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Article ; Online: Simulation of time-intensity curve based on k-space filling in breast dynamic contrast-enhanced three-dimensional magnetic resonance imaging.

Takatsu, Yasuo / Ueyama, Tsuyoshi / Iwasaki, Takahiro / Tateyama, Tomoko / Miyati, Tosiaki

2024

Abstract: This study elucidated the effects of a three-dimensional k-space trajectory incorporating ... The order of the k-space trajectory was set as Linear (sequential), Low-High (centric), PF (62.5%; Z-, Y ... and both directions), and Low-High Radial. k0 (center of the k-space) timing and TIC shape were ...

Abstract	This study elucidated the effects of a three-dimensional k-space trajectory incorporating the partial Fourier (PF) technique on a time-intensity curve (TIC) in a dynamic contrast-enhanced magnetic resonance imaging of a typical malignant breast tumor using a digital phantom. Images were obtained from the Cancer Imaging Archive Open Data for Breast Cancer, and 1-min scans with high temporal resolution were analyzed. The order of the k-space trajectory was set as Linear (sequential), Low-High (centric), PF (62.5%; Z-, Y-, and both directions), and Low-High Radial. k0 (center of the k-space) timing and TIC shape were affected by the chosen k-space trajectory and implementation of the PF technique. A small TIC gradient was obtained using a Low-High Radial order. If the k-space filling method (particularly the radial method) produces a gentle TIC gradient, misinterpretation could arise during the assessment of tumor malignancy status.
Language	English
Publishing date	2024-04-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2433581-2
ISSN	1865-0341 ; 1865-0333
ISSN (online)	1865-0341
ISSN	1865-0333
DOI	10.1007/s12194-024-00793-y
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Article ; Online: Effects of k-space orders on the time-intensity curves in dynamic contrast-enhanced magnetic resonance imaging of the breast based on simulation study.

Takatsu, Yasuo / Ueyama, Tsuyoshi / Iwasaki, Takahiro / Asahara, Masaki / Honda, Michitaka / Miyati, Tosiaki

Magnetic resonance imaging

2021 Volume 79, Page(s) 85–96

Abstract: ... intensity in the contrast area, (3) creating the k-space in each time phase, (4) extracting data from k ... space in each time phase, (5) filling in the k-space and adding data to the k-space assembly, and (6 ...

Abstract	Purpose: This study aims to investigate the influence of time-intensity curves (TICs) on the shapes using a dynamic contrast-enhanced magnetic resonance imaging (MRI) study depending on the Cartesian and radial orders for benign and cancerous breast tumors. Methods: Based on kinetic curve parameters, the signal intensities of six concentration gradients comprising two benign and four cancer models were used. The study aimed to construct a dynamic simulated image by creating a digital phantom image according to the following steps: (1) creating a simple numerical phantom, (2) setting the signal intensity in the contrast area, (3) creating the k-space in each time phase, (4) extracting data from k-space in each time phase, (5) filling in the k-space and adding data to the k-space assembly, and (6) creating a magnitude image. The TICs of Cartesian (centric and sequential) and radial (full-length [RFL] and half-length [RHL]) orders were created and sigmoid curve fitting was performed to compare these curves. Maximum slope (MS, s Results: MS was significantly decreased by radial order in the cancer model. No change was observed in WOR in Cartesian order, whereas RFL and RHL orders increased in the cancer models. PSR increased remarkably in the radial orders of cancer models. The difference in the fill slope in radial orders was remarkable when the TIC was steeper compared with when it was gentle, especially RHL. In WOR, both radial RFL and RHL were well matched except for the one benign model, and the shape of radial TIC was similar to sequential order as compared to centric order in 256 steps. Conclusion: The effects of Cartesian and radial orders on the patterns of TICs in a dynamic contrast-enhanced MRI study of benign and cancerous breast tumors were revealed. Interestingly, the TIC gradient of radial orders became gentler, particularly in the breast cancer MRI.
MeSH term(s)	Breast/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Contrast Media ; Female ; Humans ; Image Enhancement ; Magnetic Resonance Imaging ; Phantoms, Imaging
Chemical Substances	Contrast Media
Language	English
Publishing date	2021-03-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604885-7
ISSN	1873-5894 ; 0730-725X
ISSN (online)	1873-5894
ISSN	0730-725X
DOI	10.1016/j.mri.2021.03.006
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Article: Predator cannibalism can shift prey community composition toward dominance by small prey species.

