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  1. Article ; Online: Editorial Comment.

    Pintauro, Michael / Shah, Anup A / Jackman, Stephen V

    The Journal of urology

    2021  Volume 205, Issue 6, Page(s) 1746–1747

    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001603.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of opioid and β-adrenergic receptors in bladder underactivity induced by prolonged pudendal nerve stimulation in cats.

    Pintauro, Michael / Jian, Jianan / Wang, Jicheng / Shen, Bing / Scolieri, Joseph / Madhavaram, Avanish / Chermansky, Christopher / Beckel, Jonathan / de Groat, William C / Tai, Changfeng

    Neurourology and urodynamics

    2023  Volume 42, Issue 6, Page(s) 1344–1351

    Abstract: Aims: To determine the role of opioid and β-adrenergic receptors in bladder underactivity induced by prolonged pudendal nerve stimulation (PNS).: Methods: In α-chloralose anesthetized cats, 30-min PNS was applied repeatedly for 3-9 times to induce ... ...

    Abstract Aims: To determine the role of opioid and β-adrenergic receptors in bladder underactivity induced by prolonged pudendal nerve stimulation (PNS).
    Methods: In α-chloralose anesthetized cats, 30-min PNS was applied repeatedly for 3-9 times to induce poststimulation or persistent bladder underactivity. Then, naloxone (opioid receptor antagonist, 1 mg/kg, IV) or propranolol (β-adrenergic receptor antagonist, 3 mg/kg, IV) was given to reverse the bladder underactivity. After the drug treatment, an additional 30-min PNS was applied to counteract the drug effect. Repeated cystometrograms were performed by slowly (1-2 mL/min) infusing the bladder with saline via a urethral catheter to determine the bladder underactivity and the treatment effects.
    Results: Prolonged (2-4.5 h) PNS induced bladder underactivity evident as a large bladder capacity (169 ± 49% of control) and a reduced amplitude of bladder contraction (59 ± 17% of control). Naloxone fully reversed the bladder underactivity by reducing bladder capacity to 113 ± 58% and increasing the amplitude of bladder contraction to 104 ± 34%. After administration of naloxone an additional 30-min PNS temporarily increased the bladder capacity to the underactive bladder level (193 ± 74%) without changing the amplitude of the bladder contraction. Propranolol had no effect on bladder underactivity.
    Conclusions: A tonic enkephalinergic inhibitory mechanism in the CNS plays a critical role in the bladder underactivity induced by prolonged PNS, while the peripheral β-adrenergic receptor mechanism in the detrusor is not involved. This study provides basic science evidence consistent with the clinical observation that comorbid opioid usage may contribute to voiding dysfunction in patients with Fowler's syndrome.
    MeSH term(s) Cats ; Animals ; Urinary Bladder ; Pudendal Nerve ; Analgesics, Opioid/pharmacology ; Propranolol/pharmacology ; Receptors, Adrenergic, beta ; Reflex/physiology ; Electric Stimulation ; Urinary Bladder Diseases ; Naloxone/pharmacology
    Chemical Substances Analgesics, Opioid ; Propranolol (9Y8NXQ24VQ) ; Receptors, Adrenergic, beta ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.25226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Interspinous implants: are the new implants better than the last generation? A review.

    Pintauro, Michael / Duffy, Alexander / Vahedi, Payman / Rymarczuk, George / Heller, Joshua

    Current reviews in musculoskeletal medicine

    2017  Volume 10, Issue 2, Page(s) 189–198

    Abstract: Purpose of review: Interspinous process devices (IPDs) are used in the surgical treatment of lumbar spinal stenosis. The purpose of this review is to compare the first generation with the next-generation devices in terms of complications, device failure, ...

    Abstract Purpose of review: Interspinous process devices (IPDs) are used in the surgical treatment of lumbar spinal stenosis. The purpose of this review is to compare the first generation with the next-generation devices in terms of complications, device failure, reoperation rates, symptom relief, and outcome.
    Recent findings: Thirty-seven studies were included from 2011 to 2016. Device failure occurred at a mean of 3.7%, with a lower tendency to happen with next-generation IPDs. Reoperations occurred at a lower rate with the next-generation devices, with a mean follow up of 24 months (3.7% vs. 11.1%). The clinical outcome is not influenced by the type of IPD. The long-term functionality of these devices is questionable, with radiologic changes and recurrence of symptoms often seen by 2 years following implantation. Next-generation devices do not appear to be subject to the same "bounce back" effect of symptom re-emergence after several years.
    Language English
    Publishing date 2017-03-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2407827-X
    ISSN 1935-9748 ; 1935-973X
    ISSN (online) 1935-9748
    ISSN 1935-973X
    DOI 10.1007/s12178-017-9401-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: High Areal Capacity Si/LiCoO

    Self, Ethan C / Naguib, Michael / Ruther, Rose E / McRen, Emily C / Wycisk, Ryszard / Liu, Gao / Nanda, Jagjit / Pintauro, Peter N

    ChemSusChem

    2017  Volume 10, Issue 8, Page(s) 1823–1831

    Abstract: Freestanding nanofiber mat Li-ion battery anodes containing Si nanoparticles, carbon black, and poly(acrylic acid) (Si/C/PAA) are prepared using electrospinning. The mats are compacted to a high fiber volume fraction (≈0.85), and interfiber contacts are ... ...

