LIVIVO - Search results -

Search results

Result 1 - 10 of total 73

Search options

Book ; Thesis: Inhibition of heme oxygenase-1 (HO-1) increases responsiveness of pancreatic cancer cells to anti-cancer treatment

Dambrauskas, Zilvinas

2004

Author's details	vorgelegt von Zilvinas Dambrauskas
Language	English
Size	78 Bl., Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Heidelberg, Univ., Diss., 2005
HBZ-ID	HT014561085
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2005 E 2100	order for loan	Magazin

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Editorial for the Special Issue "Acute and Chronic Pancreatitis, Pancreatic Malignancies".

Gulbinas, Antanas / Ignatavicius, Povilas / Dambrauskas, Zilvinas

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 5

Abstract: Pancreatic diseases, especially acute pancreatitis and pancreatic cancer, are associated with high rates of complications, difficult treatment that may not always be effective, and high mortality in complex cases [ ... ]. ...

Abstract	Pancreatic diseases, especially acute pancreatitis and pancreatic cancer, are associated with high rates of complications, difficult treatment that may not always be effective, and high mortality in complex cases [...].
MeSH term(s)	Humans ; Acute Disease ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/therapy ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/therapy ; Pancreatic Neoplasms
Language	English
Publishing date	2023-05-19
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59050984
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6270: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Dysregulation of Peripheral Blood Mononuclear Cells and Immune-Related Proteins during the Early Post-Operative Immune Response in Ovarian Cancer Patients.

Ulevicius, Jonas / Jasukaitiene, Aldona / Bartkeviciene, Arenida / Dambrauskas, Zilvinas / Gulbinas, Antanas / Urboniene, Daiva / Paskauskas, Saulius

Cancers

2023 Volume 16, Issue 1

Abstract: Surgical treatment is a cornerstone of ovarian cancer (OC) therapy and exerts a substantial influence on the immune system. Immune responses also play a pivotal and intricate role in OC progression. The aim of this study was to investigate the dynamics ... ...

Abstract	Surgical treatment is a cornerstone of ovarian cancer (OC) therapy and exerts a substantial influence on the immune system. Immune responses also play a pivotal and intricate role in OC progression. The aim of this study was to investigate the dynamics of immune-related protein expression and the activity of peripheral blood mononuclear cells (PBMCs) in OC patients, both before surgery and during the early postoperative phase. The study cohort comprised 23 OC patients and 20 non-cancer controls. A comprehensive analysis of PBMCs revealed significant pre-operative downregulation in the mRNA expression of multiple immune-related proteins, including interleukins, PD-1, PD-L1, and HO-1. This was followed by further dysregulation during the first 5 post-operative days. Although most serum interleukin concentrations showed only minor changes, a distinct increase in IL-6 and HO-1 levels was observed post-operatively. Reduced metabolic and phagocytic activity and increased production of reactive oxygen species (ROS) were observed on day 1 post-surgery. These findings suggest a shift towards immune tolerance during the early post-operative phase of OC, potentially creating a window for treatment. Further research into post-operative PBMC activity could lead to the development of new or improved treatment strategies for OC.
Language	English
Publishing date	2023-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16010190
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Electronic field protocols for prehospital care quality improvement in Lithuania: a randomized simulation-based study.

Paliokaite, Ieva / Dambrauskas, Zilvinas / Dobozinskas, Paulius / Pukenyte, Evelina / Mankute-Use, Aida / Vaitkaitis, Dinas

Scandinavian journal of trauma, resuscitation and emergency medicine

2023 Volume 31, Issue 1, Page(s) 83

Abstract: Background: Prehospital emergency care is complex and influenced by various factors, leading to the need for decision-support tools. Studies suggest that cognitive aids improve provider performance and patient outcomes in clinical emergencies. ... ...

