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  1. Article ; Online: The history of louse-borne typhus and geomedizine.

    Polak, Agnieszka / Pawlikowska-Łagód, Katarzyna / Zagaja, Anna / Grzybowski, Andrzej

    Clinics in dermatology

    2023  Volume 41, Issue 6, Page(s) 767–771

    Abstract: The experience of World War I made popular the concept of medical geography (geomedicine in English, geomedizine in German), which became part of Nazism's philosophy of national welfare, safety, and solidarity. The Nazis used it to create propaganda to ... ...

    Abstract The experience of World War I made popular the concept of medical geography (geomedicine in English, geomedizine in German), which became part of Nazism's philosophy of national welfare, safety, and solidarity. The Nazis used it to create propaganda to show some groups as rats, vermin, and Untermenschen (subhumans). In this way, more than 10 million people were killed under the Nazi regime: 6 million Jews, plus more than 5 million Gypsies, Jehovah's Witnesses, and other individuals who were not part of the German theory of "master race." The Germans' fear of typhus that spread in the Wehrmacht was so immense that during the occupation, Polish doctors used this phobia to organize a resistance movement. Contemporarily, the scope of geographic medicine encompasses the following research areas: spatial differentiation of disease incidents and the process of disease diffusion, geographic inequalities in the population's health level, and morbidity determinants among the inhabitants of developing countries. In the first half of the 19th century, it played an essential role in the activities aimed against epidemics of infectious diseases, including louse-borne typhus (epidemic typhus), cholera, and typhoid, linking these diseases to cultural determinants. Under the influence of this idea, the concept of doctor-hygienist emerged, and social medicine began to evolve.
    MeSH term(s) Humans ; Animals ; Rats ; Typhus, Epidemic Louse-Borne/epidemiology ; Typhus, Epidemic Louse-Borne/history ; Poland
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2023.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Erectile Dysfunction as an Obesity-Related Condition in Elderly Men with Coronary Artery Disease.

    Biernikiewicz, Małgorzata / Sobieszczańska, Małgorzata / Szuster, Ewa / Pawlikowska-Gorzelańczyk, Anna / Janocha, Anna / Rożek-Piechura, Krystyna / Rusiecka, Agnieszka / Gebala, Jana / Okrzymowska, Paulina / Kałka, Dariusz

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13072087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Typhus works of Rudolf Weigl, PhD, Ludwik Fleck, MD, and Eugeniusz Łazowski, MD, against the Nazis.

    Polak, Agnieszka / Pawlikowska-Łagód, Katarzyna / Zagaja, Anna / Grzybowski, Andrzej

    Clinics in dermatology

    2022  

    Abstract: Typhus has been present in Central Europe and Russia since the 19th century, but it was not until 1918 that it became an epidemic problem in Poland. Poverty, general devastation, unsanitary living conditions, and the extensive spread of the disease ... ...

    Abstract Typhus has been present in Central Europe and Russia since the 19th century, but it was not until 1918 that it became an epidemic problem in Poland. Poverty, general devastation, unsanitary living conditions, and the extensive spread of the disease forced the Polish government to organize effective measures to improve the population's health. One such measure was the establishment of a typhus research center in Lviv. The center was led by Rudolf Weigl, who in the 1930s succeeded in elaborating a clinically effective vaccine. In September 1939, when the Germans invaded Poland, the problem of typhus returned, primarily due to the ghettos where the Nazis confined Jews in poor, crowded, and unsanitary conditions. Later, in 1941 when Nazis tried to invade the Soviet Union (where typhus was endemic), the typhus vaccine-the work of Weigl and Ludwik Fleck (also an employee of the Lviv institute)-was in high demand. The Germans feared typhus due to its persistence and speed of spread. The Nazi typhus phobia was also used by some Polish doctors who took advantage of this disease to protect their patients from being deported or located in camps. An example of such a doctor was Eugeniusz Łazowski, who even organized a "false pandemic" to save the local population.
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2022.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Factors associated with empowerment after participating in a supported osteoarthritis self-management program: An explorative study.

