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  1. Article ; Online: High prevalence of nonalcoholic fatty liver disease in the middle east: Lifestyle and dietary habits.

    Eshraghian, Ahad

    Hepatology (Baltimore, Md.)

    2017  Volume 65, Issue 3, Page(s) 1077

    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Letter
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.28937
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    Zs.A 1660: Show issues Location:
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  2. Article ; Online: Bone metabolism in non-alcoholic fatty liver disease: vitamin D status and bone mineral density.

    Eshraghian, Ahad

    Minerva endocrinologica

    2017  Volume 42, Issue 2, Page(s) 164–172

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and abnormal liver enzyme worldwide. NAFLD is reported to be associated with other extra-hepatic diseases including cardiovascular disease, diabetes mellites and ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and abnormal liver enzyme worldwide. NAFLD is reported to be associated with other extra-hepatic diseases including cardiovascular disease, diabetes mellites and thyroid gland abnormalities. Liver is also the source of many proteins involved in bone metabolism and is the regulator of several bone metabolism pathways. Although underlying pathogenesis is not clear, the association between NAFLD and low bone mineral density (BMD) in the forms of osteoporosis and osteopenia has been recently reported. This study aimed to review current evidences supporting the association between bone metabolism including low BMD and serum vitamin D level in patients with NAFLD. Epidemiolocal studies indicating lower BMD and vitamin D in patients with NAFLD have been reviewed. The main pathophysiological mechanisms including association of insulin resistance, serum adiponectin, ghrelin, osteopontin, osteoprotegerin, and osteocalcin with NAFLD and low BMD have been briefly reviewed and summarized. Results of current clinical trials investigating the role of vitamin D supplementation for treatment of hepatic steatosis and non-alcoholic steatohepoatitis (NASH) have been also summarized. As a conclusion, increasing evidences are now available suggesting low BMD in patients with NAFLD. Some of these studies showed association of NAFLD severity with low vitamin D and BMD. Screening and surveillance of skeletal system regarding osteoporosis/osteomalacia in patients with NAFLD may be considered in future strategies and guidelines for NAFLD management.
    MeSH term(s) Bone Density ; Bone and Bones/metabolism ; Humans ; Non-alcoholic Fatty Liver Disease/metabolism ; Nutritional Status ; Osteoporosis/metabolism ; Osteoporosis/physiopathology ; Vitamin D/metabolism
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2017-06
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 423687-7
    ISSN 1827-1634 ; 0391-1977
    ISSN (online) 1827-1634
    ISSN 0391-1977
    DOI 10.23736/S0391-1977.16.02587-6
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  3. Article ; Online: Current and emerging pharmacological therapy for non-alcoholic fatty liver disease.

    Eshraghian, Ahad

    World journal of gastroenterology

    2017  Volume 23, Issue 42, Page(s) 7495–7504

    Abstract: The main treatment of patients with non-alcoholic fatty liver disease (NAFLD) is life style modification including weight reduction and dietary regimen. Majority of patients are safely treated with this management and pharmacologic interventions are not ... ...

    Abstract The main treatment of patients with non-alcoholic fatty liver disease (NAFLD) is life style modification including weight reduction and dietary regimen. Majority of patients are safely treated with this management and pharmacologic interventions are not recommended. However, a subgroup of NAFLD patients with non-alcoholic steatohepatitis (NASH) who cannot achieve goals of life style modification may need pharmacological therapy. One major obstacle is measurement of histological outcome by liver biopsy which is an invasive method and is not recommended routinely in these patients. Several medications, mainly targeting baseline mechanism of NAFLD, have been investigated in clinical trials for treatment of NASH with promising results. At present, only pioglitazone acting as insulin sensitizing agent and vitamin E as an anti-oxidant have been recommended for treatment of NASH by international guidelines. Lipid lowering agents including statins and fibrates, pentoxifylline, angiotensin receptor blockers, ursodeoxycholic acid, probiotics and synbiotics are current agents with beneficial effects for treatment of NASH but have not been approved yet. Several emerging medications are in development for treatment of NASH. Obeticholic acid, liraglutide, elafibranor, cenicriviroc and aramchol have been tested in clinical trials or are completing trials. Here in, current and upcoming medications with promising results in clinical trial for treatment of NAFLD were reviewed.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/drug therapy
    Language English
    Publishing date 2017-11-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v23.i42.7495
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  4. Article ; Online: Angiotensin receptor blockers might be protective against hepatic steatosis after liver transplantation.

