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  1. Article ; Online: Correction: Regulation of the Effect of Physical Activity Through MicroRNAs in Breast Cancer.

    Hong, Bok Sil

    International journal of sports medicine

    2022  Volume 43, Issue 5, Page(s) 465

    Language English
    Publishing date 2022-05-04
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/a-1770-7074
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1561: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: [No title information]

    Hong, Bok Sil

    International Journal of Sports Medicine

    2022  Volume 43, Issue 05, Page(s) 465–465

    Language English
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/a-1770-7074
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1561: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Regulation of the Effect of Physical Activity Through MicroRNAs in Breast Cancer.

    Hong, Bok Sil

    International journal of sports medicine

    2021  Volume 43, Issue 5, Page(s) 455–465

    Abstract: Physical activity and exercise can induce beneficial molecular and biological regulations that have been associated with an incidence of various diseases, including breast cancer. Recent studies demonstrated that the potential links between physical ... ...

    Abstract Physical activity and exercise can induce beneficial molecular and biological regulations that have been associated with an incidence of various diseases, including breast cancer. Recent studies demonstrated that the potential links between physical activity-induced circulating microRNAs (miRNAs) and cancer risk and progression. Here, we investigated whether altered miRNAs by exercise could influence breast cancer progression. After primary searching in PubMed and reviewing the full-text papers, candidate miRNAs altered by exercise in breast cancer were identified. Analysis of expression profiles and clinical outcomes of altered miRNAs using The Cancer Genome Atlas datasets showed altered miRNAs expressions were significantly associated with the patient's prognosis, whereas prognostic values of each miRNA varied in different stages and subtypes. In addition, altered miRNAs profiles regulated various target genes and key signaling pathways in tumorigenesis, including pathways in cancer and the PI3K-Akt signaling pathway; however, miRNAs regulated the expression of target genes differently according to tumor stages and subtypes. These results indicate that circulating miRNAs are promising noninvasive stable biomarkers for early detection, diagnosis, prognosis, and monitoring the response to clinical therapies of breast cancer. Moreover, stages and subtype-stratified approaches for breast cancer progression would be needed to evaluate the prognostic value of miRNAs for biomarkers and therapeutic targets.
    MeSH term(s) Biomarkers, Tumor/genetics ; Biomarkers, Tumor/therapeutic use ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Circulating MicroRNA ; Exercise ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinases/therapeutic use ; Prognosis
    Chemical Substances Biomarkers, Tumor ; Circulating MicroRNA ; MicroRNAs
    Language English
    Publishing date 2021-12-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/a-1678-7147
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1561: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: [No title information]

    Hong, Bok Sil

    International Journal of Sports Medicine

    2021  Volume 43, Issue 05, Page(s) 455–465

    Abstract: Physical activity and exercise can induce beneficial molecular and biological regulations that have been associated with an incidence of various diseases, including breast cancer. Recent studies demonstrated that ... ...

    Abstract Physical activity and exercise can induce beneficial molecular and biological regulations that have been associated with an incidence of various diseases, including breast cancer. Recent studies demonstrated that the potential links between physical activity-induced circulating microRNAs (miRNAs) and cancer risk and progression. Here, we investigated whether altered miRNAs by exercise could influence breast cancer progression. After primary searching in PubMed and reviewing the full-text papers, candidate miRNAs altered by exercise in breast cancer were identified. Analysis of expression profiles and clinical outcomes of altered miRNAs using The Cancer Genome Atlas datasets showed altered miRNAs expressions were significantly associated with the patient's prognosis, whereas prognostic values of each miRNA varied in different stages and subtypes. In addition, altered miRNAs profiles regulated various target genes and key signaling pathways in tumorigenesis, including pathways in cancer and the PI3K-Akt signaling pathway; however, miRNAs regulated the expression of target genes differently according to tumor stages and subtypes. These results indicate that circulating miRNAs are promising noninvasive stable biomarkers for early detection, diagnosis, prognosis, and monitoring the response to clinical therapies of breast cancer. Moreover, stages and subtype-stratified approaches for breast cancer progression would be needed to evaluate the prognostic value of miRNAs for biomarkers and therapeutic targets.
    Keywords circulating miRNAs ; exercise ; biomarker ; prognosis
    Language English
    Publishing date 2021-12-06
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/a-1678-7147
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1561: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Interplays between human microbiota and microRNAs in COVID-19 pathogenesis: a literature review.

