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  1. Article: Anti-osteoporotic effects of Yi Mai Jian on bone metabolism of ovariectomized rats.

    Shi, Bin / Lin, Che-Chun / Lee, Chia-Jung / Ning, De-Shan / Lin, Chao-Chi / Zhao, Hong-Wei / Yang, Chang-Syun / Deng, Shun-Xin / Chiu, Yung-Jia / Wang, Ching-Chiung

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1326415

    Abstract: Yi Mai Jian herbal formula (YMJ) is formulated with Eucommiae Folium, Astragali Radix ...

    Abstract Yi Mai Jian herbal formula (YMJ) is formulated with Eucommiae Folium, Astragali Radix, Ligustri Lucidi Fructus, and Elaeagnus Fructus to improve bone function in traditional Chinese medicine. The anti-osteoporotic effects of YMJ in bone metabolism were evaluated in ovariectomized (OVX) rats. The skeletal structure of the femur and vertebrae was analyzed after treating OVX rats with YMJ for 114 days. The results showed that YMJ significantly increased the bone mineral density (BMD) and trabecular number (Tb. N) of the femur and 5th lumbar vertebrae and reduced trabecular separation (Tb. Sp). Moreover, trabecular bone volume/total tissue volume (BV/TV), bone stiffness, and maximum femur load were significantly increased. The serum concentrations of NTX1 and PYD were significantly decreased. According to these results, YMJ could ameliorate osteoporosis in ovariectomized rats. Eucommiae Folium and Elaeagnus Fructus inhibited osteoclast differentiation, Ligustri Lucidi Fructus inhibited calcium reabsorption, Astragali Radix stimulated osteoblast proliferation, and Astragali Radix and Eucommiae Folium stimulated mineralization. Therefore, the combination of the four herbs into one formula, YMJ, could alleviate bone remodeling caused by low estrogen levels. We suggest that YMJ could be a healthy food candidate for preventing post-menopausal osteoporosis.
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1326415
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  2. Article ; Online: Qi-Po-Sheng-Mai granule ameliorates Ach-CaCl

    Shi, Shuqing / Mao, Xinxin / Lv, Jiayu / Wang, Yajiao / Zhang, Xuesong / Shou, Xintian / Zhang, Bingxuan / Li, Yumeng / Wu, Huaqin / Song, Qingqiao / Hu, Yuanhui

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2023  Volume 119, Page(s) 155017

    Abstract: ... safety of medical therapies. The Chinese herbal formula Qi-Po-Sheng-Mai Granule (QPSM) has been widely ...

    Abstract Background: Atrial fibrillation (AF) is one of the most common arrhythmias encountered in clinical settings. Currently, the pathophysiology of AF remains unclear, which severely limits the effectiveness and safety of medical therapies. The Chinese herbal formula Qi-Po-Sheng-Mai Granule (QPSM) has been widely used in China to treat AF. However, its pharmacological and molecular mechanisms remain unknown.
    Purpose: The purpose of this study was to investigate the molecular mechanisms and potential targets of QPSM for AF.
    Study design and methods: The AF model was induced by Ach (66 μg/ml) and CaCl
    Results: Based on an Ach-CaCl
    Conclusion: The present study has systematically elucidated the role of QPSM in maintaining calcium homeostasis in cardiomyocytes through the regulation of calcium transporters, which could lead to new drug development ideas for AF.
    MeSH term(s) Humans ; Atrial Fibrillation/chemically induced ; Atrial Fibrillation/drug therapy ; Myocytes, Cardiac ; Calcium ; Calcium Chloride ; Molecular Docking Simulation ; Qi ; Bone Density Conservation Agents ; Amino Acids ; Homeostasis
    Chemical Substances Calcium (SY7Q814VUP) ; Calcium Chloride (M4I0D6VV5M) ; Bone Density Conservation Agents ; Amino Acids
    Language English
    Publishing date 2023-08-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2023.155017
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  3. Article: Mechanism of new optimized Sheng-Mai-San Formula to regulate cardiomyocyte apoptosis through NMDAR pathway.

