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Article ; Online: The Treatment Outcomes of Radiotherapy and Surgical Treatment for Patients with Cavernous Sinus Hemangioma: A Meta-Analysis.

Helmy, Mohamed / Liao, Yujun / Zhang, YiYin / He, Kangmin

2023 Volume 178, Page(s) e345–e354

Abstract: Objective: Cavernous sinus hemangiomas (CSHs) are infrequent benign neoplasms. This meta-analysis was conducted with the objective of examining the prognostic outcomes of surgical interventions and radiotherapy (RT) in patients diagnosed with CSHs.: ... ...

Abstract	Objective: Cavernous sinus hemangiomas (CSHs) are infrequent benign neoplasms. This meta-analysis was conducted with the objective of examining the prognostic outcomes of surgical interventions and radiotherapy (RT) in patients diagnosed with CSHs. Methods: A comprehensive literature search was performed across PubMed, Embase, and Web of Science databases, with traceability up to June 22, 2021. The evaluation of continuous variables was conducted by applying the weighted mean difference (WMD) and 95% confidence interval. A one-arm meta-analysis was used to scrutinize the tumor control rate, clinical improvement rate, recovery rates of abducens nerve palsy and visual disturbance, total resection rate, and the incidence rate of permanent nerve palsy post-treatment. Results: In total, 29 articles were incorporated into the meta-analysis. Post-RT for CSHs, a significant reduction in tumor volume was observed (WMD [95% confidence interval] = -17.16 [-21.52, -12.80] cm Conclusions: The results of this meta-analysis underscore that RT is an effective and safe treatment modality for CSHs. Furthermore, the prognostic outcomes of RT demonstrated superiority over surgical intervention.
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.07.068
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Article ; Online: Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development.

Ma, Tiantian / Wang, Yaqing / Yu, Laikang / Liu, Jinghua / Wang, Tao / Sun, Pengyu / Feng, Yinghang / Zhang, Dan / Shi, Lei / He, Kangmin / Zhao, Li / Xu, Zhiheng

iScience

2024 Volume 27, Issue 3, Page(s) 109180

Abstract: Mutations of TRAPPC12 are associated with progressive childhood encephalopathy including abnormal white matter. However, the underlying pathogenesis is still unclear. Here, we found ... ...

Abstract	Mutations of TRAPPC12 are associated with progressive childhood encephalopathy including abnormal white matter. However, the underlying pathogenesis is still unclear. Here, we found that
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109180
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Article ; Online: The Salmonella Typhimurium Effector SpvB Subverts Host Membrane Trafficking by Targeting Clathrin and AP-1.

Yuan, Yi / Wang, Xinghao / Jin, Jie / Tang, Zhiheng / Xian, Wei / Zhang, Xinyi / Fu, Jiaqi / He, Kangmin / Liu, Xiaoyun

Molecular & cellular proteomics : MCP

2023 Volume 22, Issue 12, Page(s) 100674

Abstract: Salmonella enterica, the etiological agent of gastrointestinal and systemic diseases, translocates a plethora of virulence factors through its type III secretion systems to host cells during infection. Among them, SpvB has been reported to harbor an ADP- ... ...

Abstract	Salmonella enterica, the etiological agent of gastrointestinal and systemic diseases, translocates a plethora of virulence factors through its type III secretion systems to host cells during infection. Among them, SpvB has been reported to harbor an ADP-ribosyltransferase domain in its C terminus, which destabilizes host cytoskeleton by modifying actin. However, whether this effector targets other host factors as well as the function of its N terminus still remains to be determined. Here, we found that SpvB targets clathrin and its adaptor AP-1 (adaptor protein 1) via interactions with its N-terminal domain. Notably, our data suggest that SpvB-clathrin/AP-1 associations disrupt clathrin-mediated endocytosis and protein secretion pathway as well. In addition, knocking down of AP-1 promotes Salmonella intracellular survival and proliferation in host cells.
MeSH term(s)	Salmonella typhimurium/metabolism ; Transcription Factor AP-1/metabolism ; Salmonella enterica/metabolism ; Virulence Factors/metabolism ; Actins/metabolism ; Clathrin/metabolism
Chemical Substances	Transcription Factor AP-1 ; Virulence Factors ; Actins ; Clathrin
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075924-1
ISSN	1535-9484 ; 1535-9476
ISSN (online)	1535-9484
ISSN	1535-9476
DOI	10.1016/j.mcpro.2023.100674
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Article ; Online: The Geographical Pattern and Diversity of Strategic Industry Technological Innovation in the Guangdong-Hong Kong-Macao Greater Bay Area

Wu Kangmin / Ye Yuyao / Zhang Hong'ou / He Zuxin / Wang Xiangyu / Zheng Zhijun

Redai dili, Vol 42, Iss 2, Pp 183-

2022 Volume 194

Abstract: The dynamics of innovation in geographical space is closely related to the regional development trajectory. Evolutionary economic geography points out the path dependence characteristics of regional development, and emphasizes that the direction of ... ...

