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Article ; Online: Cross-section measurements of the 86Kr(γ,n) reaction to probe the s-process branching at 85Kr.

Raut, R / Tonchev, A P / Rusev, G / Tornow, W / Iliadis, C / Lugaro, M / Buntain, J / Goriely, S / Kelley, J H / Schwengner, R / Banu, A / Tsoneva, N

Physical review letters

2013 Volume 111, Issue 11, Page(s) 112501

Abstract: ... photon beams ranging from the neutron separation energy, S(n) = 9.86 MeV, to 13 MeV. We combine ... on the abundance flow path during s-process nucleosynthesis. Our new and more precise 85Kr(n,γ)86Kr cross section ... allows us to produce more precise predictions of the 86Kr abundance from s-process models. In particular ...

Abstract	We have carried out photodisintegration cross-section measurements on 86Kr using monoenergetic photon beams ranging from the neutron separation energy, S(n) = 9.86 MeV, to 13 MeV. We combine our experimental 86Kr(γ,n)85Kr cross section with results from our recent 86Kr(γ,γ') measurement below the neutron separation energy to obtain the complete nuclear dipole response of 86Kr. The new experimental information is used to predict the neutron capture cross section of 85Kr, an important branching point nucleus on the abundance flow path during s-process nucleosynthesis. Our new and more precise 85Kr(n,γ)86Kr cross section allows us to produce more precise predictions of the 86Kr abundance from s-process models. In particular, we find that the models of the s process in asymptotic giant branch stars of mass <1.5M⊙, where the 13C neutron source burns convectively rather than radiatively, represent a possible solution for the highest 86Kr:82Kr ratios observed in meteoritic stardust SiC grains.
Language	English
Publishing date	2013-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.111.112501
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Book ; Online: The intermediate neutron capture process

Martinet, S. / Choplin, A. / Goriely, S. / Siess, L.

IV. Impact of nuclear model and parameter uncertainties

2023

Abstract: We investigate both the systematic and statistical uncertainties associated with theoretical nuclear reaction rates of relevance during the i-process and explore their impact on the i-process elemental production, and subsequently on the surface ... ...

Abstract	We investigate both the systematic and statistical uncertainties associated with theoretical nuclear reaction rates of relevance during the i-process and explore their impact on the i-process elemental production, and subsequently on the surface enrichment, for a low-mass low-metallicity star during the early AGB phase. We use the TALYS reaction code (Koning et al. 2023) to estimate both the model and parameter uncertainties affecting the photon strength function and the nuclear level densities, hence the radiative neutron capture rates. The STAREVOL code (Siess et al. 2006) is used to determine the impact of nuclear uncertainties on the i-process nucleosynthesis in a 1 $M_{\odot}$ [Fe/H] = - 2.5 model star during the proton ingestion event in the early AGB phase. A large nuclear network of 1160 species coherently coupled to the transport processes is solved to follow the i-process nucleosynthesis. We find that the non-correlated parameter uncertainties lead the surface abundances uncertainties of element with $Z\geq 40$ to range between 0.5 and 1.0 dex, with odd-$Z$ elements displaying higher uncertainties. The correlated model uncertainties are of the same order of magnitude, and both model and parameter uncertainties have an important impact on potential observable tracers such as Eu and La. Both the correlated model and uncorrelated parameter uncertainties need to be estimated coherently before being propagated to astrophysical observables through multi-zone stellar evolution models. Many reactions are found to affect the i-process predictions and will require improved nuclear models guided by experimental constraints. Priority should be given to the reactions influencing the observable tracers. Comment: Accepted: October 11, 2023 \\ 14 Pages, 14 Figures, 2 Tables
Keywords	Astrophysics - Solar and Stellar Astrophysics ; Nuclear Experiment ; Nuclear Theory
Subject code	660
Publishing date	2023-10-12
Publishing country	us
Document type	Book ; Online
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Article ; Online: Minimal Morphoelastic Models of Solid Tumour Spheroids: A Tutorial.

