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Book: Xin xiandai Han-Ying cidian

Xie, Zhenqing

= The new modern Chinese English dictionary

1997

Title variant	The new modern Chinese English dictionary
Author's details	zhubian: Xie Zhenqing
Language	Chinese ; English
Size	1253 S.
Edition	1. ed.
Publisher	Zhongguo Guoji Guangbo Chubanshe
Publishing place	Beijing
Publishing country	China
Document type	Book
HBZ-ID	HT011170448
ISBN	7-5078-1472-6 ; 978-7-5078-1472-9
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Exploring the anti-ferroptosis mechanism of Kai-Xin-San against Alzheimer's disease through integrating network pharmacology, bioinformatics, and experimental validation strategy in vivo and in vitro.

Yan, Chenchen / Yang, Song / Shao, Simai / Zu, Runru / Lu, Hao / Chen, Yuanzhao / Zhou, Yangang / Ying, Xiran / Xiang, Shixie / Zhang, Peixu / Li, Zhonghua / Yuan, Ye / Zhang, Zhenqiang / Wang, Pan / Xie, Zhishen / Wang, Wang / Ma, Huifen / Sun, Yiran

Journal of ethnopharmacology

2024 Volume 326, Page(s) 117915

Abstract: Ethnopharmacological relevance: Kai Xin San (KXS), first proposed by Sun Simiao during the Tang ...

Abstract	Ethnopharmacological relevance: Kai Xin San (KXS), first proposed by Sun Simiao during the Tang Dynasty, has been utilized to treat dementia by tonifying qi and dispersing phlegm. Aim of the study: This study aimed to elucidate the mechanism by which KXS exerts its therapeutic effects on Alzheimer's disease (AD) by targeting ferroptosis, using a combination of network pharmacology, bioinformatics, and experimental validation strategies. Materials and methods: The active target sites and the further potential mechanisms of KXS in protecting against AD were investigated through molecular docking, molecular dynamics simulation, and network pharmacology, and combined with the validation of animal experiments. Results: Computational and experimental findings provide the first indication that KXS significantly improves learning and memory defects and inhibits neuronal ferroptosis by repairing mitochondria damage and upregulating the protein expression of ferroptosis suppressor protein 1 (FSP1) in vivo APP/PS1 mice AD model. According to bioinformatics analysis, the mechanism by which KXS inhibits ferroptosis may involve SIRT1. KXS notably upregulated the mRNA and protein expression of SIRT1 in both vivo APP/PS1 mice and in vitro APP-overexpressed HT22 cells. Additionally, KXS inhibited ferroptosis induced by APP-overexpression in HT22 cells through activating the SIRT1-FSP1 signal pathway. Conclusions: Collectively, our findings suggest that KXS may inhibit neuronal ferroptosis through activating the SIRT1/FSP1 signaling pathway. This study reveals the scientific basis and underlying modern theory of replenishing qi and eliminating phlegm, which involves the inhibition of ferroptosis. Moreover, it highlights the potential application of SIRT1 or FSP1 activators in the treatment of AD and other ferroptosis-related diseases.
MeSH term(s)	Mice ; Animals ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Sirtuin 1/genetics ; Ferroptosis ; Molecular Docking Simulation ; Network Pharmacology ; Computational Biology ; Drugs, Chinese Herbal
Chemical Substances	Kai-Xin-San ; Sirtuin 1 (EC 3.5.1.-) ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-02-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117915
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Article ; Online: From dotted lines to fetal cardiology: the pioneering contribution of Xin-Fang Wang (1934-2021).

Deng, J / Papageorghiou, A T / Xie, M

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

2022 Volume 59, Issue 5, Page(s) 574–575

MeSH term(s)	Cardiology ; Cardiovascular System ; Fetus ; Humans
Language	English
Publishing date	2022-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1073183-0
ISSN	1469-0705 ; 0960-7692
ISSN (online)	1469-0705
ISSN	0960-7692
DOI	10.1002/uog.24881
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Article: Effectiveness and Safety of Acupoint Application of Guan Xin Su He Pill () for Patients with Chronic Stable Angina Pectoris: A Multi-Center, Randomized Controlled Trial.

