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Article ; Online: Physicochemical Characteristics and Sensory Attributes of Yanggaeng Treated with Corni fructus Powder

Hyunsoo Jang / Jisu Lee / Misook Kim / Inyong Kim / Jung-Heun Ha

Applied Sciences, Vol 13, Iss 2839, p

A Pilot Study

2023 Volume 2839

Abstract: This study investigated the physicochemical properties and sensory attributes of Yanggaeng, a traditional dessert in Far East Asia, treated with a functional additive Corni fructus powder (CF) in various concentrations (0% [control; CON], 2%, 4%, and 6%). ...

Abstract	This study investigated the physicochemical properties and sensory attributes of Yanggaeng, a traditional dessert in Far East Asia, treated with a functional additive Corni fructus powder (CF) in various concentrations (0% [control; CON], 2%, 4%, and 6%). The proximate compositions, physicochemical properties, antioxidant capacities, texture properties, and consumers’ preferences of the CF-treated Yanggaeng were assessed. CF-treated Yanggaeng had decreased L* (lightness) and b* (yellowness) values and increased a* (redness) values and browning index (BI) due to the CF. Moreover, CF-treated Yanggaeng had significantly decreased pH and increased °Brix levels. Similarly, CF addition significantly increased the 1,1-diphenyl-1-picrylhydrazyl (DPPH) and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (ABTS) radical scavenging activities and ferric reducing antioxidant power (FRAP). The elevation of the radical scavenging capacities may be due to the abundance of phenolic contents in CF. Furthermore, CF addition significantly changed the textural properties of Yanggaeng, such as increased hardness, gumminess, and chewiness. Notably, 6% CF-treated Yanggaeng significantly attenuated resilience and cohesion compared to the CON. In the consumers’ preferences, 2% CF-treated Yanggaeng had similar attributes (i.e., color, scent, flavor, sweetness, taste, overall acceptance, and purchase intention) as the CON, a typical Yanggaeng. Therefore, adding CF, a natural and edible antioxidative ingredient, in Yanggaeng may be acceptable to consumers with a significant alteration of physicochemical properties.
Keywords	Corni fructus ; Yanggaeng ; physicochemical properties ; sensory attributes ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Understanding the chromatin remodeling code.

Ha, Misook

Plant science : an international journal of experimental plant biology

2013 Volume 211, Page(s) 137–145

Abstract: Remodeling a chromatin structure enables the genetic elements stored in a genome to function in a condition-specific manner and predisposes the interactions between cis-regulatory elements and trans-acting factors. A chromatin signature can be an ... ...

Abstract	Remodeling a chromatin structure enables the genetic elements stored in a genome to function in a condition-specific manner and predisposes the interactions between cis-regulatory elements and trans-acting factors. A chromatin signature can be an indicator of the activity of the underlying genetic elements. This paper reviews recent studies showing that the combination and arrangements of chromatin remodeling marks play roles as chromatin code affecting the activity of genetic elements. This paper also reviews recent studies inferring the primary DNA sequence contexts associated with chromatin remodeling that suggest interactions between genetic and epigenetic factors. We conclude that chromatin remodeling, which provides accurate models of gene expression and morphological variations, may help to find the biological marks that cannot be detected by genome-wide association study or genetic study.
MeSH term(s)	Chromatin/genetics ; Chromatin Assembly and Disassembly ; DNA Methylation ; Environment ; Epigenesis, Genetic ; Genome, Plant/genetics ; Histones/genetics ; Nucleosomes ; Plants/genetics ; Protein Binding
Chemical Substances	Chromatin ; Histones ; Nucleosomes
Language	English
Publishing date	2013-07-24
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2013.07.006
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Article: The relationship between knee joint angle and knee flexor and extensor muscle strength.

Ha, Misook / Han, Dongwook

Journal of physical therapy science

2017 Volume 29, Issue 4, Page(s) 662–664

Abstract: Purpose] The aim of this study was to determine a relationship between joint angle and muscular strength. In particular, this research investigated the differences in maximum muscular strength and average muscular strength at the knee-joint posture. [ ... ...