    Åkesson, Karin Sturesdotter / Hansson, Eva Ekvall / Pawlikowska, Teresa / Sundén, Anne / Stigmar, Kjerstin / Ageberg, Eva

    Osteoarthritis and cartilage open

    2024  Volume 6, Issue 2, Page(s) 100464

    Abstract: Objective: To explore factors associated with change in empowerment in patients that have participated in a 3-month Supported Osteoarthritis Self-Management Program (SOASP). Further, to evaluate empowerment in the longer term.: Design: An explorative ...

    Abstract Objective: To explore factors associated with change in empowerment in patients that have participated in a 3-month Supported Osteoarthritis Self-Management Program (SOASP). Further, to evaluate empowerment in the longer term.
    Design: An explorative analysis including patients from a cohort study conducted in primary healthcare in Sweden was performed. Univariable linear regression models were performed to assess associations between demographics and patient-reported outcome measures (explanatory factors), respectively, and change in empowerment from baseline to 3-month follow-up (outcome variable). Long-term follow-up of empowerment was at 9 months.
    Results: Self-reported increase in enablement at the 3-month follow-up was associated with a greater improvement in empowerment (B ​= ​0.041, 95% CI (0.011, 0.07), p ​= ​0.008). Living alone was associated with less improvement in empowerment (B ​= ​-0.278, 95% CI (-0.469, -0.086), p ​= ​0.005) compared to living together. Physical exercise >120 ​min per week at baseline was associated with less improvement in empowerment (B ​= ​-0.293, 95% CI (-0.583, -0.004), p ​= ​0.047) compared to reporting no exercise at baseline. No other associations were observed (p ​> ​0.05). Empowerment improved from baseline to the 3-month follow-up (mean 0.20 (SD 0.5), p ​< ​0.001) but there was no change from baseline to the 9-month follow-up (mean 0.02 (SD 0.6), p ​= ​0.641).
    Conclusions: Self-reported increased enablement may lead to greater improvement in empowerment after SOASP. Greater efforts may be needed to support those that live alone, are physically active, and to sustain empowerment in the longer term after SOASP. More research is needed on empowerment to provide personalized support for patients with OA after SOASP.
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ISSN 2665-9131
    ISSN (online) 2665-9131
    DOI 10.1016/j.ocarto.2024.100464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sport and physical activity in the urban area – housing estate greens for three generations

    Anna Ostrowska-Tryzno / Hanna Nałęcz / Anna Pawlikowska-Piechotka

    Sport i Turystyka, Vol 3, Iss

    2020  Volume 2

    Abstract: Research aim: Playgrounds were historically designed only for children, today we can observe new concept of recreation sites, aimed for all ages. Traditional playground was furniture with kids’ equipment, while universal playgrounds have also facilities ... ...

    Abstract Research aim: Playgrounds were historically designed only for children, today we can observe new concept of recreation sites, aimed for all ages. Traditional playground was furniture with kids’ equipment, while universal playgrounds have also facilities for adults. These facilities enable families to play together. Research methods: Research project ds-300 AWF was a continuation of the ds-114 AWF – the MNiSW grant. Using the field survey with participant observations, structured and semi-structured interviews methods, factors determining the ‘inclusive urban playground’ for three generations were identified. Research results: To achieve the open access to the universally designed, inclusive playgrounds for all ages, basic components should be included: physical accessibility, age and developmental appropriateness, physical, social and sensory-stimulating components. Conclusions: Results show that exciting, engaging and challenging sport and recreation housing green areas are important to encourage physical activities for all age and enhance social, mental and physical skills of the three generations.
    Keywords sports ; active recreation ; playgrounds for all generations ; GV557-1198.995
    Subject code 796
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Jan Długosz University in Częstochowa
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Modified polymeric biomaterials with antimicrobial and immunomodulating properties.

