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  1. Article ; Online: Model for the Simulation of the C

    Johnston, Michael A / Duff, Andrew Ian / Anderson, Richard L / Swope, William C

    The journal of physical chemistry. B

    2020  Volume 124, Issue 43, Page(s) 9701–9721

    Abstract: ... ethylene oxide) alkyl ethers, an important class of micelle-forming nonionic surfactants, usually denoted C ...

    Abstract Using a comprehensive set of recently published experimental results for training and validation, we have developed computational models appropriate for simulations of aqueous solutions of poly(ethylene oxide) alkyl ethers, an important class of micelle-forming nonionic surfactants, usually denoted C
    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.0c06132
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  2. Article: Letter from Dr. C. Johnston.

    Johnston, Chr

    The American journal of dental science

    2019  Volume 7, Issue 1, Page(s) 66–68

    Language English
    Publishing date 2019-02-12
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Adlayer formation on C-plane (0001) and R-plane

    Johnston-Peck, Aaron C / Maier, Russell A

    Journal of the American Ceramic Society. American Ceramic Society

    2022  Volume 106, Issue 2, Page(s) 1490–1499

    Abstract: Adlayers on C-plane (0001) and R-plane ...

    Abstract Adlayers on C-plane (0001) and R-plane
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008170-4
    ISSN 1551-2916 ; 0002-7820
    ISSN (online) 1551-2916
    ISSN 0002-7820
    DOI 10.1111/jace.18814
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  4. Article ; Online: The Plant DNA C-Values Database: A One-Stop Shop for Plant Genome Size Data.

    Henniges, Marie C / Johnston, Emmeline / Pellicer, Jaume / Hidalgo, Oriane / Bennett, Michael D / Leitch, Ilia J

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2703, Page(s) 111–122

    Abstract: ... The Plant DNA C-values database has established itself as a trusted and widely used central hub for users ...

    Abstract Genome size is a plant character with far-reaching implications, ranging from impacts on the financial and computing feasibility of sequencing and assembling genomes all the way to influencing the very ecology and evolution of species. The increasing recognition of the role of genome size in plant science has led to a rising demand for comprehensive and easily accessible sources of genome size data. The Plant DNA C-values database has established itself as a trusted and widely used central hub for users needing to access available plant genome size data, complemented with related cytogenetic (ploidy level) and karyological (chromosome number) information where available. Since its inception in 2001, the database has undergone six major updates to incorporate newly available genome size information, leading to the most recent release (Release 7.1), which comprises data for 12,273 species across all the major land plant and some algal lineages. Here we describe how to use the database efficiently, making use of its different query and filtering settings.
    MeSH term(s) Genome Size ; Genome, Plant ; Cytogenetics ; DNA, Plant/genetics ; Databases, Nucleic Acid
    Chemical Substances DNA, Plant
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3389-2_9
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  5. Article ; Online: C-STICH2

    Victoria Hodgetts-Morton / Catherine A. Hewitt / Laura Jones / Lisa Leighton / Nicole Pilarski / Eleanor Molloy / Kim Hinshaw / Jane Norman / Jason Waugh / Sarah Stock / Jim Thornton / Philip Toozs-Hobson / Tracey Johnston / Arri Coomarasamy / Shakila Thangaratinam / Ben Mol / Eva Pajkrt / Neil Marlow / Tracy Roberts /
    Lee Middleton / Peter Brocklehurst / Katie Morris

    Trials, Vol 22, Iss 1, Pp 1-

    emergency cervical cerclage to prevent miscarriage and preterm birth—study protocol for a randomised controlled trial

    2021  Volume 11

    Abstract: ... to an expectant approach. Methods C-STICH2 is a multicentre randomised controlled trial in which women presenting ...