    Hou, Yazhu / He, Zixun / Han, Yixiao / Zhang, Tongyan / Wang, Shuai / Wang, Xianliang / Mao, Jingyuan

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e16631

    Abstract: ... Sheng-Mai-San (NO-SMS) has been shown to be significantly effective in improving cardiac function ...

    Abstract Background and objectives: Ischemic heart failure (HF) has become a disease that seriously endangers people's life and health. As a herbal formula widely used in clinical practice, new optimized Sheng-Mai-San (NO-SMS) has been shown to be significantly effective in improving cardiac function, increasing exercise tolerance, and slowing the progression of myocardial fibrosis in heart failure patients in multi-center clinical studies in various regions of China. In our previous pharmacodynamic and toxicological studies, we found that a medium-dose formulation (8.1 g of raw drug/kg) was the most effective in the treatment of heart failure, but its mechanism of action is still being investigated. The present study is exploring its relationship with cardiomyocyte apoptosis.
    Materials and methods: We investigated and verified this through two parts of experiments, in vivo and in vitro. Firstly, we prepared male SD rats with heart failure models by ligating the left anterior descending branch of the coronary artery (EF ≤ 50%), which were treated with NO-SMS Formula (8.1 g of raw drug/kg/d), Ifenprodil (5.4 mg/kg/d) or Enalapril (0.9 mg/kg/d) prepared suspensions by gavage for 4 weeks. The cardiac and structural changes were evaluated by echocardiography, H&E, and MASSON staining. The apoptosis of cardiomyocytes in each group was detected by Western blot, qRT-PCR, and ELISA. In vitro cell experiments include H9c2 cardiomyocyte injury induced by H
    Results: Compared with the model group, the NO-SMS formula group and the Ifenprodil group could significantly improve cardiac function, delay myocardial fibrosis, reduce the expression of pro-apoptotic proteins, mRNA, and the concentration levels of Ca
    Conclusion: NO-SMS Formula improved cardiac function, inhibited ventricular remodeling and cardiomyocyte apoptosis in HF rats, and its mechanism may be related to the regulation of the NMDAR signaling pathway, inhibition of large intracellular Ca
    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16631
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  4. Article ; Online: Intra- and inter-habitat variation in sediment heavy metals, antibiotics and ecological risks in Mai Po RAMSAR, China.

    Lam, Kit-Ling / Tam, Nora Fung-Yee / Xu, Steven Jing-Liang / Mo, Wing-Yin / Chan, Ping-Lung / Lee, Fred Wang-Fat

    Marine pollution bulletin

    2023  Volume 193, Page(s) 115178

    Abstract: ... mudflat, mangrove and gei wai (inter-tidal shrimp ponds), at Mai Po RAMSAR were determined ...

    Abstract Distribution of heavy metals (HMs) and antibiotics (ABs) in surface sediments of three habitats: mudflat, mangrove and gei wai (inter-tidal shrimp ponds), at Mai Po RAMSAR were determined with inductively coupled plasma and liquid chromatograph tandem - mass spectrometry, respectively. Eight HMs (Cr, As, Pb, Cd, Mn, Ni, Cu and Zn), and ten ABs (tetracyclines, quinolones, macrolides and sulphonamides) were detected in all habitats, with relatively lower concentration in gei wai. Ecological risk assessment based on PNEC revealed that HMs posed a higher ecological risk to microorganisms than ABs. All metals except Mn were above their respective threshold effect levels according to sediment quality guidelines, indicating their potential toxicity to benthos. The enrichment factor and geo-accumulation index on background values suggested sediments were moderately polluted by Zn, Cu and Cd, possibly from anthropogenic inputs. This study implies that HMs pollution must be prevented through proper regulation of agricultural and industrial discharge.
    MeSH term(s) Cadmium ; Geologic Sediments ; Water Pollutants, Chemical/analysis ; Environmental Monitoring ; Metals, Heavy/analysis ; China ; Ecosystem
    Chemical Substances Cadmium (00BH33GNGH) ; Water Pollutants, Chemical ; Metals, Heavy
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2023.115178
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  5. Article ; Online: Sheng-Mai-Yin inhibits doxorubicin-induced ferroptosis and cardiotoxicity through regulation of Hmox1.

