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Article: Current status of transcatheter intervention for complex right ventricular outflow tract abnormalities.

Kagiyama, Yoshiyuki / Kenny, Damien / Hijazi, Ziyad M

2024 Volume 2024, Issue 1, Page(s) e202407

Abstract: Various transcatheter interventions for the right ventricular outflow tract (RVOT) have been introduced and developed in recent decades. Transcatheter pulmonary valve perforation was first introduced in the 1990s. Radiofrequency wire perforation has been ...

Abstract	Various transcatheter interventions for the right ventricular outflow tract (RVOT) have been introduced and developed in recent decades. Transcatheter pulmonary valve perforation was first introduced in the 1990s. Radiofrequency wire perforation has been the approach of choice for membranous pulmonary atresia in newborns, with high success rates, although complication rates remain relatively common. Stenting of the RVOT is a novel palliative treatment that may improve hemodynamics in neonatal patients with reduced pulmonary blood flow and RVOT obstruction. Whether this option is superior to other surgical palliative strategies or early primary repair of tetralogy of Fallot remains unclear. Transcatheter pulmonary valve replacement has been one of the biggest innovations in the last two decades. With the success of the Melody and SAPIEN valves, this technique has evolved into the gold standard therapy for RVOT abnormalities with excellent procedural safety and efficacy. Challenges remain in managing the wide heterogeneity of postoperative lesions seen in RVOT, and various technical modifications, such as pre-stenting, valve ring modification, or development of self-expanding systems, have been made. Recent large studies have revealed outcomes comparable to those of surgery, with less morbidity. Further experience and multicenter studies and registries to compare the outcomes of various strategies are necessary, with the ultimate goal of a single-step, minimally invasive approach offering the best longer-term anatomical and physiological results.
Language	English
Publishing date	2024-01-03
Publishing country	Qatar
Document type	Journal Article ; Review
ZDB-ID	2738381-7
ISSN	2305-7823
ISSN	2305-7823
DOI	10.21542/gcsp.2024.7
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Article ; Online: Private veterinarians' views of the Irish bovine TB eradication programme.

Kenny, Ursula / Finn, Siobhan / Barrett, Damien

Research in veterinary science

2024 Volume 173, Page(s) 105246

Abstract: There is limited understanding of Private Veterinary Practitioners' (PVPs) perceptions of, opinions about and attitudes towards the Irish Bovine Tuberculosis (bTB) eradication programme. Understanding their attitudes and behaviors towards the bTB ... ...

Abstract	There is limited understanding of Private Veterinary Practitioners' (PVPs) perceptions of, opinions about and attitudes towards the Irish Bovine Tuberculosis (bTB) eradication programme. Understanding their attitudes and behaviors towards the bTB eradication programme is both timely and crucial as their actions have a great influence on the effectiveness and sustainability of the programme itself. To date, PVPs have been consulted about how they view their role in the programme, however, less is known about the challenges they face in carrying out good quality bTB testing, and how likely they feel the programme will succeed to eradicate bTB in the future. The results from this study represent a good part of the probable sphere of perceptions, behaviors, attitudes and knowledge of the respective study population and several key critical points that are believed to have hindered the success of the bTB eradication programme in Ireland to date. This study progressed our understanding of the reasons for why farmers are demotivated by and disconnected with the Irish bTB eradication programme according to PVPs, how PVPs feel challenged in their role carrying out bTB testing, and their views on how, if possible, bTB can be eradicated in the future. Their insights will influence how the Department of Agriculture, Food and the Marine (DAFM) interacts with PVPs and farmers in the future with respect to the bTB and the eradication programme.
Language	English
Publishing date	2024-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2024.105246
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Article ; Online: Exploring perceptions of and attitudes towards bluetongue disease

Ursula Kenny / Sunita Jeawon / Patrick Corkery / Damien Barrett

Social Sciences and Humanities Open, Vol 9, Iss , Pp 100799- (2024)

A multi-stakeholder interview study in the beef and sheep farming sector in Ireland

2024

Abstract: Bluetongue (BT) is a vector-borne livestock disease caused by the bluetongue virus (BTV), that is currently exotic to Ireland. However, there is potential for the introduction of BTV and in the event of its introduction there is potential for substantial ...

Abstract	Bluetongue (BT) is a vector-borne livestock disease caused by the bluetongue virus (BTV), that is currently exotic to Ireland. However, there is potential for the introduction of BTV and in the event of its introduction there is potential for substantial onward transmission. Little is known about farmers attitudes towards Bluetongue disease in the Irish farming community; thus, the current study used a qualitative approach to explore multiple stakeholders’ perspectives (n = 18) on the issue. Overall, results indicated that farmers have poor awareness of Bluetongue disease, the clinical signs associated with its onset, and pay little attention to the pre-import considerations needed to prevent Bluetongue when importing livestock. Additionally, results revealed that farmers are unaware of the high-risk period associated with Bluetongue disease transmission and consequences of Bluetongue should it manifest within the national herd. These findings require attention by government, farming advisory service providers, farming organisations and breed societies considering serious outbreaks of disease can lead to substantial economic disruption, coupled with difficulties in controlling spread of the virus. It is critical that effective communication efforts with the Irish farming community are used to heighten awareness of the on-going potential threat of Bluetongue to Irish flocks and herds, as well as to the economic implications to the livestock industry and the wider economy.
Keywords	Bluetongue disease ; Qualitative research ; Multi-stakeholder study ; Ireland ; History of scholarship and learning. The humanities ; AZ20-999 ; Social sciences (General) ; H1-99
Subject code	910
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Weak femoral pulses post procedure.