Abstract	The dynamics of innovation in geographical space is closely related to the regional development trajectory. Evolutionary economic geography points out the path dependence characteristics of regional development, and emphasizes that the direction of regional development is rooted in the original industrial and technological structure characteristics. Therefore, the geographical pattern of technological innovation and the identification of its diversity characteristics are of significance to the realization of regional innovation and the evolution of industrial structure. From the perspective of strategic industry, this paper aims to reveal the geographical pattern and diversity characteristics of technological innovation in strategic industry in the Guangdong-Hong Kong-Macao Greater Bay Area (GBA). Based on the point scale spatial data of invention patents in the GBA and by means of connecting strategic industry with national economy industry classification code and patent IPC classification code, the invention patents of six major industries in the GBA are extracted, which are the new generation of electronic information industry, automobile industry, green petrochemical industry, new energy industry, advanced material industry and intelligent robot industry. And the nuclear density analysis, standard deviation tail value test, entropy method and average nearest neighbor distance analysis are used to identify the spatial distribution characteristics and differences of multiple types of technological innovation in the GBA. The results show that the geographic pattern of technological innovation in the GBA presents a significant spatial imbalance. At the regional scale, Guangzhou and Shenzhen are the two agglomeration cores. There is a large gap in the innovation ability between the east and west sides of the Pearl River. The accumulation of technological innovation on the east bank is much higher than that on the west bank. The innovation profile line on the east bank has formed two obvious peaks in Guangzhou and Shenzhen. The high value of the innovation profile line on the west bank is mainly concentrated in Guangzhou and Zhuhai, and the peak value is far lower than that on the east bank. The location of technological diversity is mainly distributed in the core areas of the GBA, mainly including Yuexiu District and Tianhe District in Guangzhou, Nanshan District and Futian District in Shenzhen, Binhai District in Dongguan and Xiangzhou District in Zhuhai. And the distribution characteristics of technological innovation data of different industrial types are different. The innovation of the new generation of electronic information industry, advanced materials industry and green petrochemical industry accounts for 51.67% of the total innovation in the GBA. The innovation of different technological types shows obvious spatial differentiation. The innovation agglomeration degree of the new generation electronic information industry is the highest, with the R value of 0.0576. And its observed value of the average nearest neighbor distance between invention patents is 32.03 m, which belongs to the minimum value in the selected analysis industries, showing strong agglomeration characteristics. There are differences in the distribution characteristics of the agglomeration core of the six major industries in the GBA. The common ground is that they have formed the largest two agglomeration cores in the core areas of Guangzhou and Shenzhen, covering Yuexiu-Tianhe area in Guangzhou and Futian-Nanshan-Luohu area in Shenzhen. And the spatial distribution is mainly concentrated in the core areas of Guangzhou, Shenzhen, Dongguan and Zhuhai. Among them, the spatial agglomeration degree of the new generation of electronic information industry innovation is the highest. Agglomeration and multi-dimensional proximity, diversity and path dependence are the main mechanisms for the formation of the geographical pattern of technological innovation in the GBA, and these two key mechanisms promote the formation of current multi-type technological innovation space in the GBA.
Keywords	technological innovation ; patent ; diversity ; spatial structure ; guangdong-hong kong-macao greater bay area ; Geography (General) ; G1-922
Subject code	910
Language	Chinese
Publishing date	2022-02-01T00:00:00Z
Publisher	Editorial Committee of Tropical Geography
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Structure and dynamics of the EGFR/HER2 heterodimer.

Bai, Xue / Sun, Pengyu / Wang, Xinghao / Long, Changkun / Liao, Shuyun / Dang, Song / Zhuang, Shangshang / Du, Yongtao / Zhang, Xinyi / Li, Nan / He, Kangmin / Zhang, Zhe

Cell discovery

2023 Volume 9, Issue 1, Page(s) 18

Abstract: HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family. Its overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 functions mainly through dimerization with other family members, such as EGFR. ...