    Meng, Peina / Chen, Zhaoyang / Sun, Tianhui / Wu, Lili / Wang, Yifan / Guo, Tianwei / Yang, Jin / Zhu, Jiebin

    Aging

    2023  Volume 15, Issue 19, Page(s) 10133–10145

    Abstract: ... Sheng-Mai-Yin (SMY), a Traditional Chinese medicine (TCM) prescription, has been reported to exert ...

    Abstract Doxorubicin (DOX) is a potent chemotherapeutic drug used for treating various cancers. However, its clinical use is limited due to its severe cardiotoxicity, which often results in high mortality rates. Sheng-Mai-Yin (SMY), a Traditional Chinese medicine (TCM) prescription, has been reported to exert a cardioprotective effect in various cardiovascular diseases, including DOX-induced cardiotoxicity (DIC). This study aimed to provide novel insights into the underlying cardioprotective mechanism of SMY. SMY, composed of Codonopsis pilosula (Franch.), Ophiopogon japonicus (Thunb.), and Schisandra chinensis (Turcz.) at a ratio of 3:2:1, was intragastrically administered to male C57BL/6 mice for five days prior to the intraperitoneal injection of mitoTEMPO. One day later, DOX was intraperitoneally injected. Hematoxylin-eosin staining and Sirius red staining were carried out to estimate the pharmacological effect of SMY on cardiotoxicity. Mitochondrial function and ferroptosis biomarkers were also examined. AAV was utilized to overexpress Hmox1 to confirm whether Hmox1-mediated ferroptosis is associated with the cardioprotective effect of SMY on DOX-induced cardiotoxicity. The findings revealed that SMY therapy reduced the number of damaged cardiomyocytes. SMY therapy also reversed the inductions of cardiac MDA, serum MDA, LDH, and CK-MB contents, which dramatically decreased nonheme iron levels. In the meantime, SMY corrected the changes to ferroptosis indices brought on by DOX stimulation. Additionally, Hmox1 overexpression prevented SMY's ability to reverse cardiotoxicity. Our results showed that SMY effectively restrained lipid oxidation, reduced iron overload, and inhibited DOX-induced ferroptosis and cardiotoxicity, possibly via the mediation of Hmox1.
    MeSH term(s) Male ; Mice ; Animals ; Cardiotoxicity/prevention & control ; Ferroptosis ; Mice, Inbred C57BL ; Doxorubicin/toxicity ; Myocytes, Cardiac/metabolism ; Oxidative Stress ; Membrane Proteins/metabolism ; Heme Oxygenase-1/metabolism
    Chemical Substances fructus schizandrae, radix ginseng, radix ophiopogonis drug combination ; Doxorubicin (80168379AG) ; Hmox1 protein, mouse (EC 1.14.14.18) ; Membrane Proteins ; Heme Oxygenase-1 (EC 1.14.14.18)
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205062
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  6. Article ; Online: A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Shen-Kui-Tong-Mai granules on a rat model with chronic heart failure.

    Huang, Hong / Xu, Junyao / Zhang, Siqi / Zhao, Jing / Liu, Shun / Tian, Lei / Wang, Haidan / Geng, Zhirong / Yan, Shihai

    The Journal of pharmacy and pharmacology

    2023  Volume 75, Issue 6, Page(s) 764–783

    Abstract: ... therapeutic mechanisms of Shen-Kui-Tong-Mai granule (SKTMG) in the treatment of heart failure.: Methods ...

