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Article ; Online: Problems and countermeasures in the standardized training of residents for master professional degree in clinical medicine

NIU Jianmin, ZHU Bin

Jichu yixue yu linchuang, Vol 43, Iss 5, Pp 857-

2023 Volume 860

Abstract: The training of graduates for clinical medicine master degree is organized by standardized training for residents during their program. The training focuses to post competencies, capacity building of clinical diagnosis and treatment. At the same time, ... ...

Abstract	The training of graduates for clinical medicine master degree is organized by standardized training for residents during their program. The training focuses to post competencies, capacity building of clinical diagnosis and treatment. At the same time, clinical medicine graduates should also have certain scientific research capacity. This puts forward higher requirements for the training of medical graduates. However, there are still some problems in the process of resident training for medical graduates including the contradiction between research training and clinical training,etc. This paper analyzes the problems in resident training for medical graduates and discusses the corresponding countermeasures to further improve the quality of resident training for graduates of clinical medicine.
Keywords	master professional degree in clinical medicine\|residents\|standardized training\|post competency ; Medicine ; R
Subject code	370
Language	Chinese
Publishing date	2023-05-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
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Article ; Online: Service composition considering energy consumption of users and transferring files in a multicloud environment

Jianmin Li / Shunzhi Zhu

Journal of Cloud Computing: Advances, Systems and Applications, Vol 12, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract In the internet and cloud environment, service composition is always used to enhance the function and processing ability of clouds. Those clouds work together for a user and provide different functions. A service request may involve multiple ... ...

Abstract	Abstract In the internet and cloud environment, service composition is always used to enhance the function and processing ability of clouds. Those clouds work together for a user and provide different functions. A service request may involve multiple clouds. The past work focuses on the method of service composition and ignores the energy composition when files are transferred between clouds, including the energy consumption for transferring files (sending files from the user to the cloud and receiving files from the cloud to the user) of the user. The paper models the service composition in a multicloud environment. Based on those models, we use the GA (genetic algorithm) algorithm (GA-C) to solve the service composition problem with multiple targets in a multicloud environment. Simulation results show that the GA-C can: (1) reduce the average number of involved clouds and the energy consumption between clouds, and (2) reduce the energy consumption of the user and the failure rate of service composition.
Keywords	Multicloud environment ; Service composition ; Energy consumption ; Atomic service ; Transferring files ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	050
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Pharmacokinetic Analyses of a Lipid Nanoparticle-Encapsulated mRNA-Encoded Antibody against Rift Valley Fever Virus.

Wang, Shuo / Zhu, Ziling / Li, Jianmin

Molecular pharmaceutics

2024 Volume 21, Issue 3, Page(s) 1342–1352

Abstract: Rift Valley fever virus (RVFV) could cause an emergency illness characterized by fever, muscle pain, and even death in humans or ruminants. However, there are no approved antiviral drugs that prevent or treat RVFV infection. While therapeutic antibodies ... ...

Abstract	Rift Valley fever virus (RVFV) could cause an emergency illness characterized by fever, muscle pain, and even death in humans or ruminants. However, there are no approved antiviral drugs that prevent or treat RVFV infection. While therapeutic antibodies have shown promising potential for prevention or treatment in several studies, many studies are ongoing, especially in the field of infectious diseases. Among these studies, the mRNA-LNP platform shows great potential for application, following the COVID-19 pandemic. Previously, we have obtained a neutralizing antibody against RVFV, which was named A38 protein and verified to have a high binding and neutralization ability. In this study, we aimed to identify an effectively optimized sequence and expressed the prioritized mRNA-encoded antibody
MeSH term(s)	Animals ; Humans ; Rift Valley fever virus/genetics ; Rift Valley Fever/prevention & control ; Pandemics ; Antibodies, Viral ; Communicable Diseases ; Liposomes ; Nanoparticles
Chemical Substances	Lipid Nanoparticles ; Antibodies, Viral ; Liposomes
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.3c01016
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Article ; Online: Hydrolysis mechanism of the cyclohexaborate anion: Unraveling the intricacies.

