LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1061

Search options

  1. Book: Molecular therapies of cancer

    Weber, Georg F.

    2015  

    Author's details Georg F. Weber
    Keywords Cancer/Chemotherapy ; Cancer/Molecular aspects
    Subject code 616.994061
    Language English
    Size XV, 488 S. : Ill., graph. Darst., 28 cm
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018725091
    ISBN 978-3-319-13277-8 ; 9783319132785 ; 3-319-13277-6 ; 3319132784
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 2844 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Crossroads: the role of biomarkers in the management of lumps in the breast.

    Weber, Georg F

    Oncotarget

    2023  Volume 14, Page(s) 358–362

    Abstract: Premalignant lesions in the breast pose a difficult decision-making problem, whether to treat proactively and accept the side effects or to engage in watchful waiting and possibly encounter a later diagnosis of invasive cancer. A biomarker or set of ... ...

    Abstract Premalignant lesions in the breast pose a difficult decision-making problem, whether to treat proactively and accept the side effects or to engage in watchful waiting and possibly encounter a later diagnosis of invasive cancer. A biomarker or set of biomarkers to inform on the individual progression risk would be beneficial to the patient and cost-effective for the healthcare system. The gene products of tumor progression may be expressed in early non-cancerous ("premalignant") lesions, where they are associated with a high probability for full transformation in breast cancers. One such molecule is the OPN splice variant-c. OPN-c is also present in a fraction of the premalignant lesions, where it reflects an elevated risk for progression to cancer within 5 years, regardless of the lesion's subtype. This marker has the properties needed to facilitate decisions to treat at the premalignant stage.
    MeSH term(s) Humans ; Female ; Breast/pathology ; Breast Neoplasms/pathology ; Precancerous Conditions/pathology ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28402
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Osteopontin induces mitochondrial biogenesis in deadherent cancer cells.

    Fnu, Gulimirerouzi / Weber, Georg F

    Oncotarget

    2023  Volume 14, Page(s) 957–969

    Abstract: Metastasizing cells display a unique metabolism, which is very different from the Warburg effect that arises in primary tumors. Over short time frames, oxidative phosphorylation and ATP generation are prominent. Over longer time frames, mitochondrial ... ...

    Abstract Metastasizing cells display a unique metabolism, which is very different from the Warburg effect that arises in primary tumors. Over short time frames, oxidative phosphorylation and ATP generation are prominent. Over longer time frames, mitochondrial biogenesis becomes a pronounced feature and aids metastatic success. It has not been known whether or how these two phenomena are connected. We hypothesized that Osteopontin splice variants, which synergize to increase ATP levels in deadherent cells, also increase the mitochondrial mass via the same signaling mechanisms. Here, we report that autocrine Osteopontin does indeed stimulate an increase in mitochondrial size, with the splice variant -c being more effective than the full-length form -a. Osteopontin-c achieves this via its receptor CD44v, jointly with the upregulation and co-ligation of the chloride-dependent cystine-glutamate transporter SLC7A11. The signaling proceeds through activation of the known mitochondrial biogenesis inducer PGC-1 (which acts as a transcription coactivator). Peroxide is an important intermediate in this cascade, but surprisingly acts upstream of PGC-1 and is likely produced as a consequence of SLC7A11 recruitment and activation.
    MeSH term(s) Humans ; Adenosine Triphosphate/metabolism ; Mitochondria/metabolism ; Neoplasms/metabolism ; Organelle Biogenesis ; Osteopontin/genetics ; Osteopontin/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Transcription Factors/metabolism
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Osteopontin (106441-73-0) ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Transcription Factors ; SPP1 protein, human
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28540
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Cancer research - can the entity be bigger than the sum of its parts?

    Weber, Georg F

    Oncoscience

    2020  Volume 7, Issue 3-4, Page(s) 17–18

    Abstract: Cancer Research has benefitted from substantial expenditures by federal and nonprofit organizations. The resulting success in patient care has been uneven. Two lessons from the ... ...

    Abstract Cancer Research has benefitted from substantial expenditures by federal and nonprofit organizations. The resulting success in patient care has been uneven. Two lessons from the 20
    Language English
    Publishing date 2020-05-01
    Publishing country United States
    Document type Journal Article
    ISSN 2331-4737
    ISSN 2331-4737
    DOI 10.18632/oncoscience.499
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Book: Cancer therapy

    Weber, Georg F.

    molecular targets in tumour-host interactions

    2005  

    Author's details [ed. by Georg F. Weber]
    Keywords Neoplasms / drug therapy ; Neoplasm Metastasis / prevention & control ; Gene Targeting / methods ; Angiogenesis Inhibitors ; Pharmacogenetics / methods
    Language English
    Size XI, 394, 3 S. : Ill., graph. Darst.
    Publisher Horizon Bioscience
    Publishing place Wymondham
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014178327
    ISBN 1-904933-11-4 ; 978-1-904933-11-3
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 1798 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book: Molecular mechanisms of cancer

    Weber, Georg F.

    2007  

    Author's details Georg F. Weber
    Keywords Neoplasms / etiology ; Neoplasms / genetics ; Cell Transformation, Neoplastic ; Molecular Biology ; Krebs ; Molekularbiologie
    Subject Molekulare Biologie ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Language English
    Size XIV, 645 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Dordrecht
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT015054666
    ISBN 978-1-402-06015-1 ; 978-1-4020-6015-1 ; 1-4020-6015-7 ; 1-402-06015-7 ; 9781402060168 ; 1402060165
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 4954 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Minimalinvasive Resektion zystischer Pankreasneoplasien.

