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Article: Designing robust chitosan-based hydrogels for stem cell nesting under oxidative stress.

Olfat Noubari, Zahra / Golchin, Asal / Fathi, Marziyeh / Nakhlband, Ailar

2021 Volume 12, Issue 1, Page(s) 57–64

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-10-16
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2604624-6
ISSN	2228-5660 ; 2228-5652
ISSN (online)	2228-5660
ISSN	2228-5652
DOI	10.34172/bi.2021.23831
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Atherosclerosis preventive effects of marrubiin against (TNF-α)-induced oxidative stress and apoptosis.

Nakhlband, Ailar / Garjani, Alireza / Saeedi, Nazli / Omidi, Yadollah / Ghaffari, Samad / Barar, Jaleh / Eskandani, Morteza

Journal of cardiovascular and thoracic research

2023 Volume 15, Issue 3, Page(s) 174–180

Abstract: Introduction: Atherosclerosis is a complicated cascade of inflammatory processes, oxidative stress, and apoptosis, making it the most prevalent cardiovascular disease. The onset and progression of cardiovascular diseases are greatly influenced by ... ...

Abstract	Introduction: Atherosclerosis is a complicated cascade of inflammatory processes, oxidative stress, and apoptosis, making it the most prevalent cardiovascular disease. The onset and progression of cardiovascular diseases are greatly influenced by oxidative stress. Targeting oxidative stress is an effective strategy for treating such diseases. Marrubiin is a bioactive furan labdane diterpenoid acts as a strong antioxidant to protect against oxidative damage. This study aimed to investigate the protective effects of marrubiin against oxidative stress and apoptosis in a cellular model of the vascular system. Methods: Human umbilical vein endothelial cells were treated with varying concentration of marrubiin and its IC50 value was determined. The antioxidant potential of marrubiin was assessed by measuring the intracellular level of glutathione (GSH) using a colorimetric technique. Since apoptosis plays a significant role in the plaque rupture, the study also evaluated the protective effects of marrubiin on the expression of key genes involved in apoptotic pathways. Results: Cells treated with marrubiin showed increased GSH levels compared to cell therapy control cells, indicating marrubiin's ability to counteract the effects of TNF-α's on GSH levels. Furthermore real-time PCR analysis demonstrated that marrubiin upregulated Bcl-xl while downregulating caspase3 and Nox4 in treated cells. These findings suggest that marrubiin protects against apoptosis and oxidative stress. Conclusion: Based on our findings, marrubiin is recommended as a preventive/therapeutic treatment for diseases caused by elevated intracellular reactive oxygen species levels in cardiovascular diseases.
Language	English
Publishing date	2023-09-23
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2654729-6
ISSN	2008-6830 ; 2008-5117
ISSN (online)	2008-6830
ISSN	2008-5117
DOI	10.34172/jcvtr.2023.31704
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Article ; Online: Interferon-beta offers promising avenues to COVID-19 treatment: a systematic review and meta-analysis of clinical trial studies.

Nakhlband, Ailar / Fakhari, Ali / Azizi, Hosein

Naunyn-Schmiedeberg's archives of pharmacology

2021 Volume 394, Issue 5, Page(s) 829–838

Abstract: Severe acute respiratory syndrome coronavirus 2 principally weakens the hosts' innate immune system by impairing the interferon function and production. Type I interferons (IFNs) especially IFN-β are best known for their antiviral activities. IFNs ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 principally weakens the hosts' innate immune system by impairing the interferon function and production. Type I interferons (IFNs) especially IFN-β are best known for their antiviral activities. IFNs accompanied by the standard care protocols have opened up unique opportunities for treating the coronavirus disease 2019 (COVID-19). The databases including PubMed, SCOPUS, EMBASE, and Google Scholar were searched up to October 30, 2020. The primary and secondary outcomes were considered discharge and mortality, respectively. The abovementioned outcomes of standard care protocol were compared with the standard care plus IFN-β in the confirmed COVID-19 patients. Out of 356 records identified, 12 randomized clinical trial studies were selected for full-text screening. Finally, 5 papers were included in the systematic review and 3 papers in the meta-analysis. The average mortality rate was reported as 6.195% and 18.02% in intervention and control groups, respectively. Likewise, the median days of hospitalization were lower in the intervention group (9 days) than the control group (12.25 days). According to meta-analysis, IFN-β was found to increase the overall discharge rate (RR = 3.05; 95% CI: 1.09-5.01). Our findings revealed that early administration of IFN-β in combination with antiviral drugs is a promising therapeutic strategy against COVID-19.
MeSH term(s)	Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Humans ; Interferon-beta/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Antiviral Agents ; Interferon-beta (77238-31-4)
Language	English
Publishing date	2021-02-15
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-021-02061-x
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Article ; Online: Interferon-alpha position in combating with COVID-19: A systematic review.

