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Book ; Online: Efficiency, Fairness and Sustainability in Social Housing Policy and Projects

Napoli, Grazia / Trovato, Maria Rosa

2023

Keywords	Research & information: general ; real estate appraisal ; capital gain ; financial feasibility ; economic sustainability ; public-private partnership ; risk assessment ; social housing ; urban regeneration ; urban rent ; affordable prices ; discounted cash flow analysis ; road infrastructures ; social sustainability ; mass appraisal ; Regional Strategic Intervention Programs ; multi-criteria analysis ; stakeholder analysis ; NAIADE method ; public housing neighborhoods ; project-induced effects ; assessment framework ; multi-criteria decision-making model ; housing affordability ; housing policy ; affordable housing ; Malaysia ; young adults ; renters ; housing costs ; parental supports ; discriminant analysis ; regression analysis ; independent living ; Nigeria ; strategies ; housing tenure ; low-income earners ; sustainability ; critical junctures ; housing delivery ; Vision 2030 ; Saudi Arabia ; affordable rent ; cluster analysis ; social fairness ; community acceptance ; housing accessibility ; India
Language	English
Size	1 electronic resource (246 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030377166
ISBN	9783036565682 ; 303656568X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Update on International Medical Taxonomies of Biomarkers and Their Applications in Management of Thyroid Cancers.

Trovato, Maria

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 3

Abstract: Biomarkers (BMs) are medical signs which can be precisely measured and reproduced. Mainly, BMs provide information on the likely disease which can occur in an individual. On the other hand, BMs also signal disease recurrence in patients receiving therapy. ...

Abstract	Biomarkers (BMs) are medical signs which can be precisely measured and reproduced. Mainly, BMs provide information on the likely disease which can occur in an individual. On the other hand, BMs also signal disease recurrence in patients receiving therapy. The U.S. Food and Drug Administration coupled with the National Institutes of Health and the European Medicines Agency have proposed two distinct procedures to validate BMs. These agencies have elaborated two glossaries to describe the role of BMs. The aim of this study was to investigate medical taxonomies adopted by different governmental agencies for BM validation. Additional goals were to analyze efficiencies of the validated and candidate BMs for thyroid cancers (TCs). Currently, thyroglobulin is validated for monitoring TCs. Sorafenib-tosylate, Doxorubicin-hydrochloride, Vandetanib, Cabozantinib-s-malate, Dabrafenib-mesylate, Trametinib-dimethyl-sulfoxide, Lenvatinib-mesylate, Pralsetinib and Selpercatinib are validated for TC treatment. Among candidate BMs for TC diagnosis, there are molecular combinations including BRAF, RAS, RET/PTC and PAX8-PPARγ mutations. Noteworthy are BRAF and RET/PTC alterations already validated as targets of Dabrafenib-mesylate, Pralsetinib and Selpercatinib. Finally, cellular expressions of c-met in nodal TC metastases have diagnostic imaging applications. On the basis of this analysis, BM taxonomies should have common standards internationally recognized. BMs show different efficiencies depending on their diagnostic or therapeutic use.
Language	English
Publishing date	2022-03-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12030662
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Update on International Medical Taxonomies of Biomarkers and Their Applications in Management of Thyroid Cancers

Maria Trovato

Diagnostics, Vol 12, Iss 662, p

2022 Volume 662

Abstract	Biomarkers (BMs) are medical signs which can be precisely measured and reproduced. Mainly, BMs provide information on the likely disease which can occur in an individual. On the other hand, BMs also signal disease recurrence in patients receiving therapy. The U.S. Food and Drug Administration coupled with the National Institutes of Health and the European Medicines Agency have proposed two distinct procedures to validate BMs. These agencies have elaborated two glossaries to describe the role of BMs. The aim of this study was to investigate medical taxonomies adopted by different governmental agencies for BM validation. Additional goals were to analyze efficiencies of the validated and candidate BMs for thyroid cancers (TCs). Currently, thyroglobulin is validated for monitoring TCs. Sorafenib-tosylate, Doxorubicin-hydrochloride, Vandetanib, Cabozantinib-s-malate, Dabrafenib-mesylate, Trametinib-dimethyl-sulfoxide, Lenvatinib-mesylate, Pralsetinib and Selpercatinib are validated for TC treatment. Among candidate BMs for TC diagnosis, there are molecular combinations including BRAF, RAS, RET/PTC and PAX8-PPARγ mutations. Noteworthy are BRAF and RET/PTC alterations already validated as targets of Dabrafenib-mesylate, Pralsetinib and Selpercatinib. Finally, cellular expressions of c-met in nodal TC metastases have diagnostic imaging applications. On the basis of this analysis, BM taxonomies should have common standards internationally recognized. BMs show different efficiencies depending on their diagnostic or therapeutic use.
Keywords	biomarkers taxonomies ; thyroid cancers biomarkers ; thyroglobulin ; BRAF and RET/PTC molecular alterations ; c-met expressions ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Landscapes in the Eastern Mediterranean between the Future and the Past

