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Article ; Online: Restoration of fertility in nonablated recipient mice after spermatogonial stem cell transplantation.

Morimoto, Hiroko / Ogonuki, Narumi / Matoba, Shogo / Kanatsu-Shinohara, Mito / Ogura, Atsuo / Shinohara, Takashi

2024 Volume 19, Issue 4, Page(s) 443–455

Abstract: Spermatogonial stem cell (SSC) transplantation is a valuable tool for studying stem cell-niche interaction. However, the conventional approach requires the removal of endogenous SSCs, causing damage to the niche. Here we introduce WIN18,446, an ALDH1A2 ... ...

Abstract	Spermatogonial stem cell (SSC) transplantation is a valuable tool for studying stem cell-niche interaction. However, the conventional approach requires the removal of endogenous SSCs, causing damage to the niche. Here we introduce WIN18,446, an ALDH1A2 inhibitor, to enhance SSC colonization in nonablated recipients. Pre-transplantation treatment with WIN18,446 induced abnormal claudin protein expression, which comprises the blood-testis barrier and impedes SSC colonization. Consequently, WIN18,446 increased colonization efficiency by 4.6-fold compared with untreated host. WIN18,446-treated testes remained small despite the cessation of WIN18,446, suggesting its irreversible effect. Offspring were born by microinsemination using donor-derived sperm. While WIN18,446 was lethal to busulfan-treated mice, cyclophosphamide- or radiation-treated animals survived after WIN18,446 treatment. Although WIN18,446 is not applicable to humans due to toxicity, similar ALDH1A2 inhibitors may be useful for SSC transplantation into nonablated testes, shedding light on the role of retinoid metabolism on SSC-niche interactions and advancing SSC research in animal models and humans.
MeSH term(s)	Humans ; Mice ; Male ; Animals ; Spermatogonia/metabolism ; Semen ; Testis/metabolism ; Fertility ; Stem Cell Transplantation ; Spermatogenesis
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2024.02.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Radiocesium-bearing microparticles discovered on masks worn during indoor cleaning.

Higaki, Shogo / Yoshida-Ohuchi, Hiroko / Shinohara, Naohide

Scientific reports

2023 Volume 13, Issue 1, Page(s) 10008

Abstract: A decade has passed since the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident on March 11, 2011. However, radioactive particles have recently been detected in the indoor air of some residences near the FDNPP. Following the recommendations of ... ...

Abstract	A decade has passed since the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident on March 11, 2011. However, radioactive particles have recently been detected in the indoor air of some residences near the FDNPP. Following the recommendations of previous research, we determined the presence of radiocesium-bearing microparticles (CsMPs) and measured the radioactivity of radiocesium that adhered on non-woven face masks worn by six persons during the indoor cleaning of 59 residences in Namie, Futaba, Okuma, and Tomioka towns in Fukushima Prefecture. Of the 284 masks worn in this study, significant
MeSH term(s)	Masks ; Radiation Monitoring/methods ; Fukushima Nuclear Accident ; Cesium Radioisotopes/analysis ; Cesium ; Dust ; Nuclear Power Plants ; Japan ; Water Pollutants, Radioactive/analysis
Chemical Substances	Cesium Radioisotopes ; Cesium (1KSV9V4Y4I) ; Dust ; Water Pollutants, Radioactive
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37191-0
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Article ; Online: Radiocesium-bearing microparticles discovered on masks worn during indoor cleaning

Shogo Higaki / Hiroko Yoshida-Ohuchi / Naohide Shinohara

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 11

Abstract: Abstract A decade has passed since the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident on March 11, 2011. However, radioactive particles have recently been detected in the indoor air of some residences near the FDNPP. Following the ... ...

