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  1. Article ; Online: Antithymocyte globulin for aplastic anemia secondary to pembrolizumab: a case report and review of literature.

    Yeung, Cynthia / Relke, Nicole / Good, David / Satkunam, Natasha / Mates, Mihaela

    Immunotherapy

    2023  Volume 15, Issue 5, Page(s) 323–333

    Abstract: Aplastic anemia is a rare but potentially serious complication of immune checkpoint inhibitor therapy. The authors present a case of pembrolizumab-induced aplastic anemia that was refractory to steroids but had some hematologic response to modified- ... ...

    Abstract Aplastic anemia is a rare but potentially serious complication of immune checkpoint inhibitor therapy. The authors present a case of pembrolizumab-induced aplastic anemia that was refractory to steroids but had some hematologic response to modified-dosing antithymocyte globulin (ATG). This is the first reported case of hematological response to ATG for immune checkpoint inhibitor-induced aplastic anemia and the first reported case of modified ATG dosing for this indication. Cases of immune checkpoint inhibitor-induced aplastic anemia and management options are also summarized. Given the high morbidity and mortality associated with ICI-induced aplastic anemia, more data is necessary to guide evidence-based management recommendations.
    MeSH term(s) Humans ; Anemia, Aplastic/drug therapy ; Antilymphocyte Serum/adverse effects ; Immune Checkpoint Inhibitors ; Antibodies, Monoclonal, Humanized/adverse effects
    Chemical Substances pembrolizumab (DPT0O3T46P) ; Antilymphocyte Serum ; Immune Checkpoint Inhibitors ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2022-0210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Internal medicine residents' and program directors' perception of virtual interviews during COVID-19: a national survey.

    Relke, Nicole / Soleas, Eleftherios / Lui, C Janet

    Canadian medical education journal

    2022  Volume 13, Issue 3, Page(s) 37–42

    Abstract: Purpose: Due to the coronavirus disease 2019 pandemic, all Canadian Resident Matching Service interviews for internal medicine subspecialty programs were conducted virtually for the first time. This study explored the perceptions and experiences of ... ...

    Abstract Purpose: Due to the coronavirus disease 2019 pandemic, all Canadian Resident Matching Service interviews for internal medicine subspecialty programs were conducted virtually for the first time. This study explored the perceptions and experiences of internal medicine residents, subspecialty medicine program directors, and interviewers during virtual interviews.
    Methods: We invited all Canadian third-year IM residents, subspecialty program directors, and interviewers who participated in the 2020 medical subspecialty medicine interviews to complete a branching survey with a section for residents and one for program directors and interviewers. We distributed the anonymous survey after the submission of the rank order lists, to not affect residency match outcomes. Qualitative data were open-coded thematically and quantitative data were cleaned and then statistically analyzed using descriptive statistics and Analysis of Variance tests.
    Results: 62 residents, 59 program directors, and 113 interviewers responded to the survey with representation from almost all Canadian medical faculties and medical subspecialties. Strengths of virtual interviews included reduced cost, stress, pandemic infection risk, and carbon footprint. Weaknesses of virtual interviews included decreased ability to connect personally and informally, and inability to tour medical facilities and cities. A majority of both resident respondents (59.6%) and program directors/interviewer respondents (54.6%) supported conducting interviews virtually in the future.
    Conclusions: This study showed that the majority of both sampled residents and program directors/interviewers would prefer to conduct medicine subspecialty match interviews virtually in the future, and provides suggestions on how to improve the virtual interviews for the next iteration.
    Language English
    Publishing date 2022-07-06
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2689512-2
    ISSN 1923-1202
    ISSN 1923-1202
    DOI 10.36834/cmej.72982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Internal medicine residents' and program directors' perception of virtual interviews during COVID-19: a national survey.

    Relke, Nicole / Soleas, Eleftherios / Lui, Janet

    Canadian medical education journal

    2021  Volume 12, Issue 2, Page(s) e129–e130

    Language English
    Publishing date 2021-04-30
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2689512-2
    ISSN 1923-1202
    ISSN 1923-1202
    DOI 10.36834/cmej.71041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tranexamic acid evidence and controversies: An illustrated review.

    Relke, Nicole / Chornenki, Nicholas L J / Sholzberg, Michelle

    Research and practice in thrombosis and haemostasis

    2021  Volume 5, Issue 5, Page(s) e12546

    Abstract: Tranexamic acid (TXA) is an antifibrinolytic agent commonly used for the treatment or prevention of bleeding. Indications for TXA are diverse, including heavy menstrual bleeding, trauma, postpartum hemorrhage, traumatic brain injury, and surgical site ... ...

