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Article ; Online: Recalling Obaid.

Fox, Maurice S

2014 Volume 39, Issue 4, Page(s) 545

MeSH term(s)	Career Choice ; Genetics/history ; History, 20th Century ; History, 21st Century ; India ; Neurosciences/history ; Research/history
Language	English
Publishing date	2014-07-24
Publishing country	India
Document type	Historical Article ; Journal Article
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
DOI	10.1007/s12038-014-9445-9
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Article ; Online: Purcell-enhanced single photons at telecom wavelengths from a quantum dot in a photonic crystal cavity.

Phillips, Catherine L / Brash, Alistair J / Godsland, Max / Martin, Nicholas J / Foster, Andrew / Tomlinson, Anna / Dost, René / Babazadeh, Nasser / Sala, Elisa M / Wilson, Luke / Heffernan, Jon / Skolnick, Maurice S / Fox, A Mark

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4450

Abstract: Quantum dots are promising candidates for telecom single photon sources due to their tunable emission across the different low-loss telecommunications bands, making them compatible with existing fiber networks. Their suitability for integration into ... ...

Abstract	Quantum dots are promising candidates for telecom single photon sources due to their tunable emission across the different low-loss telecommunications bands, making them compatible with existing fiber networks. Their suitability for integration into photonic structures allows for enhanced brightness through the Purcell effect, supporting efficient quantum communication technologies. Our work focuses on InAs/InP QDs created via droplet epitaxy MOVPE to operate within the telecoms C-band. We observe a short radiative lifetime of 340 ps, arising from a Purcell factor of 5, owing to integration of the QD within a low-mode-volume photonic crystal cavity. Through in-situ control of the sample temperature, we show both temperature tuning of the QD's emission wavelength and a preserved single photon emission purity at temperatures up to 25K. These findings suggest the viability of QD-based, cryogen-free C-band single photon sources, supporting applicability in quantum communication technologies.
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55024-6
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Article ; Online: Photon Statistics of Filtered Resonance Fluorescence.

Phillips, Catherine L / Brash, Alistair J / McCutcheon, Dara P S / Iles-Smith, Jake / Clarke, Edmund / Royall, Benjamin / Skolnick, Maurice S / Fox, A Mark / Nazir, Ahsan

Physical review letters

2020 Volume 125, Issue 4, Page(s) 43603

Abstract: Spectral filtering of resonance fluorescence is widely employed to improve single photon purity and indistinguishability by removing unwanted backgrounds. For filter bandwidths approaching the emitter linewidth, complex behavior is predicted due to ... ...

Abstract	Spectral filtering of resonance fluorescence is widely employed to improve single photon purity and indistinguishability by removing unwanted backgrounds. For filter bandwidths approaching the emitter linewidth, complex behavior is predicted due to preferential transmission of components with differing photon statistics. We probe this regime using a Purcell-enhanced quantum dot in both weak and strong excitation limits, finding excellent agreement with an extended sensor theory model. By changing only the filter width, the photon statistics can be transformed between antibunched, bunched, or Poissonian. Our results verify that strong antibunching and a subnatural linewidth cannot simultaneously be observed, providing new insight into the nature of coherent scattering.
Language	English
Publishing date	2020-08-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.125.043603
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Article ; Online: A phase 1/2 study of pepinemab in children, adolescents, or young adults with recurrent or refractory solid tumors: A children's oncology group consortium report (ADVL1614).

Greengard, Emily / Williams, Robin / Moriarity, Branden / Liu, Xiaowei / Minard, Charles G / Reid, Joel M / Fisher, Terrence / Evans, Elizabeth / Pastore, Desa Rae / Zauderer, Maurice / Voss, Stephan / Fox, Elizabeth / Weigel, Brenda J

Pediatric blood & cancer

2024 Volume 71, Issue 6, Page(s) e30938

Abstract: Purpose: Pepinemab, a humanized IgG4 monoclonal antibody, targets the SEMA4D (CD100) antigen to inhibit binding to its high-affinity receptors (plexin B1/PLXNB1, plexin B2/PLXNB2) and low-affinity receptor (CD72). SEMA4D blockade leads to increased ... ...