Li, De-Hua / Xie, Jin / Ren, Yu-Lan / Zheng, Hui / Lyu, Jun-Ling / Leng, Jun-Yan / Zhang, Ling-Lin / Zhang, Jie / Fan, Hai-Long / Liang, Fan-Rong

Chinese journal of integrative medicine

2021 Volume 27, Issue 11, Page(s) 838–845

Abstract: Objective: To assess the clinical effectiveness of acupoint application (AP) of Guan Xin Su ...

Abstract	Objective: To assess the clinical effectiveness of acupoint application (AP) of Guan Xin Su He Pill (, GXSHP) for patients with chronic stable angina pectoris (CSAP). Methods: This study was carried out in 3 local hospitals in Chengdu, China. After baseline evaluation, eligible patients were randomly assigned to the placebo application for acupoints (PAA) group or the herbal application for acupoints (HAA) group. Patients in the HAA group underwent AP with herbal powder, which was mainly GXSHP, and patients in the PAA group underwent AP with sham drugs. For each treatment session, unilateral acupoints including Neiguan (PC 6), Danzhong (RN 17), Xinshu (BL 15) and Jueyinshu (BL 14), were stimulated for both groups. AP was performed 3 times a week with a 2-day interval for 4 weeks. The primary outcome was the frequency of angina pectoris attacks per week, while the secondary outcomes included angina pain intensity measured by the Visual Analogue Scale (VAS), dose of rescue oral drugs (nitroglycerin), scores on the Seattle Angina Questionnaire (SAQ), Self-Rating Anxiety Scale scores (SAS) and Self-Rating Depression Scale scores (SDS). Clinical outcomes were measured at week 0, 4 and 8. The safety of AP of GXSHP treatment for CSAP were assessed. Results: A total of 121 patients were enrolled. Baseline characteristics were comparable across the 2 groups. After treatment, the angina attack numbers in the HAA group were significantly reduced from 11.00 to 4.81 (P<0.05). While, for PAA group, the angina frequency was not significantly improved (baseline 10.55; post-treatment 11.05). The HAA group had significantly fewer angina attacks than the PAA group (P<0.05). Pain intensity measured by VAS in HAA group was significantly reduced from 4.06 to 3.02 (P<0.05). While, for PAA group, the VAS was significantly increased (baseline 3.62; post-treatment 3.96; P<0.05). Clinical outcomes showed better improvement after treatment in the HAA group than in the PAA group in terms of oral administration of rescue drugs, SAS, SDS and SAQ scores (P<0.05). The adverse events were also reported. Conclusion: AP of GXSHP is a safe and effective treatment for CSAP patients (Registration No. NCT02029118).
MeSH term(s)	Acupuncture Points ; Angina, Stable/drug therapy ; China ; Drugs, Chinese Herbal/adverse effects ; Female ; Humans ; Male ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-08-13
Publishing country	China
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-021-2870-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Corrigendum: Ion Channel Targeted Mechanisms of Anti-arrhythmic Chinese Herbal Medicine Xin Su Ning.

Wang, Taiyi / Xie, Weiwei / Yu, Jiahui / Ellory, Clive / Wilkins, Robert / Zhu, Yan / Ma, Yu-Ling

Frontiers in pharmacology

2019 Volume 10, Page(s) 493

Abstract: This corrects the article DOI: 10.3389/fphar.2019.00070.]. ...

Abstract	[This corrects the article DOI: 10.3389/fphar.2019.00070.].
Language	English
Publishing date	2019-05-09
Publishing country	Switzerland
Document type	Journal Article ; Published Erratum
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2019.00493
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Article ; Online: Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway.

Guo, Sirui / Wang, Jiahong / Xu, Huarong / Rong, Weiwei / Gao, Cheng / Yuan, Ziyue / Xie, Fucheng / Bi, Kaishun / Zhang, Zhou / Li, Qing

Oxidative medicine and cellular longevity

2019 Volume 2019, Page(s) 9096409

Abstract: ... in multiple pathomechanisms of AD. The anti-AD effect with multiple action targets of Kai-Xin-San (KXS ...

Abstract	Alzheimer's disease (AD) is a widespread neurodegenerative disease caused by complicated disease-causing factors. Unsatisfactorily, curative effects of approved anti-AD drugs were not good enough due to their actions on single-target, which led to desperate requirements for more effective drug therapies involved in multiple pathomechanisms of AD. The anti-AD effect with multiple action targets of Kai-Xin-San (KXS), a classic prescription initially recorded in
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Animals ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Male ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/pathology ; Rats
Chemical Substances	Drugs, Chinese Herbal ; Kai-Xin-San
Language	English
Publishing date	2019-07-01
Publishing country	United States
Document type	Journal Article
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2019/9096409
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ion Channel Targeted Mechanisms of Anti-arrhythmic Chinese Herbal Medicine Xin Su Ning.

