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Article ; Online: Fostering Early Career Nursing Faculty Support in the Academy: The Power of "Academic Therapy".

Solberg, Marvin A / Schlegel, Emma C / Spurlock, Elizabeth J / Blair, Lisa M / Nowak, Alexandra L

2023 Volume 49, Issue 2, Page(s) E97–E98

MeSH term(s)	Humans ; Faculty, Nursing ; Nursing Education Research ; Mentors ; Faculty, Medical ; Career Mobility
Language	English
Publishing date	2023-08-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1034267-9
ISSN	1538-9855 ; 0363-3624
ISSN (online)	1538-9855
ISSN	0363-3624
DOI	10.1097/NNE.0000000000001504
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Zs.A 2904: Show issues

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Article ; Online: Stress Fractures in the Military: Opportunities to Advance Recognition, Treatment, and Prevention.

Nowak, Andrew S / Kennelley, Gabrielle E / Hager, Nelson / Metzger, Elizabeth C / Isaacson, Brad / Hoenig, Tim / Hollander, Karsten / Tenforde, Adam S

Military medicine

2023 Volume 188, Issue 9-10, Page(s) 244–245

MeSH term(s)	Humans ; Fractures, Stress/prevention & control ; Military Personnel
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usad067
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Un I Zs.546: Show issues

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Article ; Online: Catheter-Based Medical Device Biofilm Ablation Using Histotripsy: A Parameter Study.

Morse, Ryan / Childers, Christopher / Nowak, Elizabeth / Rao, Jayasimha / Vlaisavljevich, Eli

Ultrasound in medicine & biology

2023 Volume 49, Issue 9, Page(s) 2152–2159

Abstract: Objective: Biofilm formation in medical catheters is a major source of hospital-acquired infections which can produce increased morbidity and mortality for patients. Histotripsy is a non-invasive, non-thermal focused ultrasound therapy and recently has ... ...

Abstract	Objective: Biofilm formation in medical catheters is a major source of hospital-acquired infections which can produce increased morbidity and mortality for patients. Histotripsy is a non-invasive, non-thermal focused ultrasound therapy and recently has been found to be effective at removal of biofilm from medical catheters. Previously established histotripsy methods for biofilm removal, however, would require several hours of use to effectively treat a full-length medical catheter. Here, we investigate the potential to increase the speed and efficiency with which biofilms can be ablated from catheters using histotripsy. Methods: Pseudomonas aeruginosa (PA14) biofilms were cultured in in vitro Tygon catheter mimics and treated with histotripsy using a 1 MHz histotripsy transducer and a variety of histotripsy pulsing rates and scanning methods. The improved parameters identified in these studies were then used to explore the bactericidal effect of histotripsy on planktonic PA14 suspended in a catheter mimic. Results: Histotripsy can be used to remove biofilm and kill bacteria at substantially increased speeds compared with previously established methods. Near-complete biofilm removal was achieved at treatment speeds up to 1 cm/s, while a 4.241 log reduction in planktonic bacteria was achieved with 2.4 cm/min treatment. Conclusion: These results represent a 500-fold increase in biofilm removal speeds and a 6.2-fold increase in bacterial killing speeds compared with previously published methods. These findings indicate that histotripsy shows promise for the treatment of catheter-associated biofilms and planktonic bacteria in a clinically relevant time frame.
MeSH term(s)	Humans ; Anti-Bacterial Agents/therapeutic use ; Catheters ; Cross Infection ; Biofilms
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-07-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186150-5
ISSN	1879-291X ; 0301-5629
ISSN (online)	1879-291X
ISSN	0301-5629
DOI	10.1016/j.ultrasmedbio.2023.06.010
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Zs.A 963: Show issues

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Article ; Online: Extubation of Patients Receiving Vasopressor Infusions: Results of a Survey on Statewide Practices.

