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  1. Article ; Online: [No title information]

    Fowler, James / Sowerby, Leigh J

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2021  Volume 193, Issue 11, Page(s) E399–E400

    Title translation Utilisation des corticostéroïdes intranasaux.
    Language French
    Publishing date 2021-03-17
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.201266-f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mepolizumab for the treatment of chronic rhinosinusitis with nasal polyps in adults.

    Neposlan, Josh / Sowerby, Leigh J / Biadsee, Ameen

    Expert review of respiratory medicine

    2023  Volume 17, Issue 2, Page(s) 109–118

    Abstract: Introduction: The treatment paradigm for chronic rhinosinusitis with nasal polyps (CRSwNP) is complex, consisting of a combination of conservative, medical and surgical management. High rates of recurrence despite current standard of care has led to the ...

    Abstract Introduction: The treatment paradigm for chronic rhinosinusitis with nasal polyps (CRSwNP) is complex, consisting of a combination of conservative, medical and surgical management. High rates of recurrence despite current standard of care has led to the search for treatments that can improve outcomes and limit the treatment burden for patients living with this chronic condition.
    Areas covered: Eosinophils are granulocytic white blood cells that proliferate as part of the innate immune response. IL5 is an inflammatory cytokine implicated in the development of eosinophil-associated diseases that has emerged as a target for biologic therapy. Mepolizumab (NUCALA) is a humanized antiIL5 monoclonal antibody that represents a novel therapeutic approach to CRSwNP. The results of multiple clinical trials are encouraging but its real-world implementation requires a thorough cost-benefit analysis across a range of clinical situations.
    Expert opinion: : Mepolizumab is an emerging biologic therapy that shows promising potential for the treatment of CRSwNP. It appears to provide both objective and subjective improvement as an addon therapy to standard of care treatment. Its specific role in treatment algorithms remains a topic of discussion. Future research surrounding its efficacy and cost effectiveness as compared to alternative options is needed.
    MeSH term(s) Humans ; Adult ; Nasal Polyps/complications ; Nasal Polyps/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Chronic Disease ; Eosinophils ; Rhinitis/complications
    Chemical Substances mepolizumab (90Z2UF0E52) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2023.2181794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Using intranasal corticosteroids.

    Fowler, James / Sowerby, Leigh J

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2021  Volume 193, Issue 2, Page(s) E47

    MeSH term(s) Administration, Intranasal ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/adverse effects ; Adrenal Cortex Hormones/therapeutic use ; Humans ; Rhinitis/drug therapy ; Sinusitis/drug therapy
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-01-11
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.201266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The authors reply to: "Systemic absorption of intranasal corticosteroids may occur and can potentially affect the hypothalamic-pituitary-adrenal axis".

    Sowerby, Leigh J / Fowler, James

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2021  Volume 193, Issue 12, Page(s) E427

    MeSH term(s) Absorption, Physiological ; Administration, Intranasal ; Adrenal Cortex Hormones ; Humans ; Hypothalamo-Hypophyseal System ; Pituitary-Adrenal System
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-03-22
    Publishing country Canada
    Document type Letter ; Comment
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.78206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Can we make biologic therapy more affordable?

    Biadsee, Ameen / Payne, Spencer / Sowerby, Leigh J

    International forum of allergy & rhinology

    2022  Volume 12, Issue 9, Page(s) 1087–1088

    MeSH term(s) Biological Therapy ; Chronic Disease ; Humans ; Nasal Polyps ; Rhinitis
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Assessing the safety and tolerability of rhinologic surgery under local anesthetic: an 8-year retrospective analysis.

    Kokavec, Andrew / Zahabi, Sarah / Rocha, Taciano / Rotenberg, Brian W / Sowerby, Leigh J

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  

    Abstract: Purpose: Office-based rhinologic procedures (OBRP) have become widely available in North America due to technological advances and appropriate patient selection. Nevertheless, the literature exploring the safety of these procedures remains limited. The ... ...

    Abstract Purpose: Office-based rhinologic procedures (OBRP) have become widely available in North America due to technological advances and appropriate patient selection. Nevertheless, the literature exploring the safety of these procedures remains limited. The objective of this study was to further evaluate the safety, tolerability and efficacy of these procedures with a more robust sample size to allow for capture of rare events.
    Methods: A retrospective chart review of all patients who underwent OBRP from May 2015 to March 2023. Information regarding patient demographics, the indication for surgery, wait time, tolerability, intra- and postoperative complications, need for revisions, and type of revision (if applicable) was recorded.
    Results: 1208 patients underwent OBRP during the study period. No patients were excluded. These included turbinoplasties (35%), endoscopic sinus surgeries (ESS) (26%), septoplasties (15%), nasal fracture reductions (7%), and a variety of other procedures. For ESS procedures, the anterior ethmoids and the maxillary sinuses were the most common sinuses treated. 1.1% of procedures were aborted prior to completion. The post-operative complication rate was 3.2%, with 2 major complications (significant bleeding and sepsis) encountered. The mean follow-up overall was 11 months and for ESS it was 15.8 months.
    Conclusion: Office-based rhinologic procedures are well tolerated and safe for the appropriate patient and associated with shorter wait-times as well as avoidance of general anesthesia. The complication rates are similar to or lower than previously reported rates for rhinologic surgeries done in the operating room. The low rates of revision surgery also demonstrate the efficacy of these procedures.
    Language English
    Publishing date 2024-04-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-024-08655-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction to: Evaluation of septal perforation size using a novel measuring device.

    Hamilton, Stefan / Rotenberg, Brian W / Sowerby, Leigh J

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 12, Page(s) 5683

    Language English
    Publishing date 2022-09-02
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07625-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reply: Correspondence-International Registry of Otolaryngologist-Head and Neck Surgeons with COVID-19.