Takatsu, Kunio

Ecology and evolution

2022 Volume 12, Issue 5, Page(s) e8894

Abstract: Cannibalism among predators is a key intraspecific interaction affecting their density and foraging behavior, eventually modifying the strength of predation on heterospecific prey. Interestingly, previous studies showed that cannibalism among predators ... ...

Abstract	Cannibalism among predators is a key intraspecific interaction affecting their density and foraging behavior, eventually modifying the strength of predation on heterospecific prey. Interestingly, previous studies showed that cannibalism among predators can increase or reduce predation on heterospecific prey; however, we know less about the factors that lead to these outcomes. Using a simple pond community consisting of
Language	English
Publishing date	2022-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.8894
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Article ; Online: The inflammasomes and immunometabolism: A small molecule inhibitor of the NLRP3 inflammasome.

Takatsu, Kiyoshi

Biochemical and biophysical research communications

2022 Volume 633, Page(s) 84–87

Abstract: The mammalian immune system consists of two arms, innate and acquired immunity. When I was nominated in 2003 as editorial board members of B.B.R.C., it was in line with the paradigm shift in trends of immunology in the way of thinking from acquired ... ...

Abstract	The mammalian immune system consists of two arms, innate and acquired immunity. When I was nominated in 2003 as editorial board members of B.B.R.C., it was in line with the paradigm shift in trends of immunology in the way of thinking from acquired immunity represented by peptide recognition by T-cell receptor to innate immunity represented by the recognition of pathogen-derived molecular pattern including lipid and carbohydrate. In this short perspective, I will introduce hot-spot of recent researches of inflammation, particularly inflammasome and immunometabolism. Here, particular attention is given to small molecule inhibitors of NLRP3 inflammasome activation.
MeSH term(s)	Animals ; Humans ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Immunity, Innate ; Inflammation ; Mammals
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein
Language	English
Publishing date	2022-11-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.09.118
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Article ; Online: Repeated elevational clines of early life‐history traits and their proximate mechanisms in brown trout

Takatsu, Kunio / Brodersen, Jakob

Freshwater Biology. 2023 Apr., v. 68, no. 4 p.609-620

2023

Abstract: Climate warming imposes a severe threat to freshwater ecosystems, which are dominated by ectotherms such as fish and aquatic insects. To better predict the effects of climate warming on thermally sensitive ecosystems, information on how temperature ... ...

