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  1. Book ; Thesis: Immunologische Charakterisierung protektiver CD4 + -T-Lymphozyten bei der murinen Masernvirus-Enzephalitis

    Finke, Daniela

    1994  

    Author's details vorgelegt von Daniela Finke
    Language German
    Size VII, 122 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1994
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT006701409
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 MB 1955 order for loan Magazin

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  2. Article: Lower visual processing speed relates to greater subjective cognitive complaints in community-dwelling healthy older adults.

    Marrero-Polegre, Daniela / Finke, Kathrin / Roaschio, Naomi / Haupt, Marleen / Reyes-Moreno, Cristian / Ruiz-Rizzo, Adriana L

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1063151

    Abstract: Introduction: Subjective cognitive complaints in older age may reflect subtle objective impairments in basic cognitive functions that might foreshadow broader cognitive problems. Such cognitive functions, however, are not captured by standard ... ...

    Abstract Introduction: Subjective cognitive complaints in older age may reflect subtle objective impairments in basic cognitive functions that might foreshadow broader cognitive problems. Such cognitive functions, however, are not captured by standard neuropsychological testing. Visual processing speed is a basic visual attention function that underlies the performance of cognitive tasks relying on visual stimuli. Here, we test the hypothesis that lower visual processing speed correlates with greater subjective cognitive complaints in healthy older adults from the community.
    Methods: To do so, we assessed a sample of 30 healthy, cognitively normal older adults (73.07 ± 7.73 years old; range: 60-82; 15 females) with respect to individual subjective cognitive complaints and visual processing speed. We quantified the degree of subjective cognitive complaints with two widely-used questionnaires: the Memory Functioning Questionnaire and the Everyday Cognition. We used verbal report tasks and the theory of visual attention to estimate a visual processing speed parameter independently from motor speed and other visual attention parameters, i.e., visual threshold, visual short-term memory storage capacity, top-down control, and spatial weighting.
    Results: We found that lower visual processing speed correlated with greater subjective complaints and that this relationship was not explained by age, education, or depressive symptoms. The association with subjective cognitive complaints was specific to visual processing speed, as it was not observed for other visual attention parameters.
    Discussion: These results indicate that subjective cognitive complaints reflect a reduction in visual processing speed in healthy older adults. Together, our results suggest that the combined assessment of subjective cognitive complaints and visual processing speed has the potential to identify individuals at risk for cognitive impairment before the standard tests show any abnormal results.
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1063151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cellular and Humoral SARS-CoV-2 Vaccination Responses in 192 Adult Recipients of Allogeneic Hematopoietic Cell Transplantation.

    Meyer, Thomas / Ihorst, Gabriele / Bartsch, Ingrid / Zeiser, Robert / Wäsch, Ralph / Bertz, Hartmut / Finke, Jürgen / Huzly, Daniela / Wehr, Claudia

    Vaccines

    2022  Volume 10, Issue 11

    Abstract: To determine factors influencing the vaccination response against SARS-CoV-2 is of importance in recipients of allogeneic hematopoietic cell transplantation (allo-HCT) as they display an increased mortality after SARS-CoV-2 infection, an increased risk ... ...

    Abstract To determine factors influencing the vaccination response against SARS-CoV-2 is of importance in recipients of allogeneic hematopoietic cell transplantation (allo-HCT) as they display an increased mortality after SARS-CoV-2 infection, an increased risk of extended viral persistence and reduced vaccination response. Real-life data on anti-SARS-CoV-2-S1-IgG titers (
    Language English
    Publishing date 2022-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10111782
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  4. Article ; Online: Induction of intestinal lymphoid tissue formation by intrinsic and extrinsic signals.

    Finke, Daniela

    Seminars in immunopathology

    2009  Volume 31, Issue 2, Page(s) 151–169

    Abstract: Since the discovery of inducer cells as a separate lineage for organogenesis of Peyer's patches in the small intestine of fetal mice, a lot of progress has been made in understanding the molecular pathways involved in the generation of lymphoid tissue ... ...

    Abstract Since the discovery of inducer cells as a separate lineage for organogenesis of Peyer's patches in the small intestine of fetal mice, a lot of progress has been made in understanding the molecular pathways involved in the generation of lymphoid tissue and the maintenance of the lymphoid architecture. The findings that inducer cells also exist in adult mice and in humans, have a lineage relationship to natural killer cells, and can be stimulated during infections highlight their possible role in establishing innate and adaptive immune responses. Novel concepts in the development of intestinal lymphoid tissues have been made in the past few years suggesting that lymphoid organs are more plastic as previously thought and depend on antigenic stimulation. In addition, the generation of novel lymphoid organs in the gut under inflammatory conditions indicates a function in chronic diseases. The present review summarizes current knowledge on the basic framework of signals required for developing lymphoid tissue under normal and inflammatory conditions.
    MeSH term(s) Adult ; Animals ; Chronic Disease ; Humans ; Immunity, Innate ; Immunity, Mucosal ; Inflammation/immunology ; Inflammation/pathology ; Intestinal Diseases/immunology ; Intestinal Diseases/pathology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Mice ; Peyer's Patches/immunology ; Peyer's Patches/pathology
    Language English
    Publishing date 2009-06-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-009-0163-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Personzentrierte Therapie von Schmerzsyndromen

    Leithner, Daniela / Finke, Jobst

    Person

    2016  Volume 20, Issue 1, Page(s) 39

    Language German
    Document type Article
    ZDB-ID 1457385-4
    ISSN 1028-6837
    Database Current Contents Medicine

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    Zs.A 5148: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: NKp46 Calibrates Tumoricidal Potential of Type 1 Innate Lymphocytes by Regulating TRAIL Expression.