Abstract	Abstract A decade has passed since the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident on March 11, 2011. However, radioactive particles have recently been detected in the indoor air of some residences near the FDNPP. Following the recommendations of previous research, we determined the presence of radiocesium-bearing microparticles (CsMPs) and measured the radioactivity of radiocesium that adhered on non-woven face masks worn by six persons during the indoor cleaning of 59 residences in Namie, Futaba, Okuma, and Tomioka towns in Fukushima Prefecture. Of the 284 masks worn in this study, significant 137Cs radioactivity was detected in 268, and 44 new CsMPs were discovered in 28. The results of this study also suggest the presence of highly concentrated soluble radiocesium particles or soluble radioactive cesium aerosols adhered to house dust. This implies that the CsMPs constituted a large proportion of radioactivity in the indoor air contamination for particles in the 1.0–2.5 µm size range due to the radioactive radiocesium particles. It is desirable to wear masks during cleaning to prevent inhalation of CsMPs.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article: Multidisciplinary Approach for the Management of a Case With Craniofacial Penetrating Injury Compressing the Internal Carotid Artery.

Hamamoto, Ayami / Michida, Tetsuhiko / Kawabata, Tomoya / Fukumitsu, Ryu / Shinohara, Shogo

Cureus

2023 Volume 15, Issue 4, Page(s) e37340

Abstract: A craniofacial penetrating injury can be severe when a foreign object reaches the skull base, causing an intracranial hemorrhage or a pseudoaneurysm. We report a case of sharp craniofacial injury in which a thin wooden rod moved from the orbit to the ... ...

Abstract	A craniofacial penetrating injury can be severe when a foreign object reaches the skull base, causing an intracranial hemorrhage or a pseudoaneurysm. We report a case of sharp craniofacial injury in which a thin wooden rod moved from the orbit to the internal carotid artery. With a multidisciplinary team consisting of neurosurgeons, plastic surgeons, and otolaryngologists, the foreign body was safely removed, and the patient healed without complications or sequelae. Careful risk management is necessary when treating a case of craniofacial penetrating injury because the depth of the foreign body cannot be determined from the external appearance, making it challenging to decide on the severity of the damage from the injury.
Language	English
Publishing date	2023-04-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.37340
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Article ; Online: High Riding Jugular Bulb Protruding Into Tympanic Cavity: Longitudinal Radiologic Study in a Deaf Child.

Ueda, Keishi / Yamazaki, Hiroshi / Michida, Tetsuhiko / Shinohara, Shogo / Naito, Yasushi

Ear, nose, & throat journal

2022 , Page(s) 1455613221079494

Abstract: Background: High riding jugular bulb (HRJB) develops after 2 years and is rare at younger ages. High riding jugular bulb sometimes protrudes into the tympanic cavity, which can cause hemorrhagic complications during otologic surgery.: Case ... ...

Abstract	Background: High riding jugular bulb (HRJB) develops after 2 years and is rare at younger ages. High riding jugular bulb sometimes protrudes into the tympanic cavity, which can cause hemorrhagic complications during otologic surgery. Case presentation: We describe a congenitally deaf child with bilateral inner ear malformations and a right-sided HRJB on CT at 9 months. This child had undergone left cochlear implantation (CI) at 19 months, and right CI was planned at 6 years. However, we decided not to perform the right CI because preoperative CT images revealed that the right jugular bulb (JB) was enlarged and protruded into the tympanic cavity, completely covering the round window (RW). Conclusion: This is the first pediatric case in which a longitudinal CT scan proves that HRJB develops and protrudes over time. These findings suggest that the earlier the HRJB forms, the larger it may grow. We must keep in mind the possibility of the enlargement and protrusion of HRJB.
Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613221079494
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Article ; Online: Management of Already Inserted Ventilation Tubes During Pediatric Cochlear Implantation: To Remove or Leave the Tube?

Tobe, Yota / Yamazaki, Hiroshi / Shirakawa, Chigusa / Shinohara, Shogo / Fujiwara, Keizo / Naito, Yasushi

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

2023 Volume 44, Issue 3, Page(s) e140–e145

Abstract: Objective: Ventilation tube (VT) insertion is usually recommended before cochlear implantation (CI) in pediatric cochlear implant candidates with recurrent acute otitis media (AOM) or chronic otitis media with effusion (OME). However, there is no ... ...