Kendall, Ian Scott / Bates, Rachel / Karyiannas, Steven / Sands, Andrew J / Kenny, Damien

Archives of disease in childhood. Education and practice edition

2024

Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2148818-6
ISSN	1743-0593 ; 1743-0585
ISSN (online)	1743-0593
ISSN	1743-0585
DOI	10.1136/archdischild-2023-326725
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Article: Interventional Cardiology for Congenital Heart Disease.

Kenny, Damien

Korean circulation journal

2018 Volume 48, Issue 5, Page(s) 350–364

Abstract: Congenital heart interventions are now replacing surgical palliation and correction in an evolving number of congenital heart defects. Right ventricular outflow tract and ductus arteriosus stenting have demonstrated favorable outcomes compared to ... ...

Abstract	Congenital heart interventions are now replacing surgical palliation and correction in an evolving number of congenital heart defects. Right ventricular outflow tract and ductus arteriosus stenting have demonstrated favorable outcomes compared to surgical systemic to pulmonary artery shunting, and it is likely surgical pulmonary valve replacement will become an uncommon procedure within the next decade, mirroring current practices in the treatment of atrial septal defects. Challenges remain, including the lack of device design focused on smaller infants and the inevitable consequences of somatic growth. Increasing parental and physician expectancy has inevitably lead to higher risk interventions on smaller infants and appreciation of the consequences of these interventions on departmental outcome data needs to be considered. Registry data evaluating congenital heart interventions remain less robust than surgical registries, leading to a lack of insight into the longer-term consequences of our interventions. Increasing collaboration with surgical colleagues has not been met with necessary development of dedicated equipment for hybrid interventions aimed at minimizing the longer-term consequences of scar to the heart. Therefore, great challenges remain to ensure children and adults with congenital heart disease continue to benefit from an exponential growth in minimally invasive interventions and technology. This can only be achieved through a concerted collaborative approach from physicians, industry, academia and regulatory bodies supporting great innovators to continue the philosophy of thinking beyond the limits that has been the foundation of our specialty for the past 50 years.
Language	English
Publishing date	2018-03-29
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2557464-4
ISSN	1738-5520
ISSN	1738-5520
DOI	10.4070/kcj.2018.0064
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Article ; Online: ARCAPA in Pulmonary Atresia, Ventricular Septal Defect, and Major Aortopulmonary Collateral Arteries.

McCay, Nicola / Ramanayake, Harumi / Bates, Rachel / McGuinness, Jonathan / Kenny, Damien / Morrison, Louise

JACC. Case reports

2024 Volume 29, Issue 10, Page(s) 102318

Abstract: We report a case of anomalous origin of the right coronary artery from the pulmonary artery in a patient with pulmonary atresia, ventricular septal defect, and major aortopulmonary collateral arteries. The diagnosis was made during a proposed hybrid ... ...

Abstract	We report a case of anomalous origin of the right coronary artery from the pulmonary artery in a patient with pulmonary atresia, ventricular septal defect, and major aortopulmonary collateral arteries. The diagnosis was made during a proposed hybrid approach to stent the native right ventricular outflow tract, and an alternative surgical strategy was created.
Language	English
Publishing date	2024-04-05
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2024.102318
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Article ; Online: The Behavioral Profile of SYNGAP1-Related Intellectual Disability.

Wright, Damien / Kenny, Aisling / Mizen, Lindsay A M / McKechanie, Andrew G / Stanfield, Andrew C

American journal on intellectual and developmental disabilities

2024 Volume 129, Issue 3, Page(s) 199–214

Abstract: This study aimed to describe the behavioral profile of individuals with SYNGAP1-ID. Parents/carers of 30 individuals aged 3-18 years old with a diagnosis of SYNGAP1-ID and 21 typically developing individuals completed the Vineland-3 Adaptive Behavior ... ...

Abstract	This study aimed to describe the behavioral profile of individuals with SYNGAP1-ID. Parents/carers of 30 individuals aged 3-18 years old with a diagnosis of SYNGAP1-ID and 21 typically developing individuals completed the Vineland-3 Adaptive Behavior Scale and the Child Behavior Checklist. We found that those with SYNGAP1-ID showed fewer adaptive behaviors and higher levels of internalizing and externalizing behaviors across almost all domains compared to typically developing controls. There was some evidence that these differences were greatest in older children, and more apparent in those with co-occuring epilepsy. This characterization of the phenotype of SYNGAP1-ID significantly aids our understanding of the behavioral profile of this population and is a step towards the development of tailored interventions.
MeSH term(s)	Humans ; Child ; Male ; Female ; Intellectual Disability ; Child, Preschool ; ras GTPase-Activating Proteins/genetics ; Adolescent ; Adaptation, Psychological/physiology ; Child Behavior/physiology ; Epilepsy
Chemical Substances	ras GTPase-Activating Proteins ; SYNGAP1 protein, human
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2477909-X
ISSN	1944-7558 ; 1944-7515
ISSN (online)	1944-7558
ISSN	1944-7515
DOI	10.1352/1944-7558-129.3.199
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Article ; Online: Visual social attention in SYNGAP1-related intellectual disability.

