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Article ; Online: Response to "Comments on Economic Evaluation of Ultrasound-guided Central Venous Catheter Confirmation vs Chest Radiography in Critically Ill Patients: A Labor Cost Model".

Ablordeppey, Enyo A / Koenig, Adam M / Barker, Abigail R / Hernandez, Emily E / Simkovich, Suzanne M / Krings, James G / Brown, Derek S / Griffey, Richard T

The western journal of emergency medicine

2023 Volume 24, Issue 2, Page(s) 370–371

MeSH term(s)	Humans ; Central Venous Catheters ; Critical Illness/therapy ; Cost-Benefit Analysis ; Radiography ; Ultrasonography, Interventional
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2375700-0
ISSN	1936-9018 ; 1936-9018
ISSN (online)	1936-9018
ISSN	1936-9018
DOI	10.5811/westjem.2023.1.60160
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Caring for Patients with Functional Impairment in Middle Age: Perspectives from Primary Care Providers and Geriatricians.

Schmucker, Abigail M / Reyes-Farias, David / Nicosia, Francesca M / Xu, Edison / B Potter, Michael / Karliner, Leah S / Brown, Rebecca T

Journal of general internal medicine

2024

Abstract: Background: The prevalence of functional impairment is increasing among middle-aged adults and is associated with adverse health outcomes. Primary care providers (PCPs) and geriatricians may have important insights about optimal approaches to caring for ...

Abstract	Background: The prevalence of functional impairment is increasing among middle-aged adults and is associated with adverse health outcomes. Primary care providers (PCPs) and geriatricians may have important insights about optimal approaches to caring for these patients, but little is known about their perspectives. Objective: To examine PCPs' and geriatricians' perspectives on clinical needs and optimal approaches to care for middle-aged patients with functional impairment. Design: Qualitative study using semi-structured interviews. Participants: PCPs and geriatricians from outpatient practices in the San Francisco Bay area. Approach: Interviews focused on characteristics and care needs of middle-aged patients with functional impairment and models of care to address these needs. We analyzed interviews using hybrid deductive-inductive qualitative thematic analysis. Key results: Clinicians (14 PCPs, 15 geriatricians) described distinct characteristics of functional impairment in middle-aged versus older adults, such as different rates of onset, but similar clinical needs. Despite these similar needs, clinicians identified age-specific barriers to delivering optimal care to middle-aged patients. These included system-level challenges such as limited access to insurance and social services; practice- and clinician-level barriers including inadequate clinician training; and patient-level factors including less access to family caregivers and perceptions of stigma. To overcome these challenges, clinicians suggested clinical approaches including addressing health-related social needs within healthcare systems; implementing practice-based models that are multi-disciplinary, team-based, and coordinated; training clinicians to effectively manage functional impairment; and expanding community-based services and supports to help patients navigate the medical system. Identified needs, challenges, and solutions were generally similar across geriatricians and PCPs. Conclusions: Clinicians face challenges in delivering optimal care to middle-aged patients who have functional impairments similar to their older counterparts but lack access to services and supports available to older people. These findings suggest the importance of increasing access to care models that address functional impairment regardless of age.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-024-08701-1
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Hines, Abigail C / Rose, Alexandra L / Regenauer, Kristen S / Brown, Imani / Johnson, Kim / Bonumwezi, Jessica / Ndamase, Sibabalwe / Ciya, Nonceba / Magidson, Jessica F / Myers, Bronwyn

Global mental health (Cambridge, England)

2024 Volume 11, Page(s) e45

Abstract: Stress is a challenge among non-specialist health workers worldwide, particularly in low-resource settings. Understanding and targeting stress is critical for supporting non-specialists and their patients, as stress negatively affects patient care. ... ...

Abstract	Stress is a challenge among non-specialist health workers worldwide, particularly in low-resource settings. Understanding and targeting stress is critical for supporting non-specialists and their patients, as stress negatively affects patient care. Further, stigma toward mental health and substance use conditions also impacts patient care. However, there is little information on the intersection of these factors. This sub-analysis aims to explore how substance use and mental health stigma intersect with provider stress and resource constraints to influence the care of people with HIV/TB. We conducted semi-structured interviews (
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2806466-5
ISSN	2054-4251
ISSN	2054-4251
DOI	10.1017/gmh.2024.41
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Article ; Online: Interhospital transport of patients with COVID-19: Cleveland Clinic approach.

Brown, Abigail S / Hustey, Fredric M / Reddy, Anita J

Cleveland Clinic journal of medicine

2020

Abstract: Hospital-to-hospital transportation of patients in the COVID-19 era presents unique challenges to ensuring the safety of both patients and health care providers. Crucial factors to address include having adequate supplies of protective equipment and ... ...

