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  1. Article ; Online: Gas Chromatography-mass Spectrometry (GC-MS) analysis of alkaloids isolated from Epipremnum aureum (Linden and Andre) Bunting

    Anju Meshram / Ajai Kumar / Nidhi Srivastava

    International Journal of Pharma Sciences and Research , Vol 6, Iss 2, Pp 337-

    2015  Volume 342

    Abstract: ... of alkaloids from Epipremnum aureum (Linden and Andre) Bunting. It has been observed that the plant is very ...

    Abstract Recent advances in the use of GC coupled to MS have allowed a chemically guided isolation of uncommon and bioactive alkaloids. The present study was aimed to focus on the extraction and screening of alkaloids from Epipremnum aureum (Linden and Andre) Bunting. It has been observed that the plant is very rich in alkaloids and the modified method employed for the extraction of alkaloid is efficient and selective, where the interference of other secondary metabolites is negligible. The identification of each compound was made through gas chromatography-mass spectrometry (GC-MS). A total of twenty six structurally different alkaloids were identified for the first time from this plant. E. aureum is highly rich in alkaloids and twenty six different alkaloids were characterized. The present study may help in the field of natural products’ chemistry and pharmaceuticals as well as drug discovery science and technology.
    Keywords Araceae ; alkaloids ; isolation ; gas chromatography-mass spectrometry ; Epipremnum aureum ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
    Subject code 540
    Language English
    Publishing date 2015-02-01T00:00:00Z
    Publisher KEJA Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Occurrence of vegetable mite, Tetranychus neocaldeonicus Andre on Passion fruit, Passiflora edulis Sims and evaluation of certain acaricides against it

    Singh, S.P / Rao, N.S / Kumar, K.K

    Pestology. Jan 1981. v. 5 (1)

    1981  

    Keywords plant pests ; plant health ; arthropod pests
    Language English
    Dates of publication 1981-01
    Size p. 25-27.
    Document type Article
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: How Chatbots and Large Language Model Artificial Intelligence Systems Will Reshape Modern Medicine: Fountain of Creativity or Pandora's Box?

    Li, Ron / Kumar, Andre / Chen, Jonathan H

    JAMA internal medicine

    2023  Volume 183, Issue 6, Page(s) 596–597

    MeSH term(s) Humans ; Artificial Intelligence
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.1835
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Coordinated hydraulic traits influence the two phases of time to hydraulic failure in five temperate tree species differing in stomatal stringency.

    Waite, Pierre-André / Kumar, Manish / Link, Roman M / Schuldt, Bernhard

    Tree physiology

    2024  Volume 44, Issue 5

    Abstract: Worldwide, forests are increasingly exposed to extreme droughts causing tree mortality. Because of the complex nature of the mechanisms involved, various traits have been linked to tree drought responses with contrasting results. This may be due to ... ...

    Abstract Worldwide, forests are increasingly exposed to extreme droughts causing tree mortality. Because of the complex nature of the mechanisms involved, various traits have been linked to tree drought responses with contrasting results. This may be due to species-specific strategies in regulating water potential, a process that unfolds in two distinct phases: a first phase until stomatal closure, and a second phase until reaching lethal xylem hydraulic thresholds. We conducted dry-down experiments with five broadleaved temperate tree species differing in their degree of isohydry to estimate the time to stomatal closure (tsc) and subsequent time to critical hydraulic failure (tcrit). We measured various traits linked to tree drought responses, such as the water potentials at turgor loss point (Ptlp), stomatal closure (Pgs90), and 12%, 50% and 88% loss of xylem hydraulic conductance (P12, P50, P88), hydraulic capacitance (C), minimum leaf conductance (gmin), hydroscape area (HSA) and hydraulic safety margins (HSM). We found that Pgs90 followed previously recorded patterns of isohydry and was associated with HSA. Species ranked from more to less isohydric in the sequence Acer pseudoplatanus < Betula pendula < Tilia cordata < Sorbus aucuparia < Fagus sylvatica. Their degree of isohydry was associated with leaf safety (Ptlp and gmin), drought avoidance (C) and tsc, but decoupled from xylem safety (HSM and P88) and tcrit. Regardless of their stomatal stringency, species with wider HSM and lower P88 reached critical hydraulic failure later. We conclude that the duration of the first phase is determined by stomatal regulation, while the duration of the second phase is associated with xylem safety. Isohydry is thus linked to water use rather than to drought survival strategies, confirming the proposed use of HSA as a complement to HSM for describing plant drought responses before and after stomatal closure.
    MeSH term(s) Plant Stomata/physiology ; Trees/physiology ; Xylem/physiology ; Water/metabolism ; Water/physiology ; Droughts ; Species Specificity ; Plant Transpiration/physiology
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2024-04-12
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 743341-4
    ISSN 1758-4469 ; 0829-318X
    ISSN (online) 1758-4469
    ISSN 0829-318X
    DOI 10.1093/treephys/tpae038
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    In stock of ZB MED Bonn / Germany

