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Article ; Online: Interleukin-6 blockade treatment for COVID-19 associated cytokine release syndrome in a patient with poorly controlled chronic myeloid leukaemia.

Ranger, Amita / Haji, Ruby / Kaczmarski, Richard / Danga, Akila

2020 Volume 190, Issue 3, Page(s) e128–e130

MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/virology ; Humans ; Immunosuppressive Agents/therapeutic use ; Interleukin-6/antagonists & inhibitors ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Tomography, X-Ray Computed
Chemical Substances	Antibodies, Monoclonal, Humanized ; Immunosuppressive Agents ; Interleukin-6 ; tocilizumab (I031V2H011)
Keywords	covid19
Language	English
Publishing date	2020-06-26
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.16901
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Article: Interleukin-6 blockade treatment for COVID-19 associated cytokine release syndrome in a patient with poorly controlled chronic myeloid leukaemia

Ranger, Amita / Haji, Ruby / Kaczmarski, Richard / Danga, Akila

Br J Haematol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #457160
Database	COVID19

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Article ; Online: Interleukin‐6 blockade treatment for COVID‐19 associated cytokine release syndrome in a patient with poorly controlled chronic myeloid leukaemia

Ranger, Amita / Haji, Ruby / Kaczmarski, Richard / Danga, Akila

British Journal of Haematology

2020 Volume 190, Issue 3

Keywords	Hematology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.16901
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical and biological features of cerebral venous sinus thrombosis following ChAdOx1 nCov-19 vaccination.

Crossette-Thambiah, Christina / Pericleous, Charis / Asmar, Namir / Bomsztyk, Joshua / Ranger, Amita / Shlebak, Abdul / Ramji, Saipriya / Banerjee, Soma / Laffan, Mike / J Arachchillage, Deepa

Journal of neurology, neurosurgery, and psychiatry

2021 Volume 93, Issue 4, Page(s) 445–448

MeSH term(s)	COVID-19 ; ChAdOx1 nCoV-19 ; Humans ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Sinus Thrombosis, Intracranial/etiology ; Vaccination/adverse effects
Chemical Substances	ChAdOx1 nCoV-19 (B5S3K2V0G8)
Language	English
Publishing date	2021-09-29
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp-2021-327340
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Article ; Online: The heparin-von Willebrand factor interaction and conventional tests of haemostasis - the challenges in predicting bleeding in cardiopulmonary bypass.

Ranger, Amita / Gaspar, Mihaela / Elkhatteb, Amira / Jackson, Tim / Fox, Steve / Aw, T C / Vipond, Lisa / Cotterill, Judy / Ghori, Arshad / Laffan, Mike / Arachchillage, Deepa R J

British journal of haematology

2020 Volume 192, Issue 6, Page(s) 1073–1081

Abstract: Bleeding is a significant complication of cardiopulmonary bypass (CPB), despite routine anticoagulation monitoring. This is likely to be multifactorial. In this prospective, single-centre cohort study of 30 patients undergoing CPB surgery, our aim was to ...

Abstract	Bleeding is a significant complication of cardiopulmonary bypass (CPB), despite routine anticoagulation monitoring. This is likely to be multifactorial. In this prospective, single-centre cohort study of 30 patients undergoing CPB surgery, our aim was to characterise the changes in von Willebrand factor (VWF) function, platelet interaction and the global coagulation changes during and after CPB surgery and to determine whether bleeding can be predicted. Samples were taken at six time points before, during and after CPB surgery. We observed a significant rise in VWF antigen (VWF:Ag) throughout surgery, which continued postoperatively. The absolute VWF collagen-binding assays (VWF:CB) and VWF ristocetin cofactor (VWF:RCo) rose significantly but the VWF:CB/VWF:Ag and VWF:Ag/VWF:RCo fell significantly (P = 0·0015 and P = 0·0143), suggesting loss of large multimers. We detected a non-significant trend to loss of VWF:RCo after heparinisation and a significant recovery after protamine reversal which could reflect a direct heparin effect. There was a significant increase in the R and K times with a fall in alpha angle and maximum amplitude after heparin administration, using heparinase-thromboelastography (TEG). The parameters both significantly improved following protamine (P = 0·007 and P = 0·0054). The activated clotting time (ACT) and heparin anti-Xa level correlated poorly; neither predicted clinically significant bleeding. None of these parameters had a relationship with intraoperative blood loss or requirement for blood product replacement.
MeSH term(s)	Aged ; Aged, 80 and over ; Blood Coagulation Tests ; Blood Loss, Surgical ; Cardiopulmonary Bypass/adverse effects ; Female ; Heparin/administration & dosage ; Heparin/pharmacokinetics ; Humans ; Male ; Middle Aged ; Prospective Studies ; von Willebrand Factor/metabolism
Chemical Substances	von Willebrand Factor ; Heparin (9005-49-6)
Language	English
Publishing date	2020-12-05
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.17263
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Article ; Online: An uncommon morphological variant of acute promyelocytic leukemia.

