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Article ; Online: Clinical functional outcome measures for children with cerebral palsy after gait corrective orthopaedic surgery: A scoping review.

Fong, Maxine M / Gibson, Noula / Williams, Sian A / Jensen, Lynn

Developmental medicine and child neurology

2023 Volume 65, Issue 12, Page(s) 1573–1586

Abstract: Aim: To identify the most frequently reported non-instrumented measures of gait, activity, and participation in children with cerebral palsy (CP) after undergoing gait corrective orthopaedic surgery.: Method: Four databases were searched from ... ...

Abstract	Aim: To identify the most frequently reported non-instrumented measures of gait, activity, and participation in children with cerebral palsy (CP) after undergoing gait corrective orthopaedic surgery. Method: Four databases were searched from database inception to the 9th December 2021 for studies that evaluated functional outcomes for children with CP under 18 years undergoing gait corrective orthopaedic surgery. Results: Of 547 citations, 44 publications (n = 3535 participants, n = 1789 males, mean age 10 years 5 months [SD = 3 years 3 months], Gross Motor Function Classification System levels I-III at the time of surgery) were eligible for inclusion. Fourteen different outcome measures were used: one measure of gait, 10 measures of activity, and three measures of participation. Gait was measured with the Edinburgh Visual Gait Scale (EVGS; 4 out of 44). The most common activity and participation measures were the Functional Mobility Scale (FMS; 15 out of 44) and Pediatric Outcomes Data Collection Instrument (11 out of 44) respectively. No studies reported a combination of gait, activity, and participation measures. Interpretation: The EVGS and FMS should be considered as core outcome measures in gait corrective orthopaedic surgery, while a measure of participation is unclear. Additional considerations for developing a comprehensive suite of outcomes include identifying a combination of clinical measures and performance-reflective questionnaires that are standardized for children with CP undergoing surgery and meaningful to clinicians and families.
MeSH term(s)	Male ; Child ; Humans ; Adolescent ; Cerebral Palsy/complications ; Cerebral Palsy/surgery ; Gait ; Orthopedic Procedures ; Outcome Assessment, Health Care
Language	English
Publishing date	2023-05-06
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	80369-8
ISSN	1469-8749 ; 0012-1622
ISSN (online)	1469-8749
ISSN	0012-1622
DOI	10.1111/dmcn.15622
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Article ; Online: A Case of a Missing Proximal Humerus.

Williams, Jessica Lynn / Hochman, Steven M

Clinical practice and cases in emergency medicine

2020 Volume 4, Issue 3, Page(s) 487–488

Abstract: Case presentation: In this case, we demonstrate how a small radiolucency in the proximal humerus can progress to an even larger problem within a few months in a patient without follow-up. Our patient's ultimate diagnosis was renal cell carcinoma with ... ...

Abstract	Case presentation: In this case, we demonstrate how a small radiolucency in the proximal humerus can progress to an even larger problem within a few months in a patient without follow-up. Our patient's ultimate diagnosis was renal cell carcinoma with metastasis to the right proximal humerus, completely obliterating the affected bone. Discussion: In many underserved communities, patients have limited access to medical care, particularly specialty care. These patients often present to the emergency department and are unable to acquire appropriate follow-up. This situation illustrates the social issues that our patients face every day affecting their access to healthcare and ultimately necessary medical treatment.
Language	English
Publishing date	2020-09-18
Publishing country	United States
Document type	Journal Article
ISSN	2474-252X
ISSN (online)	2474-252X
DOI	10.5811/cpcem.2020.6.48396
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Article ; Online: Mapping the Postpartum Experience Through Obstetric Patient Navigation for Low-Income Individuals.

Green, Hannah M / Diaz, Laura / Carmona-Barrera, Viridiana / Grobman, William A / Yeh, Chen / Williams, Brittney / Davis, Ka'Derricka / Kominiarek, Michelle A / Feinglass, Joe / Zera, Chloe / Yee, Lynn M

Journal of women's health (2002)

2024

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1139774-3
ISSN	1931-843X ; 1059-7115 ; 1540-9996
ISSN (online)	1931-843X
ISSN	1059-7115 ; 1540-9996
DOI	10.1089/jwh.2023.0459
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Article: Biphasic pleural mesothelioma in a goat.

