Article ; Online: Pharmacologic methods to minimise coughing during extubation in the era of COVID-19.
Journal of perioperative practice
2022 Volume 33, Issue 7-8, Page(s) 248–252
Abstract: Background/aim: Given the current severe acute respiratory syndrome coronavirus 2 pandemic, coughing at the time of extubation is at risk of creating aerosolisation. This may place health care workers at risk of nosocomial infection during the ... ...
| Abstract | Background/aim: Given the current severe acute respiratory syndrome coronavirus 2 pandemic, coughing at the time of extubation is at risk of creating aerosolisation. This may place health care workers at risk of nosocomial infection during the perioperative period. This study aims to summarise the current pharmacologic methods to minimise cough at the time of extubation, and to determine whether some strategies could be more beneficial than others. Methods: This is a summary of systematic reviews. A comprehensive search through MEDLINE was performed. Thirty-three publications were screened for eligibility. Only the manuscripts discussing pharmacologic methods to minimise coughing on extubation were included in this review. Findings: Many pharmacological agents have been proposed to decrease the incidence of cough at the time of extubation. Of these, intravenous administration of dexmedetomidine (relative risk 0.4; 95% CI: 0.4-0.5) or remifentanil (RR 0.4; 95% CI: 0.4-0.5) seems to have the largest effect to reduce cough on extubation. Conclusion: The available data in the current literature is sparse. Yet, dexmedetomidine and remifentanil seem to be the most efficient agents to decrease the incidence of emergence coughing. |
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| MeSH term(s) | Humans ; Cough/prevention & control ; Cough/drug therapy ; Cough/epidemiology ; Remifentanil ; Dexmedetomidine/therapeutic use ; Airway Extubation ; COVID-19 ; Systematic Reviews as Topic ; Intubation, Intratracheal/methods |
| Chemical Substances | Remifentanil (P10582JYYK) ; Dexmedetomidine (67VB76HONO) |
| Language | English |
| Publishing date | 2022-12-08 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 2226186-2 |
| ISSN | 2515-7949 ; 1750-4589 |
| ISSN (online) | 2515-7949 |
| ISSN | 1750-4589 |
| DOI | 10.1177/17504589221132404 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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