Abstract	[Purpose] The aim of this study was to determine a relationship between joint angle and muscular strength. In particular, this research investigated the differences in maximum muscular strength and average muscular strength at the knee-joint posture. [Subjects and Methods] The study subjects comprised eight female students in their 20s attending S University in Busan. None of the subjects had functional disabilities or had experienced damage to the lower extremities in terms of measurement of muscular strength. A BIODEX system III model (Biodex medical system, USA) was used to measure joint angles and muscular strength. The axis of the dynamometer was consistent with the axis of motion, and measurements were made at 25° and 67° to examine differences in maximum muscular strength according to joint angle. [Results] The maximum muscular strength both knee-joint extension value, at 67° and flexion value, at 25° the value was larger. The average muscular strength both knee-joint extension value, at 67° and flexion value, at 25° the value was larger. [Conclusion] The results of this study reveal that muscular strength does not reach maximum at particular range angles, such as the knee-joint resting posture angle or the knee-joint middle range angle. Rather, a stretched muscle is stronger than a contracted muscle. Therefore, it is considered that it will be necessary to study the effects of the joint change ratio on muscular strength on the basis of the maximum stretched muscle.
Language	English
Publishing date	2017-04-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.29.662
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Article ; Online: Gene-regulatory interactions in embryonic stem cells represent cell-type specific gene regulatory programs.

Ha, Misook / Hong, Soondo

Nucleic acids research

2017 Volume 45, Issue 18, Page(s) 10428–10435

Abstract: Pluripotency, the ability of embryonic stem cells to differentiate into specialized cell types, is determined by ESC-specific gene regulators such as transcription factors and chromatin modification factors. It is not well understood how ESCs are poised ... ...

Abstract	Pluripotency, the ability of embryonic stem cells to differentiate into specialized cell types, is determined by ESC-specific gene regulators such as transcription factors and chromatin modification factors. It is not well understood how ESCs are poised for differentiation, however, and methods are needed for prognosis of the molecular changes in the differentiation of ESCs into specific organs. We describe a new approach to infer cell-type specific gene regulatory programs based on gene regulatory interactions in ESCs. Our method infers the molecular logic of gene regulatory mechanisms by mapping the position-specific combinatory patterns of numerous regulators in ESCs into cell-type specific gene regulations. We validate the proposed approach by recapitulating the RNA-seq and microarray data of neuronal progenitor cells, adult liver cells, and ESCs from the integrated patterns of diverse gene regulators in ESCs. We find that the collective functions of diverse gene regulators in ESCs represent distinct gene regulatory programs in specialized cell types. Our new approach expands our understanding of the differential gene regulatory information in developments encoded in regulatory networks of ESCs.
MeSH term(s)	Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Cells, Cultured ; Gene Expression Regulation ; Gene Regulatory Networks/physiology ; Genes, Regulator ; Mice ; Mouse Embryonic Stem Cells/metabolism ; Organ Specificity/genetics ; Promoter Regions, Genetic
Language	English
Publishing date	2017-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkx752
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Article ; Online: The Effect of Fermented Momordica charantia with Leuconostoc mesenteroides MKSR on Metabolic Complications Induced by High-Fat High-Cholesterol Diet in C57BL/6 Mice

Moon, Heewon / Ha, Jung-Heun / Lee, Jisu / Jang, Hyunsoo / Kwon, Dain / Cho, Minji / Kang, Dahyun / Kim, Inyong / Kim, Misook

Fermentation. 2023 July 28, v. 9, no. 8

2023

Abstract: This study aimed to investigate the beneficial effects of Momordica charantia (MC) extract and MC fermented with Leuconostoc mesenteroides MKSR (FMC) on high-fat and high-cholesterol diet-induced metabolic complications. Male C57BL/6 mice were divided ... ...

