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  1. Article ; Online: Homeopathy Has Survived the Test of Time.

    Basu, Nilanjana

    Homeopathy : the journal of the Faculty of Homeopathy

    2020  Volume 109, Issue 4, Page(s) 273–274

    MeSH term(s) Homeopathy ; Violence
    Language English
    Publishing date 2020-07-27
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0040-1714401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Homeopathy Has Survived the Test of Time

    Basu, Nilanjana

    Homeopathy

    2020  Volume 109, Issue 04, Page(s) 273–274

    Language English
    Publishing date 2020-07-27
    Publisher The Faculty of Homeopathy
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0040-1714401
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Interim Management of COVID-19 by Repurposed Homeopathic Medicines.

    Basu, Nilanjana / Das, Bhudev Chandra / Tandon, Simran

    Homeopathy : the journal of the Faculty of Homeopathy

    2020  Volume 109, Issue 3, Page(s) 182–183

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Homeopathy ; Humans ; Materia Medica/therapeutic use ; Pandemics ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Chemical Substances Materia Medica
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0040-1713004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Reprogramming of glucose metabolism via PFKFB4 is critical in FGF16-driven invasion of breast cancer cells.

    Kar, Swarnali / Maji, Nilanjana / Sen, Kamalika / Roy, Stuti / Maity, Atanu / Ghosh Dastidar, Shubhra / Nath, Somsubhra / Basu, Gautam / Basu, Moitri

    Bioscience reports

    2023  Volume 43, Issue 8

    Abstract: Fibroblast growth factors (FGFs) are expressed in both developing and adult tissues and play important roles in embryogenesis, tissue homeostasis, angiogenesis, and neoplastic transformation. Here, we report the elevated expression of FGF16 in human ... ...

    Abstract Fibroblast growth factors (FGFs) are expressed in both developing and adult tissues and play important roles in embryogenesis, tissue homeostasis, angiogenesis, and neoplastic transformation. Here, we report the elevated expression of FGF16 in human breast tumor and investigate its potential involvement in breast cancer progression. The onset of epithelial-mesenchymal transition (EMT), a prerequisite for cancer metastasis, was observed in human mammary epithelial cell-line MCF10A by FGF16. Further study unveiled that FGF16 alters mRNA expression of a set of extracellular matrix genes to promote cellular invasion. Cancer cells undergoing EMT often show metabolic alteration to sustain their continuous proliferation and energy-intensive migration. Similarly, FGF16 induced a significant metabolic shift toward aerobic glycolysis. At the molecular level, FGF16 enhanced GLUT3 expression to facilitate glucose transport into cells, which through aerobic glycolysis generates lactate. The bi-functional protein, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 (PFKFB4) was found to be a mediator in FGF16-driven glycolysis and subsequent invasion. Furthermore, PFKFB4 was found to play a critical role in promoting lactate-induced cell invasion since silencing PFKFB4 decreased lactate level and rendered the cells less invasive. These findings support potential clinical intervention of any of the members of FGF16-GLUT3-PFKFB4 axis to control the invasion of breast cancer cells.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Glucose Transporter Type 3 ; Phosphofructokinase-2/genetics ; Phosphofructokinase-2/metabolism ; Glucose/metabolism ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism
    Chemical Substances Glucose Transporter Type 3 ; Phosphofructokinase-2 (EC 2.7.1.105) ; Glucose (IY9XDZ35W2) ; PFKFB4 protein, human ; FGF16 protein, human ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1042/BSR20230677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1676: Show issues Location:
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  5. Article ; Online: Arsenicum album Induces Cell Cycle Arrest and Apoptosis, and Inhibits Epithelial-Mesenchymal Transition in Hormone-Dependent MCF7 Breast Cancer Cells.