    Abstract Objectives: This study aimed to comprehensively investigate the potential active components and therapeutic mechanisms of Shen-Kui-Tong-Mai granule (SKTMG) in the treatment of heart failure.
    Methods: Network pharmacology combined with ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), molecular docking, and in vivo validation was performed to identify the active components and the potential targets for SKTMG to improve chronic heart failure (CHF).
    Key findings: The network pharmacology identified 192 active compounds and 307 potential consensus targets for SKTMG. On the other hand, network analysis discovered 10 core target genes related to the MAPK signal pathway. These genes include AKT1, STAT3, MAPK1, P53, SRC, JUN, TNF, APP, MAPK8 and IL6. The molecular docking results revealed that the SKTMG components were luteolin, quercetin, astragaloside IV and kaempferol, which could bind AKT1, MAPK1, P53, JUN, TNF and MAPK8. Additionally, SKTMG inhibited phosphorylation of AKT, P38, P53 and c-JUN, and reduced TNF-α expression in CHF rats.
    Conclusions: The present results demonstrated that network pharmacology combined with UHPLC-MS/MS, molecular docking and in vivo validation can facilitate the identification of active components and the potential targets for SKTMG to improve CHF.
    MeSH term(s) Animals ; Rats ; Molecular Docking Simulation ; Network Pharmacology ; Tandem Mass Spectrometry ; Tumor Suppressor Protein p53 ; Chronic Disease ; Drugs, Chinese Herbal/pharmacology ; Heart Failure/drug therapy
    Chemical Substances Tumor Suppressor Protein p53 ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 3107-0
    ISSN 2042-7158 ; 0022-3573 ; 0373-1022
    ISSN (online) 2042-7158
    ISSN 0022-3573 ; 0373-1022
    DOI 10.1093/jpp/rgad009
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  7. Article ; Online: Yang-Xin-Shu-Mai granule alleviates atherosclerosis by regulating macrophage polarization via the TLR9/MyD88/NF-κB signaling pathway.

    Huang, Hong / Sun, Zeqi / Xu, Junyao / Wang, Linjie / Zhao, Jing / Li, Jie / Zhang, Siqi / Yuan, Fang / Liu, Ming / Fang, Zhuyuan

    Journal of ethnopharmacology

    2023  Volume 318, Issue Pt A, Page(s) 116868

    Abstract: Ethnopharmacological relevance: Previous studies have found that Yang-Xin-Shu-Mai granule (YXSMG ...

    Abstract Ethnopharmacological relevance: Previous studies have found that Yang-Xin-Shu-Mai granule (YXSMG) has certain advantages in the treatment of stable coronary heart disease. However, YXSMG can inhibit the progression of atherosclerotic plaque and stabilize vulnerable plaque needs to be further explored and studied. This research, mass spectrometry analysis, network pharmacology, in vivo and in vitro experimental studies were conducted to explore the mechanism of YXSMG on atherosclerosis.
    Aim of the study: To decipher the mechanism of atherosclerotic plaque, stabilization for YXSMG by analysis of its active ingredients and biological network and activity in whole animal and at cellular and molecular levels.
    Methods: The active components of YXSMG were determined using high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) analysis. The 'Disease-Compound-Target-Pathway' network diagram was constructed using network pharmacology, and the stability of binding between core targets and core compounds was analyzed with molecular docking. After intervention with YXSMG, the pathology of aortic plaque, inflammation in the surrounding tissue, expression of TLR9/MyD88/NF-κB pathway protein in plaque and M1/M2 polarization of plaque macrophages were evaluated in vivo in apolipoprotein E-deficient (ApoE
    Results: Five active compounds were identified in YXSMG: catechin, formononetin, tanshinone IIA, cryptotanshinone and glycitein. Network pharmacology studies revealed TLR9 as one of the core targets of YXSMG intervention in atherosclerosis. Computer simulation of molecular docking showed that TLR9 could interact with the core compound to form a stable complex. In vivo experiments confirmed that YXSMG could significantly inhibit atherosclerotic plaque, reduce levels of blood lipids and inflammatory factors, downregulate TLR9/MyD88/NF-κB pathway protein and inhibit aortic sinus macrophages polarization to M1, but promote their polarization to M2 to inhibit inflammation. In vitro experiments revealed that YXSMG could downregulate expression of TLR9 gene and protein in ODN1826-activated RAW264.7 macrophages. ODN2088 had a synergistic effect with YXSMG on the TLR9/MyD88/NF-κB signaling pathway, and reprogrammed macrophages polarization from M1 to M2 by inhibiting TLR9, thus reducing immuno-inflammatory response.
    Conclusion: YXSMG can reduce the level of blood lipid and improve the size of atherosclerotic plaque and inflammatory infiltration in ApoE
    MeSH term(s) Mice ; Animals ; Plaque, Atherosclerotic/pathology ; NF-kappa B/metabolism ; Myeloid Differentiation Factor 88/metabolism ; Toll-Like Receptor 9/metabolism ; Computer Simulation ; Molecular Docking Simulation ; Tandem Mass Spectrometry ; Atherosclerosis/genetics ; Signal Transduction ; Macrophages ; Adaptor Proteins, Signal Transducing/metabolism ; Inflammation/pathology ; Lipids/pharmacology ; Apolipoproteins E/genetics ; Mice, Inbred C57BL
    Chemical Substances NF-kappa B ; Myeloid Differentiation Factor 88 ; Toll-Like Receptor 9 ; Adaptor Proteins, Signal Transducing ; Lipids ; Apolipoproteins E
    Language English
    Publishing date 2023-07-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116868
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    Zs.A 1494: Show issues Location:
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  8. Article ; Online: Sheng Mai Yin shows anti-fatigue, anti-hypoxia and cardioprotective potential in an experimental joint model of fatigue and acute myocardial infarction.