Jacob, Elizabeth / Ranger, Amita / Sohal, Mamta / Bain, Barbara J

American journal of hematology

2012 Volume 87, Issue 3, Page(s) 294

MeSH term(s)	Adult ; Antigens, CD34/analysis ; Biomarkers, Tumor/blood ; Blood Coagulation Tests ; Bone Marrow/pathology ; Cell Nucleus/ultrastructure ; Chromosomes, Human, Pair 15/ultrastructure ; Chromosomes, Human, Pair 17/ultrastructure ; Cytoplasmic Granules/chemistry ; Cytoplasmic Granules/ultrastructure ; Female ; HLA-DR Antigens/analysis ; Humans ; Immunophenotyping ; Leukemia, Promyelocytic, Acute/classification ; Leukemia, Promyelocytic, Acute/diagnosis ; Leukemia, Promyelocytic, Acute/genetics ; Leukemia, Promyelocytic, Acute/pathology ; Nuclear Proteins/blood ; Pregnancy ; Pregnancy Complications, Neoplastic/diagnosis ; Pregnancy Complications, Neoplastic/pathology ; Promyelocytic Leukemia Protein ; Transcription Factors/blood ; Translocation, Genetic ; Tumor Suppressor Proteins/blood
Chemical Substances	Antigens, CD34 ; Biomarkers, Tumor ; HLA-DR Antigens ; Nuclear Proteins ; Promyelocytic Leukemia Protein ; Transcription Factors ; Tumor Suppressor Proteins ; PML protein, human (143220-95-5)
Language	English
Publishing date	2012-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.22129
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Article ; Online: Losing all sense: a case of meningeal carcinomatosis.

Kirthi, Varo / Penn, Henry / Hamdulay, Shahir / Ranger, Amita / Higgens, Clare

BMJ case reports

2011 Volume 2011

Abstract: Meningeal carcinomatosis (MC) is diffuse infiltration of the meninges by metastatic carcinoma. Though a known complication of solid tumours, it is rarely seen as a presenting feature of such cancers. Here, the authors describe the case of a 64-year-old ... ...

Abstract	Meningeal carcinomatosis (MC) is diffuse infiltration of the meninges by metastatic carcinoma. Though a known complication of solid tumours, it is rarely seen as a presenting feature of such cancers. Here, the authors describe the case of a 64-year-old lady who presented with rapid-onset hearing loss and progressive visual loss, among other cranial nerve palsies. A primary non-small cell lung cancer was later identified by CT, but the diagnosis of MC was only confirmed after cytological analysis of a repeat lumbar puncture. Immunophenotyping of cells from the lung biopsy correlated with cells obtained from cerebrospinal fluid. In view of her rapid clinical deterioration, chemotherapy was not pursued, and the patient was transferred to a hospice 3 weeks after admission.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/pathology ; Cranial Nerve Diseases/diagnosis ; Cranial Nerve Diseases/etiology ; Female ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/etiology ; Humans ; Meningeal Carcinomatosis/cerebrospinal fluid ; Meningeal Carcinomatosis/complications ; Meningeal Carcinomatosis/diagnosis ; Meningeal Carcinomatosis/secondary ; Middle Aged ; Radiography ; Vision Disorders/diagnosis ; Vision Disorders/etiology
Language	English
Publishing date	2011-03-24
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr.10.2010.3446
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Article ; Online: PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison Project.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2017 Volume 12, Issue 2, Page(s) 208–222

Abstract: Introduction: The Blueprint Programmed Death Ligand 1 (PD-L1) Immunohistochemistry (IHC) Assay Comparison Project is an industrial-academic collaborative partnership to provide information on the analytical and clinical comparability of four PD-L1 IHC ... ...

