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Article ; Online: [No title information]

Malandrini, Francesco / Borroni, Cesare / Meregaglia, Michela / Sarra, Massimiliano / Ciani, Oriana

Global & regional health technology assessment

2023 Volume 10, Page(s) 12–17

Title translation	Il ruolo degli esiti riferiti dal paziente nelle decisioni di rimborso e innovatività dei farmaci in Italia.
Language	Italian
Publishing date	2023-02-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2963961-X
ISSN	2283-5733 ; 2284-2403
ISSN (online)	2283-5733
ISSN	2284-2403
DOI	10.33393/grhta.2023.2514
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Article ; Online: Novel method for rapid monitoring of OPFRs by LLE and GC-MS as a tool for assessing biodegradation: validation and applicability.

Losantos, Diana / Palacios, Oscar / Berge, María Jesús / Sarrà, Montserrat / Caminal, Gloria / Eustaquio, Alba

Analytical and bioanalytical chemistry

2024 Volume 416, Issue 6, Page(s) 1493–1504

Abstract: Organophosphate flame retardants (OPFRs) are high-production volume chemicals widely present in environmental compartments. The presence of water-soluble OPFRs (tri-n-butyl phosphate (TnBP), tris(2-butoxyethyl) phosphate (TBEP), tris(2-chloroethyl) ... ...

Abstract	Organophosphate flame retardants (OPFRs) are high-production volume chemicals widely present in environmental compartments. The presence of water-soluble OPFRs (tri-n-butyl phosphate (TnBP), tris(2-butoxyethyl) phosphate (TBEP), tris(2-chloroethyl) phosphate (TCEP), tris(2-chloroisopropyl) phosphate (TCPP), and triethyl phosphate (TEP)) in water compartments evidences the struggle of conventional wastewater treatment plants (WWTPs) to effectively eliminate these toxic compounds. This study reports for the first time the use of white-rot fungi as a promising alternative for the removal of these OPFRs. To accomplish this, a simple and cost-efficient quantification method for rapid monitoring of these contaminants' concentrations by GC-MS while accounting for matrix effects was developed. The method proved to be valid and reliable for all the tested parameters. Sample stability was examined under various storage conditions, showing the original samples to be stable after 60 days of freezing, while post-extraction storage techniques were also effective. Finally, a screening of fungal degraders while assessing the influence of the glucose regime on OPFR removal was performed. Longer chain organophosphate flame retardants, TBP and TBEP, could be easily and completely removed by the fungus Ganoderma lucidum after only 4 days. This fungus also stood out as the sole organism capable of partially degrading TCEP (35% removal). The other chlorinated compound, TCPP, was more easily degraded and 70% of its main isomer was removed by T. versicolor. However, chlorinated compounds were only partially degraded under nutrient-limiting conditions. TEP was either not degraded or poorly degraded, and it is likely that it is a transformation product from another OPFR's degradation. These results suggest that degradation of chlorinated compounds is dependent on the concentration of the main carbon source and that more polar OPFRs are less susceptible to degradation, given that they are less accessible to radical removal by fungi. Overall, the findings of the present study pave the way for further planned research and a potential application for the degradation of these contaminants in real wastewaters.
MeSH term(s)	Organophosphorus Compounds/analysis ; Flame Retardants/analysis ; Gas Chromatography-Mass Spectrometry ; Organophosphates/analysis ; Wastewater ; Water ; Phosphates ; Phosphines
Chemical Substances	Organophosphorus Compounds ; Flame Retardants ; tris(2-carboxyethyl)phosphine (22OAC2MO2S) ; triethyl phosphate (QIH4K96K7J) ; tris(chloroethyl)phosphate (32IVO568B0) ; Organophosphates ; Wastewater ; Water (059QF0KO0R) ; Phosphates ; Phosphines
Language	English
Publishing date	2024-01-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-024-05154-7
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Article ; Online: Enhanced breast mass mammography classification approach based on pre-processing and hybridization of transfer learning models.

Boudouh, Saida Sarra / Bouakkaz, Mustapha

Journal of cancer research and clinical oncology

2023 Volume 149, Issue 16, Page(s) 14549–14564

Abstract: ... cancer, surpassing heart disease. Mammography images must accurately identify breast masses ... to the diversity of breast masses and the complexity of their microenvironment, it is still a significant issue ... Hence, an issue that researchers need to continue searching into is how to establish a reliable breast mass ...