    Eshraghian, Ahad / Taghavi, Alireza / Nikoupour, Hamed / Nikeghbalian, Saman / Malek-Hosseini, Seyed Ali

    BMC gastroenterology

    2023  Volume 23, Issue 1, Page(s) 152

    Abstract: Background: Hepatic steatosis is an increasing complication in liver transplant recipients. Currently, there is no pharmacologic therapy for treatment of hepatic steatosis after liver transplantation. The aim of this study was to determine the ... ...

    Abstract Background: Hepatic steatosis is an increasing complication in liver transplant recipients. Currently, there is no pharmacologic therapy for treatment of hepatic steatosis after liver transplantation. The aim of this study was to determine the association between use of angiotensin receptor blockers (ARB) and hepatic steatosis in liver transplant recipients.
    Methods: We conducted a case-control analysis on data from Shiraz Liver Transplant Registry. Liver transplant recipients with and without hepatic steatosis were compared for risk factors including use of ARB.
    Results: A total of 103 liver transplant recipients were included in the study. Thirty five patients treated with ARB and 68 patients (66%) did not receive these medications. In univariate analysis, ARB use (P = 0.002), serum triglyceride (P = 0.006), weight after liver transplantation (P = 0.011) and etiology of liver disease (P = 0.008) were associated with hepatic steatosis after liver transplantation. In multivariate regression analysis, ARB use was associated with lower likelihood of hepatic steatosis in liver transplant recipients (OR = 0.303, 95% CI: 0.117-0.784; P = 0.014). Mean duration of ARB use (P = 0.024) and mean cumulative daily dose of ARB (P = 0.015) were significantly lower in patients with hepatic steatosis.
    Conclusion: Our study showed that ARB use was associated with reduced incidence of hepatic steatosis in liver transplant recipients.
    MeSH term(s) Humans ; Liver Transplantation/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Angiotensin Receptor Antagonists/therapeutic use ; Fatty Liver/etiology ; Fatty Liver/prevention & control ; Risk Factors
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-023-02781-9
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  5. Article ; Online: Religion, tradition, culture, and solid organ transplantation.

    Eshraghian, Ahad

    Critical care medicine

    2013  Volume 41, Issue 7, Page(s) e134

    MeSH term(s) Continental Population Groups/statistics & numerical data ; Humans ; Informed Consent/statistics & numerical data ; Tissue Donors/supply & distribution
    Language English
    Publishing date 2013-07
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0b013e31828a2613
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    Zs.A 1261: Show issues Location:
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  6. Article ; Online: Epidemiology of Helicobacter pylori infection among the healthy population in Iran and countries of the Eastern Mediterranean Region: a systematic review of prevalence and risk factors.

    Eshraghian, Ahad

    World journal of gastroenterology

    2014  Volume 20, Issue 46, Page(s) 17618–17625

    Abstract: Aim: To investigate the epidemiology of Helicobacter pylori (H. pylori) infection among the healthy asymptomatic population in Iran and countries of the Eastern Mediterranean Region.: Methods: A computerized English language literature search of ... ...

