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Article ; Online: Gut microbiome profiles may be related to atypical antipsychotic associated overweight in Asian children with psychiatric disorder: a preliminary study.

Hao, Shao-Rui / Zhou, Yuan-Yue / Zhang, Xue / Jiang, Hai-Yin

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1124846

Abstract: Objective: Atypical antipsychotics (APs) modify the gut microbiome, and weight gain in response to AP could be mediated by the gut microbiome. Thus, the present study aimed to explore the changes in the gut bacterial microbiome in AP-exposed children ... ...

Abstract	Objective: Atypical antipsychotics (APs) modify the gut microbiome, and weight gain in response to AP could be mediated by the gut microbiome. Thus, the present study aimed to explore the changes in the gut bacterial microbiome in AP-exposed children with obesity. Methods: To rule out the confounder of AP indication, the gut bacterial microbiome was compared between healthy controls (Con) and AP-exposed individuals with overweight (APO) or normal weight (APN). Fifty-seven AP-treated outpatients (21 APO and 36 APN) and 25 Con were included in this cross-sectional microbiota study. Results: AP users, regardless of body mass index, exhibited decreased microbial richness and diversity and a distinct metagenomic composition compared to the Con. Although no differences in the microbiota structure were observed between APO and APN groups, the APO group was characterised by a higher abundance of Conclusions: The gut bacterial microbiota of APO children revealed taxonomic and functional differences compared to Con and APN. Further studies are needed to verify these findings and to explore the temporal and causal relationships between these variables.
MeSH term(s)	Humans ; Child ; Overweight/chemically induced ; Overweight/drug therapy ; Overweight/microbiology ; Gastrointestinal Microbiome/physiology ; Antipsychotic Agents/adverse effects ; Cross-Sectional Studies ; Mental Disorders ; Bacteria/genetics ; RNA, Ribosomal, 16S/genetics ; Feces/microbiology
Chemical Substances	Antipsychotic Agents ; RNA, Ribosomal, 16S
Language	English
Publishing date	2023-05-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1124846
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Article ; Online: Altered gut bacterial-fungal interkingdom networks in children and adolescents with depression.

Hao, Shao-Rui / Zhang, Zhe / Zhou, Yuan-Yue / Zhang, Xue / Sun, Wen-Jun / Yang, Zi / Zhao, Jian-Hua / Jiang, Hai-Yin

Journal of affective disorders

2023 Volume 332, Page(s) 64–71

Abstract: Background: Most studies of the gut-brain axis have focused on bacteria; little is known about commensal fungi. Children and adolescents with depression were reported to have gut bacterial microbiota dysbiosis, but the role of the mycobiota has not been ...

Abstract	Background: Most studies of the gut-brain axis have focused on bacteria; little is known about commensal fungi. Children and adolescents with depression were reported to have gut bacterial microbiota dysbiosis, but the role of the mycobiota has not been evaluated. Methods: Faecal samples were obtained from 145 children and adolescents with depression and 110 age- and gender-matched healthy controls. We analysed the fungal microbiota, including in terms of their associations with the gut microbiota, and subjected the internal transcribed spacer 2 (ITS2) rRNA gene to mitochondrial sequencing. Results: Our findings revealed unaltered fungal diversity, but altered taxonomic composition, of the faecal fungal microbiota in the children and adolescents with depression. Key fungi such as Saccharomyces and Apiotrichum were enriched in the depressed patients, while Aspergillus and Xeromyces showed significantly decreased abundance. Interestingly, the bacterial-fungal interkingdom network was markedly altered in the children and adolescents with depression, and mycobiome profiles were associated with different bacterial microbiomes. Limitation: The cross-sectional design precluded the establishment of a causal relationship between the gut mycobiota and the children and adolescents with depression. Conclusions: The gut mycobiome is altered in the children and adolescents with depression. Our findings suggest that fungi play an important role in the balance of the gut microbiota and may help identify novel therapeutic targets for depression.
MeSH term(s)	Humans ; Adolescent ; Child ; Gastrointestinal Microbiome/genetics ; Fungi/genetics ; Cross-Sectional Studies ; Depression ; Bacteria ; Feces/microbiology
Language	English
Publishing date	2023-03-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2023.03.086
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Article ; Online: Deep learning-based design and screening of benzimidazole-pyrazine derivatives as adenosine A

Qin, Rui / Zhang, Hao / Huang, Weifeng / Shao, Zhenglin / Lei, Jinping

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–17

Abstract: The Adenosine ... ...