Abstract	Purpose: Pepinemab, a humanized IgG4 monoclonal antibody, targets the SEMA4D (CD100) antigen to inhibit binding to its high-affinity receptors (plexin B1/PLXNB1, plexin B2/PLXNB2) and low-affinity receptor (CD72). SEMA4D blockade leads to increased cytotoxic T-cell infiltration, delayed tumor growth, and durable tumor rejection in murine tumor models. Pepinemab was well tolerated and improved T cell infiltration in clinical studies in adults with refractory tumors. SEMA4D was identified as a strong candidate proto-oncogene in a model of osteosarcoma. Based on these preclinical and clinical data, we conducted a phase 1/2 study to determine the recommended phase 2 dose (RP2D), pharmacokinetics, pharmacodynamics, and immunogenicity, of pepinemab in pediatric patients with recurrent/refractory solid tumors, and activity in osteosarcoma. Experimental design: Pepinemab was administered intravenously on Days 1 and 15 of a 28-day cycle at 20 mg/kg, the adult RP2D. Part A (phase 1) used a Rolling 6 design; Part B (phase 2) used a Simon 2-stage design in patients with osteosarcoma. Pharmacokinetics and target saturation were evaluated in peripheral blood. Results: Pepinemab (20 mg/kg) was well tolerated and no dose-limiting toxicities were observed during Part A. There were no objective responses. Two patients with osteosarcoma achieved disease control and prolonged stable disease. Pepinemab pharmacokinetics were similar to adults. Conclusions: Pepinemab (20 mg/kg) is safe, well tolerated and resulted in adequate and sustained target saturation in pediatric patients. Encouraging disease control in two patients with osteosarcoma warrants further investigation with novel combination strategies to modulate the tumor microenvironment and antitumor immune response. Clinical trial registry: This trial is registered as NCT03320330 at Clinicaltrials.gov. Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
MeSH term(s)	Humans ; Adolescent ; Child ; Female ; Male ; Young Adult ; Adult ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Neoplasms/drug therapy ; Child, Preschool ; Antibodies, Monoclonal, Humanized/pharmacokinetics ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Osteosarcoma/drug therapy ; Osteosarcoma/pathology ; Maximum Tolerated Dose ; Drug Resistance, Neoplasm
Chemical Substances	Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-03-23
Publishing country	United States
Document type	Journal Article ; Clinical Trial, Phase I ; Clinical Trial, Phase II ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Multicenter Study
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30938
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Article ; Online: Light Scattering from Solid-State Quantum Emitters: Beyond the Atomic Picture.

Brash, Alistair J / Iles-Smith, Jake / Phillips, Catherine L / McCutcheon, Dara P S / O'Hara, John / Clarke, Edmund / Royall, Benjamin / Wilson, Luke R / Mørk, Jesper / Skolnick, Maurice S / Fox, A Mark / Nazir, Ahsan

Physical review letters

2019 Volume 123, Issue 16, Page(s) 167403

Abstract: Coherent scattering of light by a single quantum emitter is a fundamental process at the heart of many proposed quantum technologies. Unlike atomic systems, solid-state emitters couple to their host lattice by phonons. Using a quantum dot in an optical ... ...

Abstract	Coherent scattering of light by a single quantum emitter is a fundamental process at the heart of many proposed quantum technologies. Unlike atomic systems, solid-state emitters couple to their host lattice by phonons. Using a quantum dot in an optical nanocavity, we resolve these interactions in both time and frequency domains, going beyond the atomic picture to develop a comprehensive model of light scattering from solid-state emitters. We find that even in the presence of a low-Q cavity with high Purcell enhancement, phonon coupling leads to a sideband that is completely insensitive to excitation conditions and to a nonmonotonic relationship between laser detuning and coherent fraction, both of which are major deviations from atomlike behavior.
Language	English
Publishing date	2019-11-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.123.167403
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Article ; Online: Interruption of cell transformation and cancer formation.