    Abstract Freestanding nanofiber mat Li-ion battery anodes containing Si nanoparticles, carbon black, and poly(acrylic acid) (Si/C/PAA) are prepared using electrospinning. The mats are compacted to a high fiber volume fraction (≈0.85), and interfiber contacts are welded by exposing the mat to methanol vapor. A compacted+welded fiber mat anode containing 40 wt % Si exhibits high capacities of 1484 mA h g
    MeSH term(s) Cobalt/chemistry ; Electric Power Supplies ; Electrochemistry ; Microscopy, Electron, Scanning ; Oxides/chemistry ; Silicon/chemistry ; X-Ray Diffraction
    Chemical Substances Oxides ; lithium cobalt oxide ; Cobalt (3G0H8C9362) ; Silicon (Z4152N8IUI)
    Language English
    Publishing date 2017-04-22
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.201700096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Repair of dense connective tissues via biomaterial-mediated matrix reprogramming of the wound interface.

    Qu, Feini / Pintauro, Michael P / Haughan, Joanne E / Henning, Elizabeth A / Esterhai, John L / Schaer, Thomas P / Mauck, Robert L / Fisher, Matthew B

    Biomaterials

    2014  Volume 39, Page(s) 85–94

    Abstract: Repair of dense connective tissues in adults is limited by their intrinsic hypocellularity and is exacerbated by a dense extracellular matrix (ECM) that impedes cellular migration to and local proliferation at the wound site. Conversely, healing in fetal ...

    Abstract Repair of dense connective tissues in adults is limited by their intrinsic hypocellularity and is exacerbated by a dense extracellular matrix (ECM) that impedes cellular migration to and local proliferation at the wound site. Conversely, healing in fetal tissues occurs due in part to an environment conducive to cell mobility and division. Here, we investigated whether the application of a degradative enzyme, collagenase, could reprogram the adult wound margin to a more fetal-like state, and thus abrogate the biophysical impediments that hinder migration and proliferation. We tested this concept using the knee meniscus, a commonly injured structure for which few regenerative approaches exist. To focus delivery and degradation to the wound interface, we developed a system in which collagenase was stored inside poly(ethylene oxide) (PEO) electrospun nanofibers and released upon hydration. Through a series of in vitro and in vivo studies, our findings show that partial digestion of the wound interface improves repair by creating a more compliant and porous microenvironment that expedites cell migration to and/or proliferation at the wound margin. This innovative approach of targeted manipulation of the wound interface, focused on removing the naturally occurring barriers to adult tissue repair, may find widespread application in the treatment of injuries to a variety of dense connective tissues.
    MeSH term(s) Animals ; Biocompatible Materials/chemistry ; Connective Tissue/physiology ; Microscopy, Atomic Force ; Polyethylene Glycols/chemistry ; Rats ; Sheep ; Tissue Scaffolds/chemistry ; Wound Healing/physiology
    Chemical Substances Biocompatible Materials ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2014-11-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2014.10.067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Repair of dense connective tissues via biomaterial-mediated matrix reprogramming of the wound interface

    Qu, Feini / Pintauro, Michael P / Haughan, Joanne E / Henning, Elizabeth A / Esterhai, John L / Schaer, Thomas P / Mauck, Robert L / Fisher, Matthew B

    Biomaterials. 2015 Jan., v. 39

    2015  

    Abstract: Repair of dense connective tissues in adults is limited by their intrinsic hypocellularity and is exacerbated by a dense extracellular matrix (ECM) that impedes cellular migration to and local proliferation at the wound site. Conversely, healing in fetal ...

    Abstract Repair of dense connective tissues in adults is limited by their intrinsic hypocellularity and is exacerbated by a dense extracellular matrix (ECM) that impedes cellular migration to and local proliferation at the wound site. Conversely, healing in fetal tissues occurs due in part to an environment conducive to cell mobility and division. Here, we investigated whether the application of a degradative enzyme, collagenase, could reprogram the adult wound margin to a more fetal-like state, and thus abrogate the biophysical impediments that hinder migration and proliferation. We tested this concept using the knee meniscus, a commonly injured structure for which few regenerative approaches exist. To focus delivery and degradation to the wound interface, we developed a system in which collagenase was stored inside poly(ethylene oxide) (PEO) electrospun nanofibers and released upon hydration. Through a series of in vitro and in vivo studies, our findings show that partial digestion of the wound interface improves repair by creating a more compliant and porous microenvironment that expedites cell migration to and/or proliferation at the wound margin. This innovative approach of targeted manipulation of the wound interface, focused on removing the naturally occurring barriers to adult tissue repair, may find widespread application in the treatment of injuries to a variety of dense connective tissues.
    Keywords adults ; cell movement ; collagenase ; connective tissues ; digestion ; extracellular matrix ; in vivo studies ; nanofibers ; polyethylene glycol ; tissue repair
    Language English
    Dates of publication 2015-01
    Size p. 85-94.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2014.10.067
    Database NAL-Catalogue (AGRICOLA)

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