    Guo, Hao / Li, Pengqi / Zhao, Jun / Xin, Qiqi / Miao, Yu / Li, Li / Li, Xin / Wang, Shanglong / Mo, Hui / Zeng, Li / Ju, Zhenyu / Liu, Zimin / Shen, Xiaoxu / Cong, Weihong

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 3, Page(s) 117338

    Abstract: ... cardiovascular diseases that cause fatigue-induced sudden death. Sheng Mai Yin (SMY), a Chinese medicine prescription, is ...

    Abstract Ethnopharmacological relevance: Cardiovascular disease (CVD) and fatigue are two common diseases endangering human life and health that may interact and reinforce one another. Myocardial infarction survivors frequently experience fatigue, and acute myocardial infarction (AMI) is one of the most common cardiovascular diseases that cause fatigue-induced sudden death. Sheng Mai Yin (SMY), a Chinese medicine prescription, is traditionally used for the treatment of diabetes and cardiovascular disease, and has been demonstrated to reduce fatigue and safeguard cardiac function.
    Aim of the study: This study aims to investigate the effects and underlying mechanisms of SMY in treating fatigue and AMI.
    Materials and methods: The pharmacological mechanisms of SMY in treating fatigue and AMI were predicted by bioinformatics and network pharmacology methods. After administering SMY at high, medium and low doses, the swimming time to exhaustion, hemoglobin level, serological parameters and hypoxia tolerance time were detected in C57BL/6N mice, and the left ventricular ejection fractions (LVEF), left ventricular fractional shortening (LVFS), grasp strength, cardiac histopathology, serological parameters and the expression of PINK1 and Parkin proteins were examined in Wistar rats.
    Results: 371 core targets for SMY and 282 disease targets for fatigue and AMI were obtained using bioinformatics and network pharmacology methods. Enrichment analysis of target genes revealed that SMY might interfere with fatigue and AMI through biological processes such as mitochondrial autophagy, apoptosis, and oxidative stress. For in vivo experiments, SMY showed significant anti-fatigue and hypoxia tolerance effects in mice; It also improved the cardiac function and grasp strength, decreased their cardiac index, myocardial injury and fibrosis degree, and induced serological parameters levels and the expression of PTEN-induced putative kinase 1 (PINK1) and Parkin proteins in myocardium, suggesting that SMY may exert cardioprotective effects in a joint rat model of fatigue and AMI by inhibiting excessive mitochondrial autophagy.
    Conclusion: This study revealed the anti-fatigue, anti-hypoxia and cardioprotective effects of SMY in a joint model of fatigue-AMI, and the pharmacological mechanism may be related to the inhibition of mitochondrial autophagy in cardiomyocytes through the PINK1/Parkin pathway. The discoveries may provide new ideas for the mechanism study of traditional Chinese medicine, especially complex prescriptions, in treating fatigue and AMI.
    MeSH term(s) Humans ; Animals ; Mice ; Rats ; Mice, Inbred C57BL ; Rats, Wistar ; Myocardial Infarction/drug therapy ; Hypoxia ; Ubiquitin-Protein Ligases ; Protein Kinases
    Chemical Substances Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Protein Kinases (EC 2.7.-)
    Language English
    Publishing date 2023-10-27
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117338
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  9. Article ; Online: Air Pollution-Related Respiratory Diseases and Associated Environmental Factors in Chiang Mai, Thailand, in 2011-2020.

