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Article ; Online: Posterior Myocardial Infarction-a Hidden ECG Emergency Presentation.

Macherey-Meyer, Sascha / Halbach, Marcel / Mauri, Victor

2023 Volume 120, Issue 23, Page(s) 404

MeSH term(s)	Humans ; Myocardial Infarction/diagnosis ; Electrocardiography ; Emergency Service, Hospital
Language	English
Publishing date	2023-08-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2406159-1
ISSN	1866-0452 ; 1866-0452
ISSN (online)	1866-0452
ISSN	1866-0452
DOI	10.3238/arztebl.m2023.0057
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clothes4all: A Novel Resource for Studying and Improving Web Accessibility.

Halbach, Till / Haugstvedt, Vegard

Studies in health technology and informatics

2021 Volume 282, Page(s) 201–209

Abstract: We present a novel and versatile online resource named Clothes4all which is a website, web application, and tool likewise, and which can be used to study various aspects of web accessibility. The article elaborates on the tool's development, its features ...

Abstract	We present a novel and versatile online resource named Clothes4all which is a website, web application, and tool likewise, and which can be used to study various aspects of web accessibility. The article elaborates on the tool's development, its features and possibilities, as well as use and potential methodology. Clothes4all mimics a web shop for clothes and consists as such of a set of coherent web pages that can be freely used, studied, and extended as desired, in particular aiming at user trials. The site's main feature is that single or multiple accessibility barriers can be injected into or removed from its web pages in a controlled manner. The primary application area of Clothes4all is the testing and validation of accessibility checkers and validators themselves, and hereby the site is expected to eventually contribute to more accessible web pages. A secondary application area is education, as Clothes4all is a great resource to learn about web technologies, web accessibility, assistive technology, user diversity, impairments, and other aspects of online accessibility.
MeSH term(s)	Disabled Persons ; Humans ; Self-Help Devices
Language	English
Publishing date	2021-06-04
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI210397
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Article ; Online: Calf Barn Design to Optimize Health and Ease of Management.

Nordlund, Kenneth V / Halbach, Courtney E

The Veterinary clinics of North America. Food animal practice

2019 Volume 35, Issue 1, Page(s) 29–45

Abstract: This article offers general calf barn design recommendations to optimize calf health gleaned from clinical and research experience in a Midwestern US climate. Barn components that are discussed include sizing the barn, ventilating the facility, and ... ...

Abstract	This article offers general calf barn design recommendations to optimize calf health gleaned from clinical and research experience in a Midwestern US climate. Barn components that are discussed include sizing the barn, ventilating the facility, and providing a clean, deeply bedded, dry area for the calf. In addition, considerations for maximizing labor efficiency and reducing the spread of disease by caregivers are discussed.
MeSH term(s)	Animal Husbandry ; Animals ; Cattle/physiology ; Female ; Housing, Animal/standards
Language	English
Publishing date	2019-02-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	286086-7
ISSN	1558-4240 ; 0749-0720
ISSN (online)	1558-4240
ISSN	0749-0720
DOI	10.1016/j.cvfa.2018.10.002
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Article ; Online: Morphological and behavioral analysis of Slc35f1-deficient mice revealed no neurodevelopmental phenotype.

Ehlers, Julia Sophie / Bracke, Katharina / von Bohlen Und Halbach, Viola / Siegerist, Florian / Endlich, Nicole / von Bohlen Und Halbach, Oliver

Brain structure & function

2023 Volume 228, Issue 3-4, Page(s) 895–906

Abstract: SLC35F1 is a member of the sugar-like carrier (SLC) superfamily that is expressed in the mammalian brain. Malfunction of SLC35F1 in humans is associated with neurodevelopmental disorders. To get insight into the possible roles of Slc35f1 in the brain, we ...

