LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 388

Search options

  1. Book ; Conference proceedings: Hypertension and cardiovascular risk in chronic kidney disease

    Luño, José / Rodríguez-Iturbe, Bernardo

    [contains some of the proceedings of the Eighth International Conference on Hypertension and the Kidney ... in Madrid in February 2012]

    (Nephrology, dialysis, transplantation ; 27, Suppl. 4)

    2012  

    Event/congress International Conference on Hypertension and the Kidney (8, 2012, Madrid)
    Series title Nephrology, dialysis, transplantation ; 27, Suppl. 4
    Collection
    Language English
    Size 62 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT017532995
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2198 -27,Suppl.4- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Autoimmunity in Acute Poststreptococcal GN: A Neglected Aspect of the Disease.

    Rodriguez-Iturbe, Bernardo

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 3, Page(s) 534–542

    Abstract: Acute poststreptococcal GN (APSGN) is the prototype of immune complex GN and is associated with manifestations of autoimmune reactivity that have been neglected as epiphenomena. Recently, studies have demonstrated transient antifactor B autoantibodies ... ...

    Abstract Acute poststreptococcal GN (APSGN) is the prototype of immune complex GN and is associated with manifestations of autoimmune reactivity that have been neglected as epiphenomena. Recently, studies have demonstrated transient antifactor B autoantibodies that activate the alternative complement pathway, bringing self-immunity to a central position in the pathogenesis of APSGN. Therefore, examining other manifestations of autoimmunity that have been reported in association with poststreptococcal GN is of interest. This article reviews the renal and extrarenal manifestations of autoimmune reactivity in APSGN and considers their potential relevance in modifying the usually benign clinical course of the disease. It also discusses related aspects of the nephritogenic antigens, complement activation, and genetic elements associated with immune reactivity and their potential relevance to the familial incidence of the disease.
    MeSH term(s) Antigens, Bacterial/immunology ; Autoantibodies/immunology ; Autoantigens/immunology ; Autoimmunity/genetics ; Complement Pathway, Alternative ; Genetic Association Studies ; Glomerulonephritis/etiology ; Glomerulonephritis/immunology ; Glomerulonephritis/microbiology ; Humans ; Kidney Glomerulus/immunology ; Kidney Glomerulus/microbiology ; Models, Immunological ; Streptococcal Infections/complications ; Streptococcal Infections/immunology ; Streptococcal Infections/microbiology ; Streptococcus/immunology ; Streptococcus/pathogenicity
    Chemical Substances Antigens, Bacterial ; Autoantibodies ; Autoantigens
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2020081228
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The participation of immunity in the pathogenesis of arterial hypertension.

    Rodríguez-Iturbe, Bernardo

    Nefrologia

    2019  Volume 40, Issue 1, Page(s) 1–3

    Title translation La participación de la inmunidad en la patogenia de la hipertensión arterial.
    MeSH term(s) Adaptive Immunity ; Animals ; Arteritis/immunology ; Autoimmunity ; Humans ; Hypertension/immunology ; Immunity, Cellular ; Immunity, Innate ; Lymphocytes/immunology ; Mice ; Mice, Nude ; Nephritis/immunology
    Language Spanish
    Publishing date 2019-07-23
    Document type Editorial
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefro.2019.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Relationship between hyperuricemia, HSP70 and NLRP3 inflammasome in arterial hypertension.

    Rodríguez-Iturbe, Bernardo / Johnson, Richard J / Sánchez-Lozada, Laura G

    Archivos de cardiologia de Mexico

    2023  Volume 93, Issue 4, Page(s) 458–463

    Abstract: Arterial hypertension is the most important cardiovascular risk factor in chronic non-communicable diseases and is estimated to be responsible for 10.4 million deaths annually. The global prevalence of hypertension is 30% and the majority of people with ... ...

