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  1. Article ; Online: Vesicles and targetoid lesions in a postpartum woman.

    Morganroth, Pamela A / McHargue, Chauncey A

    JAMA dermatology

    2014  Volume 150, Issue 4, Page(s) 445–446

    MeSH term(s) Adult ; Anti-Inflammatory Agents/therapeutic use ; Female ; Humans ; Pemphigoid Gestationis/drug therapy ; Pemphigoid Gestationis/pathology ; Postpartum Period ; Prednisone/therapeutic use ; Pregnancy
    Chemical Substances Anti-Inflammatory Agents ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2014-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2013.7581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Irregular pigmented lesion on the oral mucosa.

    Morganroth, Pamela A / Jackson, Diane / Chaffins, Marsha

    JAMA dermatology

    2014  Volume 150, Issue 5, Page(s) 563–564

    MeSH term(s) Acanthoma/pathology ; Biopsy, Needle ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Hyperpigmentation/pathology ; Immunohistochemistry ; Lip ; Middle Aged ; Monitoring, Physiologic ; Mouth Diseases/pathology ; Mouth Mucosa/pathology ; Risk Assessment ; Skin Neoplasms/pathology
    Language English
    Publishing date 2014-05
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2013.7699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Subcutaneous nodules on the fingers.

    Morganroth, Pamela A / Chaffins, Marsha L / Lim, Henry W

    JAMA dermatology

    2013  Volume 149, Issue 2, Page(s) 223

    MeSH term(s) Fingers ; Humans ; Male ; Middle Aged ; Sarcoidosis/diagnosis ; Sarcoidosis/pathology ; Skin Diseases/diagnosis ; Skin Diseases/pathology ; Subcutaneous Tissue/pathology
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/archderm.149.2.223-d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Postirradiation Morphea: A Case Report With a Review of the Literature and Summary of the Clinicopathologic Differential Diagnosis.

    Morganroth, Pamela A / Dehoratius, Danielle / Curry, Heather / Elenitsas, Rosalie

    The American Journal of dermatopathology

    2013  

    Abstract: Postirradiation morphea is a rare complication of radiation therapy which often presents as an erythematous indurated plaque and may be mistaken for recurrent or metastatic carcinoma. Histologic examination is essential for distinguishing ... ...

    Abstract : Postirradiation morphea is a rare complication of radiation therapy which often presents as an erythematous indurated plaque and may be mistaken for recurrent or metastatic carcinoma. Histologic examination is essential for distinguishing postirradiation morphea from malignant processes and from other types of radiation dermatitis and infectious cellulitis. We report a case of postirradiation morphea and review the postirradiation morphea literature. In addition, we summarize the clinical and histopathologic characteristics of the various forms of postirradiation skin disease, including postirradiation morphea; acute, subacute, and chronic radiation dermatitis; and radiation recall dermatitis.
    Language English
    Publishing date 2013-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0b013e3181cb3fdd
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Role of DNA replication and repair in thymineless death in Escherichia coli.

    Morganroth, Pamela A / Hanawalt, Philip C

    Journal of bacteriology

    2006  Volume 188, Issue 14, Page(s) 5286–5288

    Abstract: Inhibition of DNA replication with hydroxyurea during thymine starvation of Escherichia coli shows that active DNA synthesis is not required for thymineless death (TLD). Hydroxyurea experiments and thymine starvation of lexA3 and uvrA DNA repair mutants ... ...

    Abstract Inhibition of DNA replication with hydroxyurea during thymine starvation of Escherichia coli shows that active DNA synthesis is not required for thymineless death (TLD). Hydroxyurea experiments and thymine starvation of lexA3 and uvrA DNA repair mutants rule out unbalanced growth, the SOS response, and nucleotide excision repair as explanations for TLD.
    MeSH term(s) DNA Repair ; DNA Replication ; Escherichia coli/cytology ; Escherichia coli/genetics ; Kinetics ; RNA, Bacterial/genetics ; Thymine/metabolism ; Transcription, Genetic
    Chemical Substances RNA, Bacterial ; Thymine (QR26YLT7LT)
    Language English
    Publishing date 2006-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00543-06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cutaneous lupus and the Cutaneous Lupus Erythematosus Disease Area and Severity Index instrument.

    Klein, Rachel S / Morganroth, Pamela A / Werth, Victoria P

    Rheumatic diseases clinics of North America

    2010  Volume 36, Issue 1, Page(s) 33–51, vii

    Abstract: This article provides an overview of cutaneous lupus erythematosus, including classification schemes, disease subtypes, and therapy. It also describes the Cutaneous Lupus Erythematosus Disease Area and Severity Index, a novel clinical outcome instrument ... ...