Abstract	SLC35F1 is a member of the sugar-like carrier (SLC) superfamily that is expressed in the mammalian brain. Malfunction of SLC35F1 in humans is associated with neurodevelopmental disorders. To get insight into the possible roles of Slc35f1 in the brain, we generated Slc35f1-deficient mice. The Slc35f1-deficient mice are viable and survive into adulthood, which allowed examining adult Slc35f1-deficient mice on the anatomical as well as behavioral level. In humans, mutation in the SLC35F1 gene can induce a Rett syndrome-like phenotype accompanied by intellectual disability (Fede et al. Am J Med Genet A 185:2238-2240, 2021). The Slc35f1-deficient mice, however, display only a very mild phenotype and no obvious deficits in learning and memory as, e.g., monitored with the novel object recognition test or the Morris water maze test. Moreover, neuroanatomical parameters of neuronal plasticity (as dendritic spines and adult hippocampal neurogenesis) are also unaltered. Thus, Slc35f1-deficient mice display no major alterations that resemble a neurodevelopmental phenotype.
MeSH term(s)	Animals ; Humans ; Mice ; Brain ; Hippocampus ; Intellectual Disability/genetics ; Learning ; Mammals ; Maze Learning/physiology ; Membrane Transport Proteins/genetics ; Mice, Knockout ; Nerve Tissue Proteins/genetics ; Phenotype
Chemical Substances	Membrane Transport Proteins ; Nerve Tissue Proteins ; Slc35f1 protein, mouse
Language	English
Publishing date	2023-03-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2273162-3
ISSN	1863-2661 ; 1863-2653
ISSN (online)	1863-2661
ISSN	1863-2653
DOI	10.1007/s00429-023-02629-8
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Article: "And do no harm": Complications in interventional neuroradiology.

Alexander, Matthew D / Halbach, Van V / Hetts, Steven W

Handbook of clinical neurology

2020 Volume 176, Page(s) 395–399

Abstract: Complications are an unfortunate reality in the field of interventional neuroradiology. While complications cannot be eliminated entirely, their occurrence and severity can be mitigated by the competency achieved through training, knowledge of ... ...

Abstract	Complications are an unfortunate reality in the field of interventional neuroradiology. While complications cannot be eliminated entirely, their occurrence and severity can be mitigated by the competency achieved through training, knowledge of cerebrovascular anatomy and pathology, and well-conceived and executed plans crafted in conjunction with a multidisciplinary team. Frequent communication among the team throughout the entire process of care is vital. In the ensuing chapter, an overview is provided of the most common complication types-nontarget embolization and hemorrhage-followed by practical considerations for their management. Finally, the chapter concludes with a brief consideration of the emotional management for the patient, their loved ones, and the involved practitioners.
MeSH term(s)	Embolization, Therapeutic ; Hemorrhage ; Humans
Language	English
Publishing date	2020-11-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	0072-9752
ISSN	0072-9752
DOI	10.1016/B978-0-444-64034-5.00021-3
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Article: Ensuring optimal ventilation of calf buildings

Halbach, Courtney / Robertson, Jamie

In practice. 2021 Dec., v. 43, no. 10

2021

Abstract: Background: There has been considerable change over the past 10 years in the perceived value of beef and dairy calves, with potential for improvement to animal health and farm financial sustainability. One of the main calf health issues is respiratory ... ...

Abstract	Background: There has been considerable change over the past 10 years in the perceived value of beef and dairy calves, with potential for improvement to animal health and farm financial sustainability. One of the main calf health issues is respiratory disease, with multifactorial aspects that all require attention in order to produce healthy calves. Poor ventilation is often cited as a contributing factor to respiratory problems on specific farms, but it is seldom described in an objective manner that would facilitate providing an effective solution. Aim of the article: This article outlines the importance of fresh air in calf houses on calf health, with specific focus on natural ventilation, stack effect and positive pressure tube ventilation.
Keywords	air ; animal health ; beef ; natural ventilation ; respiratory tract diseases
Language	English
Dates of publication	2021-12
Size	p. 571-578.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	439810-5
ISSN	2042-7689 ; 0263-841X
ISSN (online)	2042-7689
ISSN	0263-841X
DOI	10.1002/inpr.152
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparison of vessel fractional flow reserve with invasive resting full-cycle ratio in patients with intermediate coronary lesions.