Abstract	This study aimed to investigate the beneficial effects of Momordica charantia (MC) extract and MC fermented with Leuconostoc mesenteroides MKSR (FMC) on high-fat and high-cholesterol diet-induced metabolic complications. Male C57BL/6 mice were divided into six groups: normal diet (ND), high-fat and high-cholesterol diet (HFCD), HFCD with 1% MC extract (HFCD + 1M), HFCD with 4% MC extract (HFCD + 4M), HFCD with 1% fermented MC (HFCD + 1F), and HFCD with 4% fermented MC (HFCD + 4F). After 12 weeks of dietary intervention, the consumption of MC fermented with L. mesenteroides MKSR resulted in significant decreases in white adipose tissue weights (epididymal adipose tissue and retroperitoneal adipose tissue), serum alanine aminotransferase activity, and hepatic triglyceride levels. FMC also lowered total hepatic cholesterol content, improved glucose clearance during the oral glucose tolerance and insulin tolerance tests, and increased fecal cholesterol efflux from the enterohepatic circulation. Furthermore, the FMC notably increased hepatic mRNA expressions, which may indicate a compensatory mechanism against induced cholesterol efflux. Moreover, FMC induced both adipogenic (sterol regulatory element-binding protein 1c) and lipolytic (lipoprotein lipase, peroxisome proliferator-activated receptor alpha, and adiponectin) mRNA expressions. These findings suggest that fermentation with the probiotic L. mesenteroides MKSR enhances the beneficial effects of MC, preventing metabolic complications associated with a high-fat diet.
Keywords	Leuconostoc mesenteroides ; Momordica charantia ; adiponectin ; alanine transaminase ; blood serum ; cholesterol ; epididymis ; fermentation ; glucose ; glucose tolerance ; high fat diet ; lipoprotein lipase ; males ; nutritional intervention ; peroxisome proliferator-activated receptor alpha ; probiotics ; triacylglycerols ; white adipose tissue
Language	English
Dates of publication	2023-0728
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2813985-9
ISSN	2311-5637
ISSN	2311-5637
DOI	10.3390/fermentation9080718
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: DNA context represents transcription regulation of the gene in mouse embryonic stem cells.

Ha, Misook / Hong, Soondo

Scientific reports

2016 Volume 6, Page(s) 24343

Abstract: Understanding gene regulatory information in DNA remains a significant challenge in biomedical research. This study presents a computational approach to infer gene regulatory programs from primary DNA sequences. Using DNA around transcription start sites ...

Abstract	Understanding gene regulatory information in DNA remains a significant challenge in biomedical research. This study presents a computational approach to infer gene regulatory programs from primary DNA sequences. Using DNA around transcription start sites as attributes, our model predicts gene regulation in the gene. We find that H3K27ac around TSS is an informative descriptor of the transcription program in mouse embryonic stem cells. We build a computational model inferring the cell-type-specific H3K27ac signatures in the DNA around TSS. A comparison of embryonic stem cell and liver cell-specific H3K27ac signatures in DNA shows that the H3K27ac signatures in DNA around TSS efficiently distinguish the cell-type specific H3K27ac peaks and the gene regulation. The arrangement of the H3K27ac signatures inferred from the DNA represents the transcription regulation of the gene in mESC. We show that the DNA around transcription start sites is associated with the gene regulatory program by specific interaction with H3K27ac.
MeSH term(s)	Acetylation ; Animals ; Computational Biology ; DNA/chemistry ; Embryonic Stem Cells/physiology ; Gene Expression Regulation ; Histones/metabolism ; Mice ; Protein Processing, Post-Translational ; Transcription Initiation Site ; Transcription, Genetic
Chemical Substances	Histones ; DNA (9007-49-2)
Language	English
Publishing date	2016-04-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep24343
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Article: Understanding the chromatin remodeling code

Ha, Misook

Plant science. 2013 Oct., v. 211

2013

Abstract	Remodeling a chromatin structure enables the genetic elements stored in a genome to function in a condition-specific manner and predisposes the interactions between cis-regulatory elements and trans-acting factors. A chromatin signature can be an indicator of the activity of the underlying genetic elements. This paper reviews recent studies showing that the combination and arrangements of chromatin remodeling marks play roles as chromatin code affecting the activity of genetic elements. This paper also reviews recent studies inferring the primary DNA sequence contexts associated with chromatin remodeling that suggest interactions between genetic and epigenetic factors. We conclude that chromatin remodeling, which provides accurate models of gene expression and morphological variations, may help to find the biological marks that cannot be detected by genome-wide association study or genetic study.
MeSH term(s)	Chromatin Assembly and Disassembly ; Chromatin/genetics ; DNA Methylation ; Environment ; Epigenesis, Genetic ; Genome, Plant/genetics ; Histones/genetics ; Nucleosomes ; Plants/genetics ; Protein Binding
Keywords	chromatin ; gene expression ; models ; nucleotide sequences ; transcription factors
Language	English
Dates of publication	2013-10
Size	p. 137-145.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2013.07.006
Database	NAL-Catalogue (AGRICOLA)

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Article: Effect of pelvic floor muscle exercises on pulmonary function.

