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  1. Book ; Online: TIE

    Zhao, Zihan / Chen, Lu / Cao, Ruisheng / Xu, Hongshen / Chen, Xingyu / Yu, Kai

    Topological Information Enhanced Structural Reading Comprehension on Web Pages

    2022  

    Abstract: ... Information Enhanced model (TIE), which transforms the token-level task into a tag-level task by introducing ... a two-stage process (i.e. node locating and answer refining). Based on that, TIE integrates Graph ... at the time of writing. The code of TIE will be publicly available at https://github.com/X-LANCE/TIE ...

    Abstract Recently, the structural reading comprehension (SRC) task on web pages has attracted increasing research interests. Although previous SRC work has leveraged extra information such as HTML tags or XPaths, the informative topology of web pages is not effectively exploited. In this work, we propose a Topological Information Enhanced model (TIE), which transforms the token-level task into a tag-level task by introducing a two-stage process (i.e. node locating and answer refining). Based on that, TIE integrates Graph Attention Network (GAT) and Pre-trained Language Model (PLM) to leverage the topological information of both logical structures and spatial structures. Experimental results demonstrate that our model outperforms strong baselines and achieves state-of-the-art performances on the web-based SRC benchmark WebSRC at the time of writing. The code of TIE will be publicly available at https://github.com/X-LANCE/TIE.

    Comment: Accepted to NAACL 2022
    Keywords Computer Science - Computation and Language
    Publishing date 2022-05-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: MiR-221-5p regulates blood-brain barrier dysfunction through the angiopoietin-1/-2/Tie-2 signaling axis after subarachnoid hemorrhage.

    Gu, Hua / Zhong, Xing-Ming / Cai, Yong / Dong, Zhao-Hui

    Brain injury

    2024  Volume 38, Issue 3, Page(s) 194–201

    Abstract: Aim: To explore the potential role of microRNA miR-221-5p on the angiopoietin-1 (Ang-1)/Ang-2/Tie ... using transmission electron microscopy and Evans blue extravasation. Levels of Ang-1, Ang-2, and Tie-2 ... 5p might regulate blood-brain barrier dysfunction through the Ang-1/Ang-2/Tie-2 signaling axis ...

    Abstract Aim: To explore the potential role of microRNA miR-221-5p on the angiopoietin-1 (Ang-1)/Ang-2/Tie-2 signaling axis after subarachnoid hemorrhage (SAH) in a rat model.
    Methods: Aspects of the rat's behavior were measured using the Kaoutzanis scoring system to test neurological responses. This included feeding behavior, body contraction, motor, and eye-opening responses. Brain sections were studied using transmission electron microscopy and Evans blue extravasation. Levels of Ang-1, Ang-2, and Tie-2 were determined by Western blot, while miR-221-5p was quantified using stem-loop real-time quantitative PCR (RT-qPCR).
    Results: The SAH group responded worse to the neurological response test than the sham-operated group. The intercellular space was widened in the SAH group, but not in the sham-operated group. Evans blue dye leaked significantly more into brain tissue cells of the SAH group. Stem-loop qRT-PCR showed elevated miR-221-5p levels. Additionally,
    Conclusion: The data indicate that miR-221-5p might regulate blood-brain barrier dysfunction through the Ang-1/Ang-2/Tie-2 signaling axis, suggesting that it should be further investigated as a potential novel biomarker.
    MeSH term(s) Rats ; Animals ; Blood-Brain Barrier ; Subarachnoid Hemorrhage ; Angiopoietin-1/genetics ; Angiopoietin-1/metabolism ; Evans Blue/metabolism ; MicroRNAs/metabolism
    Chemical Substances Angiopoietin-1 ; Evans Blue (45PG892GO1) ; MicroRNAs ; MIRN221 microRNA, rat
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639115-1
    ISSN 1362-301X ; 0269-9052
    ISSN (online) 1362-301X
    ISSN 0269-9052
    DOI 10.1080/02699052.2024.2309263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: TIE-EEGNet: Temporal Information Enhanced EEGNet for Seizure Subtype Classification.