Abstract	Objective: Ventilation tube (VT) insertion is usually recommended before cochlear implantation (CI) in pediatric cochlear implant candidates with recurrent acute otitis media (AOM) or chronic otitis media with effusion (OME). However, there is no consensus on whether the VT is beneficial even after CI, that is, whether the tube should be removed or left in place during CI. This study aimed to assess the effect of tube placement after CI, especially on the incidence of post-CI AOM, in pediatric cochlear implant recipients who had undergone VT insertion before CI because of recurrent AOM or chronic OME. Study design: A retrospective medical record review. Setting: A tertiary referral cochlear implant center. Patients: This study recruited 58 consecutive ears of children who underwent VT insertion followed by CI at age 7 years or younger between 2004 and 2021. Before October 2018, we removed the VT simultaneously with CI (removed group, 39 ears), while since then, the tube has remained in place during CI (retained group, 19 ears). Intervention: Therapeutic. Main outcome measure: The primary outcome was the proportion of ears that developed AOM at post-CI 6 months in the removed and retained groups. Results: The age at CI was significantly higher in the removed group than in the retained group (mean [standard deviation]: the removed group, 2.9 [1.2] yr; the retained group: 1.5 [0.8] yr; p < 0.001). The removed group showed a significantly higher proportion of ears with post-CI AOM (8 of 39 ears; 20.5%) than the retained group (none of 19 ears; 0%) 6 months after CI ( p = 0.044). The AOM-free proportion at post-CI 12 months was 76.9% in the removed group and 83.3% in the retained group, demonstrating no significant difference ( p = 0.49), probably because the VT was spontaneously extruded in the retained group at a median of 6.5 months after CI. Throughout the study period, 17 ears (13 from the removed group) were affected by post-CI AOM. Of these, three ears in the removed group and two in the retained group after spontaneous extrusion of the VT were hospitalized and treated with intravenous antibiotics for AOM that had failed to respond to oral antibiotic therapy. Only one ear in the removed group required an explanation of the infected implant. None suffered from chronic perforation of the tympanic membrane or secondary cholesteatoma after VT insertion or meningitis associated with post-CI AOM. Conclusion: Our results suggest that in CI for children who already have a VT because of a recurrent AOM or chronic OME, retaining the tube in position, rather than removing the tube, may decrease the incidence of AOM at least within 6 months after CI, during which most cochlear implant device infection was reported in the pediatric population.
MeSH term(s)	Child ; Humans ; Cochlear Implantation/adverse effects ; Retrospective Studies ; Otitis Media/surgery ; Otitis Media with Effusion/complications ; Cochlear Implants/adverse effects ; Middle Ear Ventilation/adverse effects ; Postoperative Complications
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2036790-9
ISSN	1537-4505 ; 1531-7129
ISSN (online)	1537-4505
ISSN	1531-7129
DOI	10.1097/MAO.0000000000003797
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Zs.A 1554: Show issues

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Article ; Online: Regeneration of spermatogenesis by mouse germ cell transplantation into allogeneic and xenogeneic testis primordia or organoids.

Kanatsu-Shinohara, Mito / Ogonuki, Narumi / Matoba, Shogo / Morimoto, Hiroko / Shiromoto, Yusuke / Ogura, Atsuo / Shinohara, Takashi

Stem cell reports

2022 Volume 17, Issue 4, Page(s) 924–935

Abstract: Gametogenesis requires close interactions between germ cells and somatic cells. Derivation of sperm from spermatogonial stem cells (SSCs) is hampered by the inefficiency of spermatogonial transplantation technique in many animal species because it ... ...