Lake, Philipp / Halbach, Marcel / Kardasch, Michelle / Mauri, Victor / Baldus, Stephan / Adam, Matti / Wienemann, Hendrik

International journal of cardiology

2023 Volume 377, Page(s) 1–8

Abstract: Background: Vessel fractional flow reserve (vFFR) is a novel angiography-derived index for the assessment of myocardial ischemia without the need for pressure wires and hyperemic agents. vFFR has demonstrated very good diagnostic performance compared ... ...

Abstract	Background: Vessel fractional flow reserve (vFFR) is a novel angiography-derived index for the assessment of myocardial ischemia without the need for pressure wires and hyperemic agents. vFFR has demonstrated very good diagnostic performance compared with the hyperemic index fractional flow reserve (FFR). The aim of this study was to compare vFFR to the non-hyperemic pressure ratio resting full-cycle ratio (RFR). Methods: This was a retrospective, observational, single-center study of an all-comer cohort undergoing RFR assessment. Invasive coronary angiography was obtained without a dedicated vFFR acquisition protocol, and vFFR calculation was attempted in all vessels interrogated by RFR (1483 lesions of 1030 patients). Results: vFFR could be analyzed in 986 lesions from 705 patients. Median diameter stenosis was 37% (interquartile range (IQR): 30.0-44.0%), vFFR 0.86 (IQR: 0.81-0.91) and RFR 0.94 (IQR: (0.90-0.97). The correlation between vFFR and RFR was strong (r = 0.70, 95% confidence interval (CI): 0.66-0.74, p < 0.001). Using RFR ≤0.89 as reference, the sensitivity, specificity, positive predictive value, negative predictive value, and overall diagnostic accuracy for vFFR were 77%, 93%, 77%, and 92% and 89%. vFFR yielded a high area under the curve (AUC) of 0.92 (95% CI: 0.90-0.94). The good diagnostic performance of vFFR was confirmed among subgroups of patients with diabetes, severe aortic stenosis, female gender and lesions located in the left anterior descending artery. Conclusion: vFFR has a high diagnostic performance taking RFR as the reference standard for evaluating the functional significance of coronary stenoses.
MeSH term(s)	Female ; Humans ; Coronary Angiography ; Coronary Artery Disease/diagnosis ; Coronary Stenosis ; Coronary Vessels ; Fractional Flow Reserve, Myocardial ; Heart ; Hyperemia ; Predictive Value of Tests ; Severity of Illness Index
Language	English
Publishing date	2023-01-21
Publishing country	Netherlands
Document type	Observational Study ; Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.01.062
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Zs.A 1673: Show issues

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Article: Cerebral arteriovenous fistulae.

Alexander, Matthew D / Darflinger, Robert / Cooke, Daniel L / Halbach, Van V

Handbook of clinical neurology

2020 Volume 176, Page(s) 179–198

Abstract: Dural arteriovenous fistulae (dAVFs) are diverse, complex lesions that share the common feature of arteriovenous shunting without an intervening nidus. In this chapter, the ensuing discussion is organized by dAVF location, followed by further ... ...

Abstract	Dural arteriovenous fistulae (dAVFs) are diverse, complex lesions that share the common feature of arteriovenous shunting without an intervening nidus. In this chapter, the ensuing discussion is organized by dAVF location, followed by further consideration of less common, distinct types of dAVFs-carotid cavernous fistulae, pial arteriovenous fistulae, and vein of Galen malformations. For each lesion type, epidemiology, clinical presentation, imaging findings, classification considerations, and treatment options are discussed.
MeSH term(s)	Arteriovenous Fistula/diagnostic imaging ; Arteriovenous Fistula/epidemiology ; Arteriovenous Fistula/therapy ; Central Nervous System Vascular Malformations/surgery ; Cerebral Angiography ; Cerebral Veins ; Humans ; Neurosurgical Procedures
Language	English
Publishing date	2020-11-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	0072-9752
ISSN	0072-9752
DOI	10.1016/B978-0-444-64034-5.00004-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Global Protein Profiling in Processed Immunohistochemistry Tissue Sections.