    Peng, Ruimin / Zhao, Changming / Jiang, Jun / Kuang, Guangtao / Cui, Yuqi / Xu, Yifan / Du, Hao / Shao, Jianbo / Wu, Dongrui

    IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

    2022  Volume 30, Page(s) 2567–2576

    Abstract: ... that our proposed TIE-EEGNet outperformed several traditional and deep learning models in cross-subject seizure ...

    Abstract Electroencephalogram (EEG) based seizure subtype classification is very important in clinical diagnostics. However, manual seizure subtype classification is expensive and time-consuming, whereas automatic classification usually needs a large number of labeled samples for model training. This paper proposes an EEGNet-based slim deep neural network, which relieves the labeled data requirement in EEG-based seizure subtype classification. A temporal information enhancement module with sinusoidal encoding is used to augment the first convolution layer of EEGNet. A training strategy for automatic hyper-parameter selection is also proposed. Experiments on the public TUSZ dataset and our own CHSZ dataset with infants and children demonstrated that our proposed TIE-EEGNet outperformed several traditional and deep learning models in cross-subject seizure subtype classification. Additionally, it also achieved the best performance in a challenging transfer learning scenario. Both our code and the CHSZ dataset are publicized.
    MeSH term(s) Child ; Electroencephalography ; Humans ; Neural Networks, Computer ; Seizures ; Signal Processing, Computer-Assisted
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1166307-8
    ISSN 1558-0210 ; 1063-6528 ; 1534-4320
    ISSN (online) 1558-0210
    ISSN 1063-6528 ; 1534-4320
    DOI 10.1109/TNSRE.2022.3204540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Solving the spectral gap problem with a four-mirror bow-tie cavity in waveguide free-electron laser oscillators.

    Xia, Mengqi / Xu, Yuanfang / Zhao, Zhouyu / Li, Heting

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 22653

    Abstract: ... In this paper, we propose to utilize a bow-tie cavity instead of conventional cavities to the waveguide FEL ... used to enable the modelling, for the first time, of a bow-tie cavity based FEL in the far-infrared ...

    Abstract The generation of intense coherent radiation pulses in the far-infrared and terahertz regimes is of considerable interest to the free-electron laser (FEL) radiation user community. At long wavelengths, the diffraction effect can be quite severe, therefore, an optical waveguide is required to confine the radiation field. However, it will also bring about some new phenomena, and the most noteworthy one is the spectral gap phenomenon: at some particular wavelengths, regardless of electron beam adjustments, the coupling efficiency and output power of waveguide FEL oscillators drop significantly. Such spectral gap has an adverse effect on experimental results since numerous experiments require continuous spectral scanning. In this paper, we propose to utilize a bow-tie cavity instead of conventional cavities to the waveguide FEL to solve the spectral gap problem. The simulation was carried out based on the parameters of FELiChEM, a newly built user facility in China. Numerical simulation code OPC combining with modified GENESIS is used to enable the modelling, for the first time, of a bow-tie cavity based FEL in the far-infrared wavelength regime. The simulation results indicate that this novel structure can effectively eliminate the spectral gaps and substantially enhance long-wavelength laser performance.
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-49803-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Angiopoietin-Tie signaling in kidney diseases: an updated review.

    He, Fang-Fang / Zhang, Di / Chen, Qing / Zhao, Yi / Wu, Liang / Li, Zhen-Qiong / Zhang, Chun / Jiang, Zhao-Hua / Wang, Yu-Mei

    FEBS letters

    2019  Volume 593, Issue 19, Page(s) 2706–2715

    Abstract: ... through the Tie tyrosine kinase receptors. The Ang-Tie signaling pathway participates in the developmental and ... of the Ang-Tie signaling pathway and summarize their roles in kidney development and maturation, acute and ... renal cell carcinoma. Understanding the molecular mechanisms of Ang-Tie signaling may reveal potential therapeutic ...

