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  1. Book ; Thesis: Therapieergebnisse beim rezidivierten nodulär Lymphozyten-prädominanten Hodgkin Lymphom

    Schröder, Lena / Engert, Andreas / Simon, Thorsten

    2018  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgelegt von Lena Schröder ; 1. Berichterstatter: Universitätsprofessor Dr. med. A. Engert, 2. Berichterstatter: Professor Dr. med. Th. Simon ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I Hämatologie und Onkologie
    Subject code 610
    Language German
    Size 59 Blätter, Illustrationen
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2018
    HBZ-ID HT019925066
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 D 11 order for loan Magazin

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  2. Book ; Online ; Thesis: Therapieergebnisse beim rezidivierten nodulär Lymphozyten-prädominanten Hodgkin Lymphom

    Schröder, Lena / Engert, Andreas / Simon, Thorsten

    2018  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgelegt von Lena Schröder ; 1. Berichterstatter: Universitätsprofessor Dr. med. A. Engert, 2. Berichterstatter: Professor Dr. med. Th. Simon ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I Hämatologie und Onkologie
    Subject code 610
    Language German
    Size 1 Online-Ressource (59 Seiten), Illustrationen
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2018
    Note Open Access
    HBZ-ID HT019884538
    DOI 10.4126/FRL01-006411372
    Database Repository for Life Sciences

    Full text online

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  3. Book ; Thesis: Prädiktion und Qualitätsverbesserung in der Hüftendoprothetik durch digitale Planung bezüglich des Prothesentyps, der Prothesengröße, der Beinlänge, des Offsets und des Pfanneneignungswinkels

    Schröder, Simon Malte

    2011  

    Author's details vorgelegt von Simon Malte Schröder
    Language German
    Size 107 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2011
    HBZ-ID HT017223948
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 E 793 order for loan Magazin

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  4. Article ; Online: Declining winter heat loss threatens continuing ocean convection at a Mediterranean dense water formation site

    Simon A Josey / Katrin Schroeder

    Environmental Research Letters, Vol 18, Iss 2, p

    2023  Volume 024005

    Abstract: A major change in winter sea surface heat loss between two key Mediterranean dense water formation sites, the North–West Mediterranean (NWMed) and the Aegean Sea, since 1950 is revealed using atmospheric reanalyses. The NWMed heat loss has weakened ... ...

    Abstract A major change in winter sea surface heat loss between two key Mediterranean dense water formation sites, the North–West Mediterranean (NWMed) and the Aegean Sea, since 1950 is revealed using atmospheric reanalyses. The NWMed heat loss has weakened considerably (from −154 Wm ^−2 in 1951–1985 to −137 Wm ^−2 in 1986–2020) primarily because of reduced latent heat flux. This long-term weakening threatens continued dense water formation, and we show by evaluation of historical observations that winter-time ocean convection in the NWMed has declined by 40% from 1969 to 2018. Extension of the heat flux analysis reveals changes at other key dense water formation sites that favour an eastward shift in the locus of Mediterranean convection towards the Aegean Sea (where heat loss has remained unchanged at −172 Wm ^−2 ). The contrasting behaviour is due to differing time evolution of sea-air humidity and temperature gradients. These gradients have weakened in the NWMed due to more rapid warming of the air than the sea surface but remain near-constant in the Aegean. The different time evolution reflects the combined effects of global heating and atmospheric circulation changes which tend to offset heating in the Aegean but not the NWMed. The shift in heat loss has potentially significant consequences for dense water formation at these two sites and outflow to the Atlantic. Our observation of differential changes in heat loss has implications for temporal variations in the balance of convection elsewhere e.g. the Labrador-Irminger-Nordic Seas nexus of high latitude Atlantic dense water formation sites.
    Keywords ocean-atmosphere interaction ; climate change ; dense water formation ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Science ; Q ; Physics ; QC1-999
    Subject code 551
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher IOP Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online ; Thesis: Implications of functional diversity for the pandemic risk of highly pathogenic coronaviruses

    Schroeder, Simon [Verfasser]

    2021  

    Author's details Simon Schroeder
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Freie Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  6. Article ; Online: Assessing Representation Learning and Clustering Algorithms for Computer-Assisted Image Annotation-Simulating and Benchmarking MorphoCluster.

    Schröder, Simon-Martin / Kiko, Rainer

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 7

    Abstract: Image annotation is a time-consuming and costly task. Previously, we published MorphoCluster as a novel image annotation tool to address problems of conventional, classifier-based image annotation approaches: their limited efficiency, training set bias ... ...

