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Article: Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to Ameliorate Type 2 Diabetes Mellitus in Rodent Model.

Yin, Wen / Zhang, Si-Qi / Pang, Wen-Lin / Chen, Xiao-Jiao / Wen, Jing / Hou, Jiong / Wang, Cui / Song, Li-Yun / Qiu, Zhen-Ming / Liang, Peng-Tao / Yuan, Jia-Li / Yang, Zhong-Shan / Bian, Yao

Diabetes, metabolic syndrome and obesity : targets and therapy

2022 Volume 15, Page(s) 2563–2581

Abstract: ... metabolic diseases and promote the progression of T2DM. Tang-ping-san (TPS) decoction can effectively treat T2DM ...

Abstract	Purpose: Type 2 diabetes mellitus (T2DM) is a complex genetic disease associated with genetic and environmental factors. Previous studies have shown that changes in the gut microbiota may affect the development of host metabolic diseases and promote the progression of T2DM. Tang-ping-san (TPS) decoction can effectively treat T2DM. However, its specific mechanisms must be evaluated. Patients and methods: In the present study, we established an animal model of T2DM using a high‑fat diet (HFD) with intraperitoneal injection streptozotocin injection. Results: The therapeutic effect of TPS decoction on T2DM in mice was initially evaluated. TPS decoction was found to improve hyperglycemia, hyperlipidemia, insulin resistance, and pathological liver, pancreatic, and colon changes. Moreover, it reduced the pro-inflammatory cytokine levels. Based on 16SrRNA sequencing, TPS decoction reduced the Conclusion: TPS decoction improves T2DM and liver function and reduces the risk of hyperglycemia, hyperlipidemia, insulin resistance, pathological organ changes, and inflammatory reactions. The mechanism of TPS decoction in T2DM can be correlated with the reversal of gut microbiota dysfunction and repair of the intestinal mucosal barrier.
Language	English
Publishing date	2022-08-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S375572
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Article ; Online: Salt-Stress-Induced Ion Transport Contributes to K+/Na+ Homeostasis in Roots of Ping’ou Hybrid Hazelnut

Luo, Da / Song, Fenghui / Lu, Mingyan / Shi, Yanjiang / Ma, Qinghua

Forests. 2023 Aug. 15, v. 14, no. 8

2023

Abstract: ... Soil salinization in Xinjiang of China is very serious. Ping’ou hybrid hazelnut, as an important ecological and ... Understanding the salt-tolerance mechanism of Ping’ou hybrid hazelnut is of great significance for the breeding ... variety of Ping’ou hybrid hazelnut, was selected as test material, and seedlings were treated with 0 ...

Abstract	Soil salinity is a worldwide problem that adversely affects plant growth and development. Soil salinization in Xinjiang of China is very serious. Ping’ou hybrid hazelnut, as an important ecological and economic tree species, as well as a salt-tolerant plant, has been grown in Xinjiang for over 20 years. Understanding the salt-tolerance mechanism of Ping’ou hybrid hazelnut is of great significance for the breeding of salt-tolerant varieties and the rational utilization of salinized land. In this study, ‘Liaozhen 7’, a fine variety of Ping’ou hybrid hazelnut, was selected as test material, and seedlings were treated with 0 (control), 50, 100 and 200 mM NaCl. Subsequently, the pattern of NaCl-induced fluxes of Na⁺, K⁺ and H⁺ in the root meristematic zone and their response to ion transport inhibitors were studied using non-invasive micro-test technology (NMT). Different concentrations of NaCl stress significantly increased the Na⁺ concentration in roots, while K⁺ concentration decreased first and then increased with the increase of NaCl concentration. Meanwhile, NaCl stress induced a significant decline in K⁺/Na⁺ ratio. Control and 200 mM NaCl-induced Na⁺ and K⁺ fluxes in roots exhibited an outward efflux, whereas an inward flux was observed for H⁺. Under 200 mM NaCl stress, the average rates of net Na⁺ and K⁺ efflux, as well as H⁺ influx in roots were significantly increased, which were 11.6, 6.7 and 2.3 times higher than that of control, respectively. Furthermore, pharmacological experiments showed that 200 mM NaCl-induced Na⁺ efflux; H⁺ influx was significantly suppressed by amiloride, an inhibitor of plasma membrane (PM) Na⁺/H⁺ antiporter, and sodium vanadate, an inhibitor of PM H⁺-ATPase. Net Na⁺ efflux and H⁺ influx induced by NaCl decreased by 89.9% and 135.0%, respectively. The NaCl-induced Na⁺ efflux was mediated by a Na⁺/H⁺ antiporter using energy provided by PM H⁺-ATPase. The NaCl-induced K⁺ efflux was significantly restricted by tetraethylamine chloride, a K⁺ channel inhibitor, and promoted by sodium vanadate, which decreased by 111.2% and increased by 80.8%, respectively, indicating that K⁺ efflux was regulated by depolarization-activated outward-rectifying K⁺ channels and non-selective cation channels (NSCCs). In conclusion, NMT data revealed that NaCl stress up regulated the root Na⁺/H⁺ antiporter and H⁺ pump (an activity of PM Na⁺/H⁺ antiport system) of ‘Liaozhen 7’, which compelled the Na⁺/H⁺ exchange across the PM and restricted K⁺ loss via depolarization-activated K⁺ channels and NSCCs simultaneously, thereby maintaining the K⁺/Na⁺ homeostasis and higher salt tolerance.
Keywords	antiporters ; cations ; chlorides ; energy ; growth and development ; hazelnuts ; homeostasis ; hybrids ; meristems ; plant growth ; plasma membrane ; salt stress ; salt tolerance ; sodium ; soil salinity ; soil salinization ; trees ; China
Language	English
Dates of publication	2023-0815
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f14081651
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Traditional Chinese medicine Ka-Sai-Ping suppresses the growths of gastric cancers via induction of autophagy.