    Z 4737: Show issues

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  5. Article ; Online: A call to review values, commitment, and outlook to mainstream mental health.

    Kumar, Manasi / van Rensburg, André J / Petersen, Inge

    The Lancet. Global health

    2023  Volume 11, Issue 7, Page(s) e1005–e1006

    MeSH term(s) Humans ; Mental Health ; Mental Disorders/epidemiology ; Mental Disorders/therapy
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(23)00273-5
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  6. Article ; Online: COLD Fusion: Calibrated and Ordinal Latent Distribution Fusion for Uncertainty-Aware Multimodal Emotion Recognition.

    Tellamekala, Mani Kumar / Amiriparian, Shahin / Schuller, Bjorn W / Andre, Elisabeth / Giesbrecht, Timo / Valstar, Michel

    IEEE transactions on pattern analysis and machine intelligence

    2024  Volume 46, Issue 2, Page(s) 805–822

    Abstract: Automatically recognising apparent emotions from face and voice is hard, in part because of various sources of uncertainty, including in the input data and the labels used in a machine learning framework. This paper introduces an uncertainty-aware ... ...

    Abstract Automatically recognising apparent emotions from face and voice is hard, in part because of various sources of uncertainty, including in the input data and the labels used in a machine learning framework. This paper introduces an uncertainty-aware multimodal fusion approach that quantifies modality-wise aleatoric or data uncertainty towards emotion prediction. We propose a novel fusion framework, in which latent distributions over unimodal temporal context are learned by constraining their variance. These variance constraints, Calibration and Ordinal Ranking, are designed such that the variance estimated for a modality can represent how informative the temporal context of that modality is w.r.t. emotion recognition. When well-calibrated, modality-wise uncertainty scores indicate how much their corresponding predictions are likely to differ from the ground truth labels. Well-ranked uncertainty scores allow the ordinal ranking of different frames across different modalities. To jointly impose both these constraints, we propose a softmax distributional matching loss. Our evaluation on AVEC 2019 CES, CMU-MOSEI, and IEMOCAP datasets shows that the proposed multimodal fusion method not only improves the generalisation performance of emotion recognition models and their predictive uncertainty estimates, but also makes the models robust to novel noise patterns encountered at test time.
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 1939-3539
    ISSN (online) 1939-3539
    DOI 10.1109/TPAMI.2023.3325770
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development and validation of multicentre study on novel Artificial Intelligence-based Cardiovascular Risk Score (AICVD)

    Inigo Bermejo / Prashant Gupta / Shiv Kumar Jalepalli / Andre L A J Dekker / Sujoy Kar

    Family Medicine and Community Health, Vol 12, Iss Suppl

    2024  Volume 1

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Neoprotoparmelia gen. nov. and Maronina (Lecanorales, Protoparmelioideae): species description and generic delimitation using DNA barcodes and phenotypical characters

    Singh, Garima / Aptroot, André / DIVAKAR, PRADEEP KUMAR / Lumbsch, Thorsten / Schmitt, Imke

    MycoKeys, 44:19-50

    2018  

    Abstract: Multilocus phylogenetic studies revealed a high level of cryptic diversity within the lichen-forming fungal genus Maronina (Protoparmelioideae, Parmeliaceae). Coalescent-based species delimitation suggested that most of the cryptic molecular lineages ... ...