Abstract	Background and objective: The second most prevalent cause of death among women is now breast cancer, surpassing heart disease. Mammography images must accurately identify breast masses to diagnose early breast cancer, which can significantly increase the patient's survival percentage. Although, due to the diversity of breast masses and the complexity of their microenvironment, it is still a significant issue. Hence, an issue that researchers need to continue searching into is how to establish a reliable breast mass detection approach in an effective factor application to increase patient survival. Even though several machine and deep learning-based approaches were proposed to address these issues, pre-processing strategies and network architectures were insufficient for breast mass detection in mammogram scans, which directly influences the accuracy of the proposed models. Methods: Aiming to resolve these issues, we propose a two-stage classification method for breast mass mammography scans. First, we introduce a pre-processing stage divided into three sub-strategies, which include several filters for Region Of Interest (ROI) extraction, noise removal, and image enhancements. Secondly, we propose a classification stage based on transfer learning techniques for feature extraction, and global pooling for classification instead of standard machine learning algorithms or fully connected layers. However, instead of using the traditional fine-tuning feature extraction phase, we proposed a hybrid model where we concatenate two recent pre-trained CNNs to assist the feature extraction phase, rather than using one. Results: Using the CBIS-DDSM dataset, we managed to increase mainly each of the accuracy, sensitivity, and specificity reaching the highest accuracy of 98,1% using the Median filter for noise removal. Followed by the Gaussian filter trial with 96% accuracy, meanwhile, the winner filter attained the lowest accuracy of 94.13%. Moreover, the usage of global average pooling as a classifier is suitable in our case better than global max pooling. Conclusion: The experimental findings demonstrate that the suggested strategy of breast Mass detection in mammography can outperform the top-ranked methods currently in use in terms of classification performance.
MeSH term(s)	Female ; Humans ; Neural Networks, Computer ; Mammography/methods ; Breast/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Machine Learning ; Tumor Microenvironment
Language	English
Publishing date	2023-08-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-023-05249-1
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Article ; Online: Relationship of body mass index to percent body fat determined by deuterium isotopic dilution and impedancemetry among Tunisian schoolchildren.

Houda, Ben Jemaa / Sarra, Khlifi / Karmous, Inchirah / Henda, Jamoussi / Khalid, El Kari / Hassan, Aguenaou / Abdallah, Aouidet / Amani, Mankaï

African health sciences

2024 Volume 23, Issue 3, Page(s) 664–671

Abstract: Objectives: This study aims to evaluate the relation of body mass index (BMI) to fat mass ...

Abstract	Objectives: This study aims to evaluate the relation of body mass index (BMI) to fat mass among children by two techniques impedancemetry and deuterium oxide dilution (D Methods: This study was carried out in 156 schoolchildren aged between 8 and 11 years. The children received interrogation specifying lifestyle and food habits. Body composition was determined using the impedancemetry and D2O technique. Results: The results showed a difference between the percentage of obese and overweight children according to BMIZ classification (30.1%), bioelectrical impedance method (14.7%) and D Conclusion: This study has demonstrated that the percentage of overweight and obesity varied according the methods used. Further development of body composition methods is needed in children for the real determination of the obesity prevalence and therefore a better monitoring of this public health problem.
MeSH term(s)	Male ; Female ; Child ; Humans ; Body Mass Index ; Deuterium ; Overweight/diagnosis ; Overweight/epidemiology ; Adipose Tissue ; Body Composition ; Obesity/diagnosis ; Obesity/epidemiology
Chemical Substances	Deuterium (AR09D82C7G)
Language	English
Publishing date	2024-02-03
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2240308-5
ISSN	1729-0503 ; 1680-6905
ISSN (online)	1729-0503
ISSN	1680-6905
DOI	10.4314/ahs.v23i3.77
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Article: An epigastric mass? And what if it was an intra-abdominal esophageal duplication cyst: Case report.

Sghaier, Asma / Lamloum, Eya / Debaibi, Mehdi / Rejab, Sarra Ben / Sridi, Azza / Chouchene, Adnene

International journal of surgery case reports

2023 Volume 106, Page(s) 108295

Abstract: ... without particularity except for the presence of abdominal epigastric mass. Transabdominal sonography combined with CT ... Histological exam than showed that the cystic mass was in fact an esophageal cystic duplication with no ...