Abstract	Background: Prehospital emergency care is complex and influenced by various factors, leading to the need for decision-support tools. Studies suggest that cognitive aids improve provider performance and patient outcomes in clinical emergencies. Electronic cognitive aids have rarely been investigated in prehospital care. Therefore, this study aimed to evaluate the effects of the electronic field protocol (eFP) module on performance, adherence to the standard of care, and satisfaction of prehospital care providers in a simulated environment. Methods: This randomised simulation-based study was conducted at the Lithuanian University of Health Sciences in Kaunas, Lithuania. The simulation scenarios were developed to test 12 eFPs: adult resuscitation, pediatric resuscitation, delivery and postpartum care, seizures in pregnancy, stroke, anaphylaxis, acute chest pain, acute abdominal pain, respiratory distress in children, severe trauma, severe infection and sepsis, and initial neonatal evaluation and resuscitation. Sixteen prehospital practitioners with at least 3 years of clinical experience were randomly assigned to either use the eFP module or perform without it in each of the 12 simulated scenarios. Participant scores and adherence to standardised checklists were compared between the two performance modes. Participant satisfaction was measured through a post-simulation survey. Results: A total of 190 simulation sessions were conducted. Compared to the use of memory alone, the use of the eFP module significantly improved participants' performance in 10 out of the 12 simulation scenarios. Adherence to the standardised checklist increased from 60 to 85% (p < 0.001). Post-simulation survey results indicate that participants found the eFP module easy to use and relevant to prehospital clinical practice. Conclusions: The study findings suggest that the eFP module as a cognitive aid can enhance prehospital practitioners' performance and adherence to the standard of care in simulated scenarios. These results highlight the potential of standardised eFPs as a quality improvement step in prehospital care in Lithuania.
MeSH term(s)	Adult ; Female ; Infant, Newborn ; Pregnancy ; Humans ; Child ; Lithuania ; Quality Improvement ; Resuscitation ; Emergency Medical Services ; Anaphylaxis
Language	English
Publishing date	2023-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2455990-8
ISSN	1757-7241 ; 1757-7241
ISSN (online)	1757-7241
ISSN	1757-7241
DOI	10.1186/s13049-023-01150-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Volume, but Not the Location of Necrosis, Is Associated with Worse Outcomes in Acute Pancreatitis: A Prospective Study.

Dekeryte, Inga / Zviniene, Kristina / Bieliuniene, Edita / Dambrauskas, Zilvinas / Ignatavicius, Povilas

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 5

Abstract: Background and Objectives: The course and clinical outcomes of acute pancreatitis (AP) are highly variable. Up to 20% of patients develop pancreatic necrosis. Extent and location of it might affect the clinical course and management. The aim was to ... ...

Abstract	Background and Objectives: The course and clinical outcomes of acute pancreatitis (AP) are highly variable. Up to 20% of patients develop pancreatic necrosis. Extent and location of it might affect the clinical course and management. The aim was to determine the clinical relevance of the extent and location of pancreatic necrosis in patients with AP. Materials and Methods: A cohort of patients with necrotizing AP was collected from 2012 to 2018 at the Hospital of Lithuanian University of Health Sciences. Patients were allocated to subgroups according to the location (entire pancreas, left and right sides of pancreas) and extent (<30%, 30−50%, >50%) of pancreatic necrosis. Patients were reviewed for demographic features, number of performed surgical interventions, local and systemic complications, hospital stay and mortality rate. All contrast enhanced computed tomography (CECT) scans were evaluated by at least two experienced abdominal radiologists. All patients were treated according to the standard treatment protocol based on current international guidelines. Results: The study included 83 patients (75.9% males (n = 63)) with a mean age of 53 ± 1.7. The volume of pancreatic necrosis exceeded 50% in half of the patients (n = 42, 51%). Positive blood culture (n = 14 (87.5%)), multiple organ dysfunction syndrome (n = 17 (73.9%)) and incidences of respiratory failure (n = 19 (73.1%)) were significantly more often diagnosed in patients with pancreatic necrosis exceeding 50% (p < 0.05). Patients with >50% of necrosis were significantly (p < 0.05) more often diagnosed with moderately severe (n = 24 (41.4%)) and severe (n = 18 (72%)) AP. The number of surgical interventions (n = 18 (72%)) and ultrasound-guided interventions (n = 26 (65%)) was also significantly higher. In patients with whole-pancreas necrosis, incidence of renal insufficiency (n = 11 (64.7%)) and infected pancreatic necrosis (n = 19 (57.6%)) was significantly higher (p < 0.05). Conclusions: The clinical course and outcome were worse in the case of pancreatic necrosis exceeding 50%, rendering the need for longer and more complex treatment.
MeSH term(s)	Acute Disease ; Female ; Humans ; Male ; Middle Aged ; Necrosis/complications ; Pancreatitis, Acute Necrotizing/complications ; Pancreatitis, Acute Necrotizing/surgery ; Prospective Studies
Language	English
Publishing date	2022-05-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58050645
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6270: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Volume, but Not the Location of Necrosis, Is Associated with Worse Outcomes in Acute Pancreatitis

Inga Dekeryte / Kristina Zviniene / Edita Bieliuniene / Zilvinas Dambrauskas / Povilas Ignatavicius

Medicina, Vol 58, Iss 645, p

A Prospective Study

2022 Volume 645

Abstract: Background and Objectives : The course and clinical outcomes of acute pancreatitis (AP) are highly variable. Up to 20% of patients develop pancreatic necrosis. Extent and location of it might affect the clinical course and management. The aim was to ... ...