Abstract	Introduction: The Blueprint Programmed Death Ligand 1 (PD-L1) Immunohistochemistry (IHC) Assay Comparison Project is an industrial-academic collaborative partnership to provide information on the analytical and clinical comparability of four PD-L1 IHC assays used in clinical trials. Methods: A total of 39 NSCLC tumors were stained with four PD-L1 IHC assays (22C3, 28-8, SP142, and SP263), as used in the clinical trials. Three experts in interpreting their respective assays independently evaluated the percentages of tumor and immune cells staining positive at any intensity. Clinical diagnostic performance was assessed through comparisons of patient classification above and below a selected expression cutoff and by agreement using various combinations of assays and cutoffs. Results: Analytical comparison demonstrated that the percentage of PD-L1-stained tumor cells was comparable when the 22C3, 28-8, and SP263 assays were used, whereas the SP142 assay exhibited fewer stained tumor cells overall. The variability of immune cell staining across the four assays appears to be higher than for tumor cell staining. Of the 38 cases, 19 (50.0%) were classified above and five (13%) were classified below the selected cutoffs of all assays. For 14 of the 38 cases (37%), a different PD-L1 classification would be made depending on which assay/scoring system was used. Conclusions: The Blueprint PD-L1 IHC Assay Comparison Project revealed that three of the four assays were closely aligned on tumor cell staining whereas the fourth showed consistently fewer tumor cells stained. All of the assays demonstrated immune cell staining, but with greater variability than with tumor cell staining. By comparing assays and cutoffs, the study indicated that despite similar analytical performance of PD-L1 expression for three assays, interchanging assays and cutoffs would lead to "misclassification" of PD-L1 status for some patients. More data are required to inform on the use of alternative staining assays upon which to read different specific therapy-related PD-L1 cutoffs.
Language	English
Publishing date	2017-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2016.11.2228
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Article ; Online: Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis.

Jayasena, Channa N / Nijher, Gurjinder M K / Chaudhri, Owais B / Murphy, Kevin G / Ranger, Amita / Lim, Adrian / Patel, Daksha / Mehta, Amrish / Todd, Catriona / Ramachandran, Radha / Salem, Victoria / Stamp, Gordon W / Donaldson, Mandy / Ghatei, Mohammad A / Bloom, Stephen R / Dhillo, Waljit S

The Journal of clinical endocrinology and metabolism

2009 Volume 94, Issue 11, Page(s) 4315–4323

Abstract: Background: Kisspeptin is a critical regulator of normal reproductive function. A single injection of kisspeptin in healthy human volunteers potently stimulates gonadotropin release. However, the effects of kisspeptin on gonadotropin release in women ... ...