Abstract	Introduction and importance: Duplication of the alimentary tract are uncommon congenital malformations that may be found anywhere from mouth to anus. Esophageal cystic duplication is a congenital cystic malformation of the alimentary tract consisting of a duplication of the segment of the esophagus to which it is adjacent. Case presentation: We report the case of a 29-year-old female who had complained of intermittent epigastric pain and post prandial nausea for several weeks. Physical examination was without particularity except for the presence of abdominal epigastric mass. Transabdominal sonography combined with CT scan showed an epigastric cyst with no topographic relation to the pancreas measuring about 80 mm in diameter. Because of persistence of the epigastric pain and the nausea we decided to operate the patient. Histological exam than showed that the cystic mass was in fact an esophageal cystic duplication with no histological signs of malignancy. Clinical discussion: Here we describe a case of intra-abdominal esophageal duplication cyst in adult patient. Most of duplications cause symptoms in infancy or early childhood. Digestive duplication revealed at adulthood is a condition considered rare. Conclusion: Esophageal duplication cysts are uncommon developmental lesions arising from the primitive foregut, when diagnosed or encountered incidentally. The diagnosis of this anomaly in adulthood is exceptional and requires surgery.
Language	English
Publishing date	2023-05-05
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2023.108295
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Article ; Online: Interleukin-21: a new mediator of inflammation in systemic lupus erythematosus.

Sarra, Massimiliano / Monteleone, Giovanni

Journal of biomedicine & biotechnology

2010 Volume 2010, Page(s) 294582

Abstract: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by excessive production of a variety of autoantibodies and a wide range of clinical manifestations. Pathogenesis of SLE is complex and not fully understood. There is however ... ...

Abstract	Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by excessive production of a variety of autoantibodies and a wide range of clinical manifestations. Pathogenesis of SLE is complex and not fully understood. There is however evidence that B and T cells are critical to the development of disease, and that T cell-derived cytokines are involved in the SLE-associated inflammatory response. One such cytokine seems to be interleukin (IL)-21, the latest identified member of the gamma-chain-related cytokine family. IL-21 has an important role in the control of the growth, survival, differentiation, and function of both T and B cells, and excessive production of IL-21 has been associated with the development of multiple immune-mediated diseases. Here we review data supporting the involvement of IL-21 in the pathogenesis of SLE.
MeSH term(s)	Animals ; B-Lymphocytes/metabolism ; Disease Models, Animal ; Humans ; Inflammation Mediators/metabolism ; Interleukins/metabolism ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/metabolism ; Mice ; T-Lymphocytes/metabolism
Chemical Substances	Inflammation Mediators ; Interleukins ; interleukin-21 (MKM3CA6LT1)
Language	English
Publishing date	2010-06-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2052552-7
ISSN	1110-7251 ; 1110-7243
ISSN (online)	1110-7251
ISSN	1110-7243
DOI	10.1155/2010/294582
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Article ; Online: Interleukin-21 in chronic inflammatory diseases.

Sarra, Massimiliano / Pallone, Francesco / Monteleone, Giovanni

BioFactors (Oxford, England)

2013 Volume 39, Issue 4, Page(s) 368–373

Abstract: Interleukin-21 (IL-21), a cytokine produced by various subsets of activated CD4+ T cells, regulates multiple innate and adaptive immune responses. Indeed, IL-21 controls the proliferation and function of CD4+ and CD8+ T lymphocytes, drives the ... ...

Abstract	Interleukin-21 (IL-21), a cytokine produced by various subsets of activated CD4+ T cells, regulates multiple innate and adaptive immune responses. Indeed, IL-21 controls the proliferation and function of CD4+ and CD8+ T lymphocytes, drives the differentiation of B cells into memory cells and Ig-secreting plasma cells, enhances the activity of natural killer cells and negatively regulates the differentiation and activity of regulatory T cells. Moroever, IL-21 can stimulate nonimmune cells to synthesize various inflammatory molecules. Excessive production of IL-21 has been described in many human chronic inflammatory disorders and there is evidence that blockade of IL-21 helps attenuate detrimental responses in mouse models of immune-mediated diseases. In this article we briefly review data supporting the pathogenic role of IL-21 in immune-inflammatory pathologies and discuss the benefits and risks of IL-21 neutralization in patients with such diseases.
MeSH term(s)	Animals ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/metabolism ; Gastroenteritis/metabolism ; Humans ; Interleukins/physiology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/metabolism ; Psoriasis/immunology ; Psoriasis/metabolism ; Signal Transduction
Chemical Substances	Interleukins ; interleukin-21
Language	English
Publishing date	2013-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	59230-4
ISSN	1872-8081 ; 0951-6433
ISSN (online)	1872-8081
ISSN	0951-6433
DOI	10.1002/biof.1105
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Article ; Online: Interleukin-21