    Abstract Angiopoietins (Angs) are a family of vascular growth factors that share multiple cellular functions related to cell survival, proliferation, and migration. Angs play physiological and pathological roles through the Tie tyrosine kinase receptors. The Ang-Tie signaling pathway participates in the developmental and tumor-induced angiogenesis and is also involved in many disease settings, such as vascular diseases, systemic inflammation, and cancers. Since Angs are widely expressed in the kidney, an enormous amount of research focuses on their roles in the kidney. In this review, we describe the biological functions of the Ang-Tie signaling pathway and summarize their roles in kidney development and maturation, acute and chronic kidney diseases, diabetic nephropathy, lupus nephropathy, hemolytic uremic syndrome, end-stage renal diseases, and renal cell carcinoma. Understanding the molecular mechanisms of Ang-Tie signaling may reveal potential therapeutic targets for preventing or alleviating kidney diseases.
    MeSH term(s) Angiopoietins/metabolism ; Animals ; Humans ; Kidney Diseases/metabolism ; Receptors, TIE/metabolism ; Signal Transduction
    Chemical Substances Angiopoietins ; Receptors, TIE (EC 2.7.10.1)
    Language English
    Publishing date 2019-08-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.13568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Research on the Tie Cable Replacement Method of Half-through Tied-Arch Bridge

    Guotao Shao / Binglai Zhan / Zhenyin Zhao / Yue Xu / Hui Jin

    Applied Sciences, Vol 12, Iss 16, p

    2022  Volume 8286

    Abstract: The tie cable of the half-through tied-arch bridge generally uses external prestressed cables ... in this area at present. Aiming at a method to replace the tie cable for this kind of bridge, this study takes ... the third Lingjiang bridge, which had damage to the tie cable, as an example. Based on whether there is ...

    Abstract The tie cable of the half-through tied-arch bridge generally uses external prestressed cables, which need to be replaced regularly similarly to cables and suspenders, but there is very little research in this area at present. Aiming at a method to replace the tie cable for this kind of bridge, this study takes the third Lingjiang bridge, which had damage to the tie cable, as an example. Based on whether there is a temporary cable force-replacement structure, eight replacement schemes are designed. Firstly, the replacement process of each scheme is simulated by the finite-element model, and the influence of each replacement scheme on the upper and lower structures is analyzed. Then, according to the analysis results, the replacement schemes were compared and selected, and the best scheme was determined. Finally, based on the best scheme, the design and construction method of the temporary cable force-replacement structure were given. The results show that the replacement of tie cables of the half-through tied-arch bridge significantly impacts the piles. The internal forces of the pile and arch rib change greatly with the non-substitution method. Adopting the temporary substitution method can not only ensure structural safety but also improve the replacement speed, and the temporary substitution method of replacing one by one symmetrically on both sides proved to be the best. This study can provide a reference for the tie cable replacement of a half-through tied-arch bridge.
    Keywords tie-arch bridge ; tie cable ; replacement ; temporary substitution ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 621
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Multi-Scalar Data Integration Links Glomerular Angiopoietin-Tie Signaling Pathway Activation With Progression of Diabetic Kidney Disease.

    Liu, Jiahao / Nair, Viji / Zhao, Yi-Yang / Chang, Dong-Yuan / Limonte, Christine / Bansal, Nisha / Fermin, Damian / Eichinger, Felix / Tanner, Emily C / Bellovich, Keith A / Steigerwalt, Susan / Bhat, Zeenat / Hawkins, Jennifer J / Subramanian, Lalita / Rosas, Sylvia E / Sedor, John R / Vasquez, Miguel A / Waikar, Sushrut S / Bitzer, Markus /
    Pennathur, Subramaniam / Brosius, Frank C / De Boer, Ian / Chen, Min / Kretzler, Matthias / Ju, Wenjun

    Diabetes

    2022  Volume 71, Issue 12, Page(s) 2664–2676

    Abstract: ... the Chinese Cohort Study of Chronic Kidney Disease (N = 210). Glomerular transcriptional angiopoietin/Tie (ANG ... TIE) pathway scores, derived from the expression of 154 ANG-TIE signaling mediators, correlated ... ANG-TIE pathway scores in endothelial cells corroborated potential functional effects in the kidney ...