    Turchinovich, Gleb / Ganter, Stefan / Bärenwaldt, Anne / Finke, Daniela

    Journal of immunology (Baltimore, Md. : 1950)

    2018  Volume 200, Issue 11, Page(s) 3762–3768

    Abstract: NK cells are a subset of group 1 innate lymphocytes that recognize and eliminate virus-infected and transformed cells. During the course of their development, NK cells acquire a repertoire of activating and inhibitory receptors, which ultimately define ... ...

    Abstract NK cells are a subset of group 1 innate lymphocytes that recognize and eliminate virus-infected and transformed cells. During the course of their development, NK cells acquire a repertoire of activating and inhibitory receptors, which ultimately define their reactivity against target cells. The array of receptors and their specificity during early developmental stages will control and imprint functional properties of NK cells, a process known as "NK cell education." Innate lymphoid cells (ILCs) are a diverse group of lymphocytes, which, like NK cells, do not rely on somatically rearranged Ag receptors for recognition. Among ILC subsets, ILC1s are most like NK cells functionally. Prototypic ILC1s reside in the liver, and a large part of their function is attributed to the expression of TRAIL, a TNF superfamily member with a well-documented antitumor activity. In this article, we show that TRAIL expression on mouse ILC1s is controlled by an activating receptor NKp46, which has been previously shown to control NK cell education. In the absence of NKp46, ILC1s fail to express normal levels of TRAIL on the surface, which results in diminished cytotoxicity toward TRAIL receptor-positive targets. To our knowledge, these findings provide the first evidence of a role of NKp46 in ILC1s that calibrates their antitumor response.
    MeSH term(s) Animals ; Antigens, Ly/immunology ; Cell Line ; Cytotoxicity, Immunologic/immunology ; Humans ; Immunity, Innate/immunology ; Killer Cells, Natural/immunology ; Liver/immunology ; Lymphocytes/immunology ; Mice ; Mice, Inbred C57BL ; Natural Cytotoxicity Triggering Receptor 1/immunology ; Neoplasms/immunology ; TNF-Related Apoptosis-Inducing Ligand/immunology
    Chemical Substances Antigens, Ly ; Natural Cytotoxicity Triggering Receptor 1 ; Ncr1 protein, mouse ; TNF-Related Apoptosis-Inducing Ligand ; Tnfsf10 protein, mouse
    Language English
    Publishing date 2018-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1701333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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    Zs.MG 28: Show issues

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  7. Book ; Online ; Thesis: Age-related changes in visual attention capacity and the impact of cognitive training

    Penning, Melanie Daniela [Verfasser] / Finke, Kathrin [Akademischer Betreuer]

    2019  

    Author's details Melanie Daniela Penning ; Betreuer: Kathrin Finke
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  8. Article ; Online: Cellular and Humoral SARS-CoV-2 Vaccination Responses in 192 Adult Recipients of Allogeneic Hematopoietic Cell Transplantation

    Thomas Meyer / Gabriele Ihorst / Ingrid Bartsch / Robert Zeiser / Ralph Wäsch / Hartmut Bertz / Jürgen Finke / Daniela Huzly / Claudia Wehr

    Vaccines, Vol 10, Iss 1782, p

    2022  Volume 1782

    Abstract: To determine factors influencing the vaccination response against SARS-CoV-2 is of importance in recipients of allogeneic hematopoietic cell transplantation (allo-HCT) as they display an increased mortality after SARS-CoV-2 infection, an increased risk ... ...