Fox, Maurice S / Klawansky, Sidney

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2006 Volume 20, Issue 13, Page(s) 2209–2213

Abstract: A review of the results of X-ray and chemical carcinogen induction of transformation of mouse cells supports a two-step epigenetic model of transformation. According to this model, exposure induces an epigenetic regulatory alteration that makes the cells ...

Abstract	A review of the results of X-ray and chemical carcinogen induction of transformation of mouse cells supports a two-step epigenetic model of transformation. According to this model, exposure induces an epigenetic regulatory alteration that makes the cells hypermutable so that when the cell population inheriting this alteration becomes sufficiently large, the second step, a mutation to the transformant phenotype, becomes increasingly likely. The epigenetic alteration in X-ray-exposed mouse cells has been demonstrated to be reversible by brief exposure to certain protease inhibitors. If the rodent cell experiments constitute a valid system for studying human cancer, then this two-step model may herald rich opportunities for preventing and perhaps even treating cancer in humans.
MeSH term(s)	Animals ; Carcinogens ; Cell Transformation, Neoplastic/radiation effects ; Humans ; Mice ; Neoplasms/etiology ; X-Rays
Chemical Substances	Carcinogens
Language	English
Publishing date	2006-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.06-6455hyp
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Interruption of cell transformation and cancer formation

Fox, Maurice S / Klawansky, Sidney

FASEB journal. 2006 Nov., v. 20, no. 13

2006

Abstract: ... for preventing and perhaps even treating cancer in humans.--Fox, M. S., Klawansky, S. Interruption of cell ...

Abstract	A review of the results of X-ray and chemical carcinogen induction of transformation of mouse cells supports a two-step epigenetic model of transformation. According to this model, exposure induces an epigenetic regulatory alteration that makes the cells hypermutable so that when the cell population inheriting this alteration becomes sufficiently large, the second step, a mutation to the transformant phenotype, becomes increasingly likely. The epigenetic alteration in X-ray-exposed mouse cells has been demonstrated to be reversible by brief exposure to certain protease inhibitors. If the rodent cell experiments constitute a valid system for studying human cancer, then this two-step model may herald rich opportunities for preventing and perhaps even treating cancer in humans.--Fox, M. S., Klawansky, S. Interruption of cell transformation and cancer formation.
Language	English
Dates of publication	2006-11
Size	p. 2209-2213.
Publishing place	The Federation of American Societies for Experimental Biology
Document type	Article
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: High Purcell factor generation of indistinguishable on-chip single photons.

Liu, Feng / Brash, Alistair J / O'Hara, John / Martins, Luis M P P / Phillips, Catherine L / Coles, Rikki J / Royall, Benjamin / Clarke, Edmund / Bentham, Christopher / Prtljaga, Nikola / Itskevich, Igor E / Wilson, Luke R / Skolnick, Maurice S / Fox, A Mark

Nature nanotechnology

2018 Volume 13, Issue 9, Page(s) 835–840

Abstract: On-chip single-photon sources are key components for integrated photonic quantum technologies. Semiconductor quantum dots can exhibit near-ideal single-photon emission, but this can be significantly degraded in on-chip geometries owing to nearby etched ... ...

Abstract	On-chip single-photon sources are key components for integrated photonic quantum technologies. Semiconductor quantum dots can exhibit near-ideal single-photon emission, but this can be significantly degraded in on-chip geometries owing to nearby etched surfaces. A long-proposed solution to improve the indistinguishablility is to use the Purcell effect to reduce the radiative lifetime. However, until now only modest Purcell enhancements have been observed. Here we use pulsed resonant excitation to eliminate slow relaxation paths, revealing a highly Purcell-shortened radiative lifetime (22.7 ps) in a waveguide-coupled quantum dot-photonic crystal cavity system. This leads to near-lifetime-limited single-photon emission that retains high indistinguishablility (93.9%) on a timescale in which 20 photons may be emitted. Nearly background-free pulsed resonance fluorescence is achieved under π-pulse excitation, enabling demonstration of an on-chip, on-demand single-photon source with very high potential repetition rates.
Language	English
Publishing date	2018-07-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2254964-X
ISSN	1748-3395 ; 1748-3387
ISSN (online)	1748-3395
ISSN	1748-3387
DOI	10.1038/s41565-018-0188-x
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Book: Prenatal diagnosis