Wang, Taiyi / Xie, Weiwei / Yu, Jiahui / Ellory, Clive / Wilkins, Robert / Zhu, Yan / Ma, Yu-Ling

Frontiers in pharmacology

2019 Volume 10, Page(s) 70

Abstract: Xin Su Ning (XSN) is a China patented and certified herbal medicine used to treat ...

Abstract	Xin Su Ning (XSN) is a China patented and certified herbal medicine used to treat premature ventricular contractions (PVCs) since 2005. A recent completed clinical trial of 861 patients showed that XSN had similar PVC inhibition rate to the class I antiarrhythmic drug mexiletine, at 65.85% for XSN and 63.10% for mexiletine. We have previously reported that XSN prolongs action potential duration (APD) and suppresses action potential amplitude (APA) of the cardiac ventricular myocytes. In this report we aim to reveal the effect of XSN on the ionic channels that govern APD and APA, which would help to explain the cellular electrophysiological mechanism of XSN. Our main findings are: (1) On ECG recorded in isolated rat, in the presence of XSN the amplitude of R wave was significantly decreased and the amplitude of T wave was increased significantly; (2) XSN blocked hNaV1.5 channel stably transfected cell line in a dose-dependent manner with an IC
Language	English
Publishing date	2019-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2019.00070
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy and safety of Chinese herbal medicine Wen Xin granules for the treatment of unstable angina pectoris with Yang deficiency and blood stasis syndrome: study protocol for a randomized controlled trial.

Tian, Pan-Pan / Wu, Qing-Juan / Li, Jun / Chen, Heng-Wen / Wu, Ji / Deng, Ya-Wen / Xie, Zi-Cong / Zhao, Wei / Tan, Yu-Qing

Trials

2021 Volume 22, Issue 1, Page(s) 798

Abstract: ... stasis syndrome is a common type of UAP. Wen Xin decoction, as a type of Chinese herbal medicine, has ... and blood stasis syndrome. This study aims to evaluate the efficacy and safety of Wen Xin granular ... group. Based on conventional medication, the intervention group will be treated with Wen Xin granular ...

Abstract	Introduction: Unstable angina pectoris (UAP) is the common type of coronary heart disease with the risk of developing into acute myocardial infarction (AMI). Currently, there are still numerous patients suffering from recurrent angina after revascularization or conventional medication due to the microvascular lesions, endothelial dysfunction, chronic inflammation, in-stent restenosis, and other factors. As an important part of China's medical and health care system, traditional Chinese medicine (TCM) has rich clinical experience in the treatment of UAP. According to the theory of TCM, Yang deficiency and blood stasis syndrome is a common type of UAP. Wen Xin decoction, as a type of Chinese herbal medicine, has been used in the clinic for years and shown great efficacy in the treatment of UAP with Yang deficiency and blood stasis syndrome. This study aims to evaluate the efficacy and safety of Wen Xin granular in patients with UAP. Methods and analysis: This is a double-blinded, randomized, placebo-controlled clinical trial. A total of 502 participants will be randomly allocated to the intervention group and the placebo group. Based on conventional medication, the intervention group will be treated with Wen Xin granular and the placebo group will be treated with Wen Xin granular placebo. The primary outcomes are major adverse cardiovascular events (MACE). Assessments will be performed 1 year after the treatment. The secondary outcomes include TCM symptom scale score, Seattle angina questionnaire, and thromboelastography. Assessments will be performed at baseline (before randomization) and 4 and 8 weeks after randomization. Discussion: This trial will provide high-quality data on the benefits and risks of Wen Xin granular in patients with UAP. Trial registration: ClinicalTrials.gov NCT04661709 . Registered on 30 November 2020.
MeSH term(s)	Angina, Unstable/diagnosis ; Angina, Unstable/drug therapy ; Double-Blind Method ; Drugs, Chinese Herbal/adverse effects ; Humans ; Medicine, Chinese Traditional ; Myocardial Infarction ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Yang Deficiency
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-11-13
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-021-05771-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy and safety of Chinese herbal medicine Wen Xin granules for the treatment of unstable angina pectoris with Yang deficiency and blood stasis syndrome

