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  1. Article ; Online: Epithelial stem and progenitor cells of the upper airway.

    Rouhani, Maral J / Janes, Sam M / Kim, Carla F

    Cells & development

    2024  Volume 177, Page(s) 203905

    Abstract: The upper airway acts as a conduit for the passage of air to the respiratory system and is implicated in several chronic diseases. Whilst the cell biology of the distal respiratory system has been described in great detail, less is known about the ... ...

    Abstract The upper airway acts as a conduit for the passage of air to the respiratory system and is implicated in several chronic diseases. Whilst the cell biology of the distal respiratory system has been described in great detail, less is known about the proximal upper airway. In this review, we describe the relevant anatomy of the upper airway and discuss the literature detailing the identification and roles of the progenitor cells of these regions.
    MeSH term(s) Trachea ; Stem Cells ; Larynx ; Nose
    Language English
    Publishing date 2024-02-12
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2667-2901
    ISSN (online) 2667-2901
    DOI 10.1016/j.cdev.2024.203905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An airway organoid is forever.

    Paschini, Margherita / Kim, Carla F

    The EMBO journal

    2019  Volume 38, Issue 4

    MeSH term(s) Hepatocytes ; Humans ; Organoids ; Respiratory System ; Tissue Engineering
    Language English
    Publishing date 2019-02-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2019101526
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    Zs.A 1808: Show issues Location:
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  3. Article ; Online: Intersections of lung progenitor cells, lung disease and lung cancer.

    Kim, Carla F

    European respiratory review : an official journal of the European Respiratory Society

    2017  Volume 26, Issue 144

    Abstract: The use of stem cell biology approaches to study adult lung progenitor cells and lung cancer has brought a variety of new techniques to the field of lung biology and has elucidated new pathways that may be therapeutic targets in lung cancer. Recent ... ...

    Abstract The use of stem cell biology approaches to study adult lung progenitor cells and lung cancer has brought a variety of new techniques to the field of lung biology and has elucidated new pathways that may be therapeutic targets in lung cancer. Recent results have begun to identify the ways in which different cell populations interact to regulate progenitor activity, and this has implications for the interventions that are possible in cancer and in a variety of lung diseases. Today's better understanding of the mechanisms that regulate lung progenitor cell self-renewal and differentiation, including understanding how multiple epigenetic factors affect lung injury repair, holds the promise for future better treatments for lung cancer and for optimising the response to therapy in lung cancer. Working between platforms in sophisticated organoid culture techniques, genetically engineered mouse models of injury and cancer, and human cell lines and specimens, lung progenitor cell studies can begin with basic biology, progress to translational research and finally lead to the beginnings of clinical trials.
    Language English
    Publishing date 2017-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0054-2017
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  4. Article ; Online: Comparison of Transplantation of Lung Organoid Cell Types: One Size Does Not Fit All.

    Ararat, Erhan / Louie, Sharon M / Lu, Emery / Paschini, Margherita / Raiser, David M / Kim, Carla F

    American journal of respiratory cell and molecular biology

    2022  Volume 66, Issue 3, Page(s) 340–343

    MeSH term(s) Lung ; Organoids
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2021-0263LE
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  5. Article ; Online: Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid.

    Liu, Monica Yun / Chen, Belinda / Borji, Mehdi / Garcia de Alba Rivas, Carolina / Dost, Antonella F M / Moye, Aaron L / Movval Abdulla, Nusrath / Paschini, Margherita / Rollins, Stuart D / Wang, Ruobing / Schnapp, Lynn M / Khalil, Hassan A / Wu, Catherine J / Sharma, Nirmal S / Kim, Carla F

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202310-1831LE
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  6. Article ; Online: May the (Mechanical) Force Be with AT2.

    Sainz de Aja, Julio / Kim, Carla F

    Cell

    2020  Volume 180, Issue 1, Page(s) 20–22

    Abstract: Idiopathic pulmonary fibrosis is a fatal disease involving destruction of the lung alveolar structure. In this issue of Cell, Wu et al. (2020) show that impaired alveolar (AT2) stem cells produce mechanical tension that leads to spatially regulated ... ...

    Abstract Idiopathic pulmonary fibrosis is a fatal disease involving destruction of the lung alveolar structure. In this issue of Cell, Wu et al. (2020) show that impaired alveolar (AT2) stem cells produce mechanical tension that leads to spatially regulated fibrosis, initiating a new chapter in understanding what underlies the periphery to center progression of this lung disease.
    MeSH term(s) Alveolar Epithelial Cells ; Humans ; Pulmonary Alveoli ; Pulmonary Fibrosis ; Stem Cells ; Stress, Mechanical
    Language English
    Publishing date 2020-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2019.12.020
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  7. Article: Airway injury induces alveolar epithelial and mesenchymal responses mediated by macrophages.

    Wong, Irene G / Stark, Jillian / Ya, VanNashlee / Moye, Aaron L / Vazquez, Alan Baez / Dang, Susanna M / Shehaj, Andrea / Rouhani, Maral J / Bronson, Roderick / Janes, Sam M / Rowbotham, Samuel P / Paschini, Margherita / Franklin, Ruth A / Kim, Carla F

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Acute injury in the airways or the lung activates local progenitors and stimulates changes in cell-cell interactions to restore homeostasis, but it is not appreciated how more distant niches are impacted. We utilized mouse models of airway-specific ... ...