    Abstract Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD). Prognostic biomarkers reflective of underlying molecular mechanisms are critically needed for effective management of DKD. A three-marker panel was derived from a proteomics analysis of plasma samples by an unbiased machine learning approach from participants (N = 58) in the Clinical Phenotyping and Resource Biobank study. In combination with standard clinical parameters, this panel improved prediction of the composite outcome of ESKD or a 40% decline in glomerular filtration rate. The panel was validated in an independent group (N = 68), who also had kidney transcriptomic profiles. One marker, plasma angiopoietin 2 (ANGPT2), was significantly associated with outcomes in cohorts from the Cardiovascular Health Study (N = 3,183) and the Chinese Cohort Study of Chronic Kidney Disease (N = 210). Glomerular transcriptional angiopoietin/Tie (ANG-TIE) pathway scores, derived from the expression of 154 ANG-TIE signaling mediators, correlated positively with plasma ANGPT2 levels and kidney outcomes. Higher receptor expression in glomeruli and higher ANG-TIE pathway scores in endothelial cells corroborated potential functional effects in the kidney from elevated plasma ANGPT2 levels. Our work suggests that ANGPT2 is a promising prognostic endothelial biomarker with likely functional impact on glomerular pathogenesis in DKD.
    MeSH term(s) Humans ; Angiopoietin-1/genetics ; Receptor, TIE-2/genetics ; Diabetic Nephropathies/genetics ; Cohort Studies ; Endothelial Cells ; Angiopoietin-2/genetics ; Angiopoietins ; Signal Transduction ; Biomarkers ; Kidney Failure, Chronic ; Disease Progression ; Diabetes Mellitus
    Chemical Substances Angiopoietin-1 ; Receptor, TIE-2 (EC 2.7.10.1) ; Angiopoietin-2 ; Angiopoietins ; Biomarkers
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db22-0169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Angiopoietin‐Tie signaling in kidney diseases: an updated review

    He, Fang‐Fang / Zhang, Di / Chen, Qing / Zhao, Yi / Wu, Liang / Li, Zhen‐Qiong / Zhang, Chun / Jiang, Zhao‐Hua / Wang, Yu‐Mei

    FEBS letters. 2019 Oct., v. 593, no. 19

    2019  

    Abstract: ... through the Tie tyrosine kinase receptors. The Ang‐Tie signaling pathway participates in the developmental and ... of the Ang‐Tie signaling pathway and summarize their roles in kidney development and maturation, acute and ... renal cell carcinoma. Understanding the molecular mechanisms of Ang‐Tie signaling may reveal potential therapeutic ...

    Abstract Angiopoietins (Angs) are a family of vascular growth factors that share multiple cellular functions related to cell survival, proliferation, and migration. Angs play physiological and pathological roles through the Tie tyrosine kinase receptors. The Ang‐Tie signaling pathway participates in the developmental and tumor‐induced angiogenesis and is also involved in many disease settings, such as vascular diseases, systemic inflammation, and cancers. Since Angs are widely expressed in the kidney, an enormous amount of research focuses on their roles in the kidney. In this review, we describe the biological functions of the Ang‐Tie signaling pathway and summarize their roles in kidney development and maturation, acute and chronic kidney diseases, diabetic nephropathy, lupus nephropathy, hemolytic uremic syndrome, end‐stage renal diseases, and renal cell carcinoma. Understanding the molecular mechanisms of Ang‐Tie signaling may reveal potential therapeutic targets for preventing or alleviating kidney diseases.
    Keywords angiogenesis ; angiopoietins ; cell viability ; diabetic nephropathy ; hemolytic uremic syndrome ; inflammation ; kidneys ; renal cell carcinoma ; therapeutics ; tyrosine
    Language English
    Dates of publication 2019-10
    Size p. 2706-2715.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note REVIEW
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.13568
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Predominant classic circular-stapled double-tract reconstruction after totally laparoscopic proximal gastrectomy: safe, feasible, time-saving anastomoses by technical tie-up.