Abstract	Background: Kisspeptin is a critical regulator of normal reproductive function. A single injection of kisspeptin in healthy human volunteers potently stimulates gonadotropin release. However, the effects of kisspeptin on gonadotropin release in women with hypothalamic amenorrhea (HA) and the effects of repeated administration of kisspeptin to humans are unknown. Aim: The aim of this study was to determine the effects of acute and chronic kisspeptin administration on gonadotropin release in women with HA. Methods: We performed a prospective, randomized, double-blinded, parallel design study. Women with HA received twice-daily sc injections of kisspeptin (6.4 nmol/kg) or 0.9% saline (n = 5 per group) for 2 wk. Changes in serum gonadotropin and estradiol levels, LH pulsatility, and ultrasound measurements of reproductive activity were assessed. Results: On the first injection day, potent increases in serum LH and FSH were observed after sc kisspeptin injection in women with HA (mean maximal increment from baseline within 4 h after injection: LH, 24.0 +/- 3.5 IU/liter; FSH, 9.1 +/- 2.5 IU/liter). These responses were significantly reduced on the 14th injection day (mean maximal increment from baseline within 4 h postinjection: LH, 2.5 +/- 2.2 IU/liter, P < 0.05; FSH, 0.5 +/- 0.5 IU/liter, P < 0.05). Subjects remained responsive to GnRH after kisspeptin treatment. No significant changes in LH pulsatility or ultrasound measurements of reproductive activity were observed. Conclusion: Acute administration of kisspeptin to women with infertility due to HA potently stimulates gonadotropin release, but chronic administration of kisspeptin results in desensitization to its effects on gonadotropin release. These data have important implications for the development of kisspeptin as a novel therapy for reproductive disorders in humans.
MeSH term(s)	Adult ; Amenorrhea/drug therapy ; Body Mass Index ; Body Weight ; Female ; Follicle Stimulating Hormone/blood ; Gonadotropins/blood ; Gonadotropins/metabolism ; Humans ; Hypothalamus/physiopathology ; Kisspeptins ; Luteinizing Hormone/blood ; Spectrometry, Mass, Electrospray Ionization/methods ; Tachyphylaxis/physiology ; Tumor Suppressor Proteins/adverse effects ; Tumor Suppressor Proteins/chemistry ; Tumor Suppressor Proteins/therapeutic use ; Weight Gain ; Young Adult
Chemical Substances	Gonadotropins ; KISS1 protein, human ; Kisspeptins ; Tumor Suppressor Proteins ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2009-10-09
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2009-0406
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Article ; Online: Association of obesity and smoking with PSA and PSA velocity in men with prostate cancer.

Algotar, Amit M / Stratton, Steven P / Ranger-Moore, James / Stratton, M Suzanne / Hsu, C H / Ahmann, Frederick R / Nagle, Raymond B / Thompson, Patricia A

American journal of men's health

2011 Volume 5, Issue 3, Page(s) 272–278

Abstract: Significant number of prostate tumors are slow growing and could probably be left untreated. However, many are aggressive and can spread rapidly causing patient suffering and/or death. Current technology does not allow physicians to differentiate between ...

Abstract	Significant number of prostate tumors are slow growing and could probably be left untreated. However, many are aggressive and can spread rapidly causing patient suffering and/or death. Current technology does not allow physicians to differentiate between slow growing and aggressive tumors at diagnosis. Hence, many patients are exposed to invasive treatment and its associated morbidities such as incontinence and impotence. Markers that enable differentiation between slow and fast progressing cancer will allow physicians to prevent unnecessary treatments on men who may not need them, and focus on the men with aggressive disease. A longitudinal study was conducted (N = 140) using mixed effects regression models to determine the association of obesity and smoking toward prostate cancer progression. These models account for correlation because of repeated measures over time, thus, using maximum amount of information provided by the subject. Estimates thus obtained are more robust and reliable than those obtained using data from a single time point. Rate of change of prostate-specific antigen (PSA) over time (PSA velocity) was used as a measure of prostate cancer progression. Results indicate that PSA velocity of overweight and obese subjects (0.59 and 1.05 ng/mL/year) was not significantly different as compared with normal weight subjects (p values .91 and .31, respectively). For men in the highest tertile of pack-years of smoking, PSA velocity was significantly higher as compared with never smokers 1.57 ng/mL/year (p = .04). Further studies with larger sample sizes and study designs specific to above exposures are needed before recommendations can be made to reduce weight or reduce/quit smoking.
MeSH term(s)	Aged ; Body Mass Index ; Disease Progression ; Humans ; Male ; Middle Aged ; Obesity/complications ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/pathology ; Smoking/adverse effects
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2011-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2275106-3
ISSN	1557-9891 ; 1557-9883
ISSN (online)	1557-9891
ISSN	1557-9883
DOI	10.1177/1557988310390030
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