Abstract	Climate warming imposes a severe threat to freshwater ecosystems, which are dominated by ectotherms such as fish and aquatic insects. To better predict the effects of climate warming on thermally sensitive ecosystems, information on how temperature affects individual traits within populations is fundamental. Patterns of intraspecific variation in thermal reaction norms along geographic thermal gradients provide valuable information. Immediate temperature effects on individual traits can be inferred from the shape of the thermal reaction norm. The way that temperature and associated environmental conditions (to which populations have been exposed over generations) affect individual traits through transgenerational plasticity in, and/or natural selection on, these traits can also be inferred from patterns of trait variation along a geographic thermal gradient. Many studies have documented patterns of intraspecific variation in thermal reaction norms along geographic thermal gradients. However, most previous studies cannot exclude the possibility that the observed geographic patterns are solely explained by random processes, such as isolation by distance, due to the lack of replication of geographic gradients. Here, we show consistent patterns in intraspecific trait variation along geographic thermal gradients using Salmo trutta (brown trout), which is an ecologically and economically important fish in alpine streams. We kept trout embryos collected from 52 families from 14 populations along wide and replicated elevational gradients from three Alpine drainages (Danube, Po, and Rhine) in two temperature treatments (3.2 and 6.2°C). Timing and body size at emergence from the nest, which are key early life‐history traits of trout affecting their early growth and survival, were measured. Besides faster embryonic development at warmer temperatures, we found that offspring from low‐elevation parents took very slightly longer to reach emergence from fertilisation and were larger than offspring from high‐elevation parents. Importantly, this was evident for all three drainages. Further analyses found that the longer duration until‐ and larger body length at‐ emergence of low‐elevation trout were mainly due to the larger eggs laid by low‐elevation females, which had larger body size than high‐elevation females. Trout female body size, which is positively correlated with egg size, is susceptible to temperatures and associated environmental conditions. Consequently, climate warming may not only immediately accelerate development rate but also shift timing and size at emergence through egg size‐mediated maternal effects within a relatively short time scale.
Keywords	Salmo trutta ; body length ; climate ; ectothermy ; eggs ; embryogenesis ; females ; freshwater ; intraspecific variation ; life history ; limnology ; natural selection ; nests ; phenotypic plasticity ; progeny ; temperature ; trout
Language	English
Dates of publication	2023-04
Size	p. 609-620.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	121180-8
ISSN	0046-5070
ISSN	0046-5070
DOI	10.1111/fwb.14050
Database	NAL-Catalogue (AGRICOLA)

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Article: [IL-5 AND ALLERGIC INFLAMMATION].

Takatsu, Kiyoshi

Arerugi = [Allergy

2018 Volume 67, Issue 2, Page(s) 108–113

MeSH term(s)	Animals ; Eosinophils/immunology ; Humans ; Hypersensitivity/drug therapy ; Hypersensitivity/immunology ; Inflammation/drug therapy ; Inflammation/immunology ; Interleukin-5/biosynthesis ; Interleukin-5/immunology ; Lymphocytes/immunology ; Molecular Targeted Therapy
Chemical Substances	Interleukin-5
Language	Japanese
Publishing date	2018-03-02
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	974201-3
ISSN	0021-4884
ISSN	0021-4884
DOI	10.15036/arerugi.67.108
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Article ; Online: IgA nephropathy preceded by erythroderma with eosinophilia.

Takatsu, Mina / Natsuga, Ken / Hattanda, Fumihiko / Ujiie, Hideyuki

European journal of dermatology : EJD

2023 Volume 32, Issue 1, Page(s) 127–129

Title translation	IgA nephropathy preceded by erythroderma with eosinophilia.
MeSH term(s)	Dermatitis, Exfoliative/complications ; Eosinophilia/complications ; Eosinophilia/drug therapy ; Glomerulonephritis, IGA/complications ; Humans ; Immunoglobulin A
Chemical Substances	Immunoglobulin A
Language	English
Publishing date	2023-08-09
Publishing country	France
Document type	Journal Article
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2022.4199
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Zs.A 3484: Show issues

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Book: Interleukin-5 and its receptor system

Takatsu, Kiyoshi

from genes to disease

(Molecular biology intelligence unit)

1995

Author's details	Kiyoshi Takatsu
Series title	Molecular biology intelligence unit
Keywords	Interleukin-5 / physiology ; Receptors, Interleukin / physiology ; Immunity, Cellular ; Interleukin 5 ; Rezeptor ; Pathophysiologie
Subject	Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie
Language	English
Size	167 S. : Ill., graph. Darst.
Publisher	Springer u.a.
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT007151968
ISBN	1-57059-233-0 ; 3-540-59212-1 ; 978-1-57059-233-1 ; 978-3-540-59212-9
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
1996 A 2294	order for loan	Magazin

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Article ; Online: Study of X-ray topography using the super-Borrmann effect.