Fry, Lindsay M / DenHerder, Johnathan / Clyde, Gay Lynn / Williams, Laura A / Schneider, David A

The Canadian veterinary journal = La revue veterinaire canadienne

2023 Volume 64, Issue 9, Page(s) 828–832

Abstract: An 8-year-old Saanen goat doe was seen for inappetence, tachycardia, and intermittent bluish-grey discoloration of the oral mucous membranes. On physical examination, the goat was mildly tachypneic and tachycardic, with reduced sounds auscultated on the ... ...

Abstract	An 8-year-old Saanen goat doe was seen for inappetence, tachycardia, and intermittent bluish-grey discoloration of the oral mucous membranes. On physical examination, the goat was mildly tachypneic and tachycardic, with reduced sounds auscultated on the left side of the thorax. Euthanasia was elected. Necropsy revealed an infiltrative, multinodular mass within the left thoracic cavity and innumerable small, tan nodules disseminated across the pleura of the lungs, thoracic walls, and diaphragm. Upon histologic examination, the mass was composed of highly pleomorphic, fusiform to polygonal cells. Neoplastic cells exhibited positive immunoreactivity for both cytokeratin and vimentin, consistent with a diagnosis of biphasic pleural mesothelioma. Key clinical message: Mesothelioma has rarely been described in the goat but should be considered as a differential diagnosis for thoracic masses in small ruminants, along with thymoma; metastatic neoplasia; carcinomatosis; and granulomatous lesions caused by parasites, bacteria, and fungi.
MeSH term(s)	Animals ; Goats ; Euthanasia, Animal ; Mesothelioma/diagnosis ; Mesothelioma/veterinary ; Autopsy/veterinary ; Carcinoma/veterinary ; Goat Diseases/diagnosis
Language	English
Publishing date	2023-07-08
Publishing country	Canada
Document type	Case Reports
ZDB-ID	41603-4
ISSN	0008-5286
ISSN	0008-5286
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Article ; Online: Evaluating feedback from an implementation advisory board to assess the rollout of a postpartum patient navigation program.

Green, Hannah M / Williams, Brittney / Diaz, Laura / Carmona-Barrera, Viridiana / Davis, Ka'Derricka / Feinglass, Joe / Kominiarek, Michelle A / Dolan, Brigid M / Grobman, William A / Yee, Lynn M

Implementation science communications

2024 Volume 5, Issue 1, Page(s) 50

Abstract: Background: Patient navigation is an individualized intervention to facilitate comprehensive care which has not yet been fully implemented in obstetric or postpartum care.: Methods: We aimed to develop and evaluate a mechanism to incorporate feedback ...

Abstract	Background: Patient navigation is an individualized intervention to facilitate comprehensive care which has not yet been fully implemented in obstetric or postpartum care. Methods: We aimed to develop and evaluate a mechanism to incorporate feedback regarding implementation of postpartum patient navigation for low-income birthing individuals at an urban academic medical center. This study analyzed the role of an Implementation Advisory Board (IAB) in supporting an ongoing randomized trial of postpartum navigation. Over the first 24 months of the trial, the IAB included 11 rotating obstetricians, one clinic resource coordinator, one administrative leader, two obstetric nurses, one primary care physician, one social worker, and one medical assistant. Members completed serial surveys regarding program implementation, effects on patient care, and areas for improvement. Quarterly IAB meetings offered opportunities for additional feedback. Survey responses and meeting notes were analyzed using the constant comparative method and further interpreted within the Exploration, Preparation, Implementation, Sustainment (EPIS) Framework. Results: Members of the IAB returned 37 surveys and participated in five meetings over 24 months. Survey analysis revealed four themes among the inner context: reduced clinician burden, connection of care teams, communication strategies, and clinic workflow. Bridging factors included improved patient access to care, improved follow-up, and adding social context to care. Innovation factors included availability of navigators, importance of consistent communication, and adaptation over time. Meeting notes highlighted the importance of bidirectional feedback regarding implementation, and members expressed positive opinions regarding navigators' effects on patient care, integration into clinic workflow, and responsiveness to feedback. IAB members initially suggested changes to improve implementation; later survey responses demonstrated successful program adaptations. Conclusions: Members of an implementation advisory board provided key insights into the implementation of postpartum patient navigation that may be useful to promote dissemination of navigation and establish avenues for the engagement of implementing partners in other innovations. Trial registration: ClinicalTrials.gov, NCT03922334 . Registered April 19, 2019. The results here do not present the results of the primary trial, which is ongoing.
Language	English
Publishing date	2024-05-03
Publishing country	England
Document type	Journal Article
ISSN	2662-2211
ISSN (online)	2662-2211
DOI	10.1186/s43058-024-00589-6
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Article ; Online: Abatacept for the prevention of GVHD in patients receiving mismatched unrelated transplants: a real-world analysis.