Jia, Lifan / Wang, Yunxia / Song, Lulu / Liu, Ruirui / Li, Longgang / Li, Jisheng / Zhou, Yongquan / Pan, Jianmin / Zhu, Fayan

Journal of computational chemistry

2024

Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1479181-X
ISSN	1096-987X ; 0192-8651
ISSN (online)	1096-987X
ISSN	0192-8651
DOI	10.1002/jcc.27339
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Article ; Online: Armor-like Inorganic-rich Cathode Electrolyte Interphase Enabled by the Pentafluorophenylboronic Acid Additive for High-voltage Li||NCM622 Batteries.

Yang, Yulu / Wang, Huaping / Zhu, Chunlei / Ma, Jianmin

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 22, Page(s) e202300057

Abstract: Lithium metal batteries (LMBs) comprising Li metal anode and high-voltage nickel-rich cathode could potentially realize high capacity and power density. However, suitable electrolytes to tolerate the oxidation on the cathode at high cut-off voltage are ... ...

Abstract	Lithium metal batteries (LMBs) comprising Li metal anode and high-voltage nickel-rich cathode could potentially realize high capacity and power density. However, suitable electrolytes to tolerate the oxidation on the cathode at high cut-off voltage are urgently needed. Herein, we present an armor-like inorganic-rich cathode electrolyte interphase (CEI) strategy for exploring oxidation-resistant electrolytes for sustaining 4.8 V Li\|\|LiNi
Language	English
Publishing date	2023-04-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202300057
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Article ; Online: Eliciting tactile sensations in the hand through non-invasive proximal nerve stimulation: a feasibility study.

Pan, Lizhi / Ren, Zhihao / Zhu, Kun / Li, Jianmin

Medical & biological engineering & computing

2023 Volume 61, Issue 12, Page(s) 3225–3232

Abstract: Recently, non-invasive proximal nerve stimulation has been widely investigated to restore tactile sensations. It has been demonstrated that tactile sensations in the hand could be elicited by nerve stimulation on the upper arm. However, it is still ... ...

Abstract	Recently, non-invasive proximal nerve stimulation has been widely investigated to restore tactile sensations. It has been demonstrated that tactile sensations in the hand could be elicited by nerve stimulation on the upper arm. However, it is still unknown whether tactile sensations could be elicited by stimulation at a proximal location close to the neck. In this study, non-invasive proximal nerve stimulation tests were performed to elicit tactile sensations in the hand of subjects. Six Ag/AgCl gel electrodes (2 × 3) were placed on the supraclavicular fossa where the proximal parts of the brachial plexus nerves were located. Then, fifteen potential electrode pairs were tested to explore whether tactile sensations could be elicited by non-invasive proximal nerve stimulation. Eight able-bodied subjects (male) were recruited to participate in the test. The stimulated sensation regions in the hand and the sensory intensity were reported and recorded during the experiment. The results demonstrated that the tactile sensations in various regions in the hand could be elicited through non-invasive nerve stimulation at the proximal location close to the neck.
MeSH term(s)	Humans ; Male ; Feasibility Studies ; Hand/physiology ; Touch ; Arm ; Electric Stimulation
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	282327-5
ISSN	1741-0444 ; 0025-696X ; 0140-0118
ISSN (online)	1741-0444
ISSN	0025-696X ; 0140-0118
DOI	10.1007/s11517-023-02923-x
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Article ; Online: Design and synthesis of bioinspired nanomaterials for biomedical application.

Tang, Kai / Xue, Jianmin / Zhu, Yufang / Wu, Chengtie

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

2023 Volume 16, Issue 1, Page(s) e1914

Abstract: Natural materials and bioprocesses provide abundant inspirations for the design and synthesis of high-performance nanomaterials. In the past several decades, bioinspired nanomaterials have shown great potential in the application of biomedical fields, ... ...