Nakhlband, Ailar / Fakhari, Ali / Azizi, Hosein

Journal of medical virology

2021 Volume 93, Issue 9, Page(s) 5277–5284

Abstract: The newborn coronaivus disease 2019 (COVID-19) pandemic has become the foremost concern of health system worldwide. Interferon typeI (IFN-I) are among the well-known antiviruses. Hence IFN-α have gained much attention as a treatment for COVID-19 recently. ...

Abstract	The newborn coronaivus disease 2019 (COVID-19) pandemic has become the foremost concern of health system worldwide. Interferon typeI (IFN-I) are among the well-known antiviruses. Hence IFN-α have gained much attention as a treatment for COVID-19 recently. To sum up the efficiency of IFN-α against COVID-19, we searched PubMed, SCOPUS, and EMBASE, from the date of genesis to the 1st of October 2020. Discharge from hospital and virus clearance considered as primary and secondary outcomes, respectively. We compared the aforementioned outcomes of patients treated with standard care protocol and the patients treated with IFN-α in addition to standard care protocol. Out of 356 identified records, 14 studies were subjected for full-text screening. Finally, a systematic review was performed with inclusion of five studies. Majority of the participants were males (ranged from 43.50% to 90.0%). We found that time of viral clearance and polymerase chain reaction negative (days) in most studies were decreased in the INF-α + standard care group. The mean days of virus's clearance in INF-α group and standard group reported 27.3 and 32.43. Likewise, the average days of hospitalization was found also lower in INF-α group (18.55 vs. 24.36). This study provides a stand to conclude that early administration of INF-α may be accounted as a promising treatment of COVID-19.
MeSH term(s)	Adult ; Antiviral Agents/administration & dosage ; COVID-19/drug therapy ; Clinical Trials as Topic ; Female ; Humans ; Interferon-alpha/administration & dosage ; Male ; Middle Aged ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Interferon-alpha
Language	English
Publishing date	2021-06-08
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27072
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Zs.A 1320: Show issues

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Article ; Online: Designing robust chitosan-based hydrogels for stem cell nesting under oxidative stress

Zahra Olfat Noubari / Asal Golchin / Marziyeh Fathi / Ailar Nakhlband

BioImpacts, Vol 12, Iss 1, Pp 57-

2022 Volume 64

Abstract: Introduction: Hydrogels are unique candidates for a wide range of biomedical applications including drug delivery and tissue engineering. The present investigation was designed to consider the impact of chitosan-based hydrogels as a scaffold on the ... ...