    Abstract Tranexamic acid (TXA) is an antifibrinolytic agent commonly used for the treatment or prevention of bleeding. Indications for TXA are diverse, including heavy menstrual bleeding, trauma, postpartum hemorrhage, traumatic brain injury, and surgical site bleeding. Despite decades of use and a robust body of evidence, hesitancy using TXA persists in many clinical settings. This illustrated review describes the history, pharmacology, and practical considerations of TXA use. We also describe the major landmark randomized controlled trials of TXA and their implications. Finally, we review the evidence around common controversies surrounding TXA such as the risk of thrombosis, prescription along with combined hormonal contraceptives, and use in patients with gross hematuria.
    Language English
    Publishing date 2021-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Use of Janus Kinase Inhibitors in Vitiligo: A Review of the Literature.

    Relke, Nicole / Gooderham, Melinda

    Journal of cutaneous medicine and surgery

    2019  Volume 23, Issue 3, Page(s) 298–306

    Abstract: Vitiligo is a common acquired depigmenting disorder characterized by the development of white macules and patches due to the loss of melanocytes. Patients with vitiligo can be stigmatized by society, making the disease a source of psychological stress ... ...

    Abstract Vitiligo is a common acquired depigmenting disorder characterized by the development of white macules and patches due to the loss of melanocytes. Patients with vitiligo can be stigmatized by society, making the disease a source of psychological stress that can considerably affect quality of life. The goal of vitiligo treatment is to obtain skin repigmentation in the majority of cases, and less commonly to depigment the remaining normal skin. There is no consistent, long-term, durable therapy for vitiligo for all patients, highlighting the unmet need for new safe and effective therapies to control this disease. Recently, JAK inhibitors have been explored as a promising novel treatment option in vitiligo. The JAK and signal transducers and activators of transcription (STAT) pathway is an attractive therapeutic target because IFN-γ-dependent cytokines produced through this pathway have been implicated in the pathogenesis of disease. This literature review describes vitiligo pathophysiology, explains the usefulness of the JAK inhibitors for treatment, and summarizes published case reports, case series, and open-label studies. Research outlined here shows JAK inhibitors in patients with vitiligo have a favorable safety profile and effectively produce repigmentation of lesions, especially with concomitant ultraviolet exposure. Additional studies are required to confirm efficacy, establish safety, and investigate durability of repigmentation.
    MeSH term(s) Humans ; Janus Kinase Inhibitors/therapeutic use ; Vitiligo/drug therapy ; Vitiligo/physiopathology
    Chemical Substances Janus Kinase Inhibitors
    Language English
    Publishing date 2019-03-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/1203475419833609
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: Going virtual advances justice in expected and unexpected ways.

    Soleas, Eleftherios / Relke, Nicole / Fernandes, Rosephine Del / Braund, Heather / Zevin, Boris / Lui, Janet

    Canadian medical education journal

    2022  Volume 13, Issue 6, Page(s) 103–105

    Language English
    Publishing date 2022-11-15
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2689512-2
    ISSN 1923-1202
    ISSN 1923-1202
    DOI 10.36834/cmej.75111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Internal medicine residents’ and program directors’ perception of virtual interviews during COVID-19

    Nicole Relke / Eleftherios Soleas / Janet Lui

    Canadian Medical Education Journal, Vol 12, Iss

    a national survey

    2021  Volume 2

    Keywords Education (General) ; L7-991 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Canadian Medical Education Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  8. Article ; Online: Internal medicine residents’ and program directors’ perception of virtual interviews during COVID-19

    Nicole Relke / Eleftherios Soleas / Clementine Janet Pui Man Lui

    Canadian Medical Education Journal (2022)

    a national survey

    2022  

    Abstract: Purpose: Due to the coronavirus disease 2019 pandemic, all Canadian Resident Matching Service interviews for internal medicine subspecialty programs were conducted virtually for the first time. This study explored the perceptions and experiences of ... ...

    Abstract Purpose: Due to the coronavirus disease 2019 pandemic, all Canadian Resident Matching Service interviews for internal medicine subspecialty programs were conducted virtually for the first time. This study explored the perceptions and experiences of internal medicine residents, subspecialty medicine program directors, and interviewers during virtual interviews. Methods: We invited all Canadian third-year IM residents, subspecialty program directors, and interviewers who participated in the 2020 medical subspecialty medicine interviews to complete a branching survey with a section for residents and one for program directors and interviewers. We distributed the anonymous survey after the submission of the rank order lists, to not affect residency match outcomes. Qualitative data were open-coded thematically and quantitative data were cleaned and then statistically analyzed using descriptive statistics and Analysis of Variance tests. Results: 62 residents, 59 program directors, and 113 interviewers responded to the survey with representation from almost all Canadian medical faculties and medical subspecialties. Strengths of virtual interviews included reduced cost, stress, pandemic infection risk, and carbon footprint. Weaknesses of virtual interviews included decreased ability to connect personally and informally, and inability to tour medical facilities and cities. A majority of both resident respondents (59.6%) and program directors/interviewer respondents (54.6%) supported conducting interviews virtually in the future. Conclusions: This study showed that the majority of both sampled residents and program directors/interviewers would prefer to conduct medicine subspecialty match interviews virtually in the future, and provides suggestions on how to improve the virtual interviews for the next iteration.
    Keywords Education (General) ; L7-991 ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Canadian Medical Education Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Management of heavy menstrual bleeding in women with bleeding disorders in a tertiary care center.