    Title translation La relación hiperuricemia-HSP70-NLRP3 inflamosoma en la hipertensión arterial.
    Abstract Arterial hypertension is the most important cardiovascular risk factor in chronic non-communicable diseases and is estimated to be responsible for 10.4 million deaths annually. The global prevalence of hypertension is 30% and the majority of people with hypertension do not have a clear identifiable cause and are considered to have primary hypertension. Experimental and clinical investigations from several research groups, including ours, have established that inflammation and autoimmune reactivity play a role in the sodium retention and hemodynamic responses that drive primary hypertension. Hyperuricemia and heat stress proteins (HSP), particularly HSP70, are both associated with the activation of innate immunity that plays a role in the development of inflammatory reactivity in the hypertensive patient. Clinical studies have shown an association between the expression of HSP70 and anti-HSP70 antibodies and primary hypertension. This brief review aims to examine the interrelation between hyperuricemia and extracellular overexpression of HSP70 in the activation of the inflammasome that may have a central role in the pathophysiology of primary hypertension.
    MeSH term(s) Humans ; Essential Hypertension ; HSP70 Heat-Shock Proteins/metabolism ; Hypertension/epidemiology ; Hyperuricemia/complications ; Hyperuricemia/epidemiology ; Inflammasomes/metabolism ; Inflammation ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
    Chemical Substances HSP70 Heat-Shock Proteins ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human
    Language English
    Publishing date 2023-11-16
    Publishing country Mexico
    Document type Review ; Journal Article
    ZDB-ID 2059019-2
    ISSN 1665-1731 ; 1665-1731
    ISSN (online) 1665-1731
    ISSN 1665-1731
    DOI 10.24875/ACM.22000174
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book: Hypertension, reactive oxygen species, immunocompetent cells and the progression of renal damage

    Rodríguez-Iturbe, Bernardo

    based on a meeting held in September 2001, Mérida, Venezuela

    (Journal of hypertension ; 20, Suppl. 3)

    2002  

    Author's details ed.: Bernardo Rodríguez-Iturbe
    Series title Journal of hypertension ; 20, Suppl. 3
    Collection
    Language English
    Size S59 : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Hagerstown, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT013402383
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1885 -20,Suppl.3- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Insights into Salt Handling and Blood Pressure.

    Johnson, Richard J / Lanaspa, Miguel A / Rodriguez-Iturbe, Bernardo

    The New England journal of medicine

    2022  Volume 386, Issue 7, Page(s) e18

    MeSH term(s) Blood Pressure/physiology ; Humans ; Hypertension/physiopathology ; Sodium Chloride ; Sodium Chloride, Dietary/adverse effects
    Chemical Substances Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2119480
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Functional Reserve of the Kidney.

    Armenta, Armando / Madero, Magdalena / Rodriguez-Iturbe, Bernardo

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 17, Issue 3, Page(s) 458–466

    Abstract: An exploration of the normal limits of physiologic responses and how these responses are lost when the kidney is injured rarely occurs in clinical practice. However, the differences between "resting" and "stressed" responses identify an adaptive ... ...

    Abstract An exploration of the normal limits of physiologic responses and how these responses are lost when the kidney is injured rarely occurs in clinical practice. However, the differences between "resting" and "stressed" responses identify an adaptive reactiveness that is diminished before baseline function is impaired. This functional reserve is important in the evaluation of prognosis and progression of kidney disease. Here, we discuss stress tests that examine protein-induced hyperfiltration, proximal tubular secretion, urea-selective concentration defects, and acid retention. We discuss diseases in which these tests have been used to diagnose subclinical injury. The study and follow-up of abnormal functional reserve may add considerable understanding to the natural history of CKD.
    MeSH term(s) Female ; Glomerular Filtration Rate ; Humans ; Kidney ; Kidney Diseases ; Male
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.11070821
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6584: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: HSP70 and Primary Arterial Hypertension.

    Rodriguez-Iturbe, Bernardo / Johnson, Richard J / Sanchez-Lozada, Laura Gabriela / Pons, Hector

    Biomolecules

    2023  Volume 13, Issue 2

    Abstract: Heat shock protein 70 (HSP70) production is a stress-generated cellular response with high interspecies homology. HSP70 has both chaperone and cytokine functions and may induce, depending on the context, tolerogenic anti-inflammatory reactivity or ... ...