Costa, Deena Kelly / Ratliff, Hannah C / Kelly, Meghan / Prescott, Hallie C / Munroe, Elizabeth / Hyzy, Robert C / Watson, Sam / Nowak, Corine / Iwashyna, Theodore J

American journal of critical care : an official publication, American Association of Critical-Care Nurses

2023 Volume 32, Issue 2, Page(s) 127–130

Abstract: Current guidelines recommend extubation only if a patient is not receiving vasopressor therapy or is receiving minimal doses of vasopressors. However, recent data indicate that extubation of patients receiving higher vasopressor doses may be safe. This ... ...

Abstract	Current guidelines recommend extubation only if a patient is not receiving vasopressor therapy or is receiving minimal doses of vasopressors. However, recent data indicate that extubation of patients receiving higher vasopressor doses may be safe. This study was undertaken to examine practices regarding extubation of patients receiving vasopressor therapy reported by clinician respondents to a survey by the Michigan Health and Hospital Association Keystone Center. One-third of respondents indicated that they would extubate a patient receiving vasopressors, and one-quarter indicated that it depended on the agent used, but more than half reported that their unit did not have a vasopressor use protocol or they did not know whether it did. Practices regarding extubation of patients receiving vasopressor therapy differed significantly by unit type and by role as a direct care provider. These data indicate that patient and clinician factors may drive practice patterns. Additional research to inform guidelines and local protocols is warranted.
MeSH term(s)	Humans ; Airway Extubation ; Hospitals ; Patients ; Vasoconstrictor Agents/therapeutic use ; Surveys and Questionnaires
Chemical Substances	Vasoconstrictor Agents
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1130987-8
ISSN	1937-710X ; 1062-3264
ISSN (online)	1937-710X
ISSN	1062-3264
DOI	10.4037/ajcc2023489
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Zs.A 3502: Show issues

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Article ; Online: Pharmacotherapy considerations in transgender individuals living with human immunodeficiency virus.

Badowski, Melissa E / Britt, Nicholas / Huesgen, Emily C / Lewis, Michelle M / Miller, Misty M / Nowak, Kathleen / Sherman, Elizabeth / Smith, Renata O

Pharmacotherapy

2021 Volume 41, Issue 3, Page(s) 299–314

Abstract: Pharmacotherapy considerations are often a concern for transgender individuals who are living with human immunodeficiency virus (HIV) due to concerns for drug-drug interactions between their hormone and antiretroviral therapies. Many of the first-line ... ...

Abstract	Pharmacotherapy considerations are often a concern for transgender individuals who are living with human immunodeficiency virus (HIV) due to concerns for drug-drug interactions between their hormone and antiretroviral therapies. Many of the first-line therapies offered to patients for the management of HIV have reduced concerns for safety, resistance, and drug-drug interactions. In this review, we highlight common medications and important considerations for caring for transgender people living with HIV.
MeSH term(s)	Drug Interactions ; Female ; HIV Infections/drug therapy ; Humans ; Male ; Transgender Persons
Language	English
Publishing date	2021-02-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603158-4
ISSN	1875-9114 ; 0277-0008
ISSN (online)	1875-9114
ISSN	0277-0008
DOI	10.1002/phar.2499
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Zs.A 1738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 585: Show issues

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Article ; Online: VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance.

Schaafsma, Evelien / Croteau, Walburga / ElTanbouly, Mohamed / Nowak, Elizabeth C / Smits, Nicole C / Deng, Jie / Sarde, Aurelien / Webber, Cecilia A / Rabadi, Dina / Cheng, Chao / Noelle, Randolph / Lines, J Louise

Cancer immunology research

2022 Volume 11, Issue 1, Page(s) 38–55

Abstract: V domain immunoglobulin suppressor of T-cell activation (VISTA) is a premier target for cancer treatment due to its broad expression in many cancer types and enhanced expression upon development of adaptive immune checkpoint resistance. In the CT26 ... ...