Abstract	Hospital-to-hospital transportation of patients in the COVID-19 era presents unique challenges to ensuring the safety of both patients and health care providers. Crucial factors to address include having adequate supplies of protective equipment and ensuring their appropriate use, defining patient care procedures during transport, and decontamination post-transport. Transport vehicles need to have adequate physical space, an isolated driver compartment, NS HEPA filtration of air. Having a standardized intake process can help identify patients who would benefit from transport to another facility.
Keywords	covid19
Language	English
Publishing date	2020-06-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	639116-3
ISSN	1939-2869 ; 0891-1150
ISSN (online)	1939-2869
ISSN	0891-1150
DOI	10.3949/ccjm.87a.ccc045
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Article ; Online: Application of a Child Sex Trafficking Screening Tool in Patients with Abuse: A Retrospective Chart Review in the Pediatric Emergency Department.

Ellis, Andrea S / Brown, Angela M / Martini, Abigail I / Page, Erica / Lin, Li / Vaughn, Lisa M

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

2022 Volume 36, Issue 4, Page(s) 330–338

Abstract: Introduction: Human trafficking (HT) is a global problem that may affect children's health. In the United States, victims and children are at risk in most communities. History of abuse is a risk factor for HT. This study explored associations between ... ...

Abstract	Introduction: Human trafficking (HT) is a global problem that may affect children's health. In the United States, victims and children are at risk in most communities. History of abuse is a risk factor for HT. This study explored associations between pediatric patients with positive universal abuse screens and indicators from the commercial sexual exploitation of children/child sex trafficking (CSEC/CST) screening tool. Method: A retrospective chart review was conducted on random patients, aged 11-17 years, with positive universal abuse screens at emergency/urgent care departments in a large Midwest pediatric medical center in 2018. Documentation identifying at least two CSEC/CST screening tool indicators was abstracted from these records. Data analysis included descriptive statistics, univariate analyses, and correlations. Results: Two or more indicators from the CSEC/CST screening tool were identified in 43% (n = 121). Age and history of running away were significant predictors for a patient having two or more CSEC/CST positive indicators. Discussion: Targeted screening and interventions are needed to identify and help these vulnerable youth.
MeSH term(s)	Adolescent ; Child ; Child Abuse, Sexual/diagnosis ; Child Abuse, Sexual/prevention & control ; Emergency Service, Hospital ; Human Trafficking/prevention & control ; Humans ; Retrospective Studies ; Sexual Behavior ; United States/epidemiology
Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1036356-7
ISSN	1532-656X ; 0891-5245
ISSN (online)	1532-656X
ISSN	0891-5245
DOI	10.1016/j.pedhc.2022.01.002
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Article ; Online: Response to “Comments on Economic Evaluation of Ultrasound-guided Central Venous Catheter Confirmation vs Chest Radiography in Critically Ill Patients

Enyo A. Ablordeppey / Adam M. Koenig / Abigail R. Barker / Emily E. Hernandez / Suzanne M. Simkovich / James G. Krings / Derek S. Brown / Richard T. Griffey

Western Journal of Emergency Medicine, Vol 24, Iss

A Labor Cost Model”

2023 Volume 2

Keywords	Medicine ; R ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	eScholarship Publishing, University of California
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Modified Curcumins as Potential Drug Candidates for Breast Cancer: An Overview.

Flint, Abigail L / Hansen, David W / Brown, LaVauria D / Stewart, Laura E / Ortiz, Eduardo / Panda, Siva S

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 24

Abstract: Breast cancer (BC), the most common malignancy in women, results from significant alterations in genetic and epigenetic mechanisms that alter multiple signaling pathways in growth and malignant progression, leading to limited long-term survival. Current ... ...

Abstract	Breast cancer (BC), the most common malignancy in women, results from significant alterations in genetic and epigenetic mechanisms that alter multiple signaling pathways in growth and malignant progression, leading to limited long-term survival. Current studies with numerous drug therapies have shown that BC is a complex disease with tumor heterogeneity, rapidity, and dynamics of the tumor microenvironment that result in resistance to existing therapy. Targeting a single cell-signaling pathway is unlikely to treat or prevent BC. Curcumin (a natural yellow pigment), the principal ingredient in the spice turmeric, is well-documented for its diverse pharmacological properties including anti-cancer activity. However, its clinical application has been limited because of its low solubility, stability, and bioavailability. To overcome the limitation of curcumin, several modified curcumin conjugates and curcumin mimics were developed and studied for their anti-cancer properties. In this review, we have focused on the application of curcumin mimics and their conjugates for breast cancer.
Language	English
Publishing date	2022-12-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27248891
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Article: Genomic Features of the Bundle-Forming Heliobacterium

Bender, Kelly S / Madigan, Michael T / Williamson, Kyleigh L / Mayer, Marisa H / Parenteau, Mary N / Jahnke, Linda L / Welander, Paula V / Sanguedolce, Sophia A / Brown, Abigail C / Sattley, W Matthew

Microorganisms

2022 Volume 10, Issue 5

Abstract: Eight species of heliobacteria have had their genomes sequenced. However, only two of these genomes have been analyzed in detail, those from the ... ...