Venz, Simone / von Bohlen Und Halbach, Viola / Hentschker, Christian / Junker, Heike / Kuss, Andreas Walter / Sura, Thomas / Krüger, Elke / Völker, Uwe / von Bohlen Und Halbach, Oliver / Jensen, Lars Riff / Hammer, Elke

International journal of molecular sciences

2023 Volume 24, Issue 14

Abstract: Tissue sections, which are widely used in research and diagnostic laboratories and have already been examined by immunohistochemistry (IHC), may subsequently provide a resource for proteomic studies, even though only small amount of protein is available. ...

Abstract	Tissue sections, which are widely used in research and diagnostic laboratories and have already been examined by immunohistochemistry (IHC), may subsequently provide a resource for proteomic studies, even though only small amount of protein is available. Therefore, we established a workflow for tandem mass spectrometry-based protein profiling of IHC specimens and characterized defined brain area sections. We investigated the CA1 region of the hippocampus dissected from brain slices of adult C57BL/6J mice. The workflow contains detailed information on sample preparation from brain slices, including removal of antibodies and cover matrices, dissection of region(s) of interest, protein extraction and digestion, mass spectrometry measurement, and data analysis. The Gene Ontology (GO) knowledge base was used for further annotation. Literature searches and Gene Ontology annotation of the detected proteins verify the applicability of this method for global protein profiling using formalin-fixed and embedded material and previously used IHC slides.
MeSH term(s)	Mice ; Animals ; Immunohistochemistry ; Proteomics/methods ; Mice, Inbred C57BL ; Formaldehyde/chemistry ; Proteins/analysis ; Tandem Mass Spectrometry ; Paraffin Embedding ; Tissue Fixation/methods
Chemical Substances	Formaldehyde (1HG84L3525) ; Proteins
Language	English
Publishing date	2023-07-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241411308
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Article ; Online: Deletion of p75NTR enhances the cholinergic innervation pattern of the visual cortex.

VON Bohlen Und Halbach, Viola / VON Bohlen Und Halbach, Oliver

Visual neuroscience

2017 Volume 33, Page(s) E012

Abstract: ... within layer IV as well as within layer V of the visual cortex, we found that adult p75NTR deficient mice ...

Abstract	The cholinergic system is involved in cortical plasticity, attention, and learning. Within the visual cortex the cholinergic system seems to play a role in visual perception. The cholinergic neurons which project into the visual cortex are located in the basal forebrain. It has been shown that mice deficient for the low-affinity neurotrophin receptor p75NTR display increased numbers of cholinergic neurons in the basal forebrain and a denser cholinergic innervation of the hippocampus. This prompted us to analyze whether the cholinergic system is altered in adult p75NTR deficient mice. By analyzing the densities of cholinergic fibers within layer IV as well as within layer V of the visual cortex, we found that adult p75NTR deficient mice display increased cholinergic fiber densities. However, this increase was not accompanied by an increase in the density of local cholinergic neurons within the visual cortex. This indicates that the enhanced cholinergic innervation of the visual cortex is due to alteration of the cholinergic neurons located in the basal forebrain, projecting to the visual cortex. The increased cholinergic innervation of the visual cortex makes the p75NTR deficient mice an attractive model to study the necessity of the cholinergic system for the visual cortex.
MeSH term(s)	Acetylcholine/metabolism ; Animals ; Cholinergic Fibers/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Growth Factors/metabolism ; Neurons/metabolism ; Parasympathetic Nervous System/physiology ; Receptors, Nerve Growth Factor/deficiency ; Visual Cortex/physiology
Chemical Substances	Nerve Growth Factors ; Receptors, Nerve Growth Factor ; Ngfr protein, mouse ; Acetylcholine (N9YNS0M02X)
Language	English
Publishing date	2017-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639436-x
ISSN	1469-8714 ; 0952-5238
ISSN (online)	1469-8714
ISSN	0952-5238
DOI	10.1017/S0952523816000080
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