Pan-pan Tian / Qing-juan Wu / Jun Li / Heng-wen Chen / Ji Wu / Ya-wen Deng / Zi-cong Xie / Wei Zhao / Yu-qing Tan

Trials, Vol 22, Iss 1, Pp 1-

study protocol for a randomized controlled trial

2021 Volume 8

Abstract	Abstract Introduction Unstable angina pectoris (UAP) is the common type of coronary heart disease with the risk of developing into acute myocardial infarction (AMI). Currently, there are still numerous patients suffering from recurrent angina after revascularization or conventional medication due to the microvascular lesions, endothelial dysfunction, chronic inflammation, in-stent restenosis, and other factors. As an important part of China’s medical and health care system, traditional Chinese medicine (TCM) has rich clinical experience in the treatment of UAP. According to the theory of TCM, Yang deficiency and blood stasis syndrome is a common type of UAP. Wen Xin decoction, as a type of Chinese herbal medicine, has been used in the clinic for years and shown great efficacy in the treatment of UAP with Yang deficiency and blood stasis syndrome. This study aims to evaluate the efficacy and safety of Wen Xin granular in patients with UAP. Methods and analysis This is a double-blinded, randomized, placebo-controlled clinical trial. A total of 502 participants will be randomly allocated to the intervention group and the placebo group. Based on conventional medication, the intervention group will be treated with Wen Xin granular and the placebo group will be treated with Wen Xin granular placebo. The primary outcomes are major adverse cardiovascular events (MACE). Assessments will be performed 1 year after the treatment. The secondary outcomes include TCM symptom scale score, Seattle angina questionnaire, and thromboelastography. Assessments will be performed at baseline (before randomization) and 4 and 8 weeks after randomization. Discussion This trial will provide high-quality data on the benefits and risks of Wen Xin granular in patients with UAP. Trial registration ClinicalTrials.gov NCT04661709 . Registered on 30 November 2020
Keywords	Coronary heart disease ; Unstable angina pectoris ; Wen Xin decoction ; Chinese herb medicine ; Randomized controlled trial ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An integrated approach to uncover quality markers of Traditional Chinese medicine underlying chemical profiling, network target selection and metabolomics approach: Guan-Xin-Jing capsule as a model.

Zhang, Guanhua / Wang, Qi / Liu, Xin / Wang, Xu / Xie, Wenyu / Liu, Kun / Jiang, Wujun / Mu, Chenglin / Qi, Huanyang / Wang, Qiao

Journal of pharmaceutical and biomedical analysis

2020 Volume 190, Page(s) 113413

Abstract: ... Xin-Jing capsule (GXJC) was used as a model. Firstly, the UHPLC-QTOF-MS/MS was performed to identify ...

Abstract	The "multi-component and multi-target" property of traditional Chinese medicine (TCM) makes the quality control more difficult, which remains a key concern hindering the space of progress in its modernization and globalization. This study aims to provide a new strategy to discover quality markers related to the efficacy and stability of TCM based on the bioactive markers finding and differential markers finding, Guan-Xin-Jing capsule (GXJC) was used as a model. Firstly, the UHPLC-QTOF-MS/MS was performed to identify the chemical profiling of GXJC and 148 compounds were unequivocally or tentatively identified. Subsequently, the compounds with relatively low intensity, low oral bioavailability and unsuited drug likeness were removed. In addition, a network based approach by integrating candidate compound genes and disease genes was applied to further filter out the potential active compounds against coronary heart disease (CHD) and finally 7 compounds were identified as the potential bioactive markers. Moreover, to ensure the batch-to-batch consistency of GXJC, an untargeted UHPLC-QTOF-MS/MS based metabolomics approach and multivariate statistical analysis was performed and 5 compounds were identified as the potential differential markers to illustrate the discrepancy among 27 batches of GXJC. Using these strategies above, a total of 11 chemical compounds in GXJC were screened out as quality markers(Q-markers). The information generated with our strategy should be more helpful to guide the selection of the Q-markers and lay the foundation for quality control of TCM.
MeSH term(s)	Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional ; Metabolomics ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2020-08-01
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2020.113413
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