    Szałapata, Katarzyna / Pięt, Mateusz / Kasela, Martyna / Grąz, Marcin / Kapral-Piotrowska, Justyna / Mordzińska-Rak, Aleksandra / Samorek, Elżbieta / Pieniądz, Paulina / Polak, Jolanta / Osińska-Jaroszuk, Monika / Paduch, Roman / Pawlikowska-Pawlęga, Bożena / Malm, Anna / Jarosz-Wilkołazka, Anna

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8025

    Abstract: The modification of the surgical polypropylene mesh and the polytetrafluoroethylene vascular prosthesis with cecropin A (small peptide) and puromycin (aminonucleoside) yielded very stable preparations of modified biomaterials. The main emphasis was ... ...

    Abstract The modification of the surgical polypropylene mesh and the polytetrafluoroethylene vascular prosthesis with cecropin A (small peptide) and puromycin (aminonucleoside) yielded very stable preparations of modified biomaterials. The main emphasis was placed on analyses of their antimicrobial activity and potential immunomodulatory and non-cytotoxic properties towards the CCD841 CoTr model cell line. Cecropin A did not significantly affect the viability or proliferation of the CCD 841 CoTr cells, regardless of its soluble or immobilized form. In contrast, puromycin did not induce a significant decrease in the cell viability or proliferation in the immobilized form but significantly decreased cell viability and proliferation when administered in the soluble form. The covalent immobilization of these two molecules on the surface of biomaterials resulted in stable preparations that were able to inhibit the multiplication of Staphylococcus aureus and S. epidermidis strains. It was also found that the preparations induced the production of cytokines involved in antibacterial protection mechanisms and stimulated the immune response. The key regulator of this activity may be related to TLR4, a receptor recognizing bacterial LPS. In the present study, these factors were produced not only in the conditions of LPS stimulation but also in the absence of LPS, which indicates that cecropin A- and puromycin-modified biomaterials may upregulate pathways leading to humoral antibacterial immune response.
    MeSH term(s) Biocompatible Materials/pharmacology ; Lipopolysaccharides ; Anti-Infective Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Polymers/pharmacology ; Staphylococcus epidermidis ; Puromycin
    Chemical Substances Biocompatible Materials ; Lipopolysaccharides ; Anti-Infective Agents ; Anti-Bacterial Agents ; Polymers ; Puromycin (4A6ZS6Q2CL)
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58730-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Turystyka sportowa – czynne i bierne uczestniczenie w wydarzeniach sportowych (amatorzy i zawodowcy)

    Anna Pawlikowska-Piechotka

    Tourism, Vol 26, Iss 1, Pp 101-

    2016  Volume 103

    Keywords Recreation. Leisure ; GV1-1860
    Language English
    Publishing date 2016-06-01T00:00:00Z
    Publisher Lodz University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Sports tourism

    Anna Pawlikowska-Piechotka

    Tourism, Vol 26, Iss 1, Pp 94-

    Active and passive participation in sporting evants (amateur and professional)

    2016  Volume 96

    Keywords Recreation. Leisure ; GV1-1860
    Language English
    Publishing date 2016-06-01T00:00:00Z
    Publisher Lodz University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Protein-Bound Polysaccharides from

    Pawlikowska, Małgorzata / Jędrzejewski, Tomasz / Brożyna, Anna A / Wrotek, Sylwia

    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

    2020  Volume 54, Issue 4, Page(s) 591–604

    Abstract: Background/aims: The induction of necroptosis, a form of caspase-independent cell death, represents one of the most promising anticancer therapeutic modalities, as necroptosis serves as an alternative way to eliminate apoptosis-resistant tumor cells. ... ...