Raghunandan, Sharmila / Gorfinkel, Lev / Graiser, Michael / Bratrude, Brandi / Suessmuth, Yvonne / Gillespie, Scott / Westbrook, Adrianna Lynn / Williams, Kirsten M / Schoettler, Michelle L / Kean, Leslie S / Horan, John / Langston, Amelia A / Qayed, Muna / Watkins, Benjamin

Blood advances

2023 Volume 7, Issue 16, Page(s) 4395–4399

MeSH term(s)	Humans ; Abatacept/therapeutic use ; Bone Marrow Transplantation ; Hematopoietic Stem Cell Transplantation/adverse effects ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control
Chemical Substances	Abatacept (7D0YB67S97)
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023010225
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Article ; Online: Addressing racial inequality and its effects on vaccination rate: A trial comparing a pharmacist and peer educational program (MOTIVATE) in diverse older adults.

Prioli, Katherine M / Akincigil, Ayse / Namvar, Tarlan / Mitchell-Williams, Jocelyn / Schafer, Jason J / Cunningham, Renee C / Fields-Harris, Lynn / McCoy, Megan / Vertsman, Ronald / Guesnier, Ashley / Pizzi, Laura T

Journal of managed care & specialty pharmacy

2023 Volume 29, Issue 8, Page(s) 970–980

Abstract: BACKGROUND: ...

Abstract	BACKGROUND:
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Aged ; Pharmacists ; Influenza, Human/prevention & control ; Trust ; Vaccine-Preventable Diseases ; Vaccination ; Influenza Vaccines
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2023-07-30
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2376-1032
ISSN (online)	2376-1032
DOI	10.18553/jmcp.2023.29.8.970
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Article ; Online: Exoskeleton gait training to improve lower urinary tract function in people with motor-complete spinal cord injury: A randomized pilot trial.

Williams, Alison M M / Deegan, Emily / Walter, Matthias / Stothers, Lynn / Lam, Tania

Journal of rehabilitation medicine

2021 Volume 53, Issue 8, Page(s) jrm00222

Abstract: Objective: The primary aim of this study was to determine the feasibility of delivering an exoskeleton-assisted walking intervention targeting lower urinary tract function in people with motor-complete spinal cord injury. Secondary aims were to ... ...

Abstract	Objective: The primary aim of this study was to determine the feasibility of delivering an exoskeleton-assisted walking intervention targeting lower urinary tract function in people with motor-complete spinal cord injury. Secondary aims were to determine if exoskeleton walking activates the pelvic floor muscles, and compare 2 exoskeleton programmes regarding lower urinary tract function. Design: Randomized pilot trial. Subjects: Adults with motor-complete spinal cord injury at or above T10. Methods: Participants were randomized to receive Ekso or Lokomat training. Feasibility outcomes included recruitment rate, adherence, and adverse events. Pelvic floor muscle electromyography was recorded during walking. Urodynamic studies, 3-day bladder diary, and Qualiveen-30 were administered pre- and post-training. Results: Twelve people were screened and 6 people enrolled in the study. Two subjects withdrew from unrelated reasons. There was one adverse event. Pelvic floor muscle activity was greater in the Ekso group. Lower urinary tract function did not clearly change in either group. Conclusion: This pilot study demonstrates the feasibility of delivering an exoskeleton training programme targeting lower urinary tract function. Ekso-walking elicits pelvic floor muscle activity, but it remains unclear how locomotor training impacts lower urinary tract function.
MeSH term(s)	Adult ; Aged ; Electromyography ; Exercise Therapy ; Exoskeleton Device ; Female ; Gait ; Humans ; Male ; Middle Aged ; Pilot Projects ; Spinal Cord Injuries/complications ; Treatment Outcome ; Urinary Bladder/physiopathology ; Walking
Language	English
Publishing date	2021-08-26
Publishing country	Sweden
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2039427-5
ISSN	1651-2081 ; 1651-2235 ; 0891-060X ; 1650-1977
ISSN (online)	1651-2081 ; 1651-2235
ISSN	0891-060X ; 1650-1977
DOI	10.2340/16501977-2864
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Article ; Online: Provider Perspectives on Barriers and Facilitators to Postpartum Care for Low-Income Individuals.

