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Article: Diverse effect of MC4R risk alleles on obesity-related traits over a lifetime: Evidence from a well-designed cohort study

Moazzam-Jazi, Maryam / Sadat Zahedi, Asiyeh / Akbarzadeh, Mahdi / Azizi, Fereidoun / Daneshpour, Maryam S.

Gene. 2022 Jan. 10, v. 807

2022

Abstract: This population-based longitudinal study is the first investigation that assesses the association of common MC4R SNPs with the obesity-related parameters over time and determines the effect of risk alleles during the three adulthood life periods (early, ... ...

Abstract	This population-based longitudinal study is the first investigation that assesses the association of common MC4R SNPs with the obesity-related parameters over time and determines the effect of risk alleles during the three adulthood life periods (early, middle, and late) in a large Iranian cohort, a population with a unique genetic make-up that has been understudied and relatively unexplored. We obtained the genotype of 5370 unrelated adults who participated in the ongoing Tehran Cardiometabolic Genetic Study (TCGS) cohort project for the common MC4R SNPs. Linear regression and linear mixed model analyses were performed to examine the effect of MC4R polymorphisms on maximum BMI and other obesity-related factors over time. We recognized that several SNPs associated with the maximum BMI and the increased BMI, waist circumference, and waist-hip ratio across Iranian adults over a lifetime. Interestingly, we found that rs9954571-A has a yet unreported protective role against obesity-related factors, including BMI, waist circumference, waist-hip ratio, and triglyceride level. Additionally, a survey of the impact of the MC4R risk score throughout the adulthood life periods indicated that the MC4R risk score is influenced both the elevated BMI and waist circumference only during the early adulthood period. Our findings can expand our knowledge about the MC4R genetic variant's contributions to adulthood obesity and highlight the importance of evaluating the genetic components affecting obesity over a lifetime, which could be considered for obesity clinical screening and treatment.
Keywords	adulthood ; cohort studies ; genotype ; longitudinal studies ; obesity ; protective effect ; regression analysis ; risk ; statistical models ; triacylglycerols ; waist circumference ; waist-to-hip ratio
Language	English
Dates of publication	2022-0110
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2021.145950
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The role of FTO variant rs1421085 in the relationship with obesity: a systematic review and meta-analysis.

Najd-Hassan-Bonab, Leila / Safarpour, Mahdi / Moazzam-Jazi, Maryam / Azizi, Fereidoun / Daneshpour, Maryam S

Eating and weight disorders : EWD

2022

Abstract: Purpose: Fat mass and obesity-associated (FTO) is considered the first locus associated with adiposity, a concerning health problem worldwide. Many studies have evaluated the relationship between the FTO variants and obesity susceptibility. While the ... ...

Abstract	Purpose: Fat mass and obesity-associated (FTO) is considered the first locus associated with adiposity, a concerning health problem worldwide. Many studies have evaluated the relationship between the FTO variants and obesity susceptibility. While the strong association of FTO rs1421085 with the risk of obesity across populations was reported in different studies, some researchers found a lack of association of this variant with adiposity. This systematic review and meta-analysis aimed to assess the association between obesity and rs1421085 polymorphism. Methods: We systematically searched PubMed, Scopus, and Google Scholar up to June 2022 to find pertinent studies. To further assess this issue, we surveyed the probable association of rs1421085 with obesity development among Iranian adults using the logistic regression analysis, and the obtained results were used for doing meta-analysis. After selection, nine eligible studies were included in the meta-analysis through the random- and fixed-effect models to determine the combined odds ratios (OR) and 95% confidence intervals (CI). Results: According to our meta-analysis conducted on 5169 obese and 7772 non-obese individuals using different genetic models, including recessive, dominant, over-dominant, and additive, rs1421085 could positively increase the risk of obesity under all tested genetic models. Also, we detected a high to moderate level of heterogeneity among different studies under various genetic models. Conclusion: This meta-analysis further verified the positive association of FTO rs1421085 with the risk of developing obesity. Study registration: This study is registered as PROSPERO CRD42021220092. Level of evidence: Level I, systematic reviews and meta-analyses.
Language	English
Publishing date	2022-11-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2038625-4
ISSN	1590-1262 ; 1124-4909
ISSN (online)	1590-1262
ISSN	1124-4909
DOI	10.1007/s40519-022-01509-0
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Article ; Online: Sex-specific association of FABP2 polymorphisms with the risk of obesity in the Tehran Cardio-Metabolic Genetic Study (TCGS).