Abstract	Background and Objectives : The course and clinical outcomes of acute pancreatitis (AP) are highly variable. Up to 20% of patients develop pancreatic necrosis. Extent and location of it might affect the clinical course and management. The aim was to determine the clinical relevance of the extent and location of pancreatic necrosis in patients with AP. Materials and Methods : A cohort of patients with necrotizing AP was collected from 2012 to 2018 at the Hospital of Lithuanian University of Health Sciences. Patients were allocated to subgroups according to the location (entire pancreas, left and right sides of pancreas) and extent (<30%, 30–50%, >50%) of pancreatic necrosis. Patients were reviewed for demographic features, number of performed surgical interventions, local and systemic complications, hospital stay and mortality rate. All contrast enhanced computed tomography (CECT) scans were evaluated by at least two experienced abdominal radiologists. All patients were treated according to the standard treatment protocol based on current international guidelines. Results : The study included 83 patients (75.9% males ( n = 63)) with a mean age of 53 ± 1.7. The volume of pancreatic necrosis exceeded 50% in half of the patients ( n = 42, 51%). Positive blood culture ( n = 14 (87.5%)), multiple organ dysfunction syndrome ( n = 17 (73.9%)) and incidences of respiratory failure ( n = 19 (73.1%)) were significantly more often diagnosed in patients with pancreatic necrosis exceeding 50% ( p < 0.05). Patients with >50% of necrosis were significantly ( p < 0.05) more often diagnosed with moderately severe ( n = 24 (41.4%)) and severe ( n = 18 (72%)) AP. The number of surgical interventions ( n = 18 (72%)) and ultrasound-guided interventions ( n = 26 (65%)) was also significantly higher. In patients with whole-pancreas necrosis, incidence of renal insufficiency ( n = 11 (64.7%)) and infected pancreatic necrosis ( n = 19 (57.6%)) was significantly higher ( p < 0.05). Conclusions : The clinical course and ...
Keywords	acute pancreatitis ; necrotizing pancreatitis ; outcomes ; computed tomography ; management ; surgery ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Targeting AHR Increases Pancreatic Cancer Cell Sensitivity to Gemcitabine through the ELAVL1-DCK Pathway.

Stukas, Darius / Jasukaitiene, Aldona / Bartkeviciene, Arenida / Matthews, Jason / Maimets, Toivo / Teino, Indrek / Jaudzems, Kristaps / Gulbinas, Antanas / Dambrauskas, Zilvinas

International journal of molecular sciences

2023 Volume 24, Issue 17

Abstract: The aryl hydrocarbon receptor (AHR) is a transcription factor that is commonly upregulated in pancreatic ductal adenocarcinoma (PDAC). AHR hinders the shuttling of human antigen R (ELAVL1) from the nucleus to the cytoplasm, where it stabilises its target ...

Abstract	The aryl hydrocarbon receptor (AHR) is a transcription factor that is commonly upregulated in pancreatic ductal adenocarcinoma (PDAC). AHR hinders the shuttling of human antigen R (ELAVL1) from the nucleus to the cytoplasm, where it stabilises its target messenger RNAs (mRNAs) and enhances protein expression. Among these target mRNAs are those induced by gemcitabine. Increased AHR expression leads to the sequestration of ELAVL1 in the nucleus, resulting in chemoresistance. This study aimed to investigate the interaction between AHR and ELAVL1 in the pathogenesis of PDAC in vitro.
MeSH term(s)	Humans ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; ELAV-Like Protein 1/genetics ; Gemcitabine ; Pancreas ; Pancreatic Hormones ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Receptors, Aryl Hydrocarbon/genetics ; RNA, Messenger/genetics ; Deoxycytidine Kinase/drug effects ; Deoxycytidine Kinase/metabolism ; Pancreatic Neoplasms
Chemical Substances	ELAV-Like Protein 1 ; ELAVL1 protein, human ; Gemcitabine ; Pancreatic Hormones ; Receptors, Aryl Hydrocarbon ; RNA, Messenger ; Deoxycytidine Kinase (EC 2.7.1.74)
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241713155
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The effect of surgical gastric plication on obesity and diabetes mellitus type 2

Hauke Heinrich Georg Meyer / Romualdas Riauka / Zilvinas Dambrauskas / Antanas Mickevicius

Videosurgery and Other Miniinvasive Techniques, Vol 16, Iss 1, Pp 10-

a systematic review and meta-analysis

2020 Volume 18

Keywords	bariatric surgery ; gastric plication ; weight loss ; type 2 diabetes ; Medicine ; R
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Heme Oxygenase-1 Polymorphism Is Associated With the Development of Necrotic Acute Pancreatitis Via Vascular Cell Adhesion Molecule-1 and the E-Selectin Expression Regulation Pathway.

