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  1. Article ; Online: Anti-diabetic properties of brewer's spent yeast peptides.

    Aquino, Marilin E / Drago, Silvina R / Sánchez de Medina, Fermín / Martínez-Augustin, Olga / Cian, Raúl E

    Food & function

    2024  Volume 15, Issue 7, Page(s) 3778–3790

    Abstract: Brewer's spent yeast (BSY) hydrolysates are a source of antidiabetic peptides. Nevertheless, the impact ... ...

    Abstract Brewer's spent yeast (BSY) hydrolysates are a source of antidiabetic peptides. Nevertheless, the impact of
    MeSH term(s) Animals ; Mice ; Saccharomyces cerevisiae/metabolism ; Mannose ; Molecular Docking Simulation ; alpha-Glucosidases ; Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Peptides/pharmacology ; Peptides/chemistry ; Diabetes Mellitus ; Digestion ; Dipeptidyl Peptidase 4/genetics ; Dipeptidyl Peptidase 4/chemistry ; Protein Hydrolysates/chemistry
    Chemical Substances Mannose (PHA4727WTP) ; alpha-Glucosidases (EC 3.2.1.20) ; Dipeptidyl-Peptidase IV Inhibitors ; Peptides ; Dipeptidyl Peptidase 4 (EC 3.4.14.5) ; Protein Hydrolysates
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo04040b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  2. Article: Corrigendum: A standardized extract of

    Tena-Garitaonaindia, Mireia / Ceacero-Heras, Diego / Montoro, María Del Mar Maldonado / de Medina, Fermín Sánchez / Martínez-Augustin, Olga / Daddaoua, Abdelali

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1183760

    Abstract: This corrects the article DOI: 10.3389/fmicb.2022.814448.]. ...

    Abstract [This corrects the article DOI: 10.3389/fmicb.2022.814448.].
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1183760
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  3. Article ; Online: Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children.

    Córdova, Samir / Tena-Garitaonaindia, Mireia / Álvarez-Mercado, Ana Isabel / Gámez-Belmonte, Reyes / Gómez-Llorente, Mª Amelia / Sánchez de Medina, Fermín / Martínez-Cañavate, Ana / Martínez-Augustin, Olga / Gómez-Llorente, Carolina

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Asthma is a multifactorial condition that can be associated with obesity. The phenotypes of asthma in lean and obese patients are different, with proinflammatory signatures being further elevated in the latter. Both obesity and asthma are associated with ...

    Abstract Asthma is a multifactorial condition that can be associated with obesity. The phenotypes of asthma in lean and obese patients are different, with proinflammatory signatures being further elevated in the latter. Both obesity and asthma are associated with alterations in intestinal barrier function and immunity, and with the composition of the intestinal microbiota and food consumption. In this study, we aimed to establish an organoid model to test the hypothesis that the intestinal content of lean and obese, allergic, asthmatic children differentially regulates epithelial intestinal gene expression. A model of mouse jejunum intestinal organoids was used. A group of healthy, normal-weight children was used as a control. The intestinal content of asthmatic obese children differentially induced the expression of inflammatory and mitochondrial response genes (
    MeSH term(s) Child ; Animals ; Mice ; Humans ; Pediatric Obesity ; Asthma ; Feces ; Claudin-1 ; Cytochromes b ; NF-kappa B
    Chemical Substances Claudin-1 ; Cytochromes b (9035-37-4) ; NF-kappa B
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020866
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  4. Article ; Online: A perspective current and past modes of inhalation therapy.

    Canto Mangana, José / Schilder, Kelsey Aguirre / Bretones-Pedrinaci, José Ignacio / Blesa, Ana Rosa Márquez / de Medina, Fermín Sánchez / Martínez-Augustin, Olga / Daddaoua, Abdelali

    Microbial biotechnology

    2024  Volume 17, Issue 2, Page(s) e14419

    Abstract: Inhalation is the preferred route of delivery for anti-asthma and chronic obstructive pulmonary disease (COPD) drugs. The use of this route has demonstrated efficacy in these and other conditions, it offers rapid onset of action, and is associated with ... ...

    Abstract Inhalation is the preferred route of delivery for anti-asthma and chronic obstructive pulmonary disease (COPD) drugs. The use of this route has demonstrated efficacy in these and other conditions, it offers rapid onset of action, and is associated with minimal systemic exposure, thereby reducing the risk of adverse effects. Therefore, the current brief covers an interesting collection of inhaler action modes, shedding light on their molecular mechanisms and clinical applications for anti-asthma, COPD and antibacterial inhalation therapy. Hence, not only enriches our understanding of inhalation therapy molecular intricacies but also provides a comprehensive overview of the evolving landscape in clinical and antibacterial inhalation therapy. In doing so, it underscores the pivotal role of microbiology and biotechnology in advancing therapeutic approaches that harness the power of inhalation.
    MeSH term(s) Humans ; Administration, Inhalation ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Nebulizers and Vaporizers ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2406063-X
    ISSN 1751-7915 ; 1751-7915
    ISSN (online) 1751-7915
    ISSN 1751-7915
    DOI 10.1111/1751-7915.14419
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  5. Article: A Standardized Extract of

    Tena-Garitaonaindia, Mireia / Ceacero-Heras, Diego / Montoro, María Del Mar Maldonado / de Medina, Fermín Sánchez / Martínez-Augustin, Olga / Daddaoua, Abdelali

    Frontiers in microbiology

    2022  Volume 13, Page(s) 814448

    Abstract: The priority pathogen list of the World Health Organization ... ...