Abstract	Natural materials and bioprocesses provide abundant inspirations for the design and synthesis of high-performance nanomaterials. In the past several decades, bioinspired nanomaterials have shown great potential in the application of biomedical fields, such as tissue engineering, drug delivery, and cancer therapy, and so on. In this review, three types of bioinspired strategies for biomedical nanomaterials, that is, inspired by the natural structures, biomolecules, and bioprocesses, are mainly introduced. We summarize and discuss the design concepts and synthesis approaches of various bioinspired nanomaterials along with their specific roles in biomedical applications. Additionally, we discuss the challenges for the development of bioinspired biomedical nanomaterials, such as mechanical failure in wet environment, limitation in scale-up fabrication, and lack of deep understanding of biological properties. It is expected that the development and clinical translation of bioinspired biomedical nanomaterials will be further promoted under the cooperation of interdisciplinary subjects in future. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Therapeutic Approaches and Drug Discovery > Emerging Technologies.
MeSH term(s)	Humans ; Nanostructures/chemistry ; Drug Delivery Systems ; Tissue Engineering
Language	English
Publishing date	2023-07-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2502698-7
ISSN	1939-0041 ; 1939-5116
ISSN (online)	1939-0041
ISSN	1939-5116
DOI	10.1002/wnan.1914
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Article ; Online: Core decompression combined with platelet-rich plasma-augmented bone grafting for femur head necrosis: a systematic review and meta-analysis.

Zhu, Bo / Li, Jianmin / Li, Xuejia / Feng, Shengyi / Li, Bo

International journal of surgery (London, England)

2024 Volume 110, Issue 3, Page(s) 1687–1698

Abstract: Background: The clinical potential of biologic augmentation in core decompression and bone grafting for femoral head necrosis is widely acknowledged, with platelet-rich plasma (PRP) being a frequently employed biologic adjunct. However, its clinical ... ...

Abstract	Background: The clinical potential of biologic augmentation in core decompression and bone grafting for femoral head necrosis is widely acknowledged, with platelet-rich plasma (PRP) being a frequently employed biologic adjunct. However, its clinical application is not standardized, and high-level evidence is lacking. This study aimed to evaluate the efficacy and safety of core decompression and bone grafting combined with PRP for femur head necrosis. Methods: Several databases were systematically retrieved for randomized controlled trials comparing core decompression and bone grafting combined with or without PRP. A systematic review and meta-analysis were conducted following the PRISMA 2020 and AMSTAR 2 guidelines. The study is registered with PROSPERO under the code CRD42022361007, and it is also listed in the research registry under the identification number reviewregistry1537. Results: Eleven studies with 642 participants (742 hips) were included. The pooled estimates revealed that when core decompression and bone grafting were combined with PRP, the Harris hip score (mean difference: 7.98; 95% CI: 5.77-10.20; P <0.001), visual analog scale (SMD: -0.68; 95% CI: -0.96 - -0.40; P <0.001) and the pain component of Harris hip score (SMD: 8.4; 95% CI: 4.12-12.68; P <0.001), and reduction of radiographic progression [risk ratio (RR): 0.40; 95% CI: 0.27-0.59; P <0.001] were superior to core decompression and bone grafting alone. Fewer patients with treatment failure (RR: 0.27; 95% CI: 0.14-0.52; P <0.001) and higher good-to-excellent results (RR: 1.48; 95% CI: 1.17-1.86; P <0.001) were observed in treatment groups than control groups. Meanwhile, the pooled analysis substantiated the superior safety profile of PRP (RR: 0.29; 95% CI: 0.11-0.77; P =0.01). Conclusions: The combination of core decompression and bone grafting with PRP is superior to the approach without PRP, demonstrating enhanced effectiveness in terms of function, pain relief, and radiographic progression. Additionally, it results in lower rates of treatment failure and adverse events. However, further high-quality RCTs are needed to evaluate their effectiveness due to methodological and implementation limitations observed in the existing evidence.
MeSH term(s)	Humans ; Femur Head Necrosis/diagnostic imaging ; Femur Head Necrosis/surgery ; Bone Transplantation ; Treatment Outcome ; Decompression, Surgical/methods ; Platelet-Rich Plasma ; Femur Head ; Pain/surgery ; Biological Products
Chemical Substances	Biological Products
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000001028
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Article ; Online: Exposure to p-dichlorobenzene and serum α-Klotho levels among US participants in their middle and late adulthood.

Zhu, Jianmin / Wei, Yudan

The Science of the total environment

2022 Volume 858, Issue Pt 1, Page(s) 159768

Abstract: P-dichlorobenzene (p-DCB) is a volatile compound commonly used as pest repellent and air deodorant in the home and public buildings, leading to a widespread exposure in indoor environments. There has been an increasing concern about its metabolic and ... ...