    Hong, Bok Sil / Kim, Myoung-Ryu

    Physical activity and nutrition

    2021  Volume 25, Issue 2, Page(s) 1–7

    Abstract: Purpose: Recent studies have shown that COVID-19 is often associated with altered gut microbiota composition and reflects disease severity. Furthermore, various reports suggest that the interaction between COVID-19 and host-microbiota homeostasis is ... ...

    Abstract Purpose: Recent studies have shown that COVID-19 is often associated with altered gut microbiota composition and reflects disease severity. Furthermore, various reports suggest that the interaction between COVID-19 and host-microbiota homeostasis is mediated through the modulation of microRNAs (miRNAs). Thus, in this review, we aim to summarize the association between human microbiota and miRNAs in COVID-19 pathogenesis.
    Methods: We searched for the existing literature using the keywords such "COVID-19 or microbiota," "microbiota or microRNA," and "COVID-19 or probiotics" in PubMed until March 31, 2021. Subsequently, we thoroughly reviewed the articles related to microbiota and miRNAs in COVID-19 to generate a comprehensive picture depicting the association between human microbiota and microRNAs in the pathogenesis of COVID-19.
    Results: There exists strong experimental evidence suggesting that the composition and diversity of human microbiota are altered in COVID-19 patients, implicating a bidirectional association between the respiratory and gastrointestinal tracts. In addition, SARS-CoV-2 encoded miRNAs and host cellular microRNAs modulated by human microbiota can interfere with viral replication and regulate host gene expression involved in the initiation and progression of COVID-19. These findings suggest that the manipulation of human microbiota with probiotics may play a significant role against SARS-CoV-2 infection by enhancing the host immune system and lowering the inflammatory status.
    Conclusion: The human microbiota-miRNA axis can be used as a therapeutic approach for COVID-19. Hence, further studies are needed to investigate the exact molecular mechanisms underlying the regulation of miRNA expression in human microbiota and how these miRNA profiles mediate viral infection through host-microbe interactions.
    Language English
    Publishing date 2021-06-30
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2733-7545
    ISSN (online) 2733-7545
    DOI 10.20463/pan.2021.0008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Skin Wound Healing and Anti-Wrinkle-Promoting In Vitro Biological Activities of

    Kim, Mi Jung / Won, Kyung Jong / Kim, Do Yoon / Won, Yu Rim / Kim, Nan Young / Lee, Da Kyoung / Hong, Bok Sil / Lee, Hwan Myung

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: ... Caragana ... ...

    Abstract Caragana sinica
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A systematic review of the biological mechanisms linking physical activity and breast cancer.

    Hong, Bok Sil / Lee, Kang Pa

    Physical activity and nutrition

    2020  Volume 24, Issue 3, Page(s) 25–31

    Abstract: Purpose: Epidemiological evidence has shown that leisure-time physical activity and structured exercise before and after breast cancer diagnosis contribute to reducing the risk of breast cancer recurrence and mortality. Thus, in this review, we aimed to ...

    Abstract Purpose: Epidemiological evidence has shown that leisure-time physical activity and structured exercise before and after breast cancer diagnosis contribute to reducing the risk of breast cancer recurrence and mortality. Thus, in this review, we aimed to summarize the physical activity-dependent regulation of systemic factors to understand the biological and molecular mechanisms involved in the initiation, progression, and survival of breast cancer.
    Methods: We systematically reviewed the studies on 1) the relationship between physical activity and the risk of breast cancer, and 2) various systemic factors induced by physical activity and exercise that are potentially linked to breast cancer outcomes. To perform this literature review, PubMed database was searched using the terms "Physical activity OR exercise" and "breast cancer", until August 5th, 2020; then, we reviewed those articles related to biological mechanisms after examining the resulting search list.
    Results: There is strong evidence that physical activity reduces the risk of breast cancer, and the protective effect of physical activity on breast cancer has been achieved by long-term regulation of various circulatory factors, such as sex hormones, metabolic hormones, inflammatory factors, adipokines, and myokines. In addition, physical activity substantially alters wholebody homeostasis by affecting numerous other factors, including plasma metabolites, reactive oxygen species, and microRNAs as well as exosomes and gut microbiota profile, and thereby every cell and organ in the whole body might be ultimately affected by the biological perturbation induced by physical activity and exercise.
    Conclusion: The understanding of integrative mechanisms will enhance how physical activity can ultimately influence the risk and prognosis of various cancers, including breast cancer. Furthermore, physical activity could be considered an efficacious non-pharmacological therapy, and the promotion of physical activity is probably an effective strategy in primary cancer prevention.
    Language English
    Publishing date 2020-09-30
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2733-7545
    ISSN (online) 2733-7545
    DOI 10.20463/pan.2020.0018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Chemical Composition of

    Won, Yu Rim / Won, Kyung Jong / Kim, Do Yoon / Kim, Mi Jung / Hong, Bok Sil / Lee, Hwan Myung

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 11

    Abstract: Impatiens ... ...