Zhu, Mo-Li / Lu, Jun-Xiu / Pan, Guo-Pin / Ping, Song / Zhao, Fan-Rong / Qi, Heng-Tian / Yu, Hai-Ya / Jian, Xu / Wan, Guang-Rui / Li, Peng

Oncotarget

2017 Volume 8, Issue 56, Page(s) 95075–95082

Abstract: ... like cardiovascular diseases and cancers. This study was designed to explore whether ka-sai-ping (KSP ...

Abstract	Traditional Chinese medication is increasingly used to treat a wide range of human chronic diseases like cardiovascular diseases and cancers. This study was designed to explore whether ka-sai-ping (KSP), a novel traditional Chinese medicine developed by us, prevents gastric cancer growths and to investigate the underlying mechanism. The xenograft model of mouse gastric cancer was established by injecting MFCs into nude mouse subcutaneously. Cell autophagy was assessed by MDC staining. Lysosome and mitochondria were detected by Lyso-Tracker Red and Mito-Traker Green staining. Incubation of cultured mouse gastric cancer cell line MFCs with KSP for 48 hours, concentration-dependently reduced cell survivals and activated autophagy, which were accompanied with damaged lysosomes and mitochondria.
Language	English
Publishing date	2017-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.18041
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Article: Effects of Yu-ping-feng granules combined with loratadine tablets on treatment efficacy and immune factor levels in allergic rhinitis patients.

Song, Jinlan

American journal of translational research

2021 Volume 13, Issue 5, Page(s) 5192–5199

Abstract: Objective: This study was designed to explore the treatment efficacy of Yu-ping-feng combined ... treated with Yu-ping-feng combined with loratadine. The immune factors and ventilation function of the two ... in group B were higher than those in group A (P < 0.05).: Conclusion: Yu-ping-feng granules combined ...

Abstract	Objective: This study was designed to explore the treatment efficacy of Yu-ping-feng combined with loratadine in allergic rhinitis patients. Methods: A total of 88 patients with allergic rhinitis who were admitted to our hospital from July 2017 to September 2018 were collected as research subjects, 43 of whom were enrolled in group A and treated with loratadine, and another 45 cases were enrolled in group B and treated with Yu-ping-feng combined with loratadine. The immune factors and ventilation function of the two groups were observed, as well as the treatment efficacy, adverse reactions and quality of life of the two groups of patients. Results: After treatment, the immune factor level and ventilation function in group B were better than those in group A (P < 0.05). The total adverse reactions and recurrence rate in group B were lower than those in group A (P < 0.05). The total effective rate and quality of life in group B were higher than those in group A (P < 0.05). Conclusion: Yu-ping-feng granules combined with loratadine tablets is effective in treating allergic rhinitis.
Language	English
Publishing date	2021-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article: Yu Ping Feng San Exert Anti-Angiogenesis Effects through the Inhibition of TSLP-STAT3 Signaling Pathways in Hepatocellular Carcinoma.