    Abstract Abstract Background Cervical cerclage is a recognised treatment to prevent late miscarriage and pre-term birth (PTB). Emergency cervical cerclage (ECC) for cervical dilatation with exposed unruptured membranes is less common and the potential benefits of cerclage are less certain. A randomised control trial is needed to accurately assess the effectiveness of ECC in preventing pregnancy loss compared to an expectant approach. Methods C-STICH2 is a multicentre randomised controlled trial in which women presenting with cervical dilatation and unruptured exposed membranes at 16 + 0 to 27 + 6 weeks gestation are randomised to ECC or expectant management. Trial design includes 18 month internal pilot with embedded qualitative process evaluation, minimal data set and a within-trial health economic analysis. Inclusion criteria are ≥16 years, singleton pregnancy, exposed membranes at the external os, gestation 16 + 0–27 + 6 weeks, and informed consent. Exclusion criteria are contraindication to cerclage, cerclage in situ or previous cerclage in this pregnancy. Randomisation occurs via an online service in a 1:1 ratio, using a minimisation algorithm to reduce chance imbalances in key prognostic variables (site, gestation and dilatation). Primary outcome is pregnancy loss; a composite including miscarriage, termination of pregnancy and perinatal mortality defined as stillbirth and neonatal death in the first week of life. Secondary outcomes include all core outcomes for PTB. Two-year development outcomes will be assessed using general health and Parent Report of Children’s Abilities-Revised (PARCA-R) questionnaires. Intended sample size is 260 participants (130 each arm) based on 60% rate of pregnancy loss in the expectant management arm and 40% in the ECC arm, with 90% power and alpha 0.05. Analysis will be by intention-to-treat. Discussion To date there has been one small trial of ECC in 23 participants which included twin and singleton pregnancies. This small trial along with the largest observational study (n = 161) ...
    Keywords Miscarriage ; Preterm birth ; Cervical cerclage ; Randomised controlled trial ; Economic evaluation ; Qualitative process evaluation ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous

    Pfeifle, Annabelle / Thulasi Raman, Sathya N / Lansdell, Casey / Zhang, Wanyue / Tamming, Levi / Cecillon, Jonathon / Laryea, Emmanuel / Patel, Devina / Wu, Jianguo / Gravel, Caroline / Frahm, Grant / Gao, Jun / Chen, Wangxue / Chaconas, George / Sauve, Simon / Rosu-Myles, Michael / Wang, Lisheng / Johnston, Michael J W / Li, Xuguang

    Frontiers in immunology

    2023  Volume 14, Page(s) 1020134

    Abstract: ... nanoparticle (LNP)-encapsulated DNA vaccine encoding outer surface protein C type A (OspC-type ...

    Abstract Introduction: The incidence of Lyme disease (LD) in Canada and the United States has risen over the last decade, nearing 480,000 cases each year.
    Methods: In this study, we developed a lipid nanoparticle (LNP)-encapsulated DNA vaccine encoding outer surface protein C type A (OspC-type A) of
    Results: Vaccination of C3H/HeN mice with two doses of the candidate vaccine induced significant OspC-type A-specific antibody titres and borreliacidal activity. Analysis of the bacterial burden following needle challenge with
    Discussion: Overall, the results of this study provide support for the use of a DNA-LNP platform for the development of LD vaccines.
    MeSH term(s) Humans ; Mice ; Animals ; Borrelia burgdorferi ; Vaccines, DNA ; Myocarditis ; Bacterial Vaccines ; Mice, Inbred C3H ; Lyme Disease ; DNA
    Chemical Substances OspC protein ; Vaccines, DNA ; Lipid Nanoparticles ; Bacterial Vaccines ; DNA (9007-49-2)
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1020134
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  7. Article ; Online: Substrate-Mediator Duality of 1,4-Dicyanobenzene in Electrochemical C(sp

    Johnston, Brandon / Loh, Daniel M / Nocera, Daniel G

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 49, Page(s) e202312128

    Abstract: Electrochemical approaches to form C(sp ...

    Abstract Electrochemical approaches to form C(sp
    Language English
    Publishing date 2023-11-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202312128
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  8. Article: Erythrocyte osmotic fragility is not linked to vitamin C nutriture in adults with well-controlled type 2 diabetes.