    Basu, Nilanjana / Garg, Manoj / Tandon, Chanderdeep / Das, Bhudev Chandra / Tandon, Simran

    Homeopathy : the journal of the Faculty of Homeopathy

    2022  Volume 112, Issue 3, Page(s) 160–169

    Abstract: Background: Arsenic trioxide (As: Methods: Breast cancer cells (MCF7) were treated with : Results: Treating breast cancer cells with : Conclusion: The findings suggest ... ...

    Abstract Background: Arsenic trioxide (As
    Methods: Breast cancer cells (MCF7) were treated with
    Results: Treating breast cancer cells with
    Conclusion: The findings suggest that
    MeSH term(s) Humans ; Female ; Arsenic Trioxide/pharmacology ; Epithelial-Mesenchymal Transition ; Arsenicals/pharmacology ; Arsenicals/therapeutic use ; Oxides/therapeutic use ; Breast Neoplasms/drug therapy ; Reactive Oxygen Species/pharmacology ; Homeopathy ; Apoptosis ; Cell Cycle Checkpoints ; Hormones/pharmacology ; MCF-7 Cells ; Cell Line, Tumor
    Chemical Substances Arsenic Trioxide (S7V92P67HO) ; Arsenicals ; Oxides ; Reactive Oxygen Species ; Hormones
    Language English
    Publishing date 2022-11-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0042-1755364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1942: Show issues Location:
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  7. Article: Interim Management of COVID-19 by Repurposed Homeopathic Medicines

    Basu, Nilanjana / Das, Bhudev Chandra / Tandon, Simran

    Homeopathy

    2020  Volume 109, Issue 03, Page(s) 182–183

    Language English
    Publishing date 2020-06-09
    Publisher The Faculty of Homeopathy
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0040-1713004
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1942: Show issues Location:
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  8. Article ; Online: Computational and In Vitro Approaches to Elucidate the Anti-cancer Effects of Arnica montana in Hormone-Dependent Breast Cancer.

    Basu, Nilanjana / Narad, Priyanka / Guptasarma, Manni Luthra / Tandon, Chanderdeep / Das, Bhudev Chandra / Tandon, Simran

    Homeopathy : the journal of the Faculty of Homeopathy

    2022  Volume 111, Issue 4, Page(s) 288–300

    Abstract: Background: Breast cancer is the most common cancer in women worldwide. Use of homeopathic medicines for the treatment of cancers has increased in the last several years. ... Arnica montana ... is an anti-inflammatory homeopathic medicine used in ... ...

    Abstract Background: Breast cancer is the most common cancer in women worldwide. Use of homeopathic medicines for the treatment of cancers has increased in the last several years. Arnica montana is an anti-inflammatory homeopathic medicine used in traumatic conditions and because of this property we performed investigations for its potential as a chemotherapeutic agent against breast cancer.
    Methods: An ethanolic extract of Arnica montana (mother tincture, MT), prepared according to the Homoeopathic Pharmacopoeia of India, was characterized by gas chromatography-mass spectroscopy (GC-MS), followed by computational (in silico) analysis using molecular docking, to identify specific compounds that can bind and modulate the activity of key proteins involved in breast cancer survival and progression. To validate the in silico findings, in a controlled experiment breast cancer cells (MCF7) were treated in vitro with Arnica montana and the cytotoxic effects assessed by flowcytometry, fluorescence microscopy, scratch assay, clonogenic potential and gene expression analysis.
    Results: Phytochemical characterization of ethanolic extract of Arn MT by GC-MS allowed identification of several compounds. Caryophyllene oxide and 7-hydroxycadalene were selected for molecular docking studies, based on their potential drug-like properties. These compounds displayed selective binding affinity to some of the recognized target proteins of breast cancer, which included estrogen receptor alpha (ERα), progesterone receptor (PR), epidermal growth factor receptor (EGFR), mTOR (mechanistic target of rapamycin) and E-cadherin. In vitro studies revealed induction of apoptosis in MCF7 cells following treatment with Arn MT. Furthermore, treatment with Arn MT revealed its ability to inhibit migration and colony forming abilities of the cancer cells.
    Conclusion: Considering the apoptotic and anti-migratory effects of Arnica montana in breast cancer cells in vitro, there is a need for this medicine to be further validated in an in vivo model.
    MeSH term(s) Humans ; Female ; Arnica/chemistry ; Breast Neoplasms/drug therapy ; Molecular Docking Simulation ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry ; Homeopathy ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Ethanol ; Hormones
    Chemical Substances Plant Extracts ; Anti-Inflammatory Agents ; Ethanol (3K9958V90M) ; Hormones
    Language English
    Publishing date 2022-07-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0042-1743565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1942: Show issues Location:
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  9. Article ; Online: Interim Management of COVID-19 by Repurposed Homeopathic Medicines