    Brunner, Maximilian / Krautz, Christian / Grützmann, Robert / Weber, Georg F

    Zentralblatt fur Chirurgie

    2023  Volume 149, Issue 1, Page(s) 27–34

    Title translation Minimally Invasive Resection of Cystic Pancreatic Neoplasia.
    MeSH term(s) Humans ; Pancreatic Neoplasms/surgery ; Pancreas/surgery ; Pancreatectomy
    Language German
    Publishing date 2023-11-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200935-3
    ISSN 1438-9592 ; 0044-409X
    ISSN (online) 1438-9592
    ISSN 0044-409X
    DOI 10.1055/a-2194-0682
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.25: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 95: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Quantitative Analysis of Protein Evolution: The Phylogeny of Osteopontin.

    Wang, Xia / Weber, Georg F

    Frontiers in genetics

    2021  Volume 12, Page(s) 700789

    Abstract: The phylogenetic analysis of proteins conventionally relies on the evaluation of amino acid sequences or coding sequences. Individual amino acids have measurable features that allow the translation from strings of letters (amino acids or bases) into ... ...

    Abstract The phylogenetic analysis of proteins conventionally relies on the evaluation of amino acid sequences or coding sequences. Individual amino acids have measurable features that allow the translation from strings of letters (amino acids or bases) into strings of numbers (physico-chemical properties). When the letters are converted to measurable properties, such numerical strings can be evaluated quantitatively with various tools of complex systems research. We build on our prior phylogenetic analysis of the cytokine Osteopontin to validate the quantitative approach toward the study of protein evolution. Phylogenetic trees constructed from the number strings differentiate among all sequences. In pairwise comparisons, autocorrelation, average mutual information and box counting dimension yield one number each for the overall relatedness between sequences. We also find that bivariate wavelet analysis distinguishes hypermutable regions from conserved regions of the protein. The investigation of protein evolution via quantitative study of the physico-chemical characteristics pertaining to the amino acid building blocks broadens the spectrum of applicable research tools, accounts for mutation as well as selection, gives assess to multiple vistas depending on the property evaluated, discriminates more accurately among sequences, and renders the analysis more quantitative than utilizing strings of letters as starting points.
    Language English
    Publishing date 2021-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.700789
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment.

    Fnu, Gulimirerouzi / Weber, Georg F

    Frontiers in oncology

    2021  Volume 11, Page(s) 765329

    Abstract: We have previously reported that metastases from all malignancies are characterized by a core program of gene expression that suppresses extracellular matrix interactions, induces vascularization/tissue remodeling, activates the oxidative metabolism, and ...

    Abstract We have previously reported that metastases from all malignancies are characterized by a core program of gene expression that suppresses extracellular matrix interactions, induces vascularization/tissue remodeling, activates the oxidative metabolism, and alters ion homeostasis. Among these features, the least elucidated component is ion homeostasis. Here we review the literature with the goal to infer a better mechanistic understanding of the progression-associated ionic alterations and identify the most promising drugs for treatment. Cancer metastasis is accompanied by skewing in calcium, zinc, copper, potassium, sodium and chloride homeostasis. Membrane potential changes and water uptake through Aquaporins may also play roles. Drug candidates to reverse these alterations are at various stages of testing, with some having entered clinical trials. Challenges to their utilization comprise differences among tumor types and the involvement of multiple ions in each case. Further, adverse effects may become a concern, as channel blockers, chelators, or supplemented ions will affect healthy and transformed cells alike.
    Language English
    Publishing date 2021-12-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.765329
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: The Phylogeny of Osteopontin-Analysis of the Protein Sequence.

    Weber, Georg F

    International journal of molecular sciences

    2018  Volume 19, Issue 9

    Abstract: Osteopontin (OPN) is important for tissue remodeling, cellular immune responses, and calcium homeostasis in milk and urine. In pathophysiology, the biomolecule contributes to the progression of multiple cancers. Phylogenetic analysis of 202 osteopontin ... ...

    Abstract Osteopontin (OPN) is important for tissue remodeling, cellular immune responses, and calcium homeostasis in milk and urine. In pathophysiology, the biomolecule contributes to the progression of multiple cancers. Phylogenetic analysis of 202 osteopontin protein sequences identifies a core block of integrin-binding sites in the center of the protein, which is well conserved. Remarkably, the length of this block varies among species, resulting in differing distances between motifs within. The amino acid sequence SSEE is a candidate phosphorylation site. Two copies of it reside in the far N-terminus and are variably affected by alternative splicing in humans. Between those motifs, birds and reptiles have a histidine-rich domain, which is absent from other species. Just downstream from the thrombin cleavage site, the common motif (Q/I)(Y/S/V)(P/H/Y)D(A/V)(T/S)EED(L/E)(-/S)T has been hitherto unrecognized. While well preserved, it is yet without assigned function. The far C-terminus, although very different between Reptilia/Aves on the one hand and Mammals on the other, is highly conserved within each group of species, suggesting important functional roles that remain to be mapped. Taxonomic variations in the osteopontin sequence include a lack of about 20 amino acids in the downstream portion, a small unique sequence stretch C-terminally, a lack of six amino acids just upstream of the RGD motifs, and variable length insertions far C-terminally.
    MeSH term(s) Amino Acid Motifs ; Amino Acid Sequence ; Integrins/metabolism ; Lipoprotein Lipase/metabolism ; Osteopontin/chemistry ; Osteopontin/genetics ; Phylogeny ; Position-Specific Scoring Matrices ; Protein Binding ; Protein Domains ; Protein Interaction Domains and Motifs
    Chemical Substances Integrins ; Osteopontin (106441-73-0) ; Lipoprotein Lipase (EC 3.1.1.34)
    Language English
    Publishing date 2018-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19092557
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top