    Abstract Impatiens textori
    Language English
    Publishing date 2022-11-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15111397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A network pharmacology approach to explore the potential role of Panax ginseng on exercise performance.

    Kim, Jisu / Lee, Kang Pa / Kim, Myoung-Ryu / Kim, Bom Sahn / Moon, Byung Seok / Shin, Chul Ho / Baek, Suji / Hong, Bok Sil

    Physical activity and nutrition

    2021  Volume 25, Issue 3, Page(s) 28–35

    Abstract: Purpose: As Panax ginseng C. A. Meyer (ginseng) exhibits various physiological activities and is associated with exercise, we investigated the potential active components of ginseng and related target genes through network pharmacological analysis. ... ...

    Abstract Purpose: As Panax ginseng C. A. Meyer (ginseng) exhibits various physiological activities and is associated with exercise, we investigated the potential active components of ginseng and related target genes through network pharmacological analysis. Additionally, we analyzed the association between ginseng-related genes, such as the G-protein-coupled receptors (GPCRs), and improved exercise capacity.
    Methods: Active compounds in ginseng and the related target genes were searched in the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). Gene ontology functional analysis was performed to identify biological processes related to the collected genes, and a compound-target network was visualized using Cytoscape 3.7.2.
    Results: A total of 21 ginseng active compounds were detected, and 110 targets regulated by 17 active substances were identified. We found that the active compound protein was involved in the biological process of adrenergic receptor activity in 80%, G-protein-coupled neurotransmitter in 10%, and leucocyte adhesion to arteries in 10%. Additionally, the biological response centered on adrenergic receptor activity showed a close relationship with G protein through the beta-1 adrenergic receptor gene reactivity.
    Conclusion: According to bioavailability analysis, ginseng comprises 21 active compounds. Furthermore, we investigated the ginseng-stimulated gene activation using ontology analysis. GPCR, a gene upregulated by ginseng, is positively correlated to exercise. Therefore, if a study on this factor is conducted, it will provide useful basic data for improving exercise performance and health.
    Language English
    Publishing date 2021-09-30
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2733-7545
    ISSN (online) 2733-7545
    DOI 10.20463/pan.2021.0018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Systematic analysis of the pharmacological function of Schisandra as a potential exercise supplement.

    Hong, Bok Sil / Baek, Suji / Kim, Myoung-Ryu / Park, Sun Mi / Kim, Bom Sahn / Kim, Jisu / Lee, Kang Pa

    Physical activity and nutrition

    2021  Volume 25, Issue 4, Page(s) 38–44

    Abstract: Purpose: Exercise can prevent conditions such as atrophy and degenerative brain diseases. However, owing to individual differences in athletic ability, exercise supplements can be used to improve a person's exercise capacity. Schisandra chinensis (SC) ... ...

    Abstract Purpose: Exercise can prevent conditions such as atrophy and degenerative brain diseases. However, owing to individual differences in athletic ability, exercise supplements can be used to improve a person's exercise capacity. Schisandra chinensis (SC) is a natural product with various physiologically active effects. In this study, we analyzed SC using a pharmacological network and determined whether it could be used as an exercise supplement.
    Methods: The active compounds of SC and target genes were identified using the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). The active compound and target genes were selected based on pharmacokinetic (PK) conditions (oral bioavailability (OB) ≥ 30%, Caco-2 permeability (Caco-2) ≥ -0.4, and drug-likeness (DL) ≥ 0.18). Gene ontology (GO) was analyzed using the Cytoscape software.
    Results: Eight active compounds were identified according to the PK conditions. Twenty-one target genes were identified after excluding duplicates in the eight active compounds. The top 10 GOs were analyzed using GO-biological process analysis. GO was subsequently divided into three representative categories: postsynaptic neurotransmitter receptor activity (53.85%), an intracellular steroid hormone receptor signaling pathway (36.46%), and endopeptidase activity (10%). SC is related to immune function.
    Conclusion: According to the GO analysis, SC plays a role in immunity and inflammation, promotes liver metabolism, improves fatigue, and regulates the function of steroid receptors. Therefore, we suggest SC as an exercise supplement with nutritional and anti-fatigue benefits.
    Language English
    Publishing date 2021-12-31
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2733-7545
    ISSN (online) 2733-7545
    DOI 10.20463/pan.2021.0024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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