    Abstract This article provides an overview of cutaneous lupus erythematosus, including classification schemes, disease subtypes, and therapy. It also describes the Cutaneous Lupus Erythematosus Disease Area and Severity Index, a novel clinical outcome instrument that quantifies cutaneous activity and damage in cutaneous lupus erythematosus.
    MeSH term(s) Humans ; Lupus Erythematosus, Cutaneous/complications ; Lupus Erythematosus, Cutaneous/diagnosis ; Sensitivity and Specificity ; Severity of Illness Index ; Skin Diseases, Vesiculobullous/complications ; Skin Diseases, Vesiculobullous/diagnosis
    Language English
    Publishing date 2010-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2009.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mycophenolate mofetil for interstitial lung disease in dermatomyositis.

    Morganroth, Pamela A / Kreider, Mary Elizabeth / Werth, Victoria P

    Arthritis care & research

    2010  Volume 62, Issue 10, Page(s) 1496–1501

    Abstract: Objective: To report our experience using mycophenolate mofetil as first-line treatment for dermatomyositis-associated interstitial lung disease.: Methods: We examined the medical records of all 16 dermatomyositis patients with interstitial lung ... ...

    Abstract Objective: To report our experience using mycophenolate mofetil as first-line treatment for dermatomyositis-associated interstitial lung disease.
    Methods: We examined the medical records of all 16 dermatomyositis patients with interstitial lung disease seen in our outpatient university hospital dermatology clinic between May 26, 2006, and May 25, 2009. In this retrospective case series, we describe the clinical course of the 4 patients with definitive evidence of interstitial lung disease on radiologic imaging who were treated with mycophenolate mofetil and had pulmonary data available to document their outcome. All of the patients also received prednisone.
    Results: All 3 patients with at least 1 year of followup receiving mycophenolate mofetil experienced complete normalization of pulmonary function tests (including diffusing capacity for carbon monoxide) and resolution of dyspnea. They were also able to reduce their prednisone doses. The only patient with pre- and posttreatment chest computed tomography imaging had total resolution of her interstitial opacities. The patient with only 5 months of posttreatment followup experienced an improvement in diffusing capacity for carbon monoxide from 44% to 77% predicted, but no change in dyspnea.
    Conclusion: These promising data indicate that mycophenolate mofetil may be a useful therapy for interstitial lung disease in patients with dermatomyositis, but larger studies are needed to more definitively evaluate the role of this medication in therapy.
    MeSH term(s) Adult ; Aged ; Dermatomyositis/complications ; Dermatomyositis/diagnosis ; Dermatomyositis/drug therapy ; Female ; Follow-Up Studies ; Humans ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/drug therapy ; Male ; Middle Aged ; Mycophenolic Acid/analogs & derivatives ; Mycophenolic Acid/therapeutic use ; Retrospective Studies
    Chemical Substances Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2010-05-27
    Publishing country United States
    Document type Case Reports ; Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.20212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Interstitial lung disease in classic and skin-predominant dermatomyositis: a retrospective study with screening recommendations.

    Morganroth, Pamela A / Kreider, Mary Elizabeth / Okawa, Joyce / Taylor, Lynne / Werth, Victoria P

    Archives of dermatology

    2010  Volume 146, Issue 7, Page(s) 729–738

    Abstract: Objectives: (1) To determine the prevalence of interstitial lung disease (ILD) and isolated low diffusing capacity for carbon monoxide (DLCO) in a large cohort of outpatients with dermatomyositis. (2) To compare the pulmonary abnormalities of patients ... ...

    Abstract Objectives: (1) To determine the prevalence of interstitial lung disease (ILD) and isolated low diffusing capacity for carbon monoxide (DLCO) in a large cohort of outpatients with dermatomyositis. (2) To compare the pulmonary abnormalities of patients with classic dermatomyositis and those with skin-predominant dermatomyositis.
    Design: Retrospective cohort study.
    Setting: University hospital outpatient dermatology referral center. Patients Medical records of 91 outpatients with adult-onset dermatomyositis seen between May 26, 2006, and May 25, 2009, were reviewed.
    Main outcome measures: Presence of ILD on thin-slice chest computed tomographic (CT) scans and DLCO.
    Results: Of the 71 patients with dermatomyositis who had CT or DLCO data, 16 (23%; 95% confidence interval [CI], 13%-33%) had ILD as defined by CT results [corrected]. All patients with ILD had a reduced DLCO, and the ILD prevalence was not different between patients with skin-predominant dermatomyositis (10 of 35 [29% ]) and those with classic dermatomyositis (6 of 36 [17% ]) (P = .27). Eighteen of 71 patients with dermatomyositis (25%; 95% CI, 15%-36%) (7 of 35 [20%] with skin-predominant dermatomyositis; 11 of 36 [31%] with classic dermatomyositis; P = .41) had a low DLCO in the absence of CT findings showing ILD. The prevalence of malignant disease was higher in patients with classic dermatomyositis than in those with skin-predominant dermatomyositis (P = .02), and no patients with skin-predominant dermatomyositis had internal malignant disease.
    Conclusions: Radiologic ILD and isolated DLCO reductions, which may signify early ILD or pulmonary hypertension, are common in dermatology outpatients with both classic and skin-predominant dermatomyositis. Because DLCO testing is both inexpensive and sensitive for pulmonary disease, it may be appropriate to screen all patients with dermatomyositis with serial DLCO measurements and base further testing on DLCO results.
    MeSH term(s) Adult ; Dermatomyositis/complications ; Dermatomyositis/diagnosis ; Dermatomyositis/epidemiology ; Female ; Follow-Up Studies ; Humans ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/epidemiology ; Male ; Mass Screening/standards ; Middle Aged ; Practice Guidelines as Topic ; Prevalence ; Pulmonary Diffusing Capacity ; Retrospective Studies ; Severity of Illness Index ; Tomography, X-Ray Computed
    Language English
    Publishing date 2010-07-19
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 212139-6
    ISSN 1538-3652 ; 0003-987X
    ISSN (online) 1538-3652
    ISSN 0003-987X
    DOI 10.1001/archdermatol.2010.134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers.