Abstract	Gametogenesis requires close interactions between germ cells and somatic cells. Derivation of sperm from spermatogonial stem cells (SSCs) is hampered by the inefficiency of spermatogonial transplantation technique in many animal species because it requires a large number of SSCs and depletion of endogenous spermatogenesis. Here we used mouse testis primordia and organoids to induce spermatogenesis from SSCs. We microinjected mouse SSCs into embryonic gonads or reaggregated neonatal testis organoids, which were transplanted under the tunica albuginea of mature testes. As few as 1 × 10
MeSH term(s)	Animals ; Hematopoietic Stem Cell Transplantation ; Male ; Mice ; Organoids ; Rats ; Spermatogenesis/genetics ; Spermatogonia/transplantation ; Stem Cell Transplantation ; Testis
Language	English
Publishing date	2022-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2022.02.013
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Article ; Online: Spermatogonial stem cell transplantation into nonablated mouse recipient testes.

Morimoto, Hiroko / Ogonuki, Narumi / Kanatsu-Shinohara, Mito / Matoba, Shogo / Ogura, Atsuo / Shinohara, Takashi

Stem cell reports

2021 Volume 16, Issue 7, Page(s) 1832–1844

Abstract: Spermatogonial transplantation has been used as a standard assay for spermatogonial stem cells (SSCs). After transplantation into the seminiferous tubules, SSCs transmigrate through the blood-testis barrier (BTB) between Sertoli cells and settle in a ... ...

Abstract	Spermatogonial transplantation has been used as a standard assay for spermatogonial stem cells (SSCs). After transplantation into the seminiferous tubules, SSCs transmigrate through the blood-testis barrier (BTB) between Sertoli cells and settle in a niche. Unlike in the repair of other self-renewing systems, SSC transplantation is generally performed after complete destruction of endogenous spermatogenesis. Here, we examined the impacts of recipient conditioning on SSC homing. Germ cell ablation downregulated the expression of glial cell line-derived neurotrophic factor, which has been shown to attract SSCs to niches, implying that nonablated niches would attract SSCs more efficiently. As expected, SSCs colonized nonablated testes when transplanted into recipients with the same genetic background. Moreover, although spermatogenesis was arrested at the spermatocyte stage in Cldn11-deficient mice without a BTB, transplantation not only enhanced donor colonization but also restored normal spermatogenesis. The results show promise for the development of a new transplantation strategy to overcome male infertility.
MeSH term(s)	Animals ; Apoptosis ; Biomarkers/metabolism ; Busulfan/pharmacology ; Claudins/metabolism ; Cytokines/metabolism ; Germ Cells/drug effects ; Germ Cells/metabolism ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Male ; Mice, Knockout ; Regeneration/drug effects ; Spermatogenesis ; Spermatogonia/cytology ; Spermatogonia/transplantation ; Stem Cell Transplantation ; Testis/cytology ; Mice
Chemical Substances	Biomarkers ; Claudins ; Cldn11 protein, mouse ; Cytokines ; Glial Cell Line-Derived Neurotrophic Factor ; Busulfan (G1LN9045DK)
Language	English
Publishing date	2021-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2720528-9
ISSN	2213-6711 ; 2213-6711
ISSN (online)	2213-6711
ISSN	2213-6711
DOI	10.1016/j.stemcr.2021.05.013
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Article: Association of Repeated Blood Cultures With Mortality in Adult Patients With Gram-Negative Bacilli Bacteremia: A Systematic Review and Meta-analysis.

Shinohara, Jun / Hanai, Shogo / Jung, Jongtak / Song, Kyoung-Ho / Iwata, Mitsunaga / Terasawa, Teruhiko

Open forum infectious diseases

2022 Volume 9, Issue 12, Page(s) ofac568

Abstract: Background: Performing repeat blood cultures after an initial positive culture (ie, follow-up blood cultures [FUBCs]) in patients with gram-negative bacilli (GNB) bacteremia is controversial. We aimed to comprehensively review the association of FUBCs ... ...