    Abstract Image annotation is a time-consuming and costly task. Previously, we published MorphoCluster as a novel image annotation tool to address problems of conventional, classifier-based image annotation approaches: their limited efficiency, training set bias and lack of novelty detection. MorphoCluster uses clustering and similarity search to enable efficient, computer-assisted image annotation. In this work, we provide a deeper analysis of this approach. We simulate the actions of a MorphoCluster user to avoid extensive manual annotation runs. This simulation is used to test supervised, unsupervised and transfer representation learning approaches. Furthermore, shrunken
    MeSH term(s) Algorithms ; Benchmarking ; Cluster Analysis ; Computers ; Data Curation ; Image Processing, Computer-Assisted/methods
    Language English
    Publishing date 2022-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22072775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Sonographic Aeration Scoring Indicates Disease Severity in Critically Ill Patients with COVID-19.

    Marggrander, Daniel T / Simon, Philippe / Schröder, Tobias / Gill-Schuster, Daniel / Mutlak, Haitham

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 22

    Abstract: Aims and methods: We evaluated an ultrasound score from 0 to 32 points in eight pulmonary regions to monitor critically ill COVID-19 patients. The score was correlated to surrogate parameters of disease severity, i.e., the oxygenation index, respiratory ...

    Abstract Aims and methods: We evaluated an ultrasound score from 0 to 32 points in eight pulmonary regions to monitor critically ill COVID-19 patients. The score was correlated to surrogate parameters of disease severity, i.e., the oxygenation index, respiratory support, mortality, plasma interleukin-6, and WHO and ARDS classifications.
    Results: A total of 27 patients were repeatedly examined, and 71 examinations were evaluated. Patients with severe COVID-19 scored higher (median 17) than those with moderate disease (median 11,
    Conclusions: The ultrasound score is a reliable tool that might help monitor disease severity and may help stratify the risk of mortality.
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13223446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Coupling and regulation mechanisms of the flavin-dependent halogenase PyrH observed by infrared difference spectroscopy.

    Schroeder, Lea / Diepold, Niklas / Gäfe, Simon / Niemann, Hartmut H / Kottke, Tilman

    The Journal of biological chemistry

    2024  Volume 300, Issue 4, Page(s) 107210

    Abstract: Flavin-dependent halogenases are central enzymes in the production of halogenated secondary metabolites in various organisms and they constitute highly promising biocatalysts for regioselective halogenation. The mechanism of these monooxygenases includes ...

    Abstract Flavin-dependent halogenases are central enzymes in the production of halogenated secondary metabolites in various organisms and they constitute highly promising biocatalysts for regioselective halogenation. The mechanism of these monooxygenases includes formation of hypohalous acid from a reaction of fully reduced flavin with oxygen and halide. The hypohalous acid then diffuses via a tunnel to the substrate-binding site for halogenation of tryptophan and other substrates. Oxidized flavin needs to be reduced for regeneration of the enzyme, which can be performed in vitro by a photoreduction with blue light. Here, we employed this photoreduction to study characteristic structural changes associated with the transition from oxidized to fully reduced flavin in PyrH from Streptomyces rugosporus as a model for tryptophan-5-halogenases. The effect of the presence of bromide and chloride or the absence of any halides on the UV-vis spectrum of the enzyme demonstrated a halide-dependent structure of the flavin-binding pocket. Light-induced FTIR difference spectroscopy was applied and the signals assigned by selective isotope labeling of the protein moiety. The identified structural changes in α-helix and β-sheet elements were strongly dependent on the presence of bromide, chloride, the substrate tryptophan, and the product 5-chloro-tryptophan, respectively. We identified a clear allosteric coupling in solution at ambient conditions between cofactor-binding site and substrate-binding site that is active in both directions, despite their separation by a tunnel. We suggest that this coupling constitutes a fine-tuned mechanism for the promotion of the enzymatic reaction of flavin-dependent halogenases in dependence of halide and substrate availability.
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Abschätzung der Bodenerwärmungen durch Erdkabel und deren Auswirkungen auf den Humusumsatz. Erdkabel, Bodentemperatur, Humus, Betriebsszenarien. underground cable, soil temperature, humus, operating scenarios

    Marschner, Bernd / König, Christoph / Schröder, Simon

    Bodenschutz

    2023  Volume 28, Issue 2, Page(s) 43

    Language German
    Document type Article
    ZDB-ID 1377620-4
    ISSN 1432-170X
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 6559: Show issues

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  10. Article ; Online: Mineral carbonation of peridotite fueled by magmatic degassing and melt impregnation in an oceanic transform fault.

    Klein, Frieder / Schroeder, Timothy / John, Cédric M / Davis, Simon / Humphris, Susan E / Seewald, Jeffrey S / Sichel, Susanna / Bach, Wolfgang / Brunelli, Daniele

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 8, Page(s) e2315662121

    Abstract: Most of the geologic ... ...

    Abstract Most of the geologic CO
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2315662121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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