Najd-Hassan-Bonab, Leila / Givi, Niloufar Javanrouh / Moazzam-Jazi, Maryam / Masjoudi, Sajedeh / Ghafari, Nasim / Daneshpour, Maryam S

Gene

2023 Volume 876, Page(s) 147519

Abstract: FABP2 is one of the key genes involved in obesity development across different populations. However, there is no comprehensive report about the FABP2 contribution to obesity incidence among Iranians. Hence, the present study was designed to assess the ... ...

Abstract	FABP2 is one of the key genes involved in obesity development across different populations. However, there is no comprehensive report about the FABP2 contribution to obesity incidence among Iranians. Hence, the present study was designed to assess the probable role of FABP2 polymorphisms in obesity incidence in the Tehran Cardio- metabolic Genetic Study (TCGS) representative Iran population. Unrelated adults who had BMI information for at least 3 consecutive phases of the TCGS cohort were included. The control and case groups were defined as individuals who always had long-term persistent normal weight (20 < BMI < 25; n = 1526) and individuals who were long-term persistent obese (30 < BMI < 35; n = 1313), respectively. The logistic regression test was used to assess the possible association between SNPs located in and around the FABP2 gene with obesity. Also, we used Haploview and SHEsis to perform haplotype analysis to detect whether or not this chromosomal region is correlated with obesity. We found a gender-dependent association between the rs10857064 FABP2 and the risk of obesity. The presence of the rs10857064-G allele could significantly increase the risk of obesity only in women, not men (OR = 1.26; 95 % CI: 1.02-1.57; p = 0.03). Through haplotype analysis, we also detected that the TG haplotype containing rs7670862 and rs10857064 could significantly enhance the risk of obesity in women, further supporting the central role of rs10857064 in women's long-term obesity risk. In the current study, we revealed that rs10857064-G FABP2 can significantly predispose women to develop obesity. It highlights the importance of different genetic variants in both genders, which could help us to distinguish more efficient obesity screening tests and treatments based on gender in the future.
MeSH term(s)	Adult ; Humans ; Female ; Male ; Iran ; Genetic Predisposition to Disease ; Obesity/genetics ; Polymorphism, Single Nucleotide ; Haplotypes ; Fatty Acid-Binding Proteins/genetics
Chemical Substances	Fatty Acid-Binding Proteins ; FABP2 protein, human
Language	English
Publishing date	2023-05-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147519
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Article ; Online: The crosstalk between long non-coding RNAs and the hedgehog signaling pathway in cancer.

Sargazi, Marzieh Lotfian / Jafarinejad-Farsangi, Saeideh / Moazzam-Jazi, Maryam / Rostamzadeh, Farzaneh / Karam, Zahra Miri

Medical oncology (Northwood, London, England)

2022 Volume 39, Issue 9, Page(s) 127

Abstract: Hedgehog (Hh) is a conserved signaling pathway that is involved in embryo development as well as adult tissue maintenance and repair in invertebrates and vertebrates. Abnormal activation of this pathway in various types of malignant drug- and apoptosis- ... ...

Abstract	Hedgehog (Hh) is a conserved signaling pathway that is involved in embryo development as well as adult tissue maintenance and repair in invertebrates and vertebrates. Abnormal activation of this pathway in various types of malignant drug- and apoptosis-resistant tumors has made it a therapeutic target against tumorigenesis. Thus, understanding the molecular mechanisms that promote the activation or inhibition of this pathway is critical. Long non-coding RNAs (lncRNAs), a subclass of non-coding RNAs with a length of > 200 nt, affect the expression of Hh signaling components via a variety of transcriptional and post-transcriptional processes. This review focuses on the crosstalk between lncRNAs and the Hh pathway in carcinogenesis, outlines the broad role of Hh-related lncRNAs in tumor progression, and illustrates their clinical diagnostic, prognostic, and therapeutic potential in tumors.
MeSH term(s)	Adult ; Animals ; Carcinogenesis/genetics ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Humans ; Neoplasms/drug therapy ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Signal Transduction/genetics
Chemical Substances	Hedgehog Proteins ; RNA, Long Noncoding
Language	English
Publishing date	2022-06-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-022-01710-2
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Article ; Online: Risk of type 2 diabetes and KCNJ11 gene polymorphisms: a nested case-control study and meta-analysis.