Abstract	V domain immunoglobulin suppressor of T-cell activation (VISTA) is a premier target for cancer treatment due to its broad expression in many cancer types and enhanced expression upon development of adaptive immune checkpoint resistance. In the CT26 colorectal cancer model, monotherapy of small tumors with anti-VISTA resulted in slowed tumor growth. In a combination therapy setting, large CT26 tumors showed complete adaptive resistance to anti-PD-1/CTLA-4, but inclusion of anti-VISTA led to rejection of half the tumors. Mechanisms of enhanced antitumor immunity were investigated using single-cell RNA sequencing (scRNA-seq), multiplex image analysis, and flow cytometry of the tumor immune infiltrate. In both treatment models, anti-VISTA upregulated stimulated antigen presentation pathways and reduced myeloid-mediated suppression. Imaging revealed an anti-VISTA stimulated increase in contacts between T cells and myeloid cells, further supporting the notion of increased antigen presentation. scRNA-seq of tumor-specific CD8+ T cells revealed that anti-VISTA therapy induced T-cell pathways highly distinct from and complementary to those induced by anti-PD-1 therapy. Whereas anti-CTLA-4/PD-1 expanded progenitor exhausted CD8+ T-cell subsets, anti-VISTA promoted costimulatory genes and reduced regulators of T-cell quiescence. Notably, this is the first report of a checkpoint regulator impacting CD8+ T-cell quiescence, and the first indication that quiescence may be a target in the context of T-cell exhaustion and in cancer. This study builds a foundation for all future studies on the role of anti-VISTA in the development of antitumor immunity and provides important mechanistic insights that strongly support use of anti-VISTA to overcome the adaptive resistance seen in contemporary treatments involving PD-1 and/or CTLA-4. See related Spotlight by Wei, p. 3.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors ; B7 Antigens/immunology ; Neoplasms/immunology ; CD8-Positive T-Lymphocytes/immunology ; Lymphocyte Activation/immunology ; Immunoglobulins
Chemical Substances	Immune Checkpoint Inhibitors ; B7 Antigens ; Immunoglobulins
Language	English
Publishing date	2022-10-21
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	2732489-8
ISSN	2326-6074 ; 2326-6066
ISSN (online)	2326-6074
ISSN	2326-6066
DOI	10.1158/2326-6066.CIR-22-0116
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Zs.A 7022: Show issues

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Article: Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis.

Chandraratna, Roshantha As / Noelle, Randolph J / Nowak, Elizabeth C

American journal of translational research

2016 Volume 8, Issue 2, Page(s) 1016–1026

Abstract: Retinoid x receptors (RXRs) are master regulators that control cell growth, differentiation, and survival and form heterodimers with many other family members. Here we show that treatment with the RXR agonist IRX4204 enhances the differentiation of CD4(+) ...

Abstract	Retinoid x receptors (RXRs) are master regulators that control cell growth, differentiation, and survival and form heterodimers with many other family members. Here we show that treatment with the RXR agonist IRX4204 enhances the differentiation of CD4(+) T cells into inducible regulatory T cells (iTreg) and suppresses the development of T helper (Th) 17 cells in vitro. Furthermore in a murine model of multiple sclerosis (experimental autoimmune encephalomyelitis (EAE)), treatment with IRX4204 profoundly attenuates both active and Th17-mediated passive disease. In the periphery, treatment with IRX4204 is associated with decreased numbers of CD4(+) T cells that produce pro-inflammatory cytokines. In addition, CD4(+) T cells express decreased levels of Ki-67 and increased expression of CTLA-4. Our findings demonstrate IRX4204 treatment during EAE results in immune modulation and profound attenuation of disease severity.
Language	English
Publishing date	2016-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Machine Learning Models for Prediction of Posttreatment Recurrence in Early-Stage Hepatocellular Carcinoma Using Pretreatment Clinical and MRI Features: A Proof-of-Concept Study.