    Institution Senckenberg Biodiversität und Klima Forschungszentrum
    Abstract Multilocus phylogenetic studies revealed a high level of cryptic diversity within the lichen-forming fungal genus Maronina (Protoparmelioideae, Parmeliaceae). Coalescent-based species delimitation suggested that most of the cryptic molecular lineages warranted recognition as separate species. Here we study the morphology and chemistry of these taxa and formally describe eight new species based on phenotypical and molecular characters. Further, we evaluate the use of ITS rDNA as a DNA barcode for identifying species in this genus. For the first time, we obtained an ITS sequence of Maronina australiensis, the type species of the genus and showed that it is phylogenetically not closely related to species currently placed in Maronina or Protoparmelia. We assembled a dataset of 66 ITS sequences to assess the interspecies genetic distances amongst the twelve Maronina species using ITS as DNA barcode. We found that Maronina and Protoparmelia form a supported monophyletic group whereas M. australiensis is sister to both. We therefore propose a new genus Neoprotoparmelia to accommodate the tropical-subtropical species within Protoparmelioideae, with Neoprotoparmelia corallifera as the type, N. amerisidiata, N. australisidiata, N. brasilisidiata, N. capensis, N. crassa, N. pauli, N. plurisporibadia and N. siamisidiata as new species and N. capitata, N. isidiata, N. multifera, N. orientalis and N. pulchra as new proposed combinations. We provide a key to Neoprotoparmelia and confirm the use of ITS for accurately identifying species in this group.
    Keywords BPP ; ITS ; Parmeliaceae ; lichenised fungi ; new genus ; new species ; taxonomy
    Language English
    Document type Article
    Database Repository for Life Sciences

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  9. Article ; Online: Medical Student Documentation Practices and Perspectives Following the 2018 CMS Billing Guidelines.

    Farber, Orly N / Dahlen, Alex / Kumar, Andre D

    Academic medicine : journal of the Association of American Medical Colleges

    2022  Volume 97, Issue 9, Page(s) 1256

    MeSH term(s) Centers for Medicare and Medicaid Services, U.S. ; Documentation ; Education, Medical, Undergraduate ; Humans ; Students, Medical ; United States
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000004779
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 112: Show issues Location:
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  10. Article ; Online: Refractory primary and secondary headache disorders that dramatically responded to combined treatment of ultrasound-guided percutaneous suprazygomatic pterygopalatine ganglion blocks and non-invasive vagus nerve stimulation: a case series.

    Boezaart, Andre P / Smith, Cameron R / Zasimovich, Yury / Przkora, Rene / Kumar, Sanjeev / Nin, Olga C / Boezaart, Louis C / Botha, Daniel Aj / Leonard, André / Reina, Miguel A / Pareja, Juan A

    Regional anesthesia and pain medicine

    2024  Volume 49, Issue 2, Page(s) 144–150

    Abstract: In 1981, Devoghel achieved an 85.6% success rate in treating patients with treatment-refractory cluster headaches with alcoholization of the pterygopalatine ganglion (PPG) via the percutaneous suprazygomatic approach. Devoghel's study led to the theory ... ...

    Abstract In 1981, Devoghel achieved an 85.6% success rate in treating patients with treatment-refractory cluster headaches with alcoholization of the pterygopalatine ganglion (PPG) via the percutaneous suprazygomatic approach. Devoghel's study led to the theory that interrupting the parasympathetic pathway by blocking its transduction at the PPG could prevent or treat symptoms related to primary headache disorders (PHDs). Furthermore, non-invasive vagus nerve stimulation (nVNS) has proven to treat PHDs and has been approved by national regulatory bodies to treat, among others, cluster headaches and migraines.In this case series, nine desperate patients who presented with 11 longstanding treatment-refractory primary headache disorders and epidural blood patch-resistant postdural puncture headache (PDPH) received ultrasound-guided percutaneous suprazygomatic pterygopalatine ganglion blocks (PPGB), and seven also received nVNS. The patients were randomly selected and were not part of a research study. They experienced dramatic, immediate, satisfactory, and apparently lasting symptom resolution (at the time of the writing of this report). The report provides the case descriptions, briefly reviews the trigeminovascular and neurogenic inflammatory theories of the pathophysiology, outlines aspects of these PPGB and nVNS interventions, and argues for adopting this treatment regime as a first-line or second-line treatment rather than desperate last-line treatment of PDPH and PHDs.
    MeSH term(s) Humans ; Cluster Headache/therapy ; Sphenopalatine Ganglion Block ; Vagus Nerve Stimulation ; Post-Dural Puncture Headache/diagnosis ; Blood Patch, Epidural ; Ultrasonography, Interventional
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1425299-5
    ISSN 1532-8651 ; 1098-7339 ; 0146-521X
    ISSN (online) 1532-8651
    ISSN 1098-7339 ; 0146-521X
    DOI 10.1136/rapm-2023-104967
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    Zs.B 2399: Show issues Location:
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