Han, DongWook / Ha, Misook

Journal of physical therapy science

2015 Volume 27, Issue 10, Page(s) 3233–3235

Abstract: Purpose] This study aimed to determine the correlation between pelvic floor muscle strength and pulmonary function. In particular, we examined whether pelvic floor muscle exercises can improve pulmonary function. [Subjects] Thirty female college ... ...

Abstract	[Purpose] This study aimed to determine the correlation between pelvic floor muscle strength and pulmonary function. In particular, we examined whether pelvic floor muscle exercises can improve pulmonary function. [Subjects] Thirty female college students aged 19-21 with no history of nervous or musculoskeletal system injury were randomly divided into experimental and control groups. [Methods] For the pulmonary function test, spirometry items included forced vital capacity and maximal voluntary ventilation. Pelvic floor muscle exercises consisted of Kegel exercises performed three times daily for 4 weeks. [Results] Kegel exercises performed in the experimental group significantly improved forced vital capacity, forced expiratory volume in 1 second, PER, FEF 25-75%, IC, and maximum voluntary ventilation compared to no improvement in the control group. [Conclusion] Kegel exercises significantly improved pulmonary function. When abdominal pressure increased, pelvic floor muscles performed contraction at the same time. Therefore, we recommend that the use of pelvic floor muscle exercises be considered for improving pulmonary function.
Language	English
Publishing date	2015-10-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.27.3233
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Article ; Online: Erratum to: Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3.

Kraushaar, Daniel C / Jin, Wenfei / Maunakea, Alika / Abraham, Brian / Ha, Misook / Zhao, Keji

Genome biology

2016 Volume 17, Page(s) 21

Language	English
Publishing date	2016-02-04
Publishing country	England
Document type	Published Erratum
ZDB-ID	2040529-7
ISSN	1474-760X ; 1465-6914 ; 1465-6906
ISSN (online)	1474-760X ; 1465-6914
ISSN	1465-6906
DOI	10.1186/s13059-016-0886-3
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Article ; Online: Diurnal regulation of SDG2 and JMJ14 by circadian clock oscillators orchestrates histone modification rhythms in Arabidopsis

Qingxin Song / Tien-Yu Huang / Helen H. Yu / Atsumi Ando / Paloma Mas / Misook Ha / Z. Jeffrey Chen

Genome Biology, Vol 20, Iss 1, Pp 1-

2019 Volume 12

Abstract: Abstract Background Circadian rhythms modulate growth and development in all organisms through interlocking transcriptional-translational feedback loops. The transcriptional loop involves chromatin modifications of central circadian oscillators in ... ...

Abstract	Abstract Background Circadian rhythms modulate growth and development in all organisms through interlocking transcriptional-translational feedback loops. The transcriptional loop involves chromatin modifications of central circadian oscillators in mammals and plants. However, the molecular basis for rhythmic epigenetic modifications and circadian regulation is poorly understood. Results Here we report a feedback relationship between diurnal regulation of circadian clock genes and histone modifications in Arabidopsis. On one hand, the circadian oscillators CCA1 and LHY regulate diurnal expression of genes coding for the eraser (JMJ14) directly and writer (SDG2) indirectly for H3K4me3 modification, leading to rhythmic H3K4me3 changes in target genes. On the other hand, expression of circadian oscillator genes including CCA1 and LHY is associated with H3K4me3 levels and decreased in the sdg2 mutant but increased in the jmj14 mutant. At the genome-wide level, diurnal rhythms of H3K4me3 and another histone mark H3K9ac are associated with diurnal regulation of 20–30% of the expressed genes. While the majority (86%) of H3K4me3 and H3K9ac target genes overlap, only 13% of morning-phased and 22% of evening-phased genes had both H3K4me3 and H3K9ac peaks, suggesting specific roles of different histone modifications in diurnal gene expression. Conclusions Circadian clock genes promote diurnal regulation of SDG2 and JMJ14 expression, which in turn regulate rhythmic histone modification dynamics for the clock and its output genes. This reciprocal regulatory module between chromatin modifiers and circadian clock oscillators orchestrates diurnal gene expression that governs plant growth and development.
Keywords	Diurnal ; Histone modification ; Arabidopsis ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
Subject code	571
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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