Walker, Benjamin J / Celora, Giulia L / Goriely, Alain / Moulton, Derek E / Byrne, Helen M

Bulletin of mathematical biology

2023 Volume 85, Issue 5, Page(s) 38

Abstract: ... classical study of the 1970 s through to contemporary agent-based models. Of the many factors that regulate ...

Abstract	Tumour spheroids have been the focus of a variety of mathematical models, ranging from Greenspan's classical study of the 1970 s through to contemporary agent-based models. Of the many factors that regulate spheroid growth, mechanical effects are perhaps some of the least studied, both theoretically and experimentally, though experimental enquiry has established their significance to tumour growth dynamics. In this tutorial, we formulate a hierarchy of mathematical models of increasing complexity to explore the role of mechanics in spheroid growth, all the while seeking to retain desirable simplicity and analytical tractability. Beginning with the theory of morphoelasticity, which combines solid mechanics and growth, we successively refine our assumptions to develop a somewhat minimal model of mechanically regulated spheroid growth that is free from many unphysical and undesirable behaviours. In doing so, we will see how iterating upon simple models can provide rigorous guarantees of emergent behaviour, which are often precluded by existing, more complex modelling approaches. Perhaps surprisingly, we also demonstrate that the final model considered in this tutorial agrees favourably with classical experimental results, highlighting the potential for simple models to provide mechanistic insight whilst also serving as mathematical examples.
MeSH term(s)	Humans ; Spheroids, Cellular ; Models, Biological ; Mathematical Concepts ; Neoplasms ; Models, Theoretical
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184905-0
ISSN	1522-9602 ; 0007-4985 ; 0092-8240
ISSN (online)	1522-9602
ISSN	0007-4985 ; 0092-8240
DOI	10.1007/s11538-023-01141-8
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Article ; Online: Agonistic anti-CD27 antibody ameliorates EAE by suppressing IL-17 production.

Vogel, Isabel / Acolty, Valerie / Keler, Tibor / Goriely, Stanislas / Leo, Oberdan / Moser, Muriel

European journal of immunology

2022 Volume 52, Issue 10, Page(s) 1620–1629

Abstract: CD27/CD70 costimulation enhances T-cell survival, memory formation and Th1-cell differentiation and effector function. In addition to promoting Th1 responses, CD27 signaling has been shown to exert a negative regulatory role on IL-17 production, ... ...

Abstract	CD27/CD70 costimulation enhances T-cell survival, memory formation and Th1-cell differentiation and effector function. In addition to promoting Th1 responses, CD27 signaling has been shown to exert a negative regulatory role on IL-17 production, resulting in increased sensitivity of CD27 KO mice to EAE. By inducing EAE in full CD27 KO mice, and in a novel, T-cell specific CD27 KO mouse strain (CD4-Cre x CD27
MeSH term(s)	Animals ; CD27 Ligand ; Encephalomyelitis, Autoimmune, Experimental ; Interleukin-17 ; Ligands ; Mice ; Mice, Inbred C57BL ; Th1 Cells ; Tumor Necrosis Factor Receptor Superfamily, Member 7
Chemical Substances	CD27 Ligand ; Interleukin-17 ; Ligands ; Tumor Necrosis Factor Receptor Superfamily, Member 7
Language	English
Publishing date	2022-08-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202149698
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs.

Bowakim-Anta, Natalia / Acolty, Valérie / Azouz, Abdulkader / Yagita, Hideo / Leo, Oberdan / Goriely, Stanislas / Oldenhove, Guillaume / Moser, Muriel

Frontiers in immunology

2023 Volume 14, Page(s) 1023064

Abstract: Introduction: Most T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic ... ...

Abstract	Introduction: Most T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and humans, but the impact on the regulatory lineage is unknown. Methods: In this report, we examined the effect of constitutive CD27 engagement on both regulatory and conventional CD4 Results: Our data show that both T cell subsets polarize into type 1 Tconvs or Tregs, characterized by cell activation, cytokine production, response to IFN-γ and CXCR3-dependent migration to inflammatory sites. Transfer experiments suggest that CD27 engagement triggers Treg activation in a cell autonomous fashion. Conclusion: We conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory.
MeSH term(s)	Animals ; Humans ; Mice ; Antigens/metabolism ; CD27 Ligand/metabolism ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Regulatory/metabolism ; Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism
Chemical Substances	Antigens ; CD27 Ligand ; CD70 protein, human ; Tumor Necrosis Factor Receptor Superfamily, Member 7
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1023064
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Article ; Online: The nonspecific face of adaptive immunity.