DiMaio, Miriam S / Fox, Joyce E / Mahoney, Maurice J

cases & clinical challenges

2010

Author's details	Miriam S. DiMaio, Joyce E. Fox, Maurice J. Mahoney
MeSH term(s)	Prenatal Diagnosis ; Congenital Abnormalities/diagnosis ; Fetal Diseases/diagnosis ; Genetic Predisposition to Disease ; Genetic Testing
Language	English
Size	viii, 121 p. :, ill.
Publisher	Wiley-Blackwell
Publishing place	Chichester, West Sussex, UK ; Hoboken, NJ
Document type	Book
ISBN	9781405191432 ; 1405191430
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Whole genome sequencing of outbreak strains from 2017 to 2018 reveals an endemic clade of dengue 1 virus in Cameroon.

Agbodzi, Bright / Sado Yousseu, Francine Berlange / Nemg Simo, Fredy Brice / Kumordjie, Selassie / Yeboah, Clara / Mosore, Mba-Tihssommah / Bentil, Ronald E / Coatsworth, Heather G / Attram, Naiki / Nimo-Paintsil, Shirley / Fox, Anne T / Bonney, Joseph H K / Ampofo, William / Dinglasan, Rhoel R / Sanders, Terrel / Wiley, Michael R / Demanou, Maurice / Letizia, Andrew G

Emerging microbes & infections

2023 Volume 12, Issue 2, Page(s) 2281352

Abstract: Dengue fever is expanding as a global public health threat including countries within Africa. For the past few decades, Cameroon has experienced sporadic cases of arboviral infections including dengue fever. Here, we conducted genomic analyses to ... ...

Abstract	Dengue fever is expanding as a global public health threat including countries within Africa. For the past few decades, Cameroon has experienced sporadic cases of arboviral infections including dengue fever. Here, we conducted genomic analyses to investigate the origin and phylogenetic profile of Cameroon DENV-1 outbreak strains and predict the impact of emerging therapeutics on these strains. Bayesian and maximum-likelihood phylogenetic inference approaches were employed in virus evolutionary analyses. An in silico analysis was performed to assess the divergence in immunotherapeutic and vaccine targets in the new genomes. Six complete DENV-1 genomes were generated from 50 samples that met a clinical definition for DENV infection. Phylogenetic analyses revealed that the strains from the current study belong to a sub-lineage of DENV-1 genotype V and form a monophyletic taxon with a 2012 strain from Gabon. The most recent common ancestor (TMRCA) of the Cameroon and Gabon strains was estimated to have existed around 2008. Comparing our sequences to the vaccine strains, 19 and 15 amino acid (aa) substitutions were observed in the immuno-protective prM-E protein segments of the Dengvaxia® and TetraVax-DV-TV003 vaccines, respectively. Epitope mapping revealed mismatches in aa residues at positions E155 and E161 located in the epitope of the human anti-DENV-1 monoclonal antibody HMAb 1F4. The new DENV strains constitute a conserved genomic pool of viruses endemic to the Central African region that needs prospective monitoring to track local viral evolution. Further work is needed to ascertain the performance of emerging therapeutics in DENV strains from the African region.
MeSH term(s)	Humans ; Dengue Virus/genetics ; Dengue/epidemiology ; Phylogeny ; Cameroon/epidemiology ; Bayes Theorem ; Prospective Studies ; Whole Genome Sequencing ; Genotype ; Disease Outbreaks ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2023.2281352
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