Massimiliano Sarra / Giovanni Monteleone

Journal of Biomedicine and Biotechnology, Vol

A New Mediator of Inflammation in Systemic Lupus Erythematosus

2010 Volume 2010

Abstract	Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by excessive production of a variety of autoantibodies and a wide range of clinical manifestations. Pathogenesis of SLE is complex and not fully understood. There is however evidence that B and T cells are critical to the development of disease, and that T cell-derived cytokines are involved in the SLE-associated inflammatory response. One such cytokine seems to be interleukin (IL)-21, the latest identified member of the γ-chain-related cytokine family. IL-21 has an important role in the control of the growth, survival, differentiation, and function of both T and B cells, and excessive production of IL-21 has been associated with the development of multiple immune-mediated diseases. Here we review data supporting the involvement of IL-21 in the pathogenesis of SLE.
Keywords	Biotechnology ; TP248.13-248.65 ; Chemical technology ; TP1-1185 ; Technology ; T ; DOAJ:Biotechnology ; DOAJ:Life Sciences ; DOAJ:Biology and Life Sciences
Subject code	610
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
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Article ; Online: Interleukin-21

Massimiliano Sarra / Giovanni Monteleone

Journal of Biomedicine and Biotechnology, Vol

A New Mediator of Inflammation in Systemic Lupus Erythematosus

2010 Volume 2010

Abstract	Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by excessive production of a variety of autoantibodies and a wide range of clinical manifestations. Pathogenesis of SLE is complex and not fully understood. There is however evidence that B and T cells are critical to the development of disease, and that T cell-derived cytokines are involved in the SLE-associated inflammatory response. One such cytokine seems to be interleukin (IL)-21, the latest identified member of the -chain-related cytokine family. IL-21 has an important role in the control of the growth, survival, differentiation, and function of both T and B cells, and excessive production of IL-21 has been associated with the development of multiple immune-mediated diseases. Here we review data supporting the involvement of IL-21 in the pathogenesis of SLE.
Keywords	Biotechnology ; TP248.13-248.65 ; Medicine ; R
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Un curieux cas de masse cardiaque : à propos d'un cas.

Chenik, Sarra / Besbes, Boutheina / Noamen, Aymen / Mejri, Islem / Arous, Younes / Fehri, Wafa

Annales de cardiologie et d'angeiologie

2022 Volume 72, Issue 1, Page(s) 48–53

Abstract: Background: Retained foreign bodies are dreadful events associated with invasive procedures. Their occurrence implicate physical complications as well as serious professional and medico-legal consequences. Cases of retained surgical items, in the ... ...

Title translation	The curious case of a cardiac mass : A case report.
Abstract	Background: Retained foreign bodies are dreadful events associated with invasive procedures. Their occurrence implicate physical complications as well as serious professional and medico-legal consequences. Cases of retained surgical items, in the pericardial space, following cardiothoracic surgery are rare and their management is delicate as the risks of their removal must be thoroughly weighed against the complications of leaving them inside the chest. Case presentation: We report the case of a retained foreign body, discovered in an asymptomatic patient, on a routine medical check-up, 4 years after cardiac surgery. Conclusions: Clinical and paraclinical manifestations of retained surgical foreign bodies are nonspecific. The progress of cardiac imaging means makes it possible to identify these rare foreign bodies with greater precision, and allows, with extreme caution, to monitor patients who are perfectly asymptomatic and who are reluctant to undergo surgery.
MeSH term(s)	Humans ; Cardiac Surgical Procedures ; Foreign Bodies/complications ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Pericardium ; Time Factors
Language	French
Publishing date	2022-11-23
Publishing country	France
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	418425-7
ISSN	1768-3181 ; 0003-3928
ISSN (online)	1768-3181
ISSN	0003-3928
DOI	10.1016/j.ancard.2022.10.008
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