    Sowerby, Leigh J / Patel, Zara M

    International forum of allergy & rhinology

    2020  Volume 10, Issue 12, Page(s) 1342

    MeSH term(s) COVID-19 ; Humans ; Otolaryngologists ; Registries ; SARS-CoV-2 ; Surgeons
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Letter
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cost minimization analysis of nasopharyngoscope reprocessing in community practice.

    Biadsee, Ameen / Crosby, Lauren / Chow, Winsion / Sowerby, Leigh J

    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

    2023  Volume 52, Issue 1, Page(s) 8

    Abstract: Background: Reprocessing of nasopharyngoscopes represents a large financial burden to community physicians. The aim of this study was to perform a cost analysis of nasopharyngoscope reprocessing methods at the community level.: Methods: Electronic ... ...

    Abstract Background: Reprocessing of nasopharyngoscopes represents a large financial burden to community physicians. The aim of this study was to perform a cost analysis of nasopharyngoscope reprocessing methods at the community level.
    Methods: Electronic surveys were distributed by email to community otolaryngologists. Surveys were comprised of 14 questions assessing clinic size, nasopharyngoscope volume, scope reprocessing method and maintenance. Four manual techniques were evaluated: (1) soak with ortho-phthalaldehyde solution (Cidex-OPA; Advanced Sterilization Products, Johnson and Johnson Inc., Markham, Canada), (2) soak with accelerated hydrogen peroxide solution (Revital-Ox; Steris Canada Inc., Mississauga, Canada), (3) disinfection with chlorine dioxide wipe (Tristel Trio Wipes System; Tristel plc., Cambridgeshire, UK), (4) UV-C light system (UV Smart, Delft, The Netherlands). All costs are reported in CAD, and consumable and capital costs for reprocessing methods were obtained from reported vendor prices. Time costs were derived from manufacturer recommendations, the Ontario Medical Association Physician's Guide to Uninsured Services, and the Ontario Nurses Association Collective Agreement. Cost analyses determined the most cost-effective reprocessing method in the community setting. Sensitivity analyses assessed the impact of reprocessing volume and labour costs.
    Results: Thirty-six (86%) otolaryngologists responded and answered the survey. The cost per reprocessing event for Cidex-OPA, Revital-Ox, Tristel and UV system were $38.59, $26.47, $30.53, and $22.74 respectively when physicians reprocessed their endoscopes themselves. Sensitivity analyses demonstrated that Revital-Ox was the least costly option in a low volume, however, the UV system remained the most cost effective in higher volumes. The cost per reprocessing event when done by clinic staff was $5.51, $4.42, $11.23 and $6.21 for Cidex-OPA, Revital-Ox, Tristel and the UV system.
    Conclusions: The UV light system appears to be the most cost-effective method in high volumes of reprocessing, and Revital-Ox is cheaper in lower volumes and when performed by clinic staff rather than physicians. It is important to consider the anticipated work volume, shared clinic space and number of co-workers prior to choosing a reprocessing method.
    MeSH term(s) Humans ; Glutaral ; Endoscopy ; Costs and Cost Analysis ; Ontario
    Chemical Substances chlorine dioxide (8061YMS4RM) ; Glutaral (T3C89M417N)
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2434004-2
    ISSN 1916-0216 ; 1916-0208 ; 0381-6605
    ISSN (online) 1916-0216
    ISSN 1916-0208 ; 0381-6605
    DOI 10.1186/s40463-022-00610-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Evaluation of septal perforation size using a novel measuring device.

    Hamilton, Stefan / Rotenberg, Brian W / Sowerby, Leigh J

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 12, Page(s) 5675–5681

    Abstract: Background: Nasal septal perforations can be managed with a septal button prosthesis. While they do not restore the physiological function of the septal mucosa, they are able to improve laminar nasal airflow. With the development of septal buttons sized ...

    Abstract Background: Nasal septal perforations can be managed with a septal button prosthesis. While they do not restore the physiological function of the septal mucosa, they are able to improve laminar nasal airflow. With the development of septal buttons sized specifically to perforations, accurate measurement of perforations has become more important for patient satisfaction and comfort. This task can be difficult to accomplish in the clinical setting. In this study, 2 new instruments developed to measure septal perforations were evaluated for accuracy and ease of use.
    Methods: Two types of measuring devices ("sizers") were created via 3D printing. One type included six serial, progressively sized instruments (serial sizers) and the other included two instruments with several size gradations (graded sizers). Septal perforations of varying sizes were surgically created in five fresh-frozen cadaver heads. Using a headlight and nasal speculum, 15 otolaryngology trainees and consultants were asked to measure the perforations (length × height) via four different methods: "eyeball" estimation, a ruler, the serial sizers, and the graded sizers. They were also asked to evaluate the methods themselves. An accurate measurement was defined as ± 1 mm of the true measurement. A combination of Chi-square analysis and ANOVA was used to assess the accuracy and ease of use of the four methods.
    Results: Chi-square analysis showed that the sizers were more accurate than the two traditional methods (eyeball and ruler) for measuring perforation length (73% vs. 44%, p = 4.8 × 10
    Conclusions: The two novel sizers studied here were significantly more accurate and easier to use than traditional methods for measuring nasal septal perforations. With broader implementation and study of these devices, there is potential to improve patient care surrounding septal perforations.
    MeSH term(s) Humans ; Nasal Septal Perforation/diagnostic imaging ; Nasal Septal Perforation/surgery ; Nose ; Prostheses and Implants ; Printing, Three-Dimensional ; Otolaryngology ; Nasal Septum/surgery
    Language English
    Publishing date 2022-06-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07460-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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