Vogiatzakis, Ioannis N. / Terkenli, Theano S. / Trovato, Maria Gabriella / Abu-Jaber, Nizar

2020

Abstract: Landscapes have long been viewed as 'multifunctional', integrating ecological, economic, sociocultural, historical, and aesthetic dimensions. Landscape science and public awareness in Europe have been progressing in leaps and bounds. The challenges ... ...

Abstract	Landscapes have long been viewed as 'multifunctional', integrating ecological, economic, sociocultural, historical, and aesthetic dimensions. Landscape science and public awareness in Europe have been progressing in leaps and bounds. The challenges involved in landscape-related issues and fields, however, are multiple and refer to landscape stewardship and protection, as well as to the development of comprehensive theoretical and methodological approaches, in tandem with public sensitization and participatory governance and in coordination with appropriate top-down planning and policy instruments. Landscape-scale approaches are fundamental to the understanding of past and present cultural evolution, and are now considered to be an appropriate spatial framework for the analysis of sustainability. Methods and tools of landscape analysis and intervention have also gone a long way since their early development in Europe and the United States.- Although significant progress has been made, there remain many issues which are understudied or not investigated at all-at least in a Mediterranean context. This Special Issue addresses the application of landscape theory and practice in the Eastern Mediterranean and mainly, but not exclusively, reports on the outcomes of an international conference held in Jordan, in December 2015, with the title "Landscapes of Eastern Mediterranean: Challenges, Opportunities, Prospects and Accomplishments". The focus of this Special Issue, landscapes of the Eastern Mediterranean region, thus constitutes a timely area of research interest, not only because these landscapes have so far been understudied, but also as a rich site of strikingly variegated, long-standing multicultural human-environmental interactions.- These interactions, resting on and taking shape through millennia of continuity in tradition, have been striving to adapt to technological advances, while currently juggling with manifold and multilayered socioeconomic and climate-environmental crises
Keywords	Science (General) ; Geography (General)
Size	1 electronic resource (164 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Document type	Book ; Online
Note	eng ; Open Access
HBZ-ID	HT020589544
ISBN	9783039217748 ; 9783039217755 ; 3039217747 ; 3039217755
DOI	10.3390/books978-3-03921-775-5
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Medical Applications of Molecular Biotechnologies in the Context of Hashimoto's Thyroiditis.

Trovato, Maria / Valenti, Andrea

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 12

Abstract: Hashimoto's thyroiditis (HT) is a gender autoimmune disease that is manifested by chronic inflammation of the thyroid. Clinical trial studies (CTSs) use molecular biotechnologies (MB) to approach HT appearance. The aims of this study were to analyze the ... ...

Abstract	Hashimoto's thyroiditis (HT) is a gender autoimmune disease that is manifested by chronic inflammation of the thyroid. Clinical trial studies (CTSs) use molecular biotechnologies (MB) to approach HT appearance. The aims of this study were to analyze the applications of MB in CTSs carried out in HT populations (HT-CTSs). Further, to evaluate the role of MB in the context of the hygiene hypothesis (HH). From 75 HT-CTSs found at clinicaltrials.gov web place, forty-five were considered for this investigation. Finally, six HT-CTSs were reported as molecular HT-CTSs (mHT-CTSs) because these were planning to utilize MB. Two of mHT-CTSs were programmed on the French population to isolate DNA viral sequences. Blood, urine, and thyroid tissue biospecimens were analyzed to pick out the parvo and polyoma viruses. Two mHT-CTSs carried out in China aimed to identify oral and fecal microbiotas by measuring PCR sequencing of the 16S rRNA gene. Two mHT-CTSs were programmed in the USA and Greece, respectively, for interception of DNA polymorphisms to associate with genetic susceptibility to HT. In conclusion, MB are mainly employed in HT-CTSs for infective pathogenesis and genetic fingerprinting of HT. Furthermore, MB do not provide evidence of HH; however, they are useful for providing direct evidence of the presence of viruses.
Language	English
Publishing date	2023-06-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13122114
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hormetic Nutrition and Redox Regulation in Gut-Brain Axis Disorders.

