineoplastic Agents/administration & dosage ; Cladribine/administration & dosage ; Humans ; Leukemia, Hairy Cell/blood ; Leukemia, Hairy Cell/drug therapy ; Leukemia, Hairy Cell/pathology ; Male ; Skin Neoplasms/blood ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology
Chemical Substances	Antigens, CD ; Antineoplastic Agents ; Cladribine (47M74X9YT5)
Language	English
Publishing date	2012-04
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2012.01.011
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Article: A chronic eosinophilic leukemia patient presenting with blurred vision.

Özbalcı, Demircan / Ergene, Ülkü / Yazgan, Harun

Turkish journal of haematology : official journal of Turkish Society of Haematology

2011 Volume 28, Issue 3, Page(s) 239–240

Title translation	Bulanık görmeyle başvuran kronik eozinofilik lösemi hastası.
Language	English
Publishing date	2011-09-05
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2185903-6
ISSN	1308-5263 ; 1300-7777
ISSN (online)	1308-5263
ISSN	1300-7777
DOI	10.5152/tjh.2011.63
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