Yuan, Qin / Yao, Fei / Zhou, Liang / Liang, Guoqiang / Song, Xiudao / Jiang, Guorong / Zhou, Man / Zhang, Lurong

Evidence-based complementary and alternative medicine : eCAM

2019 Volume 2019, Page(s) 1947156

Abstract: Background: Clinically, Yu ping feng san (YPFS) has been extensively used as a medication ...

Abstract	Background: Clinically, Yu ping feng san (YPFS) has been extensively used as a medication for treating immune deficiency, and YPFS is combined with chemotherapy drugs to treat cancer, including hepatocellular carcinoma (HCC), lung cancer, and pancreatic cancer. Previous research has shown that YPFS has a therapeutic effect on HCC by improving the immunosuppressive state of the liver cancer microenvironment. The present study aimed to investigate the effect of YPFS on angiogenesis of HCC. Methods: High-performance liquid chromatography (HPLC) was used to certify the composition of YPFS. An orthotopic transplanted model of murine HCC was entrenched. Immunohistochemistry was used to observe the changes of the microvessel density (MVD). The MTT assay was used to detect the cell viability. ELISA was performed to analyze the expression of related factors. Western blot was used to analyze the protein expression. Tube formation assay was used to analyze the anti-angiogenic efficiency. Results: YPFS significantly reduced the tumor volume and weight, thus exerted the growth inhibitory effect. The level of MVD and VEGF was obviously decreased in YPFS-treated HCC-bearing mice, and the YPFS treatment also reduced the VEGF level in Hepa1-6 cells. Further study revealed that the expression of TSLP/TSLPR and p-STAT3/STAT3 was decreased by YPFS. The level of MVD and VEGF and the expression of TSLP/TSLPR and p-STAT3/STAT3 in tumor tissue and Hepa1-6 cells were suppressed by incubation with the anti-TSLP antibody, whereas treatment with the anti-TSLP antibody in YPFS-treated cells did not cause further significant inhibition compared with the cells treated only with YPFS. More importantly, YPFS inhibited proliferation, expression of p-STAT3/STAT3, and tube formation of HUVECs induced by TSLP. Conclusions: These results indicated that YPFS attenuated the activation of the TSLP-STAT3 signaling pathway by inhibiting the immune-related factor-TSLP, thereby inhibiting the formation of hepatic microvessels and exerting an anti-HCC effect.
Language	English
Publishing date	2019-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2019/1947156
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Zs.A 5995: Show issues

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Article: Pharmacokinetic-pharmacodynamic evaluation of the major component astragaloside IV on the immunomodulatory effects of Yu-ping-feng prescription.

Song, Jue / Li, Jun / Jin, Yong / Wang, Hao / Zheng, Shirui / Gao, Jian

European journal of drug metabolism and pharmacokinetics

2013 Volume 39, Issue 2, Page(s) 103–110

Abstract: Yu-ping-feng decoction (YPF), a traditional Chinese medicine (TCM) prescription, is widely used ...

Abstract	Yu-ping-feng decoction (YPF), a traditional Chinese medicine (TCM) prescription, is widely used to treat some respiratory tract diseases. This study was aimed to set up a pharmacokinetic-pharmacodynamic (PK-PD) model to assess dose-effect relationships for immunomodulatory effects of YPF in rats and to clarify compatibility mechanisms for TCM prescription system. Serum samples taken after YPF administration were tested on spleen cells of rats in vitro and proliferation ratio of spleen cells was used as end points to evaluate pharmacodynamic properties of immunoregulatory effects of YPF prescription. And with a HPLC-MS method, concentrations of Astragaloside IV (AS), a main component of YPF, were determined to achieve pharmacokinetic parameters after administration of a simplified prescription which is composed with AS, Atractylenolide I and Prim-O-glucosylcimifugin which are representative components of YPF. A plot of serum AS concentrations versus time and effects showed that there was a correlated relationship between AS concentrations and effects of YPF, and the concentration-response curve which was based on an E max model showed a counterclockwise hysteresis manner. A PK-PD model with Sheiner's method was used to describe time course of AS concentration in blood compartment and effect compartment, and main parameters with the PK-PD model were calculated. These results showed that there is a symmetry relationship between serum AS concentrations and responses of serum containing medicine of YPF prescription, which means that AS plays an important role in immunoregulatory effects of YPF. And the investigation on dose-effect relationships has displayed a feasible method to clarify mechanisms of combination for TCM prescriptions.
MeSH term(s)	Animals ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Immunologic Factors/pharmacology ; Male ; Medicine, Chinese Traditional ; Rats ; Rats, Sprague-Dawley ; Saponins/pharmacokinetics ; Triterpenes/pharmacokinetics
Chemical Substances	Drugs, Chinese Herbal ; Immunologic Factors ; Saponins ; Triterpenes ; yu ping feng san ; astragaloside A (3A592W8XKE)
Language	English
Publishing date	2013-12-18
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196729-0
ISSN	2107-0180 ; 0378-7966 ; 0398-7639
ISSN (online)	2107-0180
ISSN	0378-7966 ; 0398-7639
DOI	10.1007/s13318-013-0161-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1236: Show issues