Moazzam-Jazi, Maryam / Najd-Hassan-Bonab, Leila / Masjoudi, Sajedeh / Tohidi, Maryam / Hedayati, Mehdi / Azizi, Fereidoun / Daneshpour, Maryam S

Scientific reports

2022 Volume 12, Issue 1, Page(s) 20709

Abstract: Due to the central role in insulin secretion, the potassium inwardly-rectifying channel subfamily J member 11 (KCNJ11) gene is one of the essential genes for type 2 diabetes (T2D) predisposition. However, the relevance of this gene to T2D development is ... ...

Abstract	Due to the central role in insulin secretion, the potassium inwardly-rectifying channel subfamily J member 11 (KCNJ11) gene is one of the essential genes for type 2 diabetes (T2D) predisposition. However, the relevance of this gene to T2D development is not consistent among diverse populations. In the current study, we aim to capture the possible association of common KCNJ11 variants across Iranian adults, followed by a meta-analysis. We found that the tested variants of KCNJ11 have not contributed to T2D incidence in Iranian adults, consistent with similar insulin secretion levels among individuals with different genotypes. The integration of our results with 72 eligible published case-control studies (41,372 cases and 47,570 controls) as a meta-analysis demonstrated rs5219 and rs5215 are significantly associated with the increased T2D susceptibility under different genetic models. Nevertheless, the stratified analysis according to ethnicity showed rs5219 is involved in the T2D risk among disparate populations, including American, East Asian, European, and Greater Middle Eastern, but not South Asian. Additionally, the meta-regression analysis demonstrated that the sample size of both case and control groups was significantly associated with the magnitude of pooled genetic effect size. The present study can expand our knowledge about the KCNJ11 common variant's contributions to T2D incidence, which is valuable for designing SNP-based panels for potential clinical applications in precision medicine. It also highlights the importance of similar sample sizes for avoiding high heterogeneity and conducting a more precise meta-analysis.
MeSH term(s)	Adult ; Humans ; Case-Control Studies ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Insulin Secretion ; Iran/epidemiology ; Polymorphism, Genetic ; Potassium Channels, Inwardly Rectifying/genetics
Chemical Substances	Kir6.2 channel ; Potassium Channels, Inwardly Rectifying
Language	English
Publishing date	2022-12-01
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-24931-x
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Article ; Online: Interplay between SARS-CoV-2 and human long non-coding RNAs.

Moazzam-Jazi, Maryam / Lanjanian, Hossein / Maleknia, Samaneh / Hedayati, Mehdi / Daneshpour, Maryam S

Journal of cellular and molecular medicine

2021 Volume 25, Issue 12, Page(s) 5823–5827

Abstract: The long non-coding RNAs (lncRNAs) play a critical regulatory role in the host response to the viral infection. However, little is understood about the transcriptome architecture, especially lncRNAs pattern during the SARS-CoV-2 infection. In the present ...

Abstract	The long non-coding RNAs (lncRNAs) play a critical regulatory role in the host response to the viral infection. However, little is understood about the transcriptome architecture, especially lncRNAs pattern during the SARS-CoV-2 infection. In the present study, using publicly available RNA sequencing data of bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) samples from COVID-19 patients and healthy individuals, three interesting findings highlighted: (a) More than half of the interactions between lncRNAs-PCGs of BALF samples established by three trans-acting lncRNAs (HOTAIRM1, PVT1 and AL392172.1), which also exhibited the high affinity for binding to the SARS-CoV-2 genome, suggesting the major regulatory role of these lncRNAs during the SARS-CoV-2 infection. (b) lncRNAs of MALAT1 and NEAT1 are possibly contributed to the inflammation development in the SARS-CoV-2 infected cells. (c) In contrast to the 3' part of the SARS-CoV-2 genome, the 5' part can interact with many human lncRNAs. Therefore, the mRNA-based vaccines will not show any side effects because of the off-label interactions with the human lncRNAs. Overall, the putative functionalities of lncRNAs can be promising to design the non-coding RNA-based drugs and to inspect the efficiency of vaccines to overcome the current pandemic.
MeSH term(s)	Bronchoalveolar Lavage Fluid/immunology ; Bronchoalveolar Lavage Fluid/virology ; COVID-19/immunology ; COVID-19/virology ; Databases, Nucleic Acid ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/virology ; RNA, Long Noncoding/metabolism ; RNA, Viral/metabolism ; SARS-CoV-2/genetics
Chemical Substances	RNA, Long Noncoding ; RNA, Viral
Language	English
Publishing date	2021-05-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.16596
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Article ; Online: Diverse effect of MC4R risk alleles on obesity-related traits over a lifetime: Evidence from a well-designed cohort study.