Abstract	The Adenosine A
Language	English
Publishing date	2023-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2295974
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Article ; Online: Bioequivalence Study of Tebipenem Pivoxil in Healthy Chinese Adults.

Hao, Rui / Shao, Yiming / Lin, Sisi / Wu, Yi / Bian, Li / Zhang, Yiwen

Drugs in R&D

2024 Volume 24, Issue 1, Page(s) 89–96

Abstract: Background and objective: Tebipenem pivoxil (TP) is a carbapenem and is applied against pneumonia, otitis media, and sinusitis. This study compared the pharmacokinetics (PK) and safety of a test (T) preparation and reference (R) preparation of TP in ... ...

Abstract	Background and objective: Tebipenem pivoxil (TP) is a carbapenem and is applied against pneumonia, otitis media, and sinusitis. This study compared the pharmacokinetics (PK) and safety of a test (T) preparation and reference (R) preparation of TP in healthy Chinese adults. Methods: This study was a single-center, randomized, open, single-dose (fasting/postprandial) oral administration, two-agent, two-sequence, two-cycle, crossover bioequivalence trial. A total of 60 participants were enrolled (24 fasting and 36 postprandial). All participants were randomly assigned to the TR sequence and RT sequence. Subsequently, they switched T sequences or R sequences 7 days later. PK blood samples were collected according to the protocol, plasma TP concentration was determined by liquid chromatography-mass spectrometry, main PK parameters were calculated based on a non-compartment model, and adverse events were recorded during the test. Results: In the feeding arm, the geometric mean ratio of maximum concentration (C Conclusion: Preparations T and R of TP were bioequivalent in the fasting and postprandial groups in clinical trials, and TP was safe.
Language	English
Publishing date	2024-03-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2020476-0
ISSN	1179-6901 ; 1174-5886
ISSN (online)	1179-6901
ISSN	1174-5886
DOI	10.1007/s40268-024-00454-w
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Article ; Online: Preparation of molecularly imprinted ratiometric fluorescence sensor for visual detection of tetrabromobisphenol A in water samples.

Shao, Yanming / Wang, Peng / Zheng, Rui / Zhao, Zhizhen / An, Jun / Hao, Caifeng / Kang, Mengyi

Mikrochimica acta

2023 Volume 190, Issue 4, Page(s) 161

Abstract: A sensitive molecularly imprinted ratiometric fluorescence sensor was constructed for the first time to visually detect tetrabromobisphenol A (TBBPA). The blue fluorescent carbon quantum dots (CQDs) were coated with ... ...

Abstract	A sensitive molecularly imprinted ratiometric fluorescence sensor was constructed for the first time to visually detect tetrabromobisphenol A (TBBPA). The blue fluorescent carbon quantum dots (CQDs) were coated with SiO
Language	English
Publishing date	2023-03-28
Publishing country	Austria
Document type	Journal Article
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-023-05745-8
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Article: Effect of hyperbaric oxygen combined with folic acid on clinical efficacy and cognitive function in patients with cerebral small vessel disease.

Liu, Rui / Hao, Ming / Hui, Jing / Shao, Jing / Ma, Wan / Dang, Lili

American journal of translational research

2023 Volume 15, Issue 3, Page(s) 1897–1904

Abstract: Objective: To identify the effect of hyperbaric oxygen combined with folic acid on clinical efficacy and cognitive function in patients with cerebral small vessel disease (CSVD), and to analyze the risk factors affecting efficacy.: Methods: Data from ...

