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  1. Article ; Online: Decomposition of Expenditures for Insulins Across the Distribution Chain-Insights Into Rising Prices?

    Good, Chester B / Hernandez, Inmaculada

    JAMA health forum

    2021  Volume 2, Issue 11, Page(s) e212258

    MeSH term(s) Drug Costs ; Health Expenditures ; Insulin/therapeutic use ; Insulins
    Chemical Substances Insulin ; Insulins
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2689-0186
    ISSN (online) 2689-0186
    DOI 10.1001/jamahealthforum.2021.2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recommendations for Addressing the Tobacco and Nicotine Use Epidemic in U.S. Military Service Members and Veterans.

    Lang, Adam Edward / Melzer, Anne C / Good, Chester B / Upson, Dona J

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 9, Page(s) 1229–1232

    MeSH term(s) Humans ; United States/epidemiology ; Veterans ; Nicotine ; Military Personnel
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202302-177VP
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association Between Weight Reduction and Employees' Healthcare Cost.

    Peasah, Samuel K / Drnach, Alek / Rosenberg, Eric / Good, Chester B

    Journal of occupational and environmental medicine

    2023  Volume 65, Issue 12, Page(s) 998–1002

    Abstract: Objective: The aim of the study is to assess the impact of ≥15% body mass index (BMI) reduction on employees' health expenditures.: Methods: We retrospectively analyzed health risk assessment surveys combined with insurance claims from January 2014 ... ...

    Abstract Objective: The aim of the study is to assess the impact of ≥15% body mass index (BMI) reduction on employees' health expenditures.
    Methods: We retrospectively analyzed health risk assessment surveys combined with insurance claims from January 2014 to December 2019. We compared costs of employees with baseline BMI > 30 who reported ≥15% BMI reduction in subsequent health risk assessment reports with employees who lost ≤5% BMI within the same period, matching the two cohorts on demographics and costs.
    Results: The study cohort of 197 lost an average of 23% of their BMI from baseline. The average age was 44 years with majority females (approximately 80%). Group health insurance payments were similar at baseline; at year 1, the study cohort had a 33% payment reduction compared with 10% reduction in the control group.
    Conclusions: A ≥15% BMI reduction was associated with a substantial medical cost savings.
    MeSH term(s) Female ; Humans ; Adult ; Retrospective Studies ; Health Care Costs ; Insurance, Health ; Weight Loss ; Health Expenditures
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002938
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    Zs.B 155: Show issues Location:
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  4. Article ; Online: Association of the Chantix Recall With US Prescribing of Varenicline and Other Medications for Nicotine Dependence.

    Lang, Adam Edward / Patel, Urvashi / Fitzpatrick, Jonathan / Lee, Tiffany / McFarland, Margo / Good, Chester B

    JAMA network open

    2023  Volume 6, Issue 2, Page(s) e2254655

    MeSH term(s) Humans ; Varenicline/therapeutic use ; Tobacco Use Disorder/drug therapy ; Nicotinic Agonists/therapeutic use ; Smoking Cessation
    Chemical Substances Varenicline (W6HS99O8ZO) ; Nicotinic Agonists
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.54655
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  5. Article: Disease-Modifying Medications in Patients with Rheumatoid Arthritis in the USA: Trends from 2016 to 2021.

    Peasah, Samuel K / Swart, Elizabeth C S / Huang, Yan / Kane-Gill, Sandra L / Seybert, Amy L / Patel, Urvashi / Manolis, Chronis / Good, Chester B

    Drugs - real world outcomes

    2024  

    Abstract: Background: Disease-modifying anti-rheumatic drugs (DMARDs), since their introduction in 1990, have revolutionized the management of rheumatoid arthritis. Newer DMARDs have recently been approved, influencing treatment patterns and clinical guidelines.!# ...

    Abstract Background: Disease-modifying anti-rheumatic drugs (DMARDs), since their introduction in 1990, have revolutionized the management of rheumatoid arthritis. Newer DMARDs have recently been approved, influencing treatment patterns and clinical guidelines.
    Objective: To update the current prescribing patterns of DMARDs in the pharmacotherapy of rheumatoid arthritis (RA) to include the pandemic era.
    Methods: This was a retrospective cross-sectional multi-year study. Using Optum's Clinformatics® Data Mart Database, we summarized trends in the prevalence of DMARD use in the USA from 2016 to 2021 by year for adult patients ≥ 18 years old with at least one medical RA claim and one pharmacy/medical claim of a DMARD medication. Trends included type of DMARD, class of DMARD (conventional (csDMARDs), biologics [tumor necrosis factor (TNFi) and Non-TNFi), and Janus kinase inhibitors (JAKs)], and triple therapy [methotrexate (MTX), hydroxychloroquine (HCQ), sulfasalazine (SUL)] used.
    Results: The total sample from 2016 to 2021 was 670,679 commercially insured patients. The average age was 63.7 years (SD 13.6), and 76.7% were female and 70% were White. csDMARDs remain the most prescribed (ranging from 77.2 to 79.2%). Although JAKs were the least prescribed DMARD class, their proportion more than doubled from 2016 (1.5%) to 2021 (4%). MTX utilization declined from 40% in 2016 to 34% in 2021. In contrast, HCQ use increased during the pandemic era from < 25% in 2018 to 30% in 2021. Although there is evidence of the therapeutic benefit of triple therapy, its use was very low (~ 1%) compared to biologics only (~ 17%) or biologics+MTX (~ 10%).
    Conclusion: About half of patients with RA were on DMARDs. As expected, csDMARDs were highly used consistently. The COVID-19 pandemic might have influenced the use of HCQ and infusion DMARDs. Triple therapy use remains low.
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806600-5
    ISSN 2198-9788 ; 2199-1154
    ISSN (online) 2198-9788
    ISSN 2199-1154
    DOI 10.1007/s40801-024-00416-3
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  6. Article ; Online: Adalimumab and the Challenges for Biosimilars.