Ruderman, Rachel S / Dahl, Emma C / Williams, Brittney R / Davis, Ka'Derricka / Feinglass, Joe M / Grobman, William A / Kominiarek, Michelle A / Yee, Lynn M

Women's health reports (New Rochelle, N.Y.)

2021 Volume 2, Issue 1, Page(s) 254–262

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-07-16
Publishing country	United States
Document type	Journal Article
ISSN	2688-4844
ISSN (online)	2688-4844
DOI	10.1089/whr.2021.0009
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Article ; Online: Unique Profile of Inflammation and Immune Activation in Pregnant People With HIV in the United States.

Shiau, Stephanie / Jacobson, Denise L / Huo, Yanling / Kacanek, Deborah / Yee, Lynn M / Williams, David B / Haddad, Lisa B / Serghides, Lena / Powis, Kathleen / Sperling, Rhoda S / Williams, Paige L / Jao, Jennifer

The Journal of infectious diseases

2023 Volume 227, Issue 5, Page(s) 720–730

Abstract: Background: Little is known about inflammation/immune activation during pregnancy in people with HIV (PWH) and growth in their children who are HIV-exposed and uninfected (CHEU).: Methods: Using data from the Pediatric HIV/AIDS Cohort Study and an ... ...

Abstract	Background: Little is known about inflammation/immune activation during pregnancy in people with HIV (PWH) and growth in their children who are HIV-exposed and uninfected (CHEU). Methods: Using data from the Pediatric HIV/AIDS Cohort Study and an HIV-seronegative comparison group, we assessed associations of (1) HIV status, mode of HIV acquisition (perinatally vs nonperinatally acquired), and type of antiretroviral therapy (ART) with inflammation/immune activation in pregnancy; and (2) inflammation/immune activation in pregnancy with growth of CHEU at 12 months. Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), soluble(s) TNF-α receptor 1 and 2 (sTNFR1, sTNFR2), sCD14, and sCD163 were measured between 13 and 27 weeks' gestation. Linear regression models were fit to estimate differences between groups for each log-transformed biomarker, adjusted for confounders. Results: Pregnant PWH (188 total, 39 perinatally acquired, 149 nonperinatally acquired) and 76 HIV-seronegative persons were included. PWH had higher IL-6, sTNFR1, sCD14, and sCD163 and lower sTNFR2 compared to HIV-seronegative persons in adjusted models. Among PWH, sCD163 was higher in those with perinatally versus nonperinatally acquired HIV and on PI-based versus INSTI-based ART. Higher maternal concentrations of IL-6, sTNFR2, and hs-CRP were associated with poorer growth at 12 months. Conclusions: Maternal HIV status is associated with a distinct profile of inflammation/immune activation during pregnancy, which may influence child growth.
MeSH term(s)	Pregnancy ; Female ; Humans ; Child ; United States ; C-Reactive Protein ; Interleukin-6 ; Cohort Studies ; Lipopolysaccharide Receptors ; Inflammation ; Biomarkers ; HIV Infections/complications ; Acquired Immunodeficiency Syndrome/complications
Chemical Substances	C-Reactive Protein (9007-41-4) ; Interleukin-6 ; Lipopolysaccharide Receptors ; Biomarkers
Language	English
Publishing date	2023-01-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiac501
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