Moazzam-Jazi, Maryam / Sadat Zahedi, Asiyeh / Akbarzadeh, Mahdi / Azizi, Fereidoun / Daneshpour, Maryam S

Gene

2021 Volume 807, Page(s) 145950

Abstract	This population-based longitudinal study is the first investigation that assesses the association of common MC4R SNPs with the obesity-related parameters over time and determines the effect of risk alleles during the three adulthood life periods (early, middle, and late) in a large Iranian cohort, a population with a unique genetic make-up that has been understudied and relatively unexplored. We obtained the genotype of 5370 unrelated adults who participated in the ongoing Tehran Cardiometabolic Genetic Study (TCGS) cohort project for the common MC4R SNPs. Linear regression and linear mixed model analyses were performed to examine the effect of MC4R polymorphisms on maximum BMI and other obesity-related factors over time. We recognized that several SNPs associated with the maximum BMI and the increased BMI, waist circumference, and waist-hip ratio across Iranian adults over a lifetime. Interestingly, we found that rs9954571-A has a yet unreported protective role against obesity-related factors, including BMI, waist circumference, waist-hip ratio, and triglyceride level. Additionally, a survey of the impact of the MC4R risk score throughout the adulthood life periods indicated that the MC4R risk score is influenced both the elevated BMI and waist circumference only during the early adulthood period. Our findings can expand our knowledge about the MC4R genetic variant's contributions to adulthood obesity and highlight the importance of evaluating the genetic components affecting obesity over a lifetime, which could be considered for obesity clinical screening and treatment.
MeSH term(s)	Adult ; Alleles ; Body Mass Index ; Cohort Studies ; Female ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Humans ; Iran/epidemiology ; Longitudinal Studies ; Male ; Mass Screening/methods ; Middle Aged ; Obesity/genetics ; Obesity/metabolism ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Receptor, Melanocortin, Type 4/genetics ; Receptor, Melanocortin, Type 4/metabolism ; Risk Factors ; Waist Circumference/genetics ; Waist-Hip Ratio/methods
Chemical Substances	MC4R protein, human ; Receptor, Melanocortin, Type 4
Language	English
Publishing date	2021-09-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2021.145950
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Article ; Online: Sex, age, and ethnic dependency of lipoprotein variants as the risk factors of ischemic heart disease: a detailed study on the different age-classes and genders in Tehran Cardiometabolic Genetic Study (TCGS).

Lanjanian, Hossein / Najd Hassan Bonab, Leila / Akbarzadeh, Mahdi / Moazzam-Jazi, Maryam / Zahedi, Asiyeh Sadat / Masjoudi, Sajedeh / Daneshpour, Maryam S

Biology of sex differences

2022 Volume 13, Issue 1, Page(s) 4

Abstract: Biological processes involving environmental and genetic factors drive the interplay between age- and sex-regulating lipid profile. The relation between variations in the LPA gene with increasing the risk of coronary heart disease is dependent on ... ...

Abstract	Biological processes involving environmental and genetic factors drive the interplay between age- and sex-regulating lipid profile. The relation between variations in the LPA gene with increasing the risk of coronary heart disease is dependent on population differences, sex, and age. The present study tried to do a gene candidate association analysis in people with myocardial infarction (MI) in a 22 year cohort family-based longitudinal cohort study, Tehran Cardiometabolic Genetic Study (TCGS). After adjusting p value by the FDR method, only the association of rs6415084 with the MI probability and the age-of-CHD-onset was significant in males in their middle age (p < 0.005). Surprisingly, a lack of association was observed for the rest of the markers (16 SNPs). These results revealed the moderator effects of age and sex on the association between the genetic variants (SNPs) of LPA and heart disease risk. Our observations may provide new insights into the biology that underlies lipid profile with age or the sexual dimorphism of Lp(a) metabolism. Finally, Lp(a) appears to be an independent risk factor; however, the role of sex and ethnicity is important.
MeSH term(s)	Coronary Disease/epidemiology ; Coronary Disease/genetics ; Ethnicity ; Female ; Humans ; Iran ; Lipoprotein(a)/genetics ; Longitudinal Studies ; Male ; Middle Aged ; Myocardial Infarction/epidemiology ; Myocardial Infarction/genetics ; Risk Factors
Chemical Substances	Lipoprotein(a)
Language	English
Publishing date	2022-01-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2587352-0
ISSN	2042-6410 ; 2042-6410
ISSN (online)	2042-6410
ISSN	2042-6410
DOI	10.1186/s13293-022-00413-7
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Article ; Online: Investigation of genes and pathways involved in breast cancer subtypes through gene expression meta-analysis.