    Kuthiala, Shikha / Grabell, Julie / Relke, Nicole / Hopman, Wilma M / Silva, Mariana / Jamieson, Mary Anne / James, Paula

    Research and practice in thrombosis and haemostasis

    2023  Volume 7, Issue 3, Page(s) 100119

    Abstract: Background: Heavy menstrual bleeding (HMB) affects a significant number of women with bleeding disorders and has a negative impact on their quality of life.: Objective: This retrospective study examined the management of patients with inherited ... ...

    Abstract Background: Heavy menstrual bleeding (HMB) affects a significant number of women with bleeding disorders and has a negative impact on their quality of life.
    Objective: This retrospective study examined the management of patients with inherited bleeding disorders who used medical treatments, alone or in combination, for HMB.
    Methods: Chart review was performed on women attending the Women with Bleeding Disorders Clinic in Kingston, Ontario, between 2005 and 2017. Data collected included patient demographics, the reason for presentation and diagnosis, medical history, treatments, and patient satisfaction.
    Results: One hundred nine women were included in this cohort. Of these, only 74 (68%) were satisfied with medical management, and only 18 (17%) with first-line therapy. Treatments included combined contraceptives (oral pill, transdermal patch, and vaginal ring), progesterone-only pills, tranexamic acid, 52-mg levonorgestrel intrauterine system (LIUS), depomedroxyprogesterone acetate, and desmopressin, either alone or in combination. Satisfactory control of HMB occurred most often with the LIUS.
    Conclusion: In this cohort, managed in a tertiary care Women with Bleeding Disorders Clinic, only 68% of patients had successful control of HMB with medical treatment, and a minority were satisfied with first-line therapy. These data clearly highlight the need for additional research, including treatment approaches and novel therapies for this population.
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2023.100119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Canadian survey of residency applicants' and interviewers' perceptions of the 2021 CaRMS R1 virtual interviews.

    Del Fernandes, Rosephine / Relke, Nicole / Soleas, Eleftherios / Braund, Heather / Lui, Clementine Janet Pui Man / Zevin, Boris

    BMC medical education

    2023  Volume 23, Issue 1, Page(s) 392

    Abstract: Background: All Canadian Residency Matching Service (CaRMS) R1 interviews were conducted virtually for the first time in 2021. We explored the facilitators, barriers, and implications of the virtual interview process for the CaRMS R1 match and provide ... ...

    Abstract Background: All Canadian Residency Matching Service (CaRMS) R1 interviews were conducted virtually for the first time in 2021. We explored the facilitators, barriers, and implications of the virtual interview process for the CaRMS R1 match and provide recommendations for improvement.
    Methods: We conducted a cross-sectional survey study of CaRMS R1 residency applicants and interviewers across Canada in 2021. Surveys were distributed by email to the interviewers, and by email, social media, or newsletter to the applicants. Inductive thematic analysis was used for open-ended items. Recommendations were provided as frequencies to demonstrate strength. Close-ended items were described and compared across groups using Chi-Square Fisher's Exact tests.
    Results: A total of 127 applicants and 400 interviewers, including 127 program directors, responded to the survey. 193/380 (50.8%) interviewers and 90/118 (76.3%) applicants preferred virtual over in-person interview formats. Facilitators of the virtual interview format included cost and time savings, ease of scheduling, reduced environmental impact, greater equity, less stress, greater reach and participation, and safety. Barriers of the virtual interview format included reduced informal conversations, limited ability for applicants to explore programs at different locations, limited ability for programs to assess applicants' interest, technological issues, concern for interview integrity, limited non-verbal communication, and reduced networking. The most helpful media for applicants to learn about residency programs were program websites, the CaRMS/AFMC websites, and recruitment videos. Additionally, panel interviews were preferred by applicants for their ability to showcase themselves and build connections with multiple interviewers. Respondents provided recommendations regarding: (1) dissemination of program information, (2) the use of technology, and (3) the virtual interview format.
    Conclusions: Perceptions of 2021 CaRMS R1 virtual interviews were favourable among applicants and interviewers. Recommendations from this study can help improve future iterations of virtual interviews.
    MeSH term(s) Humans ; Canada ; Cross-Sectional Studies ; Internship and Residency ; Communication ; Electronic Mail ; Surveys and Questionnaires
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-023-04397-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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