Abstract	Background: Performing repeat blood cultures after an initial positive culture (ie, follow-up blood cultures [FUBCs]) in patients with gram-negative bacilli (GNB) bacteremia is controversial. We aimed to comprehensively review the association of FUBCs with improvement in patient-relevant clinical outcomes in GNB bacteremia. Methods: We performed a systematic review and random-effects meta-analysis to calculate summary effect estimates. We used hazard ratios as the effect measure. The primary outcome was 30-day or in-hospital mortality, and secondary outcomes were length of treatment and length of hospital stay. We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials (Central) without language restrictions from inception to April 29, 2022. Original clinical studies evaluating the association between FUBCs and mortality in adult patients with GNB bacteremia were included. FUBC details were reviewed. Two independent reviewers used the Risk of Bias in Non-randomised Studies of Interventions tool. Results: We identified 9 eligible retrospective studies. In total, 7778 hospitalized patients with GNB bacteremia were included. The studies were clinically heterogeneous and had a critical risk of bias. The utilization of FUBCs varied across studies (18%-89%). Random-effects meta-analysis of covariate-adjusted estimates found that FUBC use was associated with reduced mortality. Although not a result of the meta-analysis, lengths of treatment and hospital stay were longer for patients with FUBCs than for those without. Adverse events were not reported. Conclusions: FUBC acquisition was associated with lower mortality and longer hospital stay and treatment duration in GNB bacteremia. The risk of bias was critical, and no firm data were available to support mechanisms.
Language	English
Publishing date	2022-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofac568
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Article ; Online: Effects of COVID-19 pandemic on hospital visit of head and neck cancer patients.

Hamaguchi, Kiyomi / Shinohara, Shogo / Michida, Tetsuhiko / Yasumoto, Mami / Hamamoto, Ayami / Yamamoto, Tomoko / Ueda, Keishi / Nakamura, Eugene

Auris, nasus, larynx

2023 Volume 50, Issue 6, Page(s) 948–951

Abstract: Objective: Head and neck cancer (HNC) often causes respiratory symptoms, so diagnostic delays due to COVID-19 are anticipated. Especially, our institute is a designated medical institute for Class 1 specified infectious diseases, and most of the severe ... ...

Abstract	Objective: Head and neck cancer (HNC) often causes respiratory symptoms, so diagnostic delays due to COVID-19 are anticipated. Especially, our institute is a designated medical institute for Class 1 specified infectious diseases, and most of the severe COVID-19 patients in this region were preferentially admitted or transferred. Hereby, we evaluated the trends of the numbers, primary sites and clinical stages of HNC patients before and after COVID-19 pandemic. Methods: A retrospective analysis of all patients diagnosed and treated for HNC from 2015 to 2021 was performed. Especially, 309 cases between 2018 and 2021 were extracted in order to examine a direct impact of COVID-19 pandemic, which were dichotomized into "Pre" group in 2018-2019 and "COVID" group in 2020-2021. They were compared about the distribution of clinical stage, the period between onset of symptom and hospital visit. Results: HNC patients decreased by 38% in 2020 and by 18% in 2021 compared to average number of patients from 2015 to 2019. Patients of stage 0 and 1 in "COVID" group significantly decreased compared to that in "Pre" group. Cases performed emergent tracheostomy in hypopharyngeal cancer and laryngeal cancer increased in "COVID" group (10.5% vs 1.3%). Conclusion: Patients with slight symptoms would hesitated to visit hospital after COVID-19, and only a few delays of HNC diagnosis could have increased tumor burden and caused narrowed airway, especially in advanced HPC and LC.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Retrospective Studies ; Pandemics ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/therapy ; Laryngeal Neoplasms/diagnosis
Language	English
Publishing date	2023-04-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604552-2
ISSN	1879-1476 ; 0385-8146
ISSN (online)	1879-1476
ISSN	0385-8146
DOI	10.1016/j.anl.2023.04.005
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