Matsui, J / Takatsu, K / Tsusaka, Y

Journal of synchrotron radiation

2022 Volume 29, Issue Pt 5, Page(s) 1251–1257

Abstract: X-ray topography exerting the super-Borrmann effect has been performed using synchrotron radiation to display dislocation images with a high-speed and high-resolution CMOS camera. Forward-transmitted X-rays are positively employed instead of reflected X- ... ...

Abstract	X-ray topography exerting the super-Borrmann effect has been performed using synchrotron radiation to display dislocation images with a high-speed and high-resolution CMOS camera. Forward-transmitted X-rays are positively employed instead of reflected X-rays to reveal dislocations in relatively thick crystals by simultaneously exciting a pair of adjacent {111} planes owing to the super-Borrmann effect. Before the experiment, minimum values of the attenuation coefficients A
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021413-3
ISSN	1600-5775 ; 0909-0495
ISSN (online)	1600-5775
ISSN	0909-0495
DOI	10.1107/S1600577522007779
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Article: Does Early and Late Weight Bearing Have an Effect on the Results of Elderly Tibial Plateau Fractures with Internal Fixation?: A Multicenter (TRON Group) Study.

Sudo, Yoshito / Takegami, Yasuhiko / Tokutake, Katsuhiro / Shimizu, Keita / Naruse, Keita / Takatsu, Tetsuro / Imagama, Shiro

Indian journal of orthopaedics

2024 Volume 58, Issue 4, Page(s) 354–361

Abstract: Introduction: There is still no consensus on the length of the non-bearing period required for tibial plateau fractures (TPFs) treated surgically. Several studies showed that full weight bearing immediately postoperatively does not affect fixation or ... ...

Abstract	Introduction: There is still no consensus on the length of the non-bearing period required for tibial plateau fractures (TPFs) treated surgically. Several studies showed that full weight bearing immediately postoperatively does not affect fixation or cause joint collapse in patients with TPF. While there are concerns about weight bearing in the elderly due to fragile bone quality, their physical disability often makes it difficult to carry out activities of daily life when weight bearing is not allowed. The purpose of this study was to assess differences in clinical and radiographic outcomes between an early weight-bearing (EWB) group and a non-weight-bearing (NWB) group following TPF in elderly patients. Material and methods: We extracted the data of 432 patients who suffered TPF from January 2011 to December 2020 from a database which is named TRON. We excluded patients with insufficient follow-up postoperatively, AO type A/C fracture, age < 60 years old, multiple trauma, and those lost to follow-up. Finally, 91 patients were eligible. EWB group patients were encouraged to perform partial weight-bearing walking at ≤ 4 weeks after surgery, whereas NWB group patients were not allowed weight bearing for > 4 weeks after surgery. Baseline intergroup differences were adjusted for by matching age, sex, body mass index, smoking history, and injury mechanism. We compared Knee Society Score (KSS), timing of full weight bearing, and X-ray findings including step-off, tibia plateau angle, plateau slope, and condylar widening in the X-rays between the two groups. Results: There were no significant statistical differences between the EWB group and NWB group after matching. The mean follow-up period was 28.0 (range 12-73) months. All cases did not require reoperation or additional procedures. The median KSS at 12 months or at the last follow up postoperatively was 100 (77-100) vs. 95 (75-100) points (P = 0.33). There were no differences in fracture-related infection rates or wound dehiscence. In the radiological evaluation of EWB and NWB, the correction loss of condylar widening was only significantly greater for EWB compared to NWB. Conclusions: We found that early weight bearing could contribute to increased condylar widening. While our short-term follow-up didn't reveal any significant clinical differences, this highlights the need for long-term follow-up to comprehensively understand the implications of these radiographic changes.
Language	English
Publishing date	2024-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	603194-8
ISSN	0019-5413
ISSN	0019-5413
DOI	10.1007/s43465-024-01113-7
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