Abstract	Introduction: Hydrogels are unique candidates for a wide range of biomedical applications including drug delivery and tissue engineering. The present investigation was designed to consider the impact of chitosan-based hydrogels as a scaffold on the proliferation of human bone marrow mesenchymal stem cells (hBM-MSCs) besides neutralization of oxidative stress in hBM-MSCs. Methods: Chitosan (CS) and CS-gelatin hydrogels were fabricated through ionic crosslinking using β-glycerophosphate. The hBM-MSCs were cultured on the prepared matrices and their proliferation was evaluated using DAPI staining and MTT assay. Furthermore, the effect of hydrogels on oxidative stress was assessed by measuring the expression of NQO1, Nrf2, and HO-1 genes using real-time PCR. Results: The developed hydrogels indicated a porous structure with high water content. The toxicity studies showed that the prepared hydrogels have a high biocompatibility/cytocompatibility. The expression of intracellular antioxidant genes was studied to ensure that stress is not imposed by the scaffold on the nested cells. The results showed that Nrf2 as a super transcription factor of antioxidant genes and its downstream antioxidant gene, NQO1 were downregulated. Unexpectedly, the upregulation of HO-1 was detected in the current study. Conclusion: The prepared CS-based hydrogels with desired properties including porous structure, high swelling ability, and cytocompatibility did not show oxidative stress for the nesting of stem cells. Therefore, they could be attractive scaffolds to support stem cells for successful tissue engineering purposes.
Keywords	hydrogel ; chitosan ; mesenchymal stem cells ; oxidative stress ; gene expression ; tissue engineering ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Tabriz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Sclareol Inhibits Hypoxia-Inducible Factor-1α Accumulation and Induces Apoptosis in Hypoxic Cancer Cells.

Vandghanooni, Somayeh / Farajzadeh Vahid, Zahra / Nakhlband, Ailar / Bahadori, Mir Babak / Eskandani, Morteza

Advanced pharmaceutical bulletin

2021 Volume 12, Issue 3, Page(s) 593–602

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2021-07-04
Publishing country	Iran
Document type	Journal Article
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2022.062
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Article ; Online: What Happens to Patients with Bipolar Disorder after Bariatric Surgery? A Review.

Majidi Zolbanin, Saeedeh / Salehian, Razieh / Nakhlband, Ailar / Ghanbari Jolfaei, Atefeh

Obesity surgery

2021 Volume 31, Issue 3, Page(s) 1313–1320

Abstract: Bipolar disorder (BD) patients are at high risk of obesity, which affects their quality of life (QOL). Since there is a high comorbidity between BD and obesity, most BD patients seek surgical intervention for obesity. Nowadays, bariatric surgery (BS) is ... ...

Abstract	Bipolar disorder (BD) patients are at high risk of obesity, which affects their quality of life (QOL). Since there is a high comorbidity between BD and obesity, most BD patients seek surgical intervention for obesity. Nowadays, bariatric surgery (BS) is considered appropriate for carefully selected patients with BD. Evaluations before performing BS and careful follow-up of patients with the bipolar spectrum are highly recommended. This study reviews the effects of BS on the course of BD and, at the same time, assesses the effect of BD on the consequences of the surgery. Our results showed that the number of studies approving the promising impact of surgery on BD was more than those disapproving it. However, more accurate results require more than 3-year follow-ups.
MeSH term(s)	Bariatric Surgery ; Bipolar Disorder ; Comorbidity ; Humans ; Obesity ; Obesity, Morbid/surgery ; Quality of Life
Language	English
Publishing date	2021-01-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-020-05187-8
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Zs.A 3381: Show issues

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Article ; Online: L-Carnitine Reduced Cellular Aging of Bone Marrow Resident C-Kit+ Hematopoietic Progenitor Cells Through Telomere Dependent Pathways.

Fathi, Ezzatollah / Montazersaheb, Soheila / Sanaat, Zohreh / Nakhlband, Ailar / Vandghanooni, Somayeh / Farahzadi, Raheleh / Vietor, Ilja

Current stem cell research & therapy

2022 Volume 18, Issue 2, Page(s) 231–236

Abstract: Background: Increased oxygen species levels can induce mitochondrial DNA damage and chromosomal aberrations and cause defective stem cell differentiation, leading finally to senescence of stem cells. In recent years, several studies have reported that ... ...