    Lundy, Ciara / Fessler, Samantha N / Johnston, Carol S

    Frontiers in nutrition

    2022  Volume 9, Page(s) 954010

    Abstract: ... microvascular disease. Vitamin C supplementation improves glycemic indices in adults with type 2 diabetes (T2D ... by improving antioxidant status. This cross-sectional study examined the relationships between vitamin C status ... Additionally, plasma was stabilized with metaphosphoric acid prior to vitamin C analysis using isocratic ...

    Abstract Erythrocyte fragility is amplified by oxidative stress and linked to diabetes-specific microvascular disease. Vitamin C supplementation improves glycemic indices in adults with type 2 diabetes (T2D) by improving antioxidant status. This cross-sectional study examined the relationships between vitamin C status and erythrocyte osmotic fragility in adults with or without T2D. Participants provided a fasting blood sample for erythrocyte osmotic fragility testing as a function of hypotonic NaCl concentrations. Additionally, plasma was stabilized with metaphosphoric acid prior to vitamin C analysis using isocratic reverse-phase UV-HPLC separation. Participants were grouped as diagnosed T2D (
    Language English
    Publishing date 2022-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.954010
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  9. Article ; Online: Steam-created grain boundaries for methane C-H activation in palladium catalysts.

    Huang, Weixin / Johnston-Peck, Aaron C / Wolter, Trenton / Yang, Wei-Chang D / Xu, Lang / Oh, Jinwon / Reeves, Benjamin A / Zhou, Chengshuang / Holtz, Megan E / Herzing, Andrew A / Lindenberg, Aaron M / Mavrikakis, Manos / Cargnello, Matteo

    Science (New York, N.Y.)

    2021  Volume 373, Issue 6562, Page(s) 1518–1523

    Abstract: ... a 12-fold increase in the mass-specific reaction rate for carbon-hydrogen (C–H) activation in methane ...

    Abstract Defects may display high reactivity because the specific arrangement of atoms differs from crystalline surfaces. We demonstrate that high-temperature steam pretreatment of palladium catalysts provides a 12-fold increase in the mass-specific reaction rate for carbon-hydrogen (C–H) activation in methane oxidation compared with conventional pretreatments. Through a combination of experimental and theoretical methods, we demonstrate that an increase in the grain boundary density through crystal twinning is achieved during the steam pretreatment and oxidation and is responsible for the increased reactivity. The grain boundaries are highly stable during reaction and show specific rates at least two orders of magnitude higher than other sites on the palladium on alumina (Pd/Al
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abj5291
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  10. Article ; Online: Hi-C detects genomic structural variants in peripheral blood of pediatric leukemia patients.

    Mallard, Claire / Johnston, Michael J / Bobyn, Anna / Nikolic, Ana / Argiropoulos, Bob / Chan, Jennifer A / Guilcher, Gregory M T / Gallo, Marco

    Cold Spring Harbor molecular case studies

    2022  Volume 8, Issue 1

    Abstract: ... are used to detect candidate translocations in bone marrow samples from B-ALL patients. Recently Hi-C ... of the nuclear genome, was shown to effectively recognize structural variants. Here, we demonstrate that Hi-C ...

    Abstract B-cell acute lymphoblastic leukemia (B-ALL) is often driven by chromosome translocations that result in recurrent and well-studied gene fusions. Currently, fluorescent in situ hybridization probes are used to detect candidate translocations in bone marrow samples from B-ALL patients. Recently Hi-C, a sequencing-based technique originally designed to reconstruct the three-dimensional architecture of the nuclear genome, was shown to effectively recognize structural variants. Here, we demonstrate that Hi-C can be used as a genome-wide assay to detect translocations and other structural variants of potential clinical interest. Structural variants were identified in both bone marrow and peripheral blood samples, including an
    MeSH term(s) Child ; Genomic Structural Variation ; Humans ; In Situ Hybridization, Fluorescence ; Oncogene Proteins, Fusion/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Translocation, Genetic/genetics
    Chemical Substances Oncogene Proteins, Fusion
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835759-0
    ISSN 2373-2873 ; 2373-2873
    ISSN (online) 2373-2873
    ISSN 2373-2873
    DOI 10.1101/mcs.a006157
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