    Hu, Jian / Zhao, Lizhi / Xue, Hongyuan / Zhang, Ziqiang / Du, Jianjun

    Surgical endoscopy

    2020  Volume 34, Issue 11, Page(s) 5181–5187

    Abstract: ... string Suture Technique (Technical Tie-Up). Demographic and clinicopathologic characteristics ... reconstruction is safe, feasible and time-saving in TLPG by the technical tie-up. ...

    Abstract Background: The double-tract reconstruction (DTR) could be a preferable option in avoiding the postoperative esophageal reflux and anastomotic stenosis during totally laparoscopic proximal gastrectomy (TLPG). An optimal procedure to achieve the DTR in TLPG remains to be established.
    Methods: During March 2018 to April 2019, 15 consecutive patients with gastric cancer in the upper third of the stomach underwent intracorporeal DTR after TLPG at our hospital. The intracorporeal esophagojejunostomy (E-J), gastrojejunostomy (G-J) and jejunojejunostomy (J-J) were, respectively, performed using circular staplers by the Self-Pulling and Holding Purse-String Suture Technique, Intraluminal Poke Technique and U-shaped Parallel Purse-string Suture Technique (Technical Tie-Up). Demographic and clinicopathologic characteristics, perioperative details and postoperative outcomes were analyzed.
    Results: The mean operating time was 216.1 ± 18.2 min. Total time for three anastomoses was 49.8 ± 6.1 min, and the time for E-J, G-J, J-J was 22.4 ± 5.0 min, 13 (range 11-16) min, 14.2 ± 2.8 min, respectively. The median proximal and distal resection margins were 2.5 (range 2-4) cm and 6 (range 5-7) cm, respectively, which were all tumor-free in 15 patients. No major complications and mortality occurred. During the median follow-up period of 14 months (range 7 to 20.5 months), there were no postoperative anastomosis-related complications observed, such as anastomotic bleeding, leakage or stenosis. No patients complained the symptoms indicating esophageal reflux and remnant gastritis.
    Conclusions: Predominant classic circular-stapled double-tract reconstruction is safe, feasible and time-saving in TLPG by the technical tie-up.
    MeSH term(s) Adult ; Aged ; Anastomosis, Surgical ; Feasibility Studies ; Female ; Gastrectomy/methods ; Gastric Bypass ; Gastroesophageal Reflux/surgery ; Humans ; Laparoscopy/methods ; Male ; Middle Aged ; Operative Time ; Postoperative Complications/surgery ; Reconstructive Surgical Procedures/methods ; Stomach Neoplasms/surgery ; Surgical Stapling/methods ; Suture Techniques
    Language English
    Publishing date 2020-07-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-020-07824-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal.

    Zhao, Qiang / Xing, Feng / Tao, Yanyan / Liu, Hongliang / Huang, Kai / Peng, Yuan / Feng, Nianping / Liu, Chenghai

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 1

    Abstract: We previously discovered that Xiaozhang Tie (XZT) was helpful for cirrhotic ascites, with obvious ...

    Abstract We previously discovered that Xiaozhang Tie (XZT) was helpful for cirrhotic ascites, with obvious abdominal distention relief, suggesting that it may improve gastrointestinal (GI) motility. However, the underlying mechanisms of GI motility in cirrhotic ascites are unclear. Here, we aimed to discover explored the effect of XZT on GI motility in animal cirrhotic ascites and probed the action mechanism affecting GI motility by regulating the stem cell factor (SCF)/c-kit pathway in interstitial cells of Cajal (ICCs) and GI hormones. First, rat models of cirrhotic ascites were developed and then divided randomly into the following three subgroups: model control, XZT group, and mosapride group. The efficacy of XZT on treating cirrhotic ascites was evaluated on the basis of ascites weight and volume, 24 h urine volume, and feces water content. GI motility of the cirrhotic model, intestine propulsion, and gastric residue were detected using the migration distance of ink
    Language English
    Publishing date 2020-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.00001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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