Abstract	Background: Increased oxygen species levels can induce mitochondrial DNA damage and chromosomal aberrations and cause defective stem cell differentiation, leading finally to senescence of stem cells. In recent years, several studies have reported that antioxidants can improve stem cell survival and subsequently affect the potency and differentiation of these cells. Finding factors, which reduce the senescence tendency of stem cells upon expansion, has great potential for cellular therapy in regenerative medicine. This study aimed to evaluate the effects of L-carnitine (LC) on the aging of C-kit+ hematopoietic progenitor cells (HPCs) via examining the expression of some signaling pathway components. Methods: For this purpose, bone marrow resident C-kit+ HPCs were enriched by the magnetic-activated cell sorting (MACS) method and were characterized using flow cytometry as well as immunocytochemistry. Cells were treated with LC, and at the end of the treatment period, the cells were subjected to the realtime PCR technique along with a western blotting assay for measurement of the telomere length and assessment of protein expression, respectively. Results: The results showed that 0.2 mM LC caused the elongation of the telomere length and increased the TERT protein expression. In addition, a significant increase was observed in the protein expression of p38, p53, BCL2, and p16 as key components of the telomere-dependent pathway. Conclusion: It can be concluded that LC can increase the telomere length as an effective factor in increasing the cell survival and maintenance of the C-kit+ HPCs via these signaling pathway components.
MeSH term(s)	Humans ; Bone Marrow ; Carnitine/pharmacology ; Carnitine/metabolism ; Cellular Senescence/genetics ; Hematopoietic Stem Cells ; Telomere/genetics ; Bone Marrow Cells
Chemical Substances	Carnitine (S7UI8SM58A)
Language	English
Publishing date	2022-05-30
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2251937-3
ISSN	2212-3946 ; 1574-888X
ISSN (online)	2212-3946
ISSN	1574-888X
DOI	10.2174/1574888X17666220511141123
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bidirectional Relations Between Anxiety, Depression, and Cancer: A Review.

Nakhlband, Ailar / Farahzadi, Raheleh / Saeedi, Nazli / Barzegar, Habibeh / Montazersaheb, Soheila / Soofiyani, Saiedeh Razi

Current drug targets

2022 Volume 24, Issue 2, Page(s) 118–130

Abstract: Epidemiological evidence continues to accumulate on the effect of stress and depression on cancer initiation and progression. Depression has been introduced as an independent predictor of increased cancer mortality. At the same time, early intervention ... ...

Abstract	Epidemiological evidence continues to accumulate on the effect of stress and depression on cancer initiation and progression. Depression has been introduced as an independent predictor of increased cancer mortality. At the same time, early intervention for depression increases the survival rate. Even some evidence has given prognostic value for depression to predict cancer recurrence and mortality. This article presents current evidence on the correlations of molecular mechanisms of cancer and depression through; I. The evidence shows the role of pre-existing depression and anxiety in the development and progression of cancer. II. The Immune system performs a crucial role in stress, depression, and cancer. III. The role of stress and depression-induced inflammation. IV. The evidence has proposed that cancer may result in depression and the effect of depression on cancer outcomes. In conclusion, the importance of preventive interventions to monitor patients' mental health during cancer treatment is very significant and should not be underestimated. In other words, the initial interventions can improve depressive symptoms and increase cancer survival. On the other hand, by identifying key biomarkers of depression, physicians can identify cancer patients at risk for depression or those who may not respond to routine treatments. Revealing the molecular mechanism of the cancer microenvironment in the development of comorbidities promises innovative therapeutic options for cancer. Identifying these mechanisms opens a new avenue in identifying cancer patients at risk for depression and can also provide considerable potential in identifying depressive patients prone to cancer.
MeSH term(s)	Humans ; Depression/complications ; Anxiety/complications ; Anxiety Disorders ; Neoplasms ; Tumor Microenvironment
Language	English
Publishing date	2022-09-25
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2064859-5
ISSN	1873-5592 ; 1389-4501
ISSN (online)	1873-5592
ISSN	1389-4501
DOI	10.2174/1389450123666220922094403
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Article: Oxidized cholesterol exacerbates toll-like receptor 4 expression and activity in the hearts of rats with myocardial infarction.

Khorrami, Arash / Ziaee, Mojtaba / Rameshrad, Maryam / Nakhlband, Ailar / Maleki-Dizaji, Nasrin / Garjani, Alireza

Journal of cardiovascular and thoracic research

2020 Volume 12, Issue 1, Page(s) 43–50

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2020-01-30
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2654729-6
ISSN	2008-6830 ; 2008-5117
ISSN (online)	2008-6830
ISSN	2008-5117
DOI	10.34172/jcvtr.2020.07
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