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Article ; Online: Developing an activity and absorption-based quality control platform for Chinese traditional medicine: Application to Zeng-Sheng-Ping(Antitumor B).

Yin, Taijun / Yang, Guanyi / Ma, Yong / Xu, Beibei / Hu, Ming / You, Ming / Gao, Song

Journal of ethnopharmacology

2015 Volume 172, Page(s) 195–201

Abstract: Ethnopharmacological relevance: Zeng-Sheng-Ping (ZSP), also called antitumor B, is a marketed ...

Abstract	Ethnopharmacological relevance: Zeng-Sheng-Ping (ZSP), also called antitumor B, is a marketed Chinese traditional medicine used for cancer prevention. Aim of the study: Currently, for the quality control of Chinese traditional medicines, marker compounds are not selected based on bioactivities and pharmaceutical behaviors in most of the cases. Therefore, even if the "quality" of the medicine is controlled, the pharmacological effect could still be inconsistent. The aim of this study is to establish an activity and absorption-based platform to select marker compound(s) for the quality control of Chinese traditional medicines. Materials and methods: We used ZSP as a reference Chinese traditional medicine to establish the platform. Activity guided fractionation approach was used to purify the major components from ZSP. NMR and MS spectra were used to elucidate the structure of the isolated compounds. MTT assay against oral carcinoma cell line (SCC2095) was performed to evaluate the activities. UPLC-MS/MS was used to quantify the pure compounds in ZSP and the active fraction. The permeabilities of the identified compounds were evaluated in the Caco-2 cell culture model. The intracellular accumulation of the isolated compounds was evaluated in the SCC2095 cells. Results: The major compounds were identified from ZSP. The contents, anti-proliferation activities, permeabilities, and intracellular accumulations of these compounds were also evaluated. The structure of these purified compounds were identified by comparing the NMR and MS data with those of references as rutaevine (1), limonin (2), evodol (3), obacunone (4), fraxinellone (5), dictamnine (6), maackiain (7), trifolirhizin (8), and matrine (9). The IC50 of compounds 5, 6, and 7 against SCC2095 cells were significantly lower than that of ZSP. The uptake permeability of compounds 5, 6, and 7 were 2.58 ± 0.3 × 10(-5), 4.33 ± 0.5 × 10(-5), and 4.27 ± 0.8 × 10(-5) respectively in the Caco-2 cell culture model. The intracellular concentrations of these compounds showed that compounds 5, 6, and 7 were significantly accumulated inside the cells. Conclusion: Based on the activity against oral carcinoma cell line as well as the absorption permeability, compound 5, 6, and 7 are selected as quality control markers for ZSP. An activity and absorption-based platform was established and successfully used for the quality control of ZSP.
MeSH term(s)	Alkaloids/analysis ; Alkaloids/isolation & purification ; Benzofurans/analysis ; Benzofurans/isolation & purification ; Benzoxepins/analysis ; Benzoxepins/isolation & purification ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Glucosides/analysis ; Glucosides/isolation & purification ; Glucosides/pharmacokinetics ; Heterocyclic Compounds, 4 or More Rings/analysis ; Heterocyclic Compounds, 4 or More Rings/isolation & purification ; Heterocyclic Compounds, 4 or More Rings/pharmacokinetics ; Humans ; Limonins/analysis ; Limonins/isolation & purification ; Medicine, Chinese Traditional/standards ; Permeability ; Pterocarpans/analysis ; Pterocarpans/isolation & purification ; Pterocarpans/pharmacokinetics ; Quality Control ; Quinolines/analysis ; Quinolines/isolation & purification ; Quinolines/pharmacokinetics ; Quinolizines/analysis ; Quinolizines/isolation & purification ; Triterpenes/analysis ; Triterpenes/isolation & purification
Chemical Substances	Alkaloids ; Antitumor B ; Benzofurans ; Benzoxepins ; Drugs, Chinese Herbal ; Glucosides ; Heterocyclic Compounds, 4 or More Rings ; Limonins ; Pterocarpans ; Quinolines ; Quinolizines ; Triterpenes ; trifolirhizin ; fraxinellone (28808-62-0) ; rutaevin (33237-37-5) ; obacunone (751-03-1) ; dictamnine (HQZ3798D0A) ; limonin (L0F260866S) ; matrine (N390W430AC) ; inermin (TF360D25IJ)
Language	English
Publishing date	2015-08-22
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2015.06.019
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Zs.A 1494: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Developing an activity and absorption-based quality control platform for Chinese traditional medicine: Application to Zeng-Sheng-Ping(Antitumor B)