Wright, Damien / Kenny, Aisling / Eley, Sarah / McKechanie, Andrew G / Stanfield, Andrew C

Autism research : official journal of the International Society for Autism Research

2024

Abstract: SYNGAP1-ID is a neurodevelopmental disorder caused by a mutation of the SYNGAP1 gene. Characterized by moderate to severe developmental delay, it is associated with several physical and behavioral issues as well as additional diagnoses, including autism. ...

Abstract	SYNGAP1-ID is a neurodevelopmental disorder caused by a mutation of the SYNGAP1 gene. Characterized by moderate to severe developmental delay, it is associated with several physical and behavioral issues as well as additional diagnoses, including autism. However, it is not known whether social cognitive differences seen in SYNGAP1-ID are similar to those previously identified in idiopathic or other forms of autism. This study therefore investigated visual social attention in SYNGAP1-ID. Eye movements were recorded across three passive viewing tasks (face scanning, pop-out, and social preference) of differing social complexity in 24 individuals with SYNGAP1-ID and 12 typically developing controls. We found that SYNGAP1-ID participants looked at faces less than the controls, and when they did look at faces, they had less time looking at and fewer fixations to the eyes. For the pop-out task, where social and nonsocial objects (Phone, car, face, bird, and face-noise) were presented in an array, those with SYNGAP1-ID spent significantly less time looking at the phone stimulus as well as fewer fixations to the face compared with the typically developing controls. When looking at two naturalistic scenes side by side, one social in nature (e.g., with children present) and the other not, there were no differences between the SYNGAP1-ID group and typically developing controls on any of the examined eye tracking measures. This study provides novel findings on the social attention of those with SYNGAP1-ID and helps to provide further evidence for using eye tracking as an objective measure of the social phenotype in this population in future clinical trials.
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2481338-2
ISSN	1939-3806 ; 1939-3792
ISSN (online)	1939-3806
ISSN	1939-3792
DOI	10.1002/aur.3148
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Article ; Online: Atrial Septal Defect Closure in Patients With Pulmonary Hypertension: Room for Punching a Hole in the Debate.

Qureshi, Athar M / Kenny, Damien

JACC. Cardiovascular interventions

2020 Volume 13, Issue 17, Page(s) 2035–2037

MeSH term(s)	Heart Septal Defects, Atrial/complications ; Heart Septal Defects, Atrial/diagnostic imaging ; Heart Septal Defects, Atrial/therapy ; Humans ; Hypertension, Pulmonary/etiology ; Septal Occluder Device ; Treatment Outcome
Language	English
Publishing date	2020-08-12
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2020.05.023
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Article ; Online: EEG as a translational biomarker and outcome measure in fragile X syndrome.

Kenny, Aisling / Wright, Damien / Stanfield, Andrew C

Translational psychiatry

2022 Volume 12, Issue 1, Page(s) 34

Abstract: Targeted treatments for fragile X syndrome (FXS) have frequently failed to show efficacy in clinical testing, despite success at the preclinical stages. This has highlighted the need for more effective translational outcome measures. EEG differences ... ...

Abstract	Targeted treatments for fragile X syndrome (FXS) have frequently failed to show efficacy in clinical testing, despite success at the preclinical stages. This has highlighted the need for more effective translational outcome measures. EEG differences observed in FXS, including exaggerated N1 ERP amplitudes, increased resting gamma power and reduced gamma phase-locking in the sensory cortices, have been suggested as potential biomarkers of the syndrome. These abnormalities are thought to reflect cortical hyper excitability resulting from an excitatory (glutamate) and inhibitory (GABAergic) imbalance in FXS, which has been the target of several pharmaceutical remediation studies. EEG differences observed in humans also show similarities to those seen in laboratory models of FXS, which may allow for greater translational equivalence and better predict clinical success of putative therapeutics. There is some evidence from clinical trials showing that treatment related changes in EEG may be associated with clinical improvements, but these require replication and extension to other medications. Although the use of EEG characteristics as biomarkers is still in the early phases, and further research is needed to establish its utility in clinical trials, the current research is promising and signals the emergence of an effective translational biomarker.
MeSH term(s)	Biomarkers ; Cortical Excitability ; Electroencephalography ; Fragile X Mental Retardation Protein/genetics ; Fragile X Syndrome/diagnosis ; Fragile X Syndrome/drug therapy ; Humans ; Outcome Assessment, Health Care
Chemical Substances	Biomarkers ; Fragile X Mental Retardation Protein (139135-51-6)
Language	English
Publishing date	2022-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-022-01796-2
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