Abstract	Eight species of heliobacteria have had their genomes sequenced. However, only two of these genomes have been analyzed in detail, those from the thermophilic
Language	English
Publishing date	2022-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10050869
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Article ; Online: Economic Evaluation of Ultrasound-guided Central Venous Catheter Confirmation vs Chest Radiography in Critically Ill Patients: A Labor Cost Model.

Ablordeppey, Enyo A / Koenig, Adam M / Barker, Abigail R / Hernandez, Emily E / Simkovich, Suzanne M / Krings, James G / Brown, Derek S / Griffey, Richard T

The western journal of emergency medicine

2022 Volume 23, Issue 5, Page(s) 760–768

Abstract: Introduction: Despite evidence suggesting that point-of-care ultrasound (POCUS) is faster and non-inferior for confirming position and excluding pneumothorax after central venous catheter (CVC) placement compared to traditional radiography, millions of ... ...

Abstract	Introduction: Despite evidence suggesting that point-of-care ultrasound (POCUS) is faster and non-inferior for confirming position and excluding pneumothorax after central venous catheter (CVC) placement compared to traditional radiography, millions of chest radiographs (CXR) are performed annually for this purpose. Whether the use of POCUS results in cost savings compared to CXR is less clear but could represent a relative advantage in implementation efforts. Our objective in this study was to evaluate the labor cost difference for POCUS-guided vs CXR-guided CVC position confirmation practices. Methods: We developed a model to evaluate the per patient difference in labor cost between POCUS-guided vs CXR-guided CVC confirmation at our local urban, tertiary academic institution. We used internal cost data from our institution to populate the variables in our model. Results: The estimated labor cost per patient was $18.48 using CXR compared to $14.66 for POCUS, resulting in a net direct cost savings of $3.82 (21%) per patient using POCUS for CVC confirmation. Conclusion: In this study comparing the labor costs of two approaches for CVC confirmation, the more efficient alternative (POCUS-guided) is not more expensive than traditional CXR. Performing an economic analysis framed in terms of labor costs and work efficiency may influence stakeholders and facilitate earlier adoption of POCUS for CVC confirmation.
MeSH term(s)	Catheterization, Central Venous/methods ; Central Venous Catheters ; Cost-Benefit Analysis ; Critical Illness ; Humans ; Prospective Studies ; Radiography ; Radiography, Thoracic ; Ultrasonography, Interventional
Language	English
Publishing date	2022-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375700-0
ISSN	1936-9018 ; 1936-9018
ISSN (online)	1936-9018
ISSN	1936-9018
DOI	10.5811/westjem.2022.7.56501
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Article ; Online: Unwrapping Nephrogenic Rests and Nephroblastomatosis for Pediatric Surgeons: A Systematic Review Utilizing the PICO Model by the APSA Cancer Committee.

Brown, Erin G / Engwall-Gill, Abigail J / Aldrink, Jennifer H / Ehrlich, Peter F / Fawcett, Andrea / Coakley, Brian A / Rothstein, David H / Rich, Barrie S / Glick, Richard D / Baertschiger, Reto M / Roach, Jonathan P / Lautz, Timothy B

Journal of pediatric surgery

2023 Volume 58, Issue 11, Page(s) 2128–2134

Abstract: Background: Nephrogenic rests (NR) may represent precursor lesions for Wilms tumor (WT), but their clinical course is not fully understood and no guidelines for treatment exist. This study sought to evaluate the outcomes of pediatric patients with NRs ... ...

Abstract	Background: Nephrogenic rests (NR) may represent precursor lesions for Wilms tumor (WT), but their clinical course is not fully understood and no guidelines for treatment exist. This study sought to evaluate the outcomes of pediatric patients with NRs related to traditional chemotherapy and surgery. Methods: A PRISMA-P-compliant literature search was conducted in MEDLINE, Embase, CINAHL, Web of Science, COCHRANE, and SCOPUS from inception to June 2021. Clinical questions regarding the treatment of NRs, including chemotherapy and surgery, were developed in the population, intervention, comparison, and outcome format. Results: Twenty-five studies including 1445 patients met inclusion criteria for evaluating chemotherapy compared to observation for NRs. Eighteen studies including 1392 patients met inclusion criteria for evaluating the role of surgery for NRs. Patients with isolated NRs who underwent observation progressed to WT 33% of the time; chemotherapy reduced the rate of WT to 3.9%. Observation of multiple NRs and diffuse hyperplastic perilobar nephroblastomatosis (DHPLN) led to progression to WT 50% and 100% of the time, respectively. Chemotherapy reduced the rate of WT to 34% for multiple NRs and 46% for DHPLN. Surgery for isolated NRs reduced the risk of WT development from 23.7% in patients with incomplete excision to 3.3% with complete excision; however, 96% of patients with incompletely excised NRs had bilateral disease. Conclusions: Observation with close surveillance for isolated NRs is safe. Treatment with chemotherapy is recommended for patients with multiple NRs and DHPLN. Surgical management of NRs should focus on renal function preservation. Level of evidence: Treatment study, Level III.
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2023.07.011
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