Yin, Taijun / Beibei Xu / Guanyi Yang / Ming Hu / Ming You / Song Gao / Yong Ma

Journal of ethnopharmacology. 2015 Aug. 22, v. 172

2015

Abstract: Zeng-Sheng-Ping (ZSP), also called antitumor B, is a marketed Chinese traditional medicine used ...

Abstract	Zeng-Sheng-Ping (ZSP), also called antitumor B, is a marketed Chinese traditional medicine used for cancer prevention.Currently, for the quality control of Chinese traditional medicines, marker compounds are not selected based on bioactivities and pharmaceutical behaviors in most of the cases. Therefore, even if the “quality” of the medicine is controlled, the pharmacological effect could still be inconsistent. The aim of this study is to establish an activity and absorption-based platform to select marker compound(s) for the quality control of Chinese traditional medicines.We used ZSP as a reference Chinese traditional medicine to establish the platform. Activity guided fractionation approach was used to purify the major components from ZSP. NMR and MS spectra were used to elucidate the structure of the isolated compounds. MTT assay against oral carcinoma cell line (SCC2095) was performed to evaluate the activities. UPLC–MS/MS was used to quantify the pure compounds in ZSP and the active fraction. The permeabilities of the identified compounds were evaluated in the Caco-2 cell culture model. The intracellular accumulation of the isolated compounds was evaluated in the SCC2095 cells.The major compounds were identified from ZSP. The contents, anti-proliferation activities, permeabilities, and intracellular accumulations of these compounds were also evaluated. The structure of these purified compounds were identified by comparing the NMR and MS data with those of references as rutaevine (1), limonin (2), evodol (3), obacunone (4), fraxinellone (5), dictamnine (6), maackiain (7), trifolirhizin (8), and matrine (9). The IC50 of compounds 5, 6, and 7 against SCC2095 cells were significantly lower than that of ZSP. The uptake permeability of compounds 5, 6, and 7 were 2.58±0.3×10−5, 4.33±0.5×10−5, and 4.27±0.8×10−5 respectively in the Caco-2 cell culture model. The intracellular concentrations of these compounds showed that compounds 5, 6, and 7 were significantly accumulated inside the cells.Based on the activity against oral carcinoma cell line as well as the absorption permeability, compound 5, 6, and 7 are selected as quality control markers for ZSP. An activity and absorption-based platform was established and successfully used for the quality control of ZSP.
Keywords	absorption ; bioactive properties ; cell culture ; fractionation ; human cell lines ; inhibitory concentration 50 ; limonin ; models ; neoplasm cells ; neoplasms ; nuclear magnetic resonance spectroscopy ; permeability ; quality control ; traditional medicine
Language	English
Dates of publication	2015-0822
Size	p. 195-201.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2015.06.019
Database	NAL-Catalogue (AGRICOLA)

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Z 90/710: Show issues

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Book: Jiang jie shi sheng ping

Song, Ping

1987

Author's details	Song ping zhu
Keywords	Presidents ; China
Language	Chinese
Size	3, 693 p., [12] p. of plates, ill., ports, 21 cm
Edition	Di 1 ban
Publisher	Ji lin ren min chu ban she
Publishing place	Chang chun
Document type	Book
Note	Includes bibliographical references (p. 685-688)
ISBN	7206000142 ; 9787206000140
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Selecting aptamers with programmed affinities.

Song, Ping / Fan, Chunhai

Nature chemistry

2023 Volume 15, Issue 6, Page(s) 747–748

MeSH term(s)	Aptamers, Nucleotide
Chemical Substances	Aptamers, Nucleotide
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2464596-5
ISSN	1755-4349 ; 1755-4330
ISSN (online)	1755-4349
ISSN	1755-4330
DOI	10.1038/s41557-023-01215-z
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