Muraille, Eric / Goriely, Stanislas

Current opinion in immunology

2017 Volume 48, Page(s) 38–43

Abstract: Memory T cells generated by infection or immunization persist in the organism and mediate specific protection upon rechallenge with microbial pathogens expressing the same molecular structures. However, multiple lines of evidence indicate that previously ...

Abstract	Memory T cells generated by infection or immunization persist in the organism and mediate specific protection upon rechallenge with microbial pathogens expressing the same molecular structures. However, multiple lines of evidence indicate that previously encountered or persisting pathogens influence the immune response to unrelated pathogens. We describe the acquisition of non-antigen specific memory features by both innate and adaptive immune cells explaining these phenomena. We also focus on the different mechanisms (homeostatic or inflammatory cytokine-driven) that lead to acquisition of memory phenotype and functions by antigen-inexperienced T lymphocytes. We discuss the implications of these new concepts for host defense, auto-immunity and vaccination strategies.
Language	English
Publishing date	2017-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2017.08.002
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Zs.A 2773: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis.

Englebert, Kevin / Taquin, Anaelle / Azouz, Abdulkader / Acolty, Valérie / Vande Velde, Sylvie / Vanhollebeke, Marie / Innes, Hadrien / Boon, Louis / Keler, Tibor / Leo, Oberdan / Goriely, Stanislas / Moser, Muriel / Oldenhove, Guillaume

Cell reports

2024 Volume 43, Issue 3, Page(s) 113824

Abstract: Adipose tissue homeostasis relies on the interplay between several regulatory lineages, such as type 2 innate lymphoid cells (ILC2s), T helper 2 (Th2) cells, regulatory T cells, eosinophils, and type 2 macrophages. Among them, ILC2s are numerically the ... ...

Abstract	Adipose tissue homeostasis relies on the interplay between several regulatory lineages, such as type 2 innate lymphoid cells (ILC2s), T helper 2 (Th2) cells, regulatory T cells, eosinophils, and type 2 macrophages. Among them, ILC2s are numerically the dominant source of type 2 cytokines and are considered as major regulators of adiposity. Despite the overlap in immune effector molecules and sensitivity to alarmins (thymic stromal lymphopoietin and interleukin-33) between ILC2s and resident memory Th2 lymphocytes, the role of the adaptive axis of type 2 immunity remains unclear. We show that mice deficient in CD27, a member of the tumor necrosis factor receptor superfamily, are more resistant to obesity and associated disorders. A comparative analysis of the CD4 compartment of both strains revealed higher numbers of fat-resident memory Th2 cells in the adipose tissue of CD27 knockout mice, which correlated with decreased programmed cell death protein 1-induced apoptosis. Our data point to a non-redundant role for Th2 lymphocytes in obesogenic conditions.
MeSH term(s)	Animals ; Mice ; Cytokines/metabolism ; Homeostasis ; Immunity, Innate ; Interleukin-33 ; Intra-Abdominal Fat/metabolism ; Lymphocytes/metabolism ; Th2 Cells ; Tumor Necrosis Factor Receptor Superfamily, Member 7
Chemical Substances	Cytokines ; Interleukin-33 ; Tumor Necrosis Factor Receptor Superfamily, Member 7 ; Cd70 protein, mouse
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.113824
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Article ; Online: La mémoire virtuelle des lymphocytes T cytotoxiques.