    Abstract To determine factors influencing the vaccination response against SARS-CoV-2 is of importance in recipients of allogeneic hematopoietic cell transplantation (allo-HCT) as they display an increased mortality after SARS-CoV-2 infection, an increased risk of extended viral persistence and reduced vaccination response. Real-life data on anti-SARS-CoV-2-S1-IgG titers ( n = 192) and IFN-γ release ( n = 110) of allo-HCT recipients were obtained using commercially available, validated assays after vaccination with either mRNA (Comirnaty™, Pfizer-BioNTech™, NY, US and Mainz, Germany or Spikevax™, Moderna™, Cambridge, Massachusetts, US) or vector-based vaccines (Vaxzevria™,AstraZeneca™, Cambridge, UK or Janssen COVID-19 vaccine™Johnson/Johnson, New Brunswick, New Jersey, US), or after a heterologous protocol (vector/mRNA). Humoral response (78% response rate) was influenced by age, time after transplantation, the usage of antithymocyte globulin (ATG) and ongoing immunosuppression, specifically corticosteroids. High counts of B cells during the vaccination period correlated with a humoral response. Only half (55%) of participants showed a cellular vaccination response. It depended on age, time after transplantation, ongoing immunosuppression with ciclosporin A, chronic graft-versus-host disease (cGvHD) and vaccination type, with vector-based protocols favoring a response. Cellular response failure correlated with a higher CD8+ count and activated/HLA-DR+ T cells one year after transplantation. Our data provide the basis to assess both humoral and cellular responses after SARS-CoV2 vaccination in daily practice, thereby opening up the possibility to identify patients at risk.
    Keywords SARS-CoV-2 ; allogeneic hematopoietic cell transplantation (allo-HCT) ; IFN-γ release assay (IGRA) ; specific antibody titer ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Fate and function of lymphoid tissue inducer cells.

    Finke, Daniela

    Current opinion in immunology

    2005  Volume 17, Issue 2, Page(s) 144–150

    Abstract: The discovery that Peyer's patch and lymph node development is regulated by the collaboration between fetal hematopoietic cells and mesenchymal cells has thrown new light on our understanding of the mechanisms underlying the formation of lymphoid organs. ...

    Abstract The discovery that Peyer's patch and lymph node development is regulated by the collaboration between fetal hematopoietic cells and mesenchymal cells has thrown new light on our understanding of the mechanisms underlying the formation of lymphoid organs. Lymphoid tissue inducer cells trigger a coordinated series of events leading to cell clustering and changes in gene expression and differentiation. Nevertheless, many questions regarding the origin, recruitment and fate of the inducer cells and cellular crosstalk with neighboring cells remain unanswered.
    MeSH term(s) Animals ; Cell Adhesion Molecules/physiology ; Cell Communication/physiology ; Cell Differentiation/physiology ; Cell Movement/physiology ; Chemokines/physiology ; Embryonic Induction/physiology ; Humans ; Lymphoid Tissue/embryology ; Lymphoid Tissue/physiology
    Chemical Substances Cell Adhesion Molecules ; Chemokines
    Language English
    Publishing date 2005-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2005.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2773: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 13: Show issues

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  10. Article ; Online: mTOR signaling mediates ILC3-driven immunopathology.

    Teufel, Claudia / Horvath, Edit / Peter, Annick / Ercan, Caner / Piscuoglio, Salvatore / Hall, Michael N / Finke, Daniela / Lehmann, Frank M

    Mucosal immunology

    2021  Volume 14, Issue 6, Page(s) 1323–1334

    Abstract: Innate lymphoid cells (ILCs) have a protective immune function at mucosal tissues but can also contribute to immunopathology. Previous work has shown that the serine/threonine kinase mammalian target of rapamycin complex 1 (mTORC1) is involved in ... ...

    Abstract Innate lymphoid cells (ILCs) have a protective immune function at mucosal tissues but can also contribute to immunopathology. Previous work has shown that the serine/threonine kinase mammalian target of rapamycin complex 1 (mTORC1) is involved in generating protective ILC3 cytokine responses during bacterial infection. However, whether mTORC1 also regulates IFN-γ-mediated immunopathology has not been investigated. In addition, the role of mTORC2 in ILC3s is unknown. Using mice specifically defective for either mTORC1 or mTORC2 in ILC3s, we show that both mTOR complexes regulate the maintenance of ILC3s at steady state and pathological immune response during colitis. mTORC1 and to a lesser extend mTORC2 promote the proliferation of ILC3s in the small intestine. Upon activation, intestinal ILC3s produce less IFN-γ in the absence of mTOR signaling. During colitis, loss of both mTOR complexes in colonic ILC3s results in the reduced production of inflammatory mediators, recruitment of neutrophils and immunopathology. Similarly, treatment with rapamycin after colitis induction ameliorates the disease. Collectively, our data show a critical role for both mTOR complexes in controlling ILC3 cell numbers and ILC3-driven inflammation in the intestine.
    MeSH term(s) Animals ; Biomarkers ; Bone Marrow Transplantation ; Colitis/etiology ; Colitis/metabolism ; Colitis/pathology ; Cytokines/metabolism ; DNA-Binding Proteins/deficiency ; Disease Susceptibility ; Immunity, Innate ; Immunomodulation ; Immunophenotyping ; Inflammation Mediators/metabolism ; Intestine, Small/immunology ; Intestine, Small/metabolism ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Mice ; Mice, Knockout ; Organ Specificity ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Transplantation Chimera
    Chemical Substances Biomarkers ; Cytokines ; DNA-Binding Proteins ; Inflammation Mediators ; Rag2 protein, mouse ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1038/s41385-021-00432-4
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    Zs.A 6796: Show issues Location:
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