Scuto, Maria / Rampulla, Francesco / Reali, Giuseppe Maria / Spanò, Sestina Maria / Trovato Salinaro, Angela / Calabrese, Vittorio

Antioxidants (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience and overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest for preventing and therapeutically ... ...

Abstract	The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience and overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest for preventing and therapeutically impacting neuropathologies and gastrointestinal diseases. Polyphenols and polyphenol-combined nanoparticles in synergy with probiotics have shown to improve gut bioavailability and blood-brain barrier (BBB) permeability, thus inhibiting the oxidative stress, metabolic dysfunction and inflammation linked to gut dysbiosis and ultimately the onset and progression of central nervous system (CNS) disorders. In accordance with hormesis, polyphenols display biphasic dose-response effects by activating at a low dose the Nrf2 pathway resulting in the upregulation of antioxidant
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13040484
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Medical Applications of Molecular Biotechnologies in the Context of Hashimoto’s Thyroiditis

Maria Trovato / Andrea Valenti

Diagnostics, Vol 13, Iss 2114, p

2023 Volume 2114

Abstract: Hashimoto’s thyroiditis (HT) is a gender autoimmune disease that is manifested by chronic inflammation of the thyroid. Clinical trial studies (CTSs) use molecular biotechnologies (MB) to approach HT appearance. The aims of this study were to analyze the ... ...

Abstract	Hashimoto’s thyroiditis (HT) is a gender autoimmune disease that is manifested by chronic inflammation of the thyroid. Clinical trial studies (CTSs) use molecular biotechnologies (MB) to approach HT appearance. The aims of this study were to analyze the applications of MB in CTSs carried out in HT populations (HT-CTSs). Further, to evaluate the role of MB in the context of the hygiene hypothesis (HH). From 75 HT-CTSs found at clinicaltrials.gov web place, forty-five were considered for this investigation. Finally, six HT-CTSs were reported as molecular HT-CTSs (mHT-CTSs) because these were planning to utilize MB. Two of mHT-CTSs were programmed on the French population to isolate DNA viral sequences. Blood, urine, and thyroid tissue biospecimens were analyzed to pick out the parvo and polyoma viruses. Two mHT-CTSs carried out in China aimed to identify oral and fecal microbiotas by measuring PCR sequencing of the 16S rRNA gene. Two mHT-CTSs were programmed in the USA and Greece, respectively, for interception of DNA polymorphisms to associate with genetic susceptibility to HT. In conclusion, MB are mainly employed in HT-CTSs for infective pathogenesis and genetic fingerprinting of HT. Furthermore, MB do not provide evidence of HH; however, they are useful for providing direct evidence of the presence of viruses.
Keywords	Hashimoto’s thyroiditis ; molecular biotechnologies ; clinical trials studies ; hygiene hypothesis ; parvoviruses ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Stimulating maximum staff performance in cross-functional and multiracial work environments: personal perspectives.

Oleribe, Obinna Ositadimma / Trovato, Guglielmo Maria

The Pan African medical journal

2022 Volume 41, Page(s) 278

Abstract: In a world where there is added stress on healthcare systems, owing to the COVID-19 pandemic, we acknowledge that healthcare systems around the globe often run in a dysfunctional way at the best of times. In this article, we identify some of the issues ... ...