Abstract	Objective: To identify the effect of hyperbaric oxygen combined with folic acid on clinical efficacy and cognitive function in patients with cerebral small vessel disease (CSVD), and to analyze the risk factors affecting efficacy. Methods: Data from 108 elderly patients with CSVD (homocysteine (Hcy) > 10 μmol/L) treated in The First Hospital of Yulin from February 2019 to February 2022 were retrospectively analyzed. Among them, 50 patients treated with folic acid were set as the control group (CG), and the remaining 58 patients treated with additional hyperbaric oxygen therapy were in the study group (SG). Clinical efficacy was compared between the two groups after treatment, and changes in Hcy level before and after treatment were observed. Montreal Cognitive Assessment (MoCA) was used to compare the improvement of cognitive function between two groups. According to the efficacy after treatment, patients with markedly effective and effective responses were set as the improved group, and patients with ineffective response as the unimproved group. Risk factors affecting the efficacy of the patients were analyzed by logistic regression. Also, changes in quality of life (assessed by activities of daily living (ADL) scale) before and after treatment as well as the incidence of adverse reactions after treatment were and compared between groups. Results: Before treatment, there was no significant difference identified in MoCA scores, plasma Hcy levels, or ADL scores between the two groups (P > 0.05). After treatment, scores of MoCA and ADL increased and plasma Hcy level decreased in both groups, and the changes in the SG were more significant than those in the CG (P < 0.05). Additionally, no notable difference was observed in the incidence of adverse reactions between the two groups (P > 0.05). Logistic regression analysis revealed that hypertension, hyperlipidemia, and diabetes were risk factors affecting the efficacy. Conclusion: Hyperbaric oxygen combined with folic acid can effectively improve cognitive function and quality of life, and reduce Hcy level in patients with CSVD. In addition, hypertension, hyperlipidemia, and diabetes are risk factors affecting efficacy.
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Heterophyllin B ameliorates gastric cancer tumor growth through activating ER stress.

Xue, Wanli / Sun, Rui / Hao, Zheng / Xing, Zhenzhen / Cheng, Hongjie / Shao, Lei

Tissue & cell

2023 Volume 83, Page(s) 102129

Abstract: Background: Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. Heterophyllin B (HB) has been proved to be a potential drug in cancer treatment.: Methods: In the current study, GC cells were treated with 0, 10, 25, or 50 ...

Abstract	Background: Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. Heterophyllin B (HB) has been proved to be a potential drug in cancer treatment. Methods: In the current study, GC cells were treated with 0, 10, 25, or 50 μM of HB. Cell viability was determined by utilizing MTT assay. Flow cytometry was carried out for cell apoptosis and cell cycle analysis. The expression levels of IRE1, CHOP, GRP78 and Bcl-2 in cells and tumors were measured by Western blot and immunohistochemistry, respectively. Results: Our data uncovered that HB administration significantly suppressed GC cell viability, but facilitated GC cell apoptosis and cell cycle arrest at G0/G1 phase. The effects of HB on GC cell proliferation, apoptosis and cell cycle showed dosage-dependent manner. Furthermore, expression of ER stress-associated proteins like IRE1, CHOP and GRP78 was markedly upregulated, while anti-apoptosis protein Bcl2 expression was inhibited by HB treatment in a dosage-dependent manner. Our data indicated that HB treatment facilitated caspase-3 expression in a dose-dependent manner, but had no effect on caspase-8 expression. Importantly, the inhibition of HB to GC cell apoptosis and cell cycle process and the promotion of HB to GC cell proliferation were partly rescued by inhibition of ER stress utilizing 4-PBA. In animal experiments, HB administration suppressed GC tumor growth, boosted IRE1, CHOP and GRP78 expression and inhibited Bcl-2 expression. Conclusion: All in all, HB treatment could effectively suppress GC cells proliferation and tumors growth and facilitate GC cells apoptosis and cell cycle arrest through activating ER stress. Our data indicated that HB may be a potential drug for GC treatment.
MeSH term(s)	Animals ; Stomach Neoplasms/pathology ; Cell Line, Tumor ; Endoplasmic Reticulum Chaperone BiP ; Proto-Oncogene Proteins c-bcl-2 ; Protein Serine-Threonine Kinases ; Cell Proliferation
Chemical Substances	heterophyllin B ; Endoplasmic Reticulum Chaperone BiP ; Proto-Oncogene Proteins c-bcl-2 ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-06-09
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2023.102129
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Article ; Online: Tetrandrine inhibits migration and invasion of BGC-823 and MKN-45 cells by regulating PI3K/AKT/mTOR signaling pathway.

Xue, Wanli / Sun, Rui / Hao, Zheng / Xing, Zhenzhen / Cheng, Hongjie / Shao, Lei

Chemical biology & drug design

2023 Volume 101, Issue 4, Page(s) 927–936

Abstract: Tetrandrine (Tet), a traditional Chinese herbal medicine extract, exhibits anti-cancer effect on many types of cancer. Nonetheless, the action mechanism of Tet in gastric cancer (GC) is still largely unclear. In the current study, proliferation, invasion, ...