    Gellad, Walid F / Good, Chester B

    JAMA

    2019  Volume 322, Issue 22, Page(s) 2171–2172

    MeSH term(s) Adalimumab/administration & dosage ; Adalimumab/economics ; Anti-Inflammatory Agents/administration & dosage ; Antibodies, Monoclonal/therapeutic use ; Antirheumatic Agents/therapeutic use ; Biosimilar Pharmaceuticals/administration & dosage ; Drug Costs ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Humans ; Patents as Topic ; Time Factors ; United States
    Chemical Substances Anti-Inflammatory Agents ; Antibodies, Monoclonal ; Antirheumatic Agents ; Biosimilar Pharmaceuticals ; Heterocyclic Compounds, 3-Ring ; upadacitinib (4RA0KN46E0) ; risankizumab (90ZX3Q3FR7) ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2019-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2019.16275
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    Ua VI Zs.88: Show issues Location:
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  7. Article ; Online: Association of PCSK9 Inhibitor Initiation on Statin Adherence and Discontinuation.

    LaFratte, Christopher / Peasah, Samuel K / Huang, Yan / Hall, Deanne / Patel, Urvashi / Good, Chester B

    Journal of the American Heart Association

    2023  Volume 12, Issue 18, Page(s) e029707

    Abstract: Background PCSK9is (proprotein convertase subtilisin/kexin type 9 inhibitors) are well tolerated, potently lower cholesterol, and decrease cardiovascular events when added to statins. However, statin adherence may decrease after PCSK9i initiation and ... ...

    Abstract Background PCSK9is (proprotein convertase subtilisin/kexin type 9 inhibitors) are well tolerated, potently lower cholesterol, and decrease cardiovascular events when added to statins. However, statin adherence may decrease after PCSK9i initiation and alter clinical outcomes. We evaluate the association of PCSK9i initiation on statin discontinuation and adherence. Methods and Results In this retrospective pre-post difference-in-difference analysis, new PCSK9i claims were propensity matched with statin-alone users (April 2017-September 2019). The primary outcomes were statin adherence (proportion of days covered) and statin discontinuation (absence of statin coverage for at least 60 days) 12 months following PCSK9i initiation. Secondary outcomes included low-density lipoprotein cholesterol levels after 1 year. A total of 220 538 statin users and 700 PCSK9i users were identified, from which 178 on PCSK9i were included and matched to 712 on statins alone. At 12 months, mean statin proportion of days covered decreased from 67% to 48% in the PCSK9i group but increased from 68% to 86% in the statin-alone groups (
    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; PCSK9 Inhibitors ; Proprotein Convertase 9 ; Retrospective Studies ; Antiviral Agents ; Cholesterol, LDL
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; PCSK9 protein, human (EC 3.4.21.-) ; PCSK9 Inhibitors ; Proprotein Convertase 9 (EC 3.4.21.-) ; Antiviral Agents ; Cholesterol, LDL
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.029707
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  8. Article ; Online: Cost-effectiveness of the Adjuvanted Herpes Zoster Subunit Vaccine.

    Good, Chester B / Hernandez, Inmaculada

    JAMA internal medicine

    2018  Volume 178, Issue 6, Page(s) 873

    MeSH term(s) Aged ; Cost-Benefit Analysis ; Herpes Zoster ; Herpes Zoster Vaccine ; Humans ; Vaccines, Subunit
    Chemical Substances Herpes Zoster Vaccine ; Vaccines, Subunit
    Language English
    Publishing date 2018-06-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2018.2029
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    Ua VI Zs.119: Show issues Location:
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  9. Article ; Online: Trends in the Use of Conventional and New Pharmaceuticals for Hemophilia Treatments Among Medicaid Enrollees, 2005-2020.

    Hernandez, Inmaculada / Rowe, Deanna / Gellad, Walid F / Good, Chester B

    JAMA network open

    2021  Volume 4, Issue 6, Page(s) e2112044

    MeSH term(s) Health Services Accessibility/statistics & numerical data ; Hemophilia A/drug therapy ; Humans ; Insurance Coverage/statistics & numerical data ; Managed Care Programs/standards ; Medicaid ; Patient Satisfaction/statistics & numerical data ; Treatment Outcome ; United States
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.12044
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  10. Article ; Online: Should Metformin Be First-line Therapy for Patients With Type 2 Diabetes and Chronic Kidney Disease?: Informed Patients Should Decide.

    Good, Chester B / Pogach, Leonard M

    JAMA internal medicine

    2018  Volume 178, Issue 7, Page(s) 911–912

    MeSH term(s) Acidosis, Lactic ; Cohort Studies ; Diabetes Mellitus, Type 2 ; Humans ; Hypoglycemic Agents ; Metformin ; Renal Insufficiency, Chronic
    Chemical Substances Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2018-06-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2018.0301
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