Jafarinejad-Farsangi, Saeideh / Moazzam-Jazi, Maryam / Naderi Ghale-Noie, Zari / Askari, Nahid / Miri Karam, Zahra / Mollazadeh, Samaneh / Hadizadeh, Morteza

Gene

2022 Volume 821, Page(s) 146328

Abstract: Background: Molecular-based studies have revealed heterogeneity in Breast cancer BC while also improving classification and treatment. However, efforts are underway to distinguish between distinct subtypes of breast cancer. In this study, the results of ...

Abstract	Background: Molecular-based studies have revealed heterogeneity in Breast cancer BC while also improving classification and treatment. However, efforts are underway to distinguish between distinct subtypes of breast cancer. In this study, the results of several microarray studies were combined to identify genes and pathways specific to each BC subtype. Methods: Meta-analysis of multiple gene expression profile datasets was screened to find differentially expressed genes (DEGs) across subtypes of BC and normal breast tissue samples. Protein-protein interaction network and gene set enrichment analysis were used to identify critical genes and pathways associated with BC subtypes. The differentially expressed genes from meta-analysis was validated using an independent comprehensive breast cancer RNA-sequencing dataset obtained from the Cancer Genome Atlas (TCGA). Results: We identified 110 DEGs (13 DEGs in all and 97 DEGs in each subtype) across subtypes of BC. All subtypes had a small set of shared DEGs enriched in the Chemokine receptor bind chemokine pathway. Luminal A specific were enriched in the translational elongation process in mitochondria, and the enhanced process in luminal B subtypes was interferon-alpha/beta signaling. Cell cycle and mitotic DEGs were enriched in the basal-like group. All subtype-specific DEG genes (100%) were successfully validated for Luminal A, Luminal B, ERBB2, and Normal-like. However, the validation percentage for Basal-like group was 77.8%. Conclusion: Integrating researches such as a meta-analysis of gene expression might be more effective in uncovering subtype-specific DEGs and pathways than a single-study analysis. It would be more beneficial to increase the number of studies that use matched BC subtypes along with GEO profiling approaches to reach a better result regarding DEGs and reduce probable biases. However, achieving 77.8% overlap in basal-specific genes and complete concordance in specific genes related to other subtypes can implicate the strength of our analysis for discovering the subtype-specific genes.
MeSH term(s)	Breast Neoplasms/classification ; Breast Neoplasms/genetics ; Databases, Genetic ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Oligonucleotide Array Sequence Analysis ; Sequence Analysis, RNA
Language	English
Publishing date	2022-02-16
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2022.146328
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Article ; Online: High genetic burden of type 2 diabetes can promote the high prevalence of disease: a longitudinal cohort study in Iran.

Moazzam-Jazi, Maryam / Najd Hassan Bonab, Leila / Zahedi, Asiyeh Sadat / Daneshpour, Maryam S

Scientific reports

2020 Volume 10, Issue 1, Page(s) 14006

Abstract: Type 2 diabetes (T2D) is emerging as one of the serious public health issues in both developed and developing counties. Here, we surveyed the worldwide population differentiation in T2D-associated variants and assessed the genetic burden of the disease ... ...

Abstract	Type 2 diabetes (T2D) is emerging as one of the serious public health issues in both developed and developing counties. Here, we surveyed the worldwide population differentiation in T2D-associated variants and assessed the genetic burden of the disease in an ongoing Tehran Cardio-Metabolic Genetic Study (TCGS) cohort represented the Iranian population. We found multiple SNPs that were significantly depleted or enriched in at least one of the five populations of 1,000 Genome Project (African, American, East Asian, European, and South Asian) as well as the Iranian population. Interestingly, TCF7L2, a well-known associated gene with T2D, harbors the highest number of enriched risk alleles almost in all populations except for East Asian, where this gene embraces the largest number of significantly depleted risk alleles. The polygenic risk score (PRS) of the enriched risk alleles was calculated for 1,867 diabetic and 2,855 non-diabetic participants in the TCGS cohort, interestingly demonstrating that the risk of developing T2D was almost two times higher in top PRS quintile compared with the lowest quintile after adjusting for other known risk factors.
MeSH term(s)	Adult ; Alleles ; Cohort Studies ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study/methods ; Humans ; Iran/epidemiology ; Longitudinal Studies ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prevalence ; Risk Factors ; Transcription Factor 7-Like 2 Protein/genetics ; Young Adult
Chemical Substances	TCF7L2 protein, human ; Transcription Factor 7-Like 2 Protein
Language	English
Publishing date	2020-08-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-70725-4
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