    Basu, Nilanjana / Das, Bhudev Chandra / Tandon, Simran

    Homeopathy

    2020  Volume 109, Issue 03, Page(s) 182–183

    Keywords Complementary and alternative medicine ; covid19
    Language English
    Publisher Georg Thieme Verlag KG
    Publishing country de
    Document type Article ; Online
    ZDB-ID 2073322-7
    ISSN 1475-4916
    ISSN 1475-4916
    DOI 10.1055/s-0040-1713004
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Computational and In Vitro Approaches to Elucidate the Anti-cancer Effects of Arnica montana in Hormone-Dependent Breast Cancer

    Basu, Nilanjana / Narad, Priyanka / Guptasarma, Manni Luthra / Tandon, Chanderdeep / Das, Bhudev Chandra / Tandon, Simran

    Homeopathy

    2022  Volume 111, Issue 04, Page(s) 288–300

    Abstract: Background: Breast cancer is the most common cancer in women worldwide. Use of homeopathic medicines for the treatment of cancers has increased in the last several years. Arnica montana is an anti-inflammatory homeopathic medicine used in traumatic ... ...

    Abstract Background: Breast cancer is the most common cancer in women worldwide. Use of homeopathic medicines for the treatment of cancers has increased in the last several years. Arnica montana is an anti-inflammatory homeopathic medicine used in traumatic conditions and because of this property we performed investigations for its potential as a chemotherapeutic agent against breast cancer.
    Methods: An ethanolic extract of Arnica montana (mother tincture, MT), prepared according to the Homoeopathic Pharmacopoeia of India, was characterized by gas chromatography–mass spectroscopy (GC–MS), followed by computational ( in silico ) analysis using molecular docking, to identify specific compounds that can bind and modulate the activity of key proteins involved in breast cancer survival and progression. To validate the in silico findings, in a controlled experiment breast cancer cells (MCF7) were treated in vitro with Arnica montana and the cytotoxic effects assessed by flowcytometry, fluorescence microscopy, scratch assay, clonogenic potential and gene expression analysis.
    Results: Phytochemical characterization of ethanolic extract of Arn MT by GC–MS allowed identification of several compounds. Caryophyllene oxide and 7-hydroxycadalene were selected for molecular docking studies, based on their potential drug-like properties. These compounds displayed selective binding affinity to some of the recognized target proteins of breast cancer, which included estrogen receptor alpha (ERα), progesterone receptor (PR), epidermal growth factor receptor (EGFR), mTOR (mechanistic target of rapamycin) and E-cadherin. In vitro studies revealed induction of apoptosis in MCF7 cells following treatment with Arn MT. Furthermore, treatment with Arn MT revealed its ability to inhibit migration and colony forming abilities of the cancer cells.
    Conclusion: Considering the apoptotic and anti-migratory effects of Arnica montana in breast cancer cells in vitro, there is a need for this medicine to be further validated in an in vivo model.
    Keywords breast cancer ; homeopathy ; GC–MS ; molecular docking ; apoptosis ; cell migration
    Language English
    Publishing date 2022-07-05
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2073322-7
    ISSN 1476-4245 ; 1475-4916
    ISSN (online) 1476-4245
    ISSN 1475-4916
    DOI 10.1055/s-0042-1743565
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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