    Abstract The priority pathogen list of the World Health Organization classified
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.814448
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  6. Article ; Online: Modulation of intestinal barrier function by glucocorticoids: Lessons from preclinical models.

    Tena-Garitaonaindia, Mireia / Arredondo-Amador, María / Mascaraque, Cristina / Asensio, Maitane / Marin, Jose J G / Martínez-Augustin, Olga / Sánchez de Medina, Fermín

    Pharmacological research

    2022  Volume 177, Page(s) 106056

    Abstract: Glucocorticoids (GCs) are widely used drugs for their anti-inflammatory and immunosuppressant effects, but they are associated with multiple adverse effects. Despite their frequent oral administration, relatively little attention has been paid to the ... ...

    Abstract Glucocorticoids (GCs) are widely used drugs for their anti-inflammatory and immunosuppressant effects, but they are associated with multiple adverse effects. Despite their frequent oral administration, relatively little attention has been paid to the effects of GCs on intestinal barrier function. In this review, we present a summary of the published studies on this matter carried out in animal models and cultured cells. In cultured intestinal epithelial cells, GCs have variable effects in basal conditions and generally enhance barrier function in the presence of inflammatory cytokines such as tumor necrosis factor (TNF). In turn, in rodents and other animals, GCs have been shown to weaken barrier function, with increased permeability and lower production of IgA, which may account for some features observed in stress models. When given to animals with experimental colitis, barrier function may be debilitated or strengthened, despite a positive anti-inflammatory activity. In sepsis models, GCs have a barrier-enhancing effect. These effects are probably related to the inhibition of epithelial cell proliferation and wound healing, modulation of the microbiota and mucus production, and interference with the mucosal immune system. The available information on underlying mechanisms is described and discussed.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Colitis/drug therapy ; Disease Models, Animal ; Glucocorticoids/pharmacology ; Glucocorticoids/therapeutic use ; Intestinal Mucosa
    Chemical Substances Anti-Inflammatory Agents ; Glucocorticoids
    Language English
    Publishing date 2022-01-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2022.106056
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Habitual nappers and non-nappers differ in circadian rhythms of

    Zambrano, Carolina / Kulyté, Agné / Luján, Juán / Rivero-Gutierrez, Belén / Sánchez de Medina, Fermín / Martínez-Augustin, Olga / Ryden, Mikael / Scheer, Frank A J L / Garaulet, Marta

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1166961

    Abstract: Background and purpose: Napping is a widespread practice worldwide and has in recent years been linked to increased abdominal adiposity. Lipase E or : Methods: Abdominal adipose tissue explants from participants with obesity (n = 17) were cultured ... ...

    Abstract Background and purpose: Napping is a widespread practice worldwide and has in recent years been linked to increased abdominal adiposity. Lipase E or
    Methods: Abdominal adipose tissue explants from participants with obesity (n = 17) were cultured for a 24-h duration and analyzed every 4 h. Habitual nappers (n = 8) were selected to match non-nappers (n = 9) in age, sex, BMI, adiposity, and metabolic syndrome traits. Circadian
    Results: Adipose tissue explants exhibited robust circadian rhythms in
    Conclusion: Our results suggest that nappers display dysregulated circadian
    MeSH term(s) Humans ; Abdominal Fat/metabolism ; Adipose Tissue/metabolism ; Circadian Rhythm ; Obesity/metabolism ; Sterol Esterase/metabolism ; Lipase
    Chemical Substances Sterol Esterase (EC 3.1.1.13) ; Lipase (EC 3.1.1.3)
    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1166961
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  8. Article ; Online: Epithelial deletion of the glucocorticoid receptor (Nr3c1) protects the mouse intestine against experimental inflammation.

    Arredondo-Amador, María / Aranda, Carlos J / Ocón, Borja / González, Raquel / Martínez-Augustin, Olga / Sánchez de Medina, Fermín

    British journal of pharmacology

    2021  Volume 178, Issue 12, Page(s) 2482–2495

    Abstract: Background and purpose: Glucocorticoids are the first line treatment for the flare-ups of inflammatory bowel disease, but they have significant limitations. The objective of this study is to investigate whether glucocorticoid epithelial actions ... ...