Gulla, Aiste / Gulbinas, Antanas / Dambrauskas, Zilvinas / Strupas, Kestutis

Pancreas

2019 Volume 48, Issue 6, Page(s) 787–791

Abstract: Objectives: Severe acute pancreatitis can lead to systemic complications. Here, we explore the mechanisms based on our previous study associated with the deregulation of heme oxygenase-1 (HO-1) and development of severe acute pancreatitis.: Methods: ... ...

Abstract	Objectives: Severe acute pancreatitis can lead to systemic complications. Here, we explore the mechanisms based on our previous study associated with the deregulation of heme oxygenase-1 (HO-1) and development of severe acute pancreatitis. Methods: Acute pancreatitis patients (n = 135) and age- and sex-matched healthy controls (n = 108) were studied. The polymerase chain reaction products were analyzed with an ABI 3130 genetic analyzer and GeneMapper software. A short allele was defined ≤27 dinucleotide (GT) repeats, whereas a long allele was defined >27 GT. Levels of 12 different cytokines in blood serum were measured by enzyme-linked immunosorbent assay. All samples in this study were consistently stored in -80°C. Results: Patients with the long long genotype expressed E-selectin and vascular cell adhesion molecule-1 at statistically significantly higher levels in serum compared with short short genotype or short long genotypes. Vascular cell adhesion molecule-1 and E-selectin serum levels significantly correlate with the total allele length of the HO-1 promoter region. Conclusion: Polymorphism of the GT repeats in the HO-1 promoter region may be a risk factor for developing acute necrotizing pancreatitis due to deregulation of the immune response.
MeSH term(s)	Adult ; Aged ; Alleles ; Cytokines/blood ; Cytokines/genetics ; E-Selectin/blood ; E-Selectin/genetics ; Female ; Gene Expression Regulation ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genotype ; Heme Oxygenase-1/genetics ; Humans ; Male ; Middle Aged ; Pancreatitis, Acute Necrotizing/blood ; Pancreatitis, Acute Necrotizing/diagnosis ; Pancreatitis, Acute Necrotizing/genetics ; Polymorphism, Genetic ; Promoter Regions, Genetic/genetics ; Prospective Studies ; Signal Transduction/genetics ; Vascular Cell Adhesion Molecule-1/blood ; Vascular Cell Adhesion Molecule-1/genetics
Chemical Substances	Cytokines ; E-Selectin ; Vascular Cell Adhesion Molecule-1 ; Heme Oxygenase-1 (EC 1.14.14.18)
Language	English
Publishing date	2019-06-18
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000001328
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2160: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The effect of surgical gastric plication on obesity and diabetes mellitus type 2: a systematic review and meta-analysis.

Meyer, Hauke Heinrich Georg / Riauka, Romualdas / Dambrauskas, Zilvinas / Mickevicius, Antanas

Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques

2020 Volume 16, Issue 1, Page(s) 10–18

Abstract: Introduction: All the bariatric procedures have evolved greatly over the past decades and laparoscopic greater curvature plication (LGCP) is one of the quite recently introduced techniques lacking systematic evaluation.: Aim: To compare and summarize ...

Abstract	Introduction: All the bariatric procedures have evolved greatly over the past decades and laparoscopic greater curvature plication (LGCP) is one of the quite recently introduced techniques lacking systematic evaluation. Aim: To compare and summarize the current data in the literature in regard to the effect of gastric plication on obesity and diabetes mellitus type 2. Material and methods: The systematic review and meta-analysis was performed according to the PRISMA guidelines and registered at PROSPERO under the registration number CRD42018114314. The literature in English and German was searched using the MEDLINE (PubMed) and BJS databases for studies published in the last 10 years. A meta-analysis was performed focusing on the effects of this operation on weight loss, glycemia control and improvement of comorbidities. Results: Mean preoperative body mass index (BMI) ranged from 34.42 to 46.3 kg/m Conclusions: Despite the quality of most of the included studies being low, the present meta-analysis revealed that, in the short term, gastric plication is an effective measure for weight loss, while the effect on diabetes mellitus type 2 is not statistically significant.
Language	English
Publishing date	2020-07-21
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596147-0
ISSN	2299-0054 ; 1895-4588
ISSN (online)	2299-0054
ISSN	1895-4588
DOI	10.5114/wiitm.2020.97424
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito