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  1. Article ; Online: The influence of bed height as a percentage of participant height on low back forces when boosting a patient up in bed.

    Larson, Robert E / Johnson, A Wayne / Bruening, Dustin A / Ridge, Sarah T / Mitchell, Ulrike H

    Work (Reading, Mass.)

    2023  Volume 75, Issue 4, Page(s) 1351–1359

    Abstract: Background: Repositioning patients is a frequent task for healthcare workers causing substantial stress to the low back. Patient handling methodologies that reduce low back load should be used. Some studies have observed the effect of bed height on back ...

    Abstract Background: Repositioning patients is a frequent task for healthcare workers causing substantial stress to the low back. Patient handling methodologies that reduce low back load should be used. Some studies have observed the effect of bed height on back forces using a limited range of heights. This study details a wider range.
    Objective: The aim of this study was to discover an optimal bed height for reducing low back force when boosting a patient.
    Methods: 11 university students and local residents participated by completing a series of boosts with a 91.6 kg research assistant acting as dependent. The bed was adjusted 3% of participant height and 3 boosts were completed at each height which resulted in 8-10 different bed heights depending on the height of the participant. Motion and force data were collected to estimate low back forces via 3DSSPP. Pearson's R was performed to observe the correlation between caregiver height and low back forces.
    Results: There were significant negative correlations between bed height and low back compression force at L4-L5 (r = -0.676, p = <0.001) and L5-S1 (r = -0.704, p = <0.001). There were no significant correlations with any shear forces.
    Conclusion: The highest bed height led to decreased low back compression forces regardless of participant height, but there was not a significant difference in shear forces. Thus, healthcare workers may experience less low back stress with the bed at a higher height. There may be a force tradeoff between the low back and other parts of the body that needs further exploration. Healthcare workers need to be made aware of the implications of adjusting the environment when performing patient handling tasks.
    MeSH term(s) Humans ; Moving and Lifting Patients ; Health Personnel
    Language English
    Publishing date 2023-02-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1394194-x
    ISSN 1875-9270 ; 1051-9815
    ISSN (online) 1875-9270
    ISSN 1051-9815
    DOI 10.3233/WOR-220260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Current trends and applications in endoscopy for otology and neurotology.

    Ridge, Sarah E / Shetty, Kunal R / Lee, Daniel J

    World journal of otorhinolaryngology - head and neck surgery

    2021  Volume 7, Issue 2, Page(s) 101–108

    Abstract: There has been a rapid increase in endoscopic ear surgery for the management of middle ear and lateral skull base disease in children and adults over the last decade. In this review paper, we discuss the current trends and applications of the endoscope ... ...

    Abstract There has been a rapid increase in endoscopic ear surgery for the management of middle ear and lateral skull base disease in children and adults over the last decade. In this review paper, we discuss the current trends and applications of the endoscope in the field of otology and neurotology. Advantages of the endoscope include excellent ergonomics, compatibility with pediatric anatomy, and improved access to the middle ear through the external auditory canal. Transcanal endoscopic ear surgery has demonstrated comparable outcomes in the management of cholesteatoma, tympanic membrane perforations, and otosclerosis as compared to microscopic approaches, while utilizing less invasive surgical corridors and reducing the need for postauricular incisions. When a postauricular approach is required, the endoscopic-assisted transmastoid approach can avoid a canal wall down mastoidectomy in cases of cholesteatoma. The endoscope also has utility in treatment of superior canal dehiscence and various skull base lesions including glomus tumors, meningiomas, and vestibular schwannomas. Outside of the operating room, the endoscope can be used during examination of the outer and middle ear and for debridement of complex mastoid cavities. For these reasons, the endoscope is currently poised to transform the field of otology and neurotology.
    Language English
    Publishing date 2021-02-06
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2589-1081
    ISSN (online) 2589-1081
    DOI 10.1016/j.wjorl.2020.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Heads-up Surgery: Endoscopes and Exoscopes for Otology and Neurotology in the Era of the COVID-19 Pandemic.

    Ridge, Sarah E / Shetty, Kunal R / Lee, Daniel J

    Otolaryngologic clinics of North America

    2020  Volume 54, Issue 1, Page(s) 11–23

    Abstract: A new era of surgical visualization and magnification is poised to disrupt the field of otology and neurotology. The once revolutionary benefits of the binocular microscope now are shared with rigid endoscopes and exoscopes. These 2 modalities are ... ...

    Abstract A new era of surgical visualization and magnification is poised to disrupt the field of otology and neurotology. The once revolutionary benefits of the binocular microscope now are shared with rigid endoscopes and exoscopes. These 2 modalities are complementary. The endoscope improves visualization of the hidden recesses through the external auditory canal or canal-up mastoidectomy. The exoscope provides an immersive visual experience and superior ergonomics compared with binocular microscopy. Endoscopes and exoscopes are poised to disrupt the standard of care for surgical visualization and magnification in otology and neurotology.
    MeSH term(s) COVID-19 ; Ear Canal/surgery ; Endoscopes/standards ; Endoscopy/instrumentation ; Endoscopy/standards ; Equipment Design/standards ; Humans ; Mastoidectomy/instrumentation ; Microsurgery/instrumentation ; Minimally Invasive Surgical Procedures/instrumentation ; Neurosurgical Procedures/instrumentation ; Neurotology/instrumentation ; Neurotology/standards ; Otolaryngology/instrumentation ; Otolaryngology/standards ; Pandemics ; Standard of Care/standards ; United States
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 417489-6
    ISSN 1557-8259 ; 0030-6665
    ISSN (online) 1557-8259
    ISSN 0030-6665
    DOI 10.1016/j.otc.2020.09.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Healthcare worker choice and low back force between self-chosen and highest bed height when boosting a patient up in bed.

    Larson, Robert E / Ridge, Sarah T / Bruening, Dustin / Johnson, A Wayne / Mitchell, Ulrike H

    Ergonomics

    2022  Volume 65, Issue 10, Page(s) 1373–1379

    Abstract: Healthcare workers have a high rate of low back injury due to patient handling tasks. These workers receive training in patient handling methods such as adjusting bed height, but often ignore them. In this study, 35 healthcare workers completed patient ... ...

    Abstract Healthcare workers have a high rate of low back injury due to patient handling tasks. These workers receive training in patient handling methods such as adjusting bed height, but often ignore them. In this study, 35 healthcare workers completed patient boosts at a self-chosen bed height and again with the bed in a higher standardised position. Motion capture and force data were collected for analysis. Given the choice, less than half of participants adjusted the bed at all and none of them moved the bed to the highest position (99.1 cm). The self-chosen bed position yielded significantly higher low back force than the higher position at L4-L5 and L5-S1 (
    MeSH term(s) Back Injuries ; Cross-Over Studies ; Cross-Sectional Studies ; Health Personnel ; Humans ; Lifting ; Moving and Lifting Patients
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1920-3
    ISSN 1366-5847 ; 0014-0139
    ISSN (online) 1366-5847
    ISSN 0014-0139
    DOI 10.1080/00140139.2022.2034985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evaluations of epistemic and practical reasons for belief in a predominantly White U.S. sample of preschoolers.

    Pesch, Annelise / Ridge, Katherine E / Suárez, Sarah / McMyler, Benjamin / Koenig, Melissa A

    Journal of experimental child psychology

    2022  Volume 223, Page(s) 105499

    Abstract: Parents and educators commonly seek to influence children's behavior by providing them with practical incentives, but how should we understand the influence of such incentives on children's beliefs? Are children capable of distinguishing between speech ... ...

    Abstract Parents and educators commonly seek to influence children's behavior by providing them with practical incentives, but how should we understand the influence of such incentives on children's beliefs? Are children capable of distinguishing between speech acts that provide practical reasons for believing, such as requests and offers, from speech acts that provide straightforward epistemic reasons, such as simple acts of telling? To investigate these questions, we randomly assigned 3- to 6-year-old children (N = 97) to one of two conditions (Request or Offer) in which two speakers each commented on a series of four exotic animals. In each condition, an agent who stated what an object was called with a simple telling ("This is a tanzer") was contrasted with an agent who made either a doxastic request ("I want you to think that this is a tanzer") or a doxastic offer ("If you think that this is a tanzer, I'll let you play with this new toy"). We then measured children's endorsement of and semantic memory for the claims as well as their knowledge attributions and resource allocation decisions. Our results suggest that children appreciate the epistemic reasons inherent in acts of telling when contrasted with doxastic requests, as evidenced by their general preference to learn from, attribute knowledge to, and share with the teller in the Request condition. When tellings were contrasted with doxastic offers, children were less systematic in their preferences. We discuss various interpretations of this finding and offer suggestions for future research.
    MeSH term(s) Humans ; Knowledge ; Parents ; Social Perception ; Speech ; Trust
    Language English
    Publishing date 2022-07-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218137-x
    ISSN 1096-0457 ; 0022-0965
    ISSN (online) 1096-0457
    ISSN 0022-0965
    DOI 10.1016/j.jecp.2022.105499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Heads-Up Surgery: Endoscopes and Exoscopes for Otology and Neurotology in the Era of the COVID-19 Pandemic

    Lee, Daniel J. / Ridge, Sarah E. / Shetty, Kunal R.

    Otolaryngologic Clinics of North America

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #801983
    Database COVID19

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  7. Article ; Online: Heads-Up Surgery

    Lee, Daniel J. / Ridge, Sarah E. / Shetty, Kunal R.

    Otolaryngologic Clinics of North America ; ISSN 0030-6665

    Endoscopes and Exoscopes for Otology and Neurotology in the Era of the COVID-19 Pandemic

    2020  

    Keywords Otorhinolaryngology ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.otc.2020.09.024
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Clinical and scientific innovations in auditory brainstem implants.

    Shetty, Kunal R / Ridge, Sarah E / Kanumuri, Vivek / Zhu, Angela / Brown, M Christian / Lee, Daniel J

    World journal of otorhinolaryngology - head and neck surgery

    2021  Volume 7, Issue 2, Page(s) 109–115

    Abstract: The auditory brainstem implant (ABI) was originally developed to provide rehabilitation of retrocochlear deafness caused by neurofibromatosis type 2 (NF2). Recent studies of the ABI have investigated outcomes in non-NF2 cohorts, such as patients with ... ...

    Abstract The auditory brainstem implant (ABI) was originally developed to provide rehabilitation of retrocochlear deafness caused by neurofibromatosis type 2 (NF2). Recent studies of the ABI have investigated outcomes in non-NF2 cohorts, such as patients with cochlear nerve aplasia or cochlear ossification and more recently, intractable tinnitus. New technologies that improve the ABI-neural tissue interface are being explored as means to improve performance and decrease side effects. Innovative discoveries in optogenetics and bioengineering present opportunities to continually evolve this technology into the future, enhancing spatial selectivity of neuronal activation in the cochlear nucleus and preventing side effects through reduction in activation of non-target neuronal circuitry. These advances will improve surgical planning and ultimately improve patients' audiological capabilities. ABI research has rapidly increased in the 21st century and applications of this technology are likely to continually evolve. Herein, we aim to characterize ongoing clinical, basic science, and bioengineering advances in ABIs and discuss future directions of this technology.
    Language English
    Publishing date 2021-04-06
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2589-1081
    ISSN (online) 2589-1081
    DOI 10.1016/j.wjorl.2021.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: US FDA Postmarketing Requirements and Commitments: A Systematic Assessment of Clinical Pharmacology Studies and Their Impact on US FDA Prescribing Information.

    Ridge, Sarah / Guinn, Daphne / Pfuma Fletcher, Elimika / Zineh, Issam / Madabushi, Rajanikanth / Ramamoorthy, Anuradha

    Journal of clinical pharmacology

    2023  Volume 63, Issue 6, Page(s) 695–703

    Abstract: Many of the conditions for the safe and effective use of new molecular entities (NMEs) are understood at the time of initial drug approval. However, some remaining knowledge gaps can be addressed after drug approval through postmarketing requirements ( ... ...

    Abstract Many of the conditions for the safe and effective use of new molecular entities (NMEs) are understood at the time of initial drug approval. However, some remaining knowledge gaps can be addressed after drug approval through postmarketing requirements (PMRs) or commitments (PMCs) established by the US Food and Drug Administration (FDA). Our objective was to conduct an assessment of clinical pharmacology-related PMRs and PMCs established at the time of approval and evaluate the impact of fulfilled PMRs and PMCs on prescription information (PI). This analysis included clinical pharmacology-related PMRs and PMCs established for NMEs approved between 2009 and 2020. Of the 1171 PMRs and PMCs, over one-third were clinical pharmacology-related. Of these, 46% were to evaluate drug interactions, 16% were to evaluate drug dosing in patients with hepatic impairment, and 10% were related to dose. The majority (57%) of PMRs and PMCs were fulfilled at the time of analysis, with a median time to fulfillment of approximately 2.3 years. The majority (94%) of the fulfilled PMRs and PMCs, either with or without a PI revision, resulted in new or modified instructions for use or supported existing instructions for use. This is the first time that clinical pharmacology-related PMRs and PMCs have been catalogued and analyzed to understand their impact on PI. An understanding of the knowledge gaps that exist at the time of drug approval could inform the most effective and efficient methods for evidence generation prior to and after new drug approval.
    MeSH term(s) United States ; Humans ; Pharmacology, Clinical ; United States Food and Drug Administration ; Product Surveillance, Postmarketing/methods ; Drug Approval/methods
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.2208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hyphae move matter and microbes to mineral microsites: Integrating the hyphosphere into conceptual models of soil organic matter stabilization.

    See, Craig R / Keller, Adrienne B / Hobbie, Sarah E / Kennedy, Peter G / Weber, Peter K / Pett-Ridge, Jennifer

    Global change biology

    2022  Volume 28, Issue 8, Page(s) 2527–2540

    Abstract: Associations between soil minerals and microbially derived organic matter (often referred to as mineral-associated organic matter or MAOM) form a large pool of slowly cycling carbon (C). The rhizosphere, soil immediately adjacent to roots, is thought to ... ...

    Abstract Associations between soil minerals and microbially derived organic matter (often referred to as mineral-associated organic matter or MAOM) form a large pool of slowly cycling carbon (C). The rhizosphere, soil immediately adjacent to roots, is thought to control the spatial extent of MAOM formation because it is the dominant entry point of new C inputs to soil. However, emphasis on the rhizosphere implicitly assumes that microbial redistribution of C into bulk (non-rhizosphere) soils is minimal. We question this assumption, arguing that because of extensive fungal exploration and rapid hyphal turnover, fungal redistribution of soil C from the rhizosphere to bulk soil minerals is common, and encourages MAOM formation. First, we summarize published estimates of fungal hyphal length density and turnover rates and demonstrate that fungal C inputs are high throughout the rhizosphere-bulk soil continuum. Second, because colonization of hyphal surfaces is a common dispersal mechanism for soil bacteria, we argue that hyphal exploration allows for the non-random colonization of mineral surfaces by hyphae-associated taxa. Third, these bacterial communities and their fungal hosts determine the chemical form of organic matter deposited on colonized mineral surfaces. Collectively, our analysis demonstrates that omission of the hyphosphere from conceptual models of soil C flow overlooks key mechanisms for MAOM formation in bulk soils. Moving forward, there is a clear need for spatially explicit, quantitative research characterizing the environmental drivers of hyphal exploration and hyphosphere community composition across systems, as these are important controls over the rate and organic chemistry of C deposited on minerals.
    MeSH term(s) Bacteria ; Carbon ; Hyphae ; Minerals ; Rhizosphere ; Soil/chemistry ; Soil Microbiology
    Chemical Substances Minerals ; Soil ; Carbon (7440-44-0)
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1281439-8
    ISSN 1365-2486 ; 1354-1013
    ISSN (online) 1365-2486
    ISSN 1354-1013
    DOI 10.1111/gcb.16073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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