Abstract	In a world where there is added stress on healthcare systems, owing to the COVID-19 pandemic, we acknowledge that healthcare systems around the globe often run in a dysfunctional way at the best of times. In this article, we identify some of the issues that surround workers´ dissatisfaction including lack of open, accountable, transparent, and honest management. We examine the theories behind a more accountable work environment and examine the potential for improved worker productivity as a result of physical, emotional, mental, intellectual, and spiritual wellbeing. We conclude that there is a need for organizational leaders and administrators to support organizational justice through the expanded use of work team processes, whereby staff is involved in assessing organizational functionality and recommending improvements. Supervisory consideration, job variety, and perceptions of training have positive effects on job satisfaction, staff performance, and organizational commitment.
MeSH term(s)	COVID-19 ; Cross-Sectional Studies ; Humans ; Organizational Culture ; Pandemics ; Social Justice
Language	English
Publishing date	2022-04-06
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2022.41.278.33267
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Axiology of Residual Green Urban Areas

Trovato, Maria Rosa

Environments. 2021 June 04, v. 8, no. 6

2021

Abstract: Our cities are often characterised by a complex, ungrammatical articulation of spaces, volumes, intended uses, and values. The residual green urban areas are representative of a low level or absence of order, but above all, of functions and values. The ... ...

Abstract	Our cities are often characterised by a complex, ungrammatical articulation of spaces, volumes, intended uses, and values. The residual green urban areas are representative of a low level or absence of order, but above all, of functions and values. The study proposes a new methodological and operational approach to the rehabilitation of green residual urban areas, participatory type that can generate a new order between values, functions and actors, to mediate private and public needs, to promote new forms of responsibility and thus to implement some of the priority objectives set out in the 2030 Agenda. The operational tools supporting the approach are the Contingent Valuation Method (CVM), public and private partnership (PPP) and crowdfunding. This approach supported the selection of the project and the creation of a budget with public and private funding to support the participatory rehabilitation of a residual green urban area in the municipality of Acireale. The amount of funding identified largely covers rehabilitation costs. The issue of the quality and quantity of urban greenery is crucial for the sustainability and resilience of cities to climate change. Rehabilitation of remaining urban green areas is an opportunity to meet the new needs of green areas, supporting communities in this new challenge.
Keywords	climate change ; contingent valuation ; new order ; urban areas ; vegetation
Language	English
Dates of publication	2021-0604
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2777960-9
ISSN	2076-3298
ISSN	2076-3298
DOI	10.3390/environments8060053
Database	NAL-Catalogue (AGRICOLA)

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Article: Climate Adaptation Heuristic Planning Support System (HPSS): Green-Blue Strategies to Support the Ecological Transition of Historic Centres

Trovato, Maria Rosa / Cappello, Cheren

Land. 2022 May 24, v. 11, no. 6

2022

Abstract: The issue of climate has posed major and urgent challenges for the global community. The European Green Deal sets out a new growth strategy aimed at turning the European Union into a just and prosperous society, with a modern, resource-efficient, and ... ...

Abstract	The issue of climate has posed major and urgent challenges for the global community. The European Green Deal sets out a new growth strategy aimed at turning the European Union into a just and prosperous society, with a modern, resource-efficient, and competitive economy, which will no longer generate net greenhouse gas emissions by 2050. Cities in this context are committed on several fronts to rapid adaptation to improve their resilience capacity. The historic centre is the most vulnerable part of a city, with a reduced capacity for adaptation, but also the densest of values, which increase the complexity of the challenge. This study proposes an integrated tool, Heuristic Planning Support System (HPSS), aimed at exploring green-blue strategies for the historic centre. The tool is integrated with classic Planning Support System (PSS), a decision process conducted from the perspective of heuristic approach and Geographic Information System (GIS). It comprises modules for technical assessment, environmental assessment Life Cycle Assessment (LCA), economic assessment Life Cycle Cost (LCC), Life Cycle Revenues (LCR), and Discounted Cash Flow Analysis (DCFA) extended to the life cycle of specific interventions, the Multi-Attribute Value Theory (MAVT) for the assessment of energy, environmental, identity, landscape, and economic values. The development of a tool to support the ecological transition of historic centres stems from the initiative of researchers at the University of Catania, who developed it based on the preferences expressed by a group of decision makers, that is, a group of local administrators, scholars, and professionals. The proposed tool supports the exploration of green-blue strategies identified by decision makers and the development of the plan for the historic district of Borgata di Santa Lucia in Syracuse.
Keywords	European Union ; cash flow analysis ; climate ; energy ; environmental assessment ; geographic information systems ; greenhouse gases ; land ; landscapes ; life cycle assessment ; life cycle costing ; society
Language	English
Dates of publication	2022-0524
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2682955-1
ISSN	2073-445X
ISSN	2073-445X
DOI	10.3390/land11060773
Database	NAL-Catalogue (AGRICOLA)

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