    Morganroth, Pamela A / Gelfand, Joel M / Jambusaria, Anokhi / Margolis, David J / Miller, Christopher J

    Journal of the American Academy of Dermatology

    2009  Volume 60, Issue 3, Page(s) 444–452

    Abstract: Objective: We sought to compare total lidocaine dose and patient comfort when using 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine during Mohs micrographic surgery.: Methods: In all, 149 patients were ... ...

    Abstract Objective: We sought to compare total lidocaine dose and patient comfort when using 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine during Mohs micrographic surgery.
    Methods: In all, 149 patients were randomized to receive 1.0% lidocaine with 1:100,000 epinephrine or 0.5% lidocaine with 1:200,000 epinephrine during Mohs micrographic surgery. The total dose of lidocaine and measures of patient comfort were recorded.
    Results: Compared with the 1.0% lidocaine group, there was a 52% reduction in lidocaine dose in the 0.5% group (mean difference, 147.85 mg; 95% confidence interval, 108.15-187.55; P < .001). Patient comfort was equivalent in both groups, as evidenced by the similar mean visual analog scale scores (P = .48) and mean volumes of rescue lidocaine administered (P = .18).
    Limitations: No lidocaine blood levels were measured, and one Mohs surgeon performed all surgeries.
    Conclusion: The dose of 0.5% lidocaine with 1:200,000 epinephrine provides pain control equivalent to 1.0% lidocaine with 1:100,000 epinephrine at approximately half the total lidocaine dose.
    MeSH term(s) Aged ; Anesthesia, Local/methods ; Anesthetics, Local/administration & dosage ; Double-Blind Method ; Epinephrine/administration & dosage ; Female ; Humans ; Lidocaine/administration & dosage ; Male ; Middle Aged ; Mohs Surgery ; Pain Measurement ; Pain, Postoperative/diagnosis ; Pain, Postoperative/prevention & control ; Patient Satisfaction ; Skin Neoplasms/surgery ; Vasoconstrictor Agents/administration & dosage
    Chemical Substances Anesthetics, Local ; Vasoconstrictor Agents ; Lidocaine (98PI200987) ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2009-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2008.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: JAAD online. Over-the-counter scar products for postsurgical patients: disparities between online advertised benefits and evidence regarding efficacy.

    Morganroth, Pamela / Wilmot, Alissa Cowden / Miller, Christopher

    Journal of the American Academy of Dermatology

    2009  Volume 61, Issue 6, Page(s) e31–47

    Abstract: Surgical patients frequently read about over-the-counter (OTC) scar products online and ask physicians for advice about product use. We summarized the characteristics of the 20 best-selling scar products on the Web site drugstore.com and reviewed the ... ...

    Abstract Surgical patients frequently read about over-the-counter (OTC) scar products online and ask physicians for advice about product use. We summarized the characteristics of the 20 best-selling scar products on the Web site drugstore.com and reviewed the medical literature for data supporting the efficacy of OTC scar products used on fresh postsurgical wounds. Products had an average price of $16.25 (range $9.49-$59.99) and an average of 9.2 ingredients (range 1-29). Silicone, vitamin E, and onion extract were common ingredients. Although weak evidence indicates that silicone gel dressings may improve postsurgical scar appearance, published evidence does not support postoperative use of most scar products. However, many products have multiple ingredients, and few clinical trials assess the ingredient combinations of specific products. The practical information about OTC scar products and published efficacy data found in this review may help physicians to counsel patients about postsurgical product use and counter unrealistic expectations gained from online advertisements.
    MeSH term(s) Advertising as Topic ; Cicatrix/drug therapy ; Cicatrix/economics ; Cicatrix/etiology ; Dermatologic Surgical Procedures ; Drug Costs ; Humans ; Nonprescription Drugs ; Treatment Outcome
    Chemical Substances Nonprescription Drugs
    Language English
    Publishing date 2009-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2009.02.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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