Martinet, Valérie / Goriely, Stanislas

Medecine sciences : M/S

2016 Volume 32, Issue 3, Page(s) 236–238

Title translation	Virtual memory of cytotoxic T lymphocytes.
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/immunology ; Humans ; Immunologic Memory ; Lymphocyte Activation ; T-Lymphocytes, Cytotoxic/immunology
Language	French
Publishing date	2016-03
Publishing country	France
Document type	News
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/20163203003
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Article ; Online: Spatially-extended nucleation-aggregation-fragmentation models for the dynamics of prion-like neurodegenerative protein-spreading in the brain and its connectome.

Fornari, Sveva / Schäfer, Amelie / Kuhl, Ellen / Goriely, Alain

Journal of theoretical biology

2019 Volume 486, Page(s) 110102

Abstract: The prion-like hypothesis of neurodegenerative diseases states that the accumulation of misfolded proteins in the form of aggregates is responsible for tissue death and its associated neurodegenerative pathology and cognitive decline. Some disease- ... ...

Abstract	The prion-like hypothesis of neurodegenerative diseases states that the accumulation of misfolded proteins in the form of aggregates is responsible for tissue death and its associated neurodegenerative pathology and cognitive decline. Some disease-specific misfolded proteins can interact with healthy proteins to form long chains that are transported through the brain along axonal pathways. Since aggregates of different sizes have different transport properties and toxicity, it is important to follow independently their evolution in space and time. Here, we model the spreading and propagation of aggregates of misfolded proteins in the brain using the general Smoluchowski theory of nucleation, aggregation, and fragmentation. The transport processes considered here are either anisotropic diffusion along axonal bundles or discrete Laplacian transport along a network. In particular, we model the spreading and aggregation of both amyloid-β and τ molecules in the brain connectome. We show that these two models lead to different size distributions and different propagation along the network. A detailed analysis of these two models also reveals the existence of four different stages with different dynamics and invasive properties.
MeSH term(s)	Amyloid beta-Peptides ; Brain/metabolism ; Connectome ; Humans ; Neurodegenerative Diseases ; Prions/metabolism ; tau Proteins
Chemical Substances	Amyloid beta-Peptides ; Prions ; tau Proteins
Language	English
Publishing date	2019-12-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2972-5
ISSN	1095-8541 ; 0022-5193
ISSN (online)	1095-8541
ISSN	0022-5193
DOI	10.1016/j.jtbi.2019.110102
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Article ; Online: Memory CD8+ T Cells: Orchestrators and Key Players of Innate Immunity?

Lauvau, Grégoire / Goriely, Stanislas

PLoS pathogens

2016 Volume 12, Issue 9, Page(s) e1005722

Abstract: Over the past decades, the dichotomy between innate and adaptive immune responses has largely dominated our understanding of immunology. Upon primary encounter with microbial pathogens, differentiation of adaptive immune cells into functional effectors ... ...

Abstract	Over the past decades, the dichotomy between innate and adaptive immune responses has largely dominated our understanding of immunology. Upon primary encounter with microbial pathogens, differentiation of adaptive immune cells into functional effectors usually takes several days or even longer, making them contribute to host protection only late during primary infection. However, once generated, antigen-experienced T lymphocytes can persist in the organism and constitute a pool of memory cells that mediate fast and effective protection to a recall infection with the same microbial pathogen. Herein, we challenge this classical paradigm by highlighting the "innate nature" of memory CD8+ T cells. First, within the thymus or in the periphery, naïve CD8+ T cells may acquire phenotypic and functional characteristics of memory CD8+ T cells independently of challenge with foreign antigens. Second, both the "unconventional" and the "conventional" memory cells can rapidly express protective effector functions in response to sets of inflammatory cytokines and chemokines signals, independent of cognate antigen triggering. Third, memory CD8+ T cells can act by orchestrating the recruitment, activation, and licensing of innate cells, leading to broad antimicrobial states. Thus, collectively, memory CD8+ T cells may represent important actors of innate immune defenses.
MeSH term(s)	Adaptive Immunity/immunology ; Animals ; Antigens/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cytokines/immunology ; Humans ; Immunity, Innate/immunology ; Immunologic Memory/immunology ; Mice
Chemical Substances	Antigens ; Cytokines
Language	English
Publishing date	2016-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1005722
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