Iseke, Simon / Zeevi, Tal / Kucukkaya, Ahmet S / Raju, Rajiv / Gross, Moritz / Haider, Stefan P / Petukhova-Greenstein, Alexandra / Kuhn, Tom N / Lin, MingDe / Nowak, Michal / Cooper, Kirsten / Thomas, Elizabeth / Weber, Marc-André / Madoff, David C / Staib, Lawrence / Batra, Ramesh / Chapiro, Julius

AJR. American journal of roentgenology

2022 Volume 220, Issue 2, Page(s) 245–255

Abstract: BACKGROUND. ...

Abstract	BACKGROUND.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/surgery ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Retrospective Studies ; Risk Factors ; Magnetic Resonance Imaging/methods ; Neoplasm Recurrence, Local/epidemiology
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.22.28077
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Article ; Online: Diagnostic TR-FRET assays for detection of antibodies in patient samples.

Cell reports methods

2023 Volume 3, Issue 3, Page(s) 100421

Abstract: Serological assays are important diagnostic tools for surveying exposure to the pathogen, monitoring immune response post vaccination, and managing spread of the infectious agent among the population. Current serological laboratory assays are often ... ...

Abstract	Serological assays are important diagnostic tools for surveying exposure to the pathogen, monitoring immune response post vaccination, and managing spread of the infectious agent among the population. Current serological laboratory assays are often limited because they require the use of specialized laboratory technology and/or work with a limited number of sample types. Here, we evaluate an alternative by developing time-resolved Förster resonance energy transfer (TR-FRET) homogeneous assays that exhibited exceptional versatility, scalability, and sensitivity and outperformed or matched currently used strategies in terms of sensitivity, specificity, and precision. We validated the performance of the assays measuring total immunoglobulin G (IgG) levels; antibodies against severe acute respiratory syndrome coronavirus (SARS-CoV) or Middle Eastern respiratory syndrome (MERS)-CoV spike (S) protein; and SARS-CoV-2 S and nucleocapsid (N) proteins and applied it to several large sample sets and real-world applications. We further established a TR-FRET-based ACE2-S competition assay to assess the neutralization propensity of the antibodies. Overall, these TR-FRET-based serological assays can be rapidly extended to other antigens and are compatible with commonly used plate readers.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; Fluorescence Resonance Energy Transfer ; Antibodies, Viral ; Nucleocapsid ; COVID-19 Testing
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2023-02-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2667-2375
ISSN (online)	2667-2375
DOI	10.1016/j.crmeth.2023.100421
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Article ; Online: Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection.

Parzych, Elizabeth M / Gulati, Sunita / Zheng, Bo / Bah, Mamadou A / Elliott, Sarah T C / Chu, Jacqueline D / Nowak, Nancy / Reed, George W / Beurskens, Frank J / Schuurman, Janine / Rice, Peter A / Weiner, David B / Ram, Sanjay

mBio

2021 Volume 12, Issue 2

Abstract: Monoclonal antibody (MAb) 2C7 recognizes a lipooligosaccharide epitope expressed by most ... ...

Abstract	Monoclonal antibody (MAb) 2C7 recognizes a lipooligosaccharide epitope expressed by most clinical
MeSH term(s)	Animals ; Antibodies, Bacterial/administration & dosage ; Antibodies, Bacterial/genetics ; Antibodies, Bacterial/immunology ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Antigens, Bacterial/immunology ; Bacterial Vaccines/administration & dosage ; Bacterial Vaccines/immunology ; Complement Activation ; Epitopes/immunology ; Female ; Gonorrhea/immunology ; Gonorrhea/prevention & control ; Immunization, Passive ; Immunoglobulin G/administration & dosage ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Mice ; Mice, Inbred BALB C ; Neisseria gonorrhoeae/immunology
Chemical Substances	Antibodies, Bacterial ; Antibodies, Monoclonal ; Antigens, Bacterial ; Bacterial Vaccines ; Epitopes ; Immunoglobulin G
Language	English
Publishing date	2021-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.00242-21
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