    Abstract Heat shock protein 70 (HSP70) production is a stress-generated cellular response with high interspecies homology. HSP70 has both chaperone and cytokine functions and may induce, depending on the context, tolerogenic anti-inflammatory reactivity or immunogenic and autoimmune reactivity. Intracellular (chaperoning transit of antigens to MHC in antigen-presenting cells) and extracellular HSP70-related effects are associated with hypertension, which is an inflammatory condition recognized as the most important risk factor for cardiovascular disease mortality. Here, we review (a) the relationship between HSP70, inflammation and immune reactivity, (b) clinical evidence relating to stress, HSP70 and anti-HSP70 reactivity with primary hypertension and (c) experimental data showing that salt-sensitive hypertension is associated with delayed hypersensitivity to HSP70. This is a consequence of anti-HSP70 reactivity in the kidneys and may be prevented and corrected by the T-cell-driven inhibition of kidney inflammation triggered by specific epitopes of HSP70. Finally, we discuss our postulate that lifelong stress signals and danger-associated molecular patterns stimulate HSP-70 and individual genetic and epigenetic characteristics determine whether the HSP70 response would drive inflammatory immune reactivity causing hypertension or, alternatively, would drive immunomodulatory responses that protect against hypertension.
    MeSH term(s) Humans ; HSP70 Heat-Shock Proteins/metabolism ; Hypertension/metabolism ; Cytokines/metabolism ; Kidney/metabolism ; Inflammation/metabolism
    Chemical Substances HSP70 Heat-Shock Proteins ; Cytokines
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13020272
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Autoimmunity in the Pathogenesis of Hypertension.

    Rodriguez-Iturbe, Bernardo

    Hypertension (Dallas, Tex. : 1979)

    2016  Volume 67, Issue 3, Page(s) 477–483

    MeSH term(s) Adaptive Immunity ; Autoantibodies/immunology ; Autoimmunity ; Blood Pressure ; Humans ; Hypertension/etiology
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.115.06418
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Fibroblast growth factor 23-Klotho and hypertension: experimental and clinical mechanisms.

    Freundlich, Michael / Gamba, Gerardo / Rodriguez-Iturbe, Bernardo

    Pediatric nephrology (Berlin, Germany)

    2020  Volume 36, Issue 10, Page(s) 3007–3022

    Abstract: Hypertension (HTN) and chronic kidney disease (CKD) are increasingly recognized in pediatric patients and represent risk factors for cardiovascular morbidity and mortality later in life. In CKD, enhanced tubular sodium reabsorption is a leading cause of ... ...

    Abstract Hypertension (HTN) and chronic kidney disease (CKD) are increasingly recognized in pediatric patients and represent risk factors for cardiovascular morbidity and mortality later in life. In CKD, enhanced tubular sodium reabsorption is a leading cause of HTN due to augmented extracellular fluid volume expansion. The renin-angiotensin-aldosterone system (RAAS) upregulates various tubular sodium cotransporters that are also targets of the hormone fibroblast growth factor 23 (FGF23) and its co-receptor Klotho. FGF23 inhibits the activation of 1,25-dihydroxyvitamin D that is a potent suppressor of renin biosynthesis. Here we review the complex interactions and disturbances of the FGF23-Klotho axis, vitamin D, and the RAAS relevant to blood pressure regulation and discuss the therapeutic strategies aimed at mitigating their pathophysiologic contributions to HTN.
    MeSH term(s) Child ; Fibroblast Growth Factor-23 ; Fibroblast Growth Factors/metabolism ; Glucuronidase ; Humans ; Hypertension ; Klotho Proteins ; Renal Insufficiency, Chronic/metabolism ; Sodium
    Chemical Substances Fibroblast Growth Factors (62031-54-3) ; Fibroblast Growth Factor-23 (7Q7P4S7RRE) ; Sodium (9NEZ333N27) ; Glucuronidase (EC 3.2.1.31) ; Klotho Proteins (EC 3.2.1.31)
    Language English
    Publishing date 2020-11-23
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04843-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top