    Jainonthee, Chalita / Wang, Ying-Lin / Chen, Colin W K / Jainontee, Karuna

    Tropical medicine and infectious disease

    2022  Volume 7, Issue 11

    Abstract: ... with two respiratory infections, influenza and pneumonia, in Chiang Mai, Thailand, which has been ...

    Abstract The unfavorable effects of global climate change, which are mostly the result of human activities, have had a particularly negative effect on human health and the planet's ecosystems. This study attempted to determine the seasonality and association of air pollution, in addition to climate conditions, with two respiratory infections, influenza and pneumonia, in Chiang Mai, Thailand, which has been considered the most polluted city on Earth during the hot season. We used a seasonal-trend decomposition procedure based on loess regression (STL) and a seasonal cycle subseries (SCS) plot to determine the seasonality of the two diseases. In addition, multivariable negative binomial regression (NBR) models were used to assess the association between the diseases and environmental variables (temperature, precipitation, relative humidity, PM
    Language English
    Publishing date 2022-10-31
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed7110341
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  10. Article: Ruan Jian Qing Mai Recipe Inhibits the Inflammatory Response in Acute Lower Limb Ischemic Mice through the JAK2/STAT3 Pathway.

    Zhu, Di / Jia, Chenglin / Cai, Tongkai / Li, Jiacheng / Feng, Xia / Chen, Nan / Zhao, Cheng / Wang, Yuzhen / Cao, Yongbing / Cao, Yemin

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 2481022

    Abstract: Ruan jian qing mai recipe (RJQM) is an empirical prescription for treating ...

    Abstract Ruan jian qing mai recipe (RJQM) is an empirical prescription for treating arteriosclerosis obliterans (ASO). However, the mechanism of RJQM recipe-mediated ASO attenuation has not yet been elucidated. Therefore, this study aimed to explore the mechanism by which the RJQM recipe relieves ASO in a mouse model of lower limb ischemia, which was established by ligating and breaking the femoral artery of the left lower limb. The surgical groups were divided into the ischemic group, beraprost sodium group, low-dose RJQM group, medium-dose RJQM group, and high-dose RJQM group. Normal mice were set as the control group. The blood flow of the lower limb was examined on days 7 and 14. At the end of animal procedures, blood samples were collected, and the rectus femoris of the left lower limb were harvested. Results revealed that mice in the ischemic group demonstrated low blood flow. Additionally, hematoxylin and eosin, and Masson staining results showed that inflammation of the rectus femoris was obvious in the ischemia group, and the level of fibrosis was increased. Blood flow was recovered in all treatment groups compared to the ischemic group, and the inflammatory infiltration and fibrosis of the rectus femoris were relieved after RJQM treatment. The serum levels of interleukin (IL)-17A and IL-21 were decreased, and the expression of JAK2/STAT3 proteins was inhibited in all RJQM treatment groups compared to the ischemia group. Furthermore, the improvement of IL-17A, IL-21, and rectus femoris fibrosis was more obvious with increasing treatment time. In conclusion, RJQM can effectively alleviate ASO and promote the recovery of lower limb blood flow by regulating the JAK2/STAT3 signaling pathway to reduce the inflammatory response.
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/2481022
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