    Abstract Background and purpose: Glucocorticoids are the first line treatment for the flare-ups of inflammatory bowel disease, but they have significant limitations. The objective of this study is to investigate whether glucocorticoid epithelial actions contribute to such limitations.
    Experimental approach: Intestinal epithelium glucocorticoid receptor knockout mice (Nr3c1
    Key results: After 7 days of DSS Nr3c1
    Conclusions and implications: The intestinal epithelial glucocorticoid receptor has deleterious effects in experimental colitis induced by DSS, probably related to inhibition of epithelial proliferative responses leading to impaired wound healing and reduced endogenous corticosterone production.
    MeSH term(s) Animals ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/genetics ; Colon ; Dextran Sulfate ; Disease Models, Animal ; Inflammation ; Intestinal Mucosa ; Intestines ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Glucocorticoid/genetics
    Chemical Substances NR3C1 protein, mouse ; Receptors, Glucocorticoid ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2021-05-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15434
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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.146: Show issues Location:
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  9. Article: Immunoregulatory Effects of Porcine Plasma Protein Concentrates on Rat Intestinal Epithelial Cells and Splenocytes.

    Hernández-Chirlaque, Cristina / Aranda, Carlos J / Ocón, Borja / Polo, Javier / Martínez-Augustin, Olga / Sánchez de Medina, Fermín

    Animals : an open access journal from MDPI

    2021  Volume 11, Issue 3

    Abstract: Serum protein concentrates have been shown to exert in vivo anti-inflammatory effects. Specific effects on different cell types and their mechanism of action remain unraveled. We aimed to characterize the immunomodulatory effect of two porcine plasma ... ...

    Abstract Serum protein concentrates have been shown to exert in vivo anti-inflammatory effects. Specific effects on different cell types and their mechanism of action remain unraveled. We aimed to characterize the immunomodulatory effect of two porcine plasma protein concentrates, spray dried serum (SDS) and an immunoglobulin concentrate (IC), currently used as animal nutritional supplements with established in vivo immunomodulatory properties. Cytokine production by the intestinal epithelial cell line IEC18 and by primary cultures of rat splenocytes was studied. The molecular pathways involved were explored with specific inhibitors and gene knockdown. Our results indicate that both products induced GROα and MCP-1 production in IEC18 cells by a MyD88/NF-κB-dependent mechanism. Inhibition of TNF production was observed in rat primary splenocyte cultures. The immunoglobulin concentrate induced IL-10 expression in primary splenocytes and lymphocytes. The effect on TNF was independent of IL-10 production or the stimulation of NF-kB, MAPKs, AKT, or RAGE. In conclusion, SDS and IC directly regulate intestinal and systemic immune response in murine intestinal epithelial cells and in T lymphocytes and monocytes.
    Language English
    Publishing date 2021-03-13
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani11030807
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  10. Article ; Online: Leptin-resistant Zucker rats with trinitrobenzene sulfonic acid colitis present a reduced inflammatory response but enhanced epithelial damage.

    Rivero-Gutiérrez, Belén / Arredondo-Amador, María / Gámez-Belmonte, Reyes / Sánchez de Medina, Fermín / Martínez-Augustin, Olga

    American journal of physiology. Gastrointestinal and liver physiology

    2021  Volume 321, Issue 2, Page(s) G157–G170

    Abstract: The role of leptin in the development of intestinal inflammation remains controversial, since proinflammatory and anti-inflammatory effects have been described. This study describes the effect of the absence of leptin signaling in intestinal inflammation. ...

    Abstract The role of leptin in the development of intestinal inflammation remains controversial, since proinflammatory and anti-inflammatory effects have been described. This study describes the effect of the absence of leptin signaling in intestinal inflammation. Experimental colitis was induced by intrarectal administration of trinitrobenzene sulfonic acid (TNBS) to lean and obese Zucker rats (
    MeSH term(s) Alkaline Phosphatase/metabolism ; Animals ; Calgranulin A/metabolism ; Chemokine CXCL1/metabolism ; Colitis, Ulcerative/etiology ; Colitis, Ulcerative/metabolism ; Colitis, Ulcerative/pathology ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Intestinal Absorption ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Leptin/metabolism ; Lipopolysaccharides/pharmacology ; MAP Kinase Signaling System ; Male ; Nitric Oxide Synthase Type II/metabolism ; Peroxidase/metabolism ; Rats ; Rats, Zucker ; Receptors, Leptin/deficiency ; Receptors, Leptin/genetics ; STAT3 Transcription Factor/metabolism ; Tight Junction Proteins/metabolism ; Trinitrobenzenesulfonic Acid/toxicity ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Calgranulin A ; Chemokine CXCL1 ; Cxcl1 protein, rat ; Interleukin-6 ; Leptin ; Lipopolysaccharides ; Receptors, Leptin ; STAT3 Transcription Factor ; Stat3 protein, rat ; Tight Junction Proteins ; Tumor Necrosis Factor-alpha ; Trinitrobenzenesulfonic Acid (8T3HQG2ZC4) ; Peroxidase (EC 1.11.1.7) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, rat (EC 1.14.13.39) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2021-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00367.2020
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    Uc I Zs.89: Show issues Location:
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