    Abstract Acute injury in the airways or the lung activates local progenitors and stimulates changes in cell-cell interactions to restore homeostasis, but it is not appreciated how more distant niches are impacted. We utilized mouse models of airway-specific epithelial injury to examine secondary tissue-wide alveolar, immune, and mesenchymal responses. Single-cell transcriptomics and
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.02.587596
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  8. Article ; Online: PR1P, a VEGF-stabilizing peptide, reduces injury and inflammation in acute lung injury and ulcerative colitis animal models.

    Adini, Avner / Ko, Victoria H / Puder, Mark / Louie, Sharon M / Kim, Carla F / Baron, Joseph / Matthews, Benjamin D

    Frontiers in immunology

    2023  Volume 14, Page(s) 1168676

    Abstract: Acute Respiratory Distress Syndrome (ARDS) and Ulcerative Colitis (UC) are each characterized by tissue damage and uncontrolled inflammation. Neutrophils and other inflammatory cells play a primary role in disease progression by acutely responding to ... ...

    Abstract Acute Respiratory Distress Syndrome (ARDS) and Ulcerative Colitis (UC) are each characterized by tissue damage and uncontrolled inflammation. Neutrophils and other inflammatory cells play a primary role in disease progression by acutely responding to direct and indirect insults to tissue injury and by promoting inflammation through secretion of inflammatory cytokines and proteases. Vascular Endothelial Growth Factor (VEGF) is a ubiquitous signaling molecule that plays a key role in maintaining and promoting cell and tissue health, and is dysregulated in both ARDS and UC. Recent evidence suggests a role for VEGF in mediating inflammation, however, the molecular mechanism by which this occurs is not well understood. We recently showed that PR1P, a 12-amino acid peptide that binds to and upregulates VEGF, stabilizes VEGF from degradation by inflammatory proteases such as elastase and plasmin thereby limiting the production of VEGF degradation products (fragmented VEGF (fVEGF)). Here we show that fVEGF is a neutrophil chemoattractant
    MeSH term(s) Animals ; Mice ; Rats ; Acute Lung Injury/metabolism ; Colitis, Ulcerative/drug therapy ; Cytokines/metabolism ; Disease Models, Animal ; Inflammation/chemically induced ; Interleukin-6 ; Peptide Hydrolases ; Peptides/adverse effects ; Respiratory Distress Syndrome/metabolism ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Cytokines ; Interleukin-6 ; Peptide Hydrolases (EC 3.4.-) ; Peptides ; Vascular Endothelial Growth Factor A ; PR1P peptide
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1168676
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  9. Article ; Online: Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair.

    Rowbotham, Samuel P / Kim, Carla F

    Cell

    2017  Volume 169, Issue 4, Page(s) 563–565

    Abstract: Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This "lineage infidelity" recreates a state ... ...

    Abstract Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This "lineage infidelity" recreates a state akin to transient wound repair that persists to maintain uncontrolled growth.
    MeSH term(s) Cell Lineage ; Chromatin ; Humans ; Skin Neoplasms ; Stem Cells ; Wound Healing
    Chemical Substances Chromatin
    Language English
    Publishing date 2017-05-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2017.04.030
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  10. Article: Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state.

    Li, Jingyun / Dang, Susanna M / Schurmann, Paul / Dost, Antonella F M / Moye, Aaron L / Paschini, Margherita / Bhetariya, Preetida J / Bronson, Roderick / Sui, Shannan J Ho / Kim, Carla F

    Research square

    2023  

    Abstract: Alveolar type 2 (AT2) cells, the epithelial progenitor cells of the distal lung, are known to be the prominent cell of origin for lung adenocarcinoma. The regulatory programs that control chromatin and gene expression in AT2 cells during the early stages ...

    Abstract Alveolar type 2 (AT2) cells, the epithelial progenitor cells of the distal lung, are known to be the prominent cell of origin for lung adenocarcinoma. The regulatory programs that control chromatin and gene expression in AT2 cells during the early stages of tumor initiation are not well understood. Here, we dissected the response of AT2 cells to Kras activation and p53 loss (KP) using combined single cell RNA and ATAC sequencing in an established tumor organoid system. Multi-omic analysis showed that KP tumor organoid cells exhibit two major cellular states: one more closely resembling AT2 cells (SPC-high) and another with loss of AT2 identity (hereafter, Hmga2-high). These cell states are characterized by unique transcription factor (TF) networks, with SPC-high states associated with TFs known to regulate AT2 cell fate during development and homeostasis, and distinct TFs associated with the Hmga2-high state. CD44 was identified as a marker of the Hmga2-high state, and was used to separate organoid cultures for functional comparison of these two cell states. Organoid assays and orthotopic transplantation studies indicated that SPC-high cells have higher tumorigenic capacity in the lung microenvironment compared to Hmga2-high cells. These findings highlight the utility of understanding chromatin regulation in the early oncogenic versions of epithelial cells, which may reveal more effective means to intervene the progression of Kras-driven lung cancer.
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2663901/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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