    Abstract Background/aims: The induction of necroptosis, a form of caspase-independent cell death, represents one of the most promising anticancer therapeutic modalities, as necroptosis serves as an alternative way to eliminate apoptosis-resistant tumor cells. Here, we investigated whether protein-bound polysaccharides (PBPs) derived from the fungus
    Methods: MCF-7 and SKMel-188 cells were exposed to PBPs either alone or in combination with necrostatin-1 (Nec-1), GSK'872 or necrosulfonamide (NSA), pharmacological inhibitors of the kinases receptor-interacting protein 1 kinase (RIPK1), receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL), respectively, which are involved in necroptotic processes. The effects of cellular treatment with these inhibitors were quantified by measuring cell viability and reactive oxygen species (ROS) generation
    Results: PBPs showed effective antitumor activity against MCF-7 and SKMel-188 cells. Cotreatment of the cells with Nec-1, GSK'872 or NSA abrogated PBP-induced cell death, and the cells were protected against membrane rupture. Moreover, breast cancer cell death caused by PBPs was mediated by induced activation of the TNF-α/TNFR1 pathway. Interestingly, the melanoma cells did not express TNF-α or TNFR1 after PBP stimulation; instead, PBPs triggered intracellular ROS generation, which was partially diminished by the inhibitors Nec-1, GSK'872 and NSA.
    Conclusion: These results suggest that PBPs from the fungus CV induce RIPK1/RIPK3/MLKL-mediated necroptosis in breast cancer and melanoma cells, providing novel insights into the molecular effects of PBPs on cancer cells.
    MeSH term(s) Acrylamides/pharmacology ; Benzothiazoles/metabolism ; Breast Neoplasms/metabolism ; Cell Survival ; Female ; Humans ; Imidazoles/pharmacology ; Indoles/pharmacology ; MCF-7 Cells ; Melanoma, Amelanotic/metabolism ; NIMA-Related Kinase 1/metabolism ; Necroptosis/drug effects ; Polysaccharides/pharmacology ; Protein Kinases/metabolism ; Quinolines/metabolism ; Reactive Oxygen Species/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/antagonists & inhibitors ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Receptors, Tumor Necrosis Factor, Type I/metabolism ; Sulfonamides/pharmacology ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Acrylamides ; Benzothiazoles ; GSK872 ; Imidazoles ; Indoles ; N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide ; Polysaccharides ; Quinolines ; Reactive Oxygen Species ; Receptors, Tumor Necrosis Factor, Type I ; Sulfonamides ; Tumor Necrosis Factor-alpha ; necrostatin-1 ; MLKL protein, human (EC 2.7.-) ; Protein Kinases (EC 2.7.-) ; NIMA-Related Kinase 1 (EC 2.7.11.1) ; RIPK1 protein, human (EC 2.7.11.1) ; RIPK3 protein, human (EC 2.7.11.1) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2020-07-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1067572-3
    ISSN 1421-9778 ; 1015-8987
    ISSN (online) 1421-9778
    ISSN 1015-8987
    DOI 10.33594/000000242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of coffee on human health

    Ewa Szuster / Anna Pawlikowska / Amanda Mandera / Paulina Kostrzewska

    Journal of Education, Health and Sport, Vol 10, Iss 9, Pp 228-

    2020  Volume 234

    Abstract: Coffee is considered as one of the most popular beverages in the world. There are many different methods of preparation which can change the taste but also it could limit the level of dipertenes which raise blood cholesterol. For many years it was ... ...

    Abstract Coffee is considered as one of the most popular beverages in the world. There are many different methods of preparation which can change the taste but also it could limit the level of dipertenes which raise blood cholesterol. For many years it was thought that the impact of coffee on human health is not very positive. Surprisingly coffee consumption is associated with lower risk of the type 2 diabetes mellitus and lower cancer risk. It also decreases mortality from cardiovascular disease, coronary heart disease, and stroke. Summarizing, the results of the analyzed studies show positive impact of coffee on human health. To maintain the advantages of this beverage, amount of caffeine, intake of sugar or cream should be limited.
    Keywords coffee ; caffeine ; cardiovascular diabetes ; Education ; L ; Sports ; GV557-1198.995 ; Medicine ; R
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Kazimierz Wielki University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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