Abstract	Tetrandrine (Tet), a traditional Chinese herbal medicine extract, exhibits anti-cancer effect on many types of cancer. Nonetheless, the action mechanism of Tet in gastric cancer (GC) is still largely unclear. In the current study, proliferation, invasion, and migration of the BGC-823 and MKN-45 cells were effectively suppressed by Tet treatment in a dose-dependent manner. Moreover, Tet suppressed expression of the proliferation-associated protein PCNA, the interstitial cell phenotype N-cadherin, and the extracellular matrix-associated MMP-2 and MMP-9 in BGC-823 and MKN-45 cells in a dose-dependent manner. PI3K/AKT/mTOR, a cancer promoting signaling, was inactivated by Tet in a dose-dependent manner in BGC-823 and MKN-45 cells. Furthermore, our results demonstrated that the inhibition of Tet to PCNA, N-cadherin, MMP-2, and MMP-9 expression was partly rescuedby AKT inhibitor or mTOR inhibitor. In animal experiments, tumor growth was inhibited by Tet administration in a dose-dependent manner. In conclusion, the current data indicated that Tet had a critical effect on inhibiting BGC-823 and MKN-45 cells proliferation, migration, invasion, and tumor growth via regulating PI3K/AKT/mTOR signaling pathway, suggesting that Tet might be a potential treatment for GC.
MeSH term(s)	Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Matrix Metalloproteinase 9/metabolism ; Matrix Metalloproteinase 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Proliferating Cell Nuclear Antigen/pharmacology ; Cell Movement ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Cell Proliferation ; Cell Line, Tumor ; Stomach Neoplasms
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; tetrandrine (29EX23D5AJ) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proliferating Cell Nuclear Antigen ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2216600-2
ISSN	1747-0285 ; 1747-0277
ISSN (online)	1747-0285
ISSN	1747-0277
DOI	10.1111/cbdd.14202
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Article ; Online: Precise Regulation on the Bond Dissociation Energy of Exocyclic C-N Bonds in Various N-Heterocycle Electron Donors via Machine Learning.

Meng, Qing-Yu / Wang, Rui / Shao, Hao-Yun / Wang, Yi-Lei / Wen, Xue-Liang / Yao, Cheng-Yu / Qiao, Juan

The journal of physical chemistry letters

2024 Volume 15, Issue 16, Page(s) 4422–4429

Abstract: Heterocycles with saturated N atoms (HetSNs) are widely used electron donors in organic light-emitting diode (OLED) materials. Their relatively low bond dissociation energy (BDE) of exocyclic C-N bonds has been closely related to material intrinsic ... ...

Abstract	Heterocycles with saturated N atoms (HetSNs) are widely used electron donors in organic light-emitting diode (OLED) materials. Their relatively low bond dissociation energy (BDE) of exocyclic C-N bonds has been closely related to material intrinsic stability and even device lifetime. Thus, it is imperative to realize fast prediction and precise regulation of those C-N BDEs, which demands a deep understanding of the relationship between the molecular structure and BDE. Herein, via machine learning (ML), we rapidly and accurately predicted C-N BDEs in various HetSNs and found that five-membered HetSNs (5-HetSNs) have much higher BDEs than almost all 6-HetSNs, except emerging boron-N blocks. Thorough analysis disclosed that high aromaticity is the foremost factor accounting for the high BDE of 5-HetSNs, and introducing intramolecular hydrogen-bond or electron-withdrawing moieties could also increase BDE. Importantly, the ML models performed well in various realistic OLED materials, showing great potential in characterizing material intrinsic stability for high-throughput virtual-screening and material design efforts.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.4c00705
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Article ; Online: Sex-biased DNA methylation in papillary thyroid cancer.

Han, Rui / Sun, Wei / Huang, Jiapeng / Shao, Liang / Zhang, Hao

Biomarkers in medicine

2021 Volume 15, Issue 2, Page(s) 109–120

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; DNA Methylation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Promoter Regions, Genetic ; Thyroid Cancer, Papillary ; Young Adult
Language	English
Publishing date	2021-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2020-0215
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