Abstract	P-dichlorobenzene (p-DCB) is a volatile compound commonly used as pest repellent and air deodorant in the home and public buildings, leading to a widespread exposure in indoor environments. There has been an increasing concern about its metabolic and endocrine effects. In this study, we explored the relation between p-DCB exposure and serum levels of soluble α-Klotho, an anti-aging hormone, in US adults. A nationally representative subsample of 1485 adults 40-79 ages in the 2013-2016 National Health and Nutrition Examination Survey was analyzed for the association between p-DCB exposure, measured as urinary concentrations of 2,5-dichlorophenol (2,5-DCP), the major metabolite of p-DCB, and serum α-Klotho levels using multiple general linear models, adjusting for potential confounders. Age- and sex-specific analyses were further conducted. The weighted geometric mean of urinary 2,5-DCP was 2.43 μg/L and the weighted mean of serum α-Klotho was 831.97 pg/mL in the study participants during 2013-2016. After adjusting for potential confounders and urinary creatinine, urinary 2,5-DCP was significantly associated with decreased serum levels of α-Klotho (regression coefficient β = -9.88; p = 0.0133) in the total study population. When age- and sex-specific analyses being conducted, a significantly inverse association was found in older adults aged 60-79 years (β = -20.40; p = 0.0001) and in males (β = -13.81; p = 0.0097), but not in the middle ages (40-59 years) and in females. The strongest association was observed in older (60-79 years) male participants, with a 25.43 pg/mL reduction of α-Klotho levels per 1-unit increase of 2,5-DCP concentrations (p = 0.0008). This is the first study demonstrating a relation between p-DCB exposure, measured as 2,5-DCP, and decreased α-Klotho levels in older males. Additional studies would further explore these interactions and elucidate the pathogenesis of the potential effects of p-DCB exposure on aging.
MeSH term(s)	Middle Aged ; Female ; Humans ; Male ; Aged ; Adult ; Nutrition Surveys ; Chlorophenols ; Chlorobenzenes/metabolism ; Urinalysis
Chemical Substances	4-dichlorobenzene (D149TYB5MK) ; Chlorophenols ; Chlorobenzenes
Language	English
Publishing date	2022-10-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.159768
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Article ; Online: Dynamic Configurable Write-Ahead Logging Framework for Memory Table

ZHU Haiming / HUANG Xiangdong / QIAO Jialin / WANG Jianmin

Jisuanji kexue yu tansuo, Vol 17, Iss 11, Pp 2777-

2023 Volume 2783

Abstract: Normally, the NoSQL database management systems’ databases or data partitions fixedly write their write-ahead logging (WAL) into one or more log files after they are started up, forming a strong-coupled rela-tionship. Since the database logical model and ...

Abstract	Normally, the NoSQL database management systems’ databases or data partitions fixedly write their write-ahead logging (WAL) into one or more log files after they are started up, forming a strong-coupled rela-tionship. Since the database logical model and partition configuration are determined by the application business and computing environments, with the write-ahead logging tightly coupled, the database management systems cannot optimize performance via simply configuring parameters such as the number and size of the write-ahead logging. In response to this problem, this paper proposes a dynamic configurable write-ahead logging framework for memory table. This framework records Redo log, and memory tables can be dynamically allocated to different write-ahead logging queues, supporting mutable relationship and decoupling write-ahead logging and applications. This paper implements this framework on the time series database Apache IoTDB, and relevant experiments are conducted. Experimental results show that, compared with strong-coupled write-ahead logging, this dynamic configurable write-ahead logging framework can find a better configuration and improve the write performance by 8% to 19%, indicating that this framework can achieve dynamic performance tuning for different computing environments and application loads.
Keywords	write-ahead logging (wal) ; redo log ; log-structured merge-tree (lsm) ; time series database ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	005
Language	Chinese
Publishing date	2023-11-01T00:00:00Z
Publisher	Journal of Computer Engineering and Applications Beijing Co., Ltd., Science Press
Document type	Article ; Online
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