Abstract	HER2 belongs to the human epidermal growth factor receptor tyrosine kinase family. Its overexpression or hyperactivation is a leading cause for multiple types of cancers. HER2 functions mainly through dimerization with other family members, such as EGFR. However, the molecular details for heterodimer assembly have not been completely understood. Here, we report cryo-EM structures of the EGF- and epiregulin-bound EGFR/HER2 ectodomain complexes at resolutions of 3.3 Å and 4.5 Å, respectively. Together with the functional analyses, we demonstrate that only the dimerization arm of HER2, but not that of EGFR, is essential for their heterodimer formation and signal transduction. Moreover, we analyze the differential membrane dynamics and transient interactions of endogenous EGFR and HER2 molecules in genome-edited cells using single-molecule live-cell imaging. Furthermore, we show that the interaction with HER2 could allow EGFR to resist endocytosis. Together, this work deepens our understanding of the unique structural properties and dynamics of the EGFR/HER2 complex.
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article
ISSN	2056-5968
ISSN	2056-5968
DOI	10.1038/s41421-023-00523-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Geometric constraint-triggered collagen expression mediates bacterial-host adhesion

Yuting Feng / Shuyi Wang / Xiaoye Liu / Yiming Han / Hongwei Xu / Xiaocen Duan / Wenyue Xie / Zhuoling Tian / Zuoying Yuan / Zhuo Wan / Liang Xu / Siying Qin / Kangmin He / Jianyong Huang

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Cells living in geometrically confined microenvironments are ubiquitous in various physiological processes, e.g., wound closure. However, it remains unclear whether and how spatially geometric constraints on host cells regulate bacteria-host ... ...

Abstract	Abstract Cells living in geometrically confined microenvironments are ubiquitous in various physiological processes, e.g., wound closure. However, it remains unclear whether and how spatially geometric constraints on host cells regulate bacteria-host interactions. Here, we reveal that interactions between bacteria and spatially constrained cell monolayers exhibit strong spatial heterogeneity, and that bacteria tend to adhere to these cells near the outer edges of confined monolayers. The bacterial adhesion force near the edges of the micropatterned monolayers is up to 75 nN, which is ~3 times higher than that at the centers, depending on the underlying substrate rigidities. Single-cell RNA sequencing experiments indicate that spatially heterogeneous expression of collagen IV with significant edge effects is responsible for the location-dependent bacterial adhesion. Finally, we show that collagen IV inhibitors can potentially be utilized as adjuvants to reduce bacterial adhesion and thus markedly enhance the efficacy of antibiotics, as demonstrated in animal experiments.
Keywords	Science ; Q
Subject code	612
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Geometric constraint-triggered collagen expression mediates bacterial-host adhesion.

Feng, Yuting / Wang, Shuyi / Liu, Xiaoye / Han, Yiming / Xu, Hongwei / Duan, Xiaocen / Xie, Wenyue / Tian, Zhuoling / Yuan, Zuoying / Wan, Zhuo / Xu, Liang / Qin, Siying / He, Kangmin / Huang, Jianyong

Nature communications

2023 Volume 14, Issue 1, Page(s) 8165

Abstract: Cells living in geometrically confined microenvironments are ubiquitous in various physiological processes, e.g., wound closure. However, it remains unclear whether and how spatially geometric constraints on host cells regulate bacteria-host interactions. ...

Abstract	Cells living in geometrically confined microenvironments are ubiquitous in various physiological processes, e.g., wound closure. However, it remains unclear whether and how spatially geometric constraints on host cells regulate bacteria-host interactions. Here, we reveal that interactions between bacteria and spatially constrained cell monolayers exhibit strong spatial heterogeneity, and that bacteria tend to adhere to these cells near the outer edges of confined monolayers. The bacterial adhesion force near the edges of the micropatterned monolayers is up to 75 nN, which is ~3 times higher than that at the centers, depending on the underlying substrate rigidities. Single-cell RNA sequencing experiments indicate that spatially heterogeneous expression of collagen IV with significant edge effects is responsible for the location-dependent bacterial adhesion. Finally, we show that collagen IV inhibitors can potentially be utilized as adjuvants to reduce bacterial adhesion and thus markedly enhance the efficacy of antibiotics, as demonstrated in animal experiments.
MeSH term(s)	Animals ; Bacterial Adhesion/physiology ; Collagen/metabolism ; Mechanical Phenomena ; Bacteria/metabolism ; Cell Adhesion
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2023-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43827-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cavernoma-Associated Epilepsy Within the Mesial Temporal Lobe: Surgical Management and Seizure Outcome.

He, Kangmin / Alriashy, M H S / Fan, Zhen / Qiao, Nidan / Liao, Yujun / An, Qingzhu / Xu, Bin / Song, Jianping / Zhang, Xin / Zhu, Wei / Chen, Liang / Mao, Ying

World neurosurgery

2022 Volume 160, Page(s) e464–e470

Abstract: Objective: We sought to explore a treatment protocol for patients with mesial temporal cerebral cavernoma (MTC)-associated epilepsy.: Methods: All MTC-associated epilepsy patients admitted to our center between January 2005 and December 2013 were ... ...