    Abstract Aim: To investigate the epidemiology of Helicobacter pylori (H. pylori) infection among the healthy asymptomatic population in Iran and countries of the Eastern Mediterranean Region.
    Methods: A computerized English language literature search of PubMed, ISI Web of Science, Scopus, and Google Scholar was performed in September 2013. The terms, "Eastern Mediterranean Regional Office (EMRO)" and "Helicobacter pylori", "H. pylori" and "prevalence" were used as key words in titles and/or abstracts. A complementary literature search was also performed in the following countries: Afghanistan, Bahrain, Djibouti, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Pakistan, Palestine, Qatar, Saudi Arabia, Somalia, Sudan, Syria, Tunisia, The United Arab Emirates, and Yemen.
    Results: In the electronic search, a total of 308 articles were initially identified. Of these articles, 26 relevant articles were identified and included in the study. There were 10 studies from Iran, 5 studies from the Kingdom of Saudi Arabia, 4 studies from Egypt, 2 from the United Arab Emirates, and one study from Libya, Oman, Tunisia, and Lebanon, respectively. The overall prevalence of H. pylori infection in Iran, irrespective of time and age group, ranged from 30.6% to 82%. The overall prevalence of H. pylori infection, irrespective of time and age group, in other EMRO countries ranged from 22% to 87.6%.
    Conclusion: The prevalence of H. pylori in EMRO countries is still high in the healthy asymptomatic population. Strategies to improve sanitary facilities, educational status, and socioeconomic status should be implemented to minimize H. pylori infection.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Aged, 80 and over ; Asymptomatic Diseases ; Child ; Child, Preschool ; Female ; Helicobacter Infections/diagnosis ; Helicobacter Infections/epidemiology ; Helicobacter Infections/microbiology ; Helicobacter pylori/isolation & purification ; Humans ; Infant ; Iran/epidemiology ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Sex Distribution ; Sex Factors ; Young Adult
    Language English
    Publishing date 2014-12-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v20.i46.17618
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  7. Article ; Online: New onset diabetes after transplantation: a type 1.5 diabetes or latent autoimmune diabetes of adults?

    Eshraghian, Ahad

    Journal of hepatology

    2013  Volume 58, Issue 5, Page(s) 1059–1060

    MeSH term(s) Asian Continental Ancestry Group/genetics ; Diabetes Mellitus, Type 2/genetics ; Female ; Genetic Predisposition to Disease/genetics ; Humans ; Liver Transplantation ; Male ; Polymorphism, Single Nucleotide/genetics ; Tissue Donors ; Transcription Factor 7-Like 2 Protein/genetics ; Transplantation
    Chemical Substances Transcription Factor 7-Like 2 Protein
    Language English
    Publishing date 2013-05
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2012.12.029
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    Zs.A 2027: Show issues Location:
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  8. Article ; Online: Metabolic syndrome after liver transplantation: is there a role for infections?

    Eshraghian, Ahad

    Nutrition (Burbank, Los Angeles County, Calif.)

    2012  Volume 28, Issue 7-8, Page(s) 825–6; author reply 827

    MeSH term(s) Alcoholism/complications ; Diet ; Female ; Humans ; Liver Transplantation ; Male ; Metabolic Syndrome/etiology ; Overweight/complications ; Postoperative Complications/epidemiology ; Sedentary Lifestyle
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2011.11.014
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  9. Article: Akhenaten's mystery remains.

    Eshraghian, Ahad

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    2011  Volume 101, Issue 11, Page(s) 780

    MeSH term(s) Eunuchism/history ; Famous Persons ; Humans ; Mummies
    Language English
    Publishing date 2011-11-01
    Publishing country South Africa
    Document type Comment ; Letter
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0256-9574 ; 0038-2469
    ISSN (online) 2078-5135
    ISSN 0256-9574 ; 0038-2469
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  10. Article ; Online: The continuous story of Helicobacter pylori infection and insulin resistance: this time in Japan.

    Eshraghian, Ahad

    Helicobacter

    2010  Volume 15, Issue 2, Page(s) 160; author reply 161

    MeSH term(s) Diabetes Mellitus, Type 2/epidemiology ; Helicobacter Infections/complications ; Humans ; Insulin Resistance ; Japan/epidemiology
    Language English
    Publishing date 2010-04
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1330665-0
    ISSN 1523-5378 ; 1083-4389
    ISSN (online) 1523-5378
    ISSN 1083-4389
    DOI 10.1111/j.1523-5378.2009.00741.x
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