Abstract	Objective: We sought to explore a treatment protocol for patients with mesial temporal cerebral cavernoma (MTC)-associated epilepsy. Methods: All MTC-associated epilepsy patients admitted to our center between January 2005 and December 2013 were analyzed. Seizure outcome for each presurgical epilepsy type was reported. The modified Engel classification was used to assess outcome. The neurologic outcome was scored by the modified Rankin Scale. Results: Fifty-three patients admitted to the center were seen by a functional electrocortigraphy (ECoG group) or vascular (non-ECoG group) neurosurgery team. There were 21 patients with drug-resistant epilepsy (DRE), 20 patients with chronic epilepsy (CE), and 12 patients with sporadic epilepsy (SE). The neurovascular team treated 37 (69.8%) patients, and the ECoG group treated 16 (30.2%) patients. All patients underwent a mean follow-up of 106.5 ± 29.1 months. Almost all SE patients (11/12, 91.7%) in both teams achieved seizure-free status at follow-up. In the CE group, the long-term seizure-free probability among patients in the ECoG and non-ECoG groups was (66.7%) and (52.9%), respectively. DRE patients in the ECoG group had a lower seizure relapse rate after surgery than those who underwent non-ECoG surgery (P = 0.042). Fifty-two patients (98.1%) complained of postsurgery memory loss. Seizure outcome in the first postoperative year was a reasonable predictor of long-term outcome. Conclusions: A comprehensive preoperative and intraoperative assessment could help the patient with MTC-associated epilepsy choose a suitable surgical time and maximize the benefit between seizure control and cognition protection. The characters of intraoperative ECoG and postoperative seizure outcome at 1-year follow-up can predict a long-term epilepsy prognosis.
MeSH term(s)	Electrocorticography/methods ; Electroencephalography ; Epilepsy/complications ; Epilepsy/surgery ; Epilepsy, Temporal Lobe ; Humans ; Neoplasm Recurrence, Local/complications ; Seizures/complications ; Seizures/surgery ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/surgery ; Treatment Outcome
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2022.01.045
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Article ; Online: Diagnosis and surgical treatment of cavernous sinus angioleiomyoma: a report of four cases.

He, Kangmin / Chen, Liang / Zhu, Wei / Cheng, Haixia / Wang, Yin / Mao, Ying

Japanese journal of clinical oncology

2015 Volume 45, Issue 1, Page(s) 134

Language	English
Publishing date	2015-01
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyu208
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Zs.A 1298: Show issues

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Article ; Online: Rationalized deep learning super-resolution microscopy for sustained live imaging of rapid subcellular processes.

Qiao, Chang / Li, Di / Liu, Yong / Zhang, Siwei / Liu, Kan / Liu, Chong / Guo, Yuting / Jiang, Tao / Fang, Chuyu / Li, Nan / Zeng, Yunmin / He, Kangmin / Zhu, Xueliang / Lippincott-Schwartz, Jennifer / Dai, Qionghai / Li, Dong

Nature biotechnology

2022 Volume 41, Issue 3, Page(s) 367–377

Abstract: The goal when imaging bioprocesses with optical microscopy is to acquire the most spatiotemporal information with the least invasiveness. Deep neural networks have substantially improved optical microscopy, including image super-resolution and ... ...

Abstract	The goal when imaging bioprocesses with optical microscopy is to acquire the most spatiotemporal information with the least invasiveness. Deep neural networks have substantially improved optical microscopy, including image super-resolution and restoration, but still have substantial potential for artifacts. In this study, we developed rationalized deep learning (rDL) for structured illumination microscopy and lattice light sheet microscopy (LLSM) by incorporating prior knowledge of illumination patterns and, thereby, rationally guiding the network to denoise raw images. Here we demonstrate that rDL structured illumination microscopy eliminates spectral bias-induced resolution degradation and reduces model uncertainty by five-fold, improving the super-resolution information by more than ten-fold over other computational approaches. Moreover, rDL applied to LLSM enables self-supervised training by using the spatial or temporal continuity of noisy data itself, yielding results similar to those of supervised methods. We demonstrate the utility of rDL by imaging the rapid kinetics of motile cilia, nucleolar protein condensation during light-sensitive mitosis and long-term interactions between membranous and membrane-less organelles.
MeSH term(s)	Microscopy, Fluorescence/methods ; Deep Learning ; Neural Networks, Computer
Language	English
Publishing date	2022-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1311932-1
ISSN	1546-1696 ; 1087-0156
ISSN (